Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice

Science

(2023) · doi:10.1126/science · Cited by 6,063 · see citing works

Neurobiology of addiction: a neurocircuitry analysis

Koob, G. F., & Volkow, N. D. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)00104-8 · Cited by 3,698 · see citing works

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046 · see citing works

Chemogenetics revealed: DREADD occupancy and activation via converted clozapine

Gomez, J. L., Bonaventura, J., Lesniak, W., Mathews, W. B., Sysa-Shah, P., Rodriguez, L. A., Ellis, R. J., Richie, C. T., Harvey, B. K., Dannals, R. F., et al. (2017) · Science · doi:10.1126/science.aan2475 · Cited by 980 · see citing works

Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice

Rhodes, J. S., Best, K., Belknap, J. K., Finn, D. A., & Crabbe, J. C. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.10.007 · Cited by 820 · see citing works

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

Krashes, M. J., Shah, B. P., Madara, J. C., Olson, D. P., Strochlic, D. E., Garfield, A. S., Vong, L., Pei, H., Watabe-Uchida, M., Uchida, N., et al. (2014) · Nature · doi:10.1038/nature12956 · Cited by 603 · see citing works

The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors

Bruchas, M. R., Land, B. B., & Chavkin, C. (2010) · Brain Research · doi:10.1016/j.brainres.2009.08.062 · Cited by 544 · see citing works

The Central Amygdala as an Integrative Hub for Anxiety and Alcohol Use Disorders

Gilpin, N. W., Herman, M. A., & Roberto, M. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.09.008 · Cited by 457 · see citing works

The Short‐Term Effects and Unintended Long‐Term Consequences of Binge Drinking in College: A 10‐Year Follow‐Up Study

Jennison, K. M. (2004) · The American Journal of Drug and Alcohol Abuse · doi:10.1081/ada-200032331 · Cited by 401 · see citing works

The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse

Wee, S., & Koob, G. F. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1825-8 · Cited by 398 · see citing works

Pharmacological evidence for a motivational role of κ-opioid systems in ethanol dependence

Walker, B. M., & Koob, G. F. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301438 · Cited by 392 · see citing works

The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice

Manvich, D. F., Webster, K. A., Foster, S. L., Farrell, M. S., Ritchie, J., Porter, J. H., & Weinshenker, D. (2018) · Scientific Reports · doi:10.1038/s41598-018-22116-z · Cited by 367 · see citing works

Mouse inbred strain differences in ethanol drinking to intoxication

Rhodes, J. S., Ford, M. M., Yu, C. ‐., Brown, L. L., Finn, D. A., Garland, T., & Crabbe, J. C. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00210.x · Cited by 340 · see citing works

Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence

Roberto, M., Cruz, M. T., Gilpin, N. W., Sabino, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S. G., Stouffer, D. G., Zorrilla, E. P., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.007 · Cited by 336 · see citing works

“Drinking in the dark” (DID) procedures: A model of binge-like ethanol drinking in non-dependent mice

Thiele, T. E., & Navarro, M. (2013) · Alcohol · doi:10.1016/j.alcohol.2013.08.005 · Cited by 268 · see citing works

Vital Signs: Binge Drinking Prevalence, Frequency, and Intensity Among Adults—United States, 2010

(2012) · JAMA · doi:10.1001/jama.307.9.908 · Cited by 250 · see citing works

Neurocircuitry of alcohol addiction

Koob, G. F. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00003-3 · Cited by 227 · see citing works

Preclinical studies of alcohol binge drinking

Crabbe, J. C., Harris, R. A., & Koob, G. F. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05895.x · Cited by 221 · see citing works

Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats

Walker, B. M., Zorrilla, E. P., & Koob, G. F. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00226.x · Cited by 202 · see citing works

NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking

Pleil, K. E., Rinker, J. A., Lowery-Gionta, E. G., Mazzone, C. M., McCall, N. M., Kendra, A. M., Olson, D. P., Lowell, B. B., Grant, K. A., Thiele, T. E., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3972 · Cited by 195 · see citing works

Continuity of Binge and Harmful Drinking From Late Adolescence to Early Adulthood

McCarty, C. A., Ebel, B. E., Garrison, M. M., DiGiuseppe, D. L., Christakis, D., & Rivara, F. P. (2004) · PEDIATRICS · doi:10.1542/peds.2003-0864-l · Cited by 180 · see citing works

