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Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids
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“Complement proteins, including C1q and C3, are upregulated in AD brain tissues36 and cerebrospinal fluid87,91, where they are pivotal in neuroinflammation and synapse elimination88,92.”
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“It is suggested that C3 is mainly released by astrocytes [77] while C1q can be secreted by activated microglia [78, 79].”
Self-citationSynaptic Pruning by Microglia Is Necessary for Normal Brain Development
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Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
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“Autism spectrum disorder (ASD) is a major neurodevelopmental disorder that currently affects 1 in 36 children in the United States [1].”
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Sorted by citations
Niu, T., Wang, S., Zhang, H., Zhu, W., Liu, K., Zhou, X., Sun, R., Niu, D., & Yuan, Y. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01534-w · Cited by 7
Metadata
- Authors
- Wu, J., Zhang, J., Chen, X., Wettschurack, K., Que, Z., Deming, B. A., Olivero-Acosta, M. I., Cui, N., Eaton, M., Zhao, Y., Li, S. M., Suzuki, M., Chen, I., Xiao, T., Halurkar, M. S., Mandal, P., Yuan, C., Xu, R., Koss, W. A., Du, D., Chen, F., Wu, L.-J., & Yang, Y.
- Venue
- Molecular Psychiatry
- Published
- 2024-03-18
- Volume
- 29
- Issue
- 8
- Pages
- 2424-2437
- ISSN
- 1359-4184
- 1476-5578
- Cited by
- 75
- References
- 26
- Language
- en
- Licence
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS123154, R01NS117585)
- the FamilieSCN2A Foundation for the Hodgkin-Huxley Award
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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