Involvement of dynorphin and the kappa opioid receptor in feeding

Morley, J. E., & Levine, A. S. (1983) · Peptides · doi:10.1016/0196-9781(83)90069-4 · Cited by 172 · see citing works

A Line of Mice Selected for High Blood Ethanol Concentrations Shows Drinking in the Dark to Intoxication

Crabbe, J. C., Metten, P., Rhodes, J. S., Yu, C.-H., Brown, L. L., Phillips, T. J., & Finn, D. A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.002 · Cited by 163 · see citing works

κ1 Receptor mRNA Distribution in the Rat CNS: Comparison to κ Receptor Binding and Prodynorphin mRNA

Mansour, A., Fox, C. A., Meng, F., Akil, H., & Watson, S. J. (1994) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1994.1015 · Cited by 154 · see citing works

Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice

Lowery-Gionta, E. G., Navarro, M., Li, C., Pleil, K. E., Rinker, J. A., Cox, B. R., Sprow, G. M., Kash, T. L., & Thiele, T. E. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6256-11.2012 · Cited by 149 · see citing works

The one-two punch of alcoholism: role of central amygdala dynorphins/kappa-opioid receptors

Kissler, J. L., Sirohi, S., Reis, D. J., Jansen, H. T., Quock, R. M., Smith, D. G., & Walker, B. M. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.014 · Cited by 145 · see citing works

“Drinking in the Dark” (DID): A Simple Mouse Model of Binge‐Like Alcohol Intake

Thiele, T. E., Crabbe, J. C., & Boehm, S. L. (2014) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0949s68 · Cited by 140 · see citing works

Presynaptic Inhibition of Gamma-Aminobutyric Acid Release in the Bed Nucleus of the Stria Terminalis by Kappa Opioid Receptor Signaling

Li, C., Pleil, K. E., Stamatakis, A. M., Busan, S., Vong, L., Lowell, B. B., Stuber, G. D., & Kash, T. L. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.015 · Cited by 139 · see citing works

CRF-1 Antagonist and CRF-2 Agonist Decrease Binge-Like Ethanol Drinking in C57BL/6J Mice Independent of the HPA Axis

Lowery, E. G., Spanos, M., Navarro, M., Lyons, A. M., Hodge, C. W., & Thiele, T. E. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.209 · Cited by 137 · see citing works

Supersensitive kappa opioid receptors promotes ethanol withdrawal-related behaviors and reduce dopamine signaling in the nucleus accumbens

Rose, J. H., Karkhanis, A. N., Chen, R., Gioia, D., Lopez, M. F., Becker, H. C., McCool, B. A., & Jones, S. R. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv127 · Cited by 136 · see citing works

Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction

Chartoff, E. H., & Mavrikaki, M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00466 · Cited by 134 · see citing works

Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment

Crowley, N. A., & Kash, T. L. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.01.001 · Cited by 132 · see citing works

Amygdala and bed nucleus of the stria terminalis circuitry: Implications for addiction-related behaviors

Stamatakis, A. M., Sparta, D. R., Jennings, J. H., McElligott, Z. A., Decot, H., & Stuber, G. D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.046 · Cited by 132 · see citing works

Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System

Karkhanis, A. N., Rose, J. H., Weiner, J. L., & Jones, S. R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.21 · Cited by 131 · see citing works

Extended Amygdala to Ventral Tegmental Area Corticotropin-Releasing Factor Circuit Controls Binge Ethanol Intake

Rinker, J. A., Marshall, S. A., Mazzone, C. M., Lowery‐Gionta, E. G., Gulati, V., Pleil, K. E., Kash, T. L., Navarro, M., & Thiele, T. E. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.02.029 · Cited by 130 · see citing works

Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration

Sperling, R. E., Gomes, S. M., Sypek, E. I., Carey, A. N., & McLaughlin, J. P. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1844-5 · Cited by 127 · see citing works

Coexpression of prodynorphin and corticotrophin‐releasing hormone in the rat central amygdala: Evidence of two distinct endogenous opioid systems in the lateral division

Marchant, N. J., Densmore, V. S., & Osborne, P. B. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21464 · Cited by 123 · see citing works

Duration of Action of a Broad Range of Selective κ-Opioid Receptor Antagonists Is Positively Correlated with c-Jun N-Terminal Kinase-1 Activation

Melief, E. J., Miyatake, M., Carroll, F. I., Béguin, C., Carlezon, W. A., Cohen, B. M., Grimwood, S., Mitch, C. H., Rorick‐Kehn, L. M., & Chavkin, C. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.074195 · Cited by 105 · see citing works

The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety

Schank, J. R., Goldstein, A., Rowe, K. E., King, C. E., Marusich, J. A., Wiley, J. L., Carroll, F. I., Thorsell, A., & Heilig, M. A. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00455.x · Cited by 101 · see citing works

Sex Differences in Sensitivity to the Depressive-like Effects of the Kappa Opioid Receptor Agonist U-50488 in Rats

Russell, S. E., Rachlin, A. B., Smith, K. L., Muschamp, J. W., Berry, L., Zhao, Z., & Chartoff, E. H. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.042 · Cited by 101 · see citing works

Orexin-1 and orexin-2 receptor antagonists reduce ethanol self-administration in high-drinking rodent models

Anderson, R. I., Becker, H. C., Adams, B. L., Jesudason, C. D., & Rorick‐Kehn, L. M. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00033 · Cited by 98 · see citing works

Dynorphin–Still an Extraordinarily Potent Opioid Peptide

Chavkin, C. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.083337 · Cited by 94 · see citing works

The neurobiology of binge-like ethanol drinking: Evidence from rodent models

Sprow, G. M., & Thiele, T. E. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.12.026 · Cited by 94 · see citing works

Oxytocin reduces ethanol self-administration in mice

King, C. E., Griffin, W. C., Luderman, L. N., Kates, M. M., McGinty, J. F., & Becker, H. C. (2017) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.13359 · Cited by 89 · see citing works

Central opioid receptor subtype antagonists differentially alter sucrose and deprivation-induced water intake in rats

Beczkowska, I. W., Bowen, W. D., & Bodnar, R. J. (1992) · Brain Research · doi:10.1016/0006-8993(92)91289-q · Cited by 88 · see citing works

Discovery of Aminobenzyloxyarylamides as κ Opioid Receptor Selective Antagonists: Application to Preclinical Development of a κ Opioid Receptor Antagonist Receptor Occupancy Tracer

Mitch, C. H., Quimby, S. J., Diaz, N., Pedregal, C., de la Torre, M. G., Jiménez, A., Shi, Q., Canada, E. J., Kahl, S. D., Statnick, M. A., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200789r · Cited by 88 · see citing works

Effects of acute ethanol on opioid peptide release in the central amygdala: an in vivo microdialysis study

Lam, M. P., Marinelli, P. W., Bai, L., & Gianoulakis, C. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1267-8 · Cited by 86 · see citing works

Role of the Dynorphin/Kappa Opioid Receptor System in the Motivational Effects of Ethanol

Anderson, R. I., & Becker, H. C. (2017) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.13406 · Cited by 79 · see citing works

Central Neuropeptide Y Modulates Binge-Like Ethanol Drinking in C57BL/6J Mice via Y1 and Y2 Receptors

Sparrow, A. M., Lowery‐Gionta, E. G., Pleil, K. E., Li, C., Sprow, G. M., Cox, B. R., Rinker, J. A., Jijon, A. M., Peňa, J., Navarro, M., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.327 · Cited by 73 · see citing works

Preclinical evaluation of the kappa-opioid receptor antagonist CERC-501 as a candidate therapeutic for alcohol use disorders

Domi, E., Barbier, E., Augier, E., Augier, G., Gehlert, D. R., Barchiesi, R., Thorsell, A., Holm, L., & Heilig, M. A. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0015-y · Cited by 73 · see citing works

Stress-Induced Enhancement of Ethanol Intake in C57BL/6J Mice with a History of Chronic Ethanol Exposure: Involvement of Kappa Opioid Receptors

Anderson, R. I., Lopez, M. F., & Becker, H. C. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00045 · Cited by 69 · see citing works

Effects of kappa opioid receptors on conditioned place aversion and social interaction in males and females

Robles, C. F., McMackin, M. Z., Campi, K. L., Doig, I. E., Takahashi, E. Y., Pride, M. C., & Trainor, B. C. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.01.003 · Cited by 65 · see citing works

Binge‐Like Consumption of Ethanol and Other Salient Reinforcers is Blocked by Orexin‐1 Receptor Inhibition and Leads to a Reduction of Hypothalamic Orexin Immunoreactivity

Olney, J. J., Navarro, M., & Thiele, T. E. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12591 · Cited by 64 · see citing works

Affective Cue-Induced Escalation of Alcohol Self-Administration and Increased 22-kHz Ultrasonic Vocalizations during Alcohol Withdrawal: Role of Kappa-Opioid Receptors

Berger, A. L., Williams, A. M., McGinnis, M. M., & Walker, B. M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.229 · Cited by 62 · see citing works

κ-Opioid Receptors in the Central Amygdala Regulate Ethanol Actions at Presynaptic GABAergic Sites

Kang-Park, M.-H., Kieffer, B. L., Roberts, A. J., Siggins, G. R., & Moore, S. D. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.202903 · Cited by 54 · see citing works

Dissociating Motivational From Physiological Withdrawal in Alcohol Dependence: Role of Central Amygdala κ-Opioid Receptors

Kissler, J. L., & Walker, B. M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.183 · Cited by 43 · see citing works

Interaction of CRF and Kappa Opioid Systems on GABAergic Neurotransmission in the Mouse Central Amygdala

Kang-Park, M.-H., Kieffer, B. L., Roberts, A. J., Siggins, G. R., & Moore, S. D. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.225870 · Cited by 37 · see citing works

Long-term ethanol effects on acute stress responses: modulation by dynorphin

Rácz, I., Markert, A., Mauer, D., Stoffel‐Wagner, B., & Zimmer, A. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00494.x · Cited by 36 · see citing works

Synergistic blockade of alcohol escalation drinking in mice by a combination of novel kappa opioid receptor agonist Mesyl Salvinorin B and naltrexone

Zhou, Y., Crowley, R. S., Ben, K. T., Prisinzano, T. E., & Kreek, M. J. (2017) · Brain Research · doi:10.1016/j.brainres.2017.02.027 · Cited by 21 · see citing works

Contribution of Dynorphin and Orexin Neuropeptide Systems to the Motivational Effects of Alcohol

Anderson, R. I., Moorman, D. E., & Becker, H. C. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_100 · Cited by 18 · see citing works

Kappa‐opioid receptors differentially regulate low and high levels of ethanol intake in female mice

Veer, A. V., Smith, K. L., Cohen, B. M., Carlezon, W. A., & Bechtholt, A. J. (2016) · Brain and Behavior · doi:10.1002/brb3.523 · Cited by 14 · see citing works

Untitled work

Barbero (2014) · doi:10.1016/j · Cited by 1 · see citing works

Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development

Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337 · see citing works

Alcohol and the brain: from genes to circuits

Egervári, G., Siciliano, C. A., Whiteley, E. L., & Dorit Ron, A. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.09.006 · Cited by 117 · see citing works

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Torruella-Suárez, M. L., Vandenberg, J. R., Cogan, E. S., Tipton, G. J., Teklezghi, A. T., Dange, K., Patel, G., McHenry, J. A., Hardaway, J. A., Kantak, P. A., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1466-19.2019 · Cited by 83 · see citing works

Kappa opioid receptor and dynorphin signaling in the central amygdala regulates alcohol intake

Bloodgood, D. W., Hardaway, J. A., Stanhope, C. M., Pati, D., Pina, M. M., Neira, S., Desai, S., Boyt, K. M., Palmiter, R. D., & Kash, T. L. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0690-z · Cited by 71 · see citing works

Circuit selectivity in drug versus natural reward seeking behaviors

Nall, R. W., Heinsbroek, J. A., Nentwig, T. B., Kalivas, P. W., & Bobadilla, A. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15297 · Cited by 59 · see citing works

Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies

Calleja‐Conde, J., Morales-Garcia, J. A., Echeverry‐Alzate, V., Bühler, K., Giné, E., & López‐Moreno, J. A. (2022) · Addiction Biology · doi:10.1111/adb.13229 · Cited by 54 · see citing works

Dynorphin and its role in alcohol use disorder

Karkhanis, A. N., & Al-Hasani, R. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146742 · Cited by 47 · see citing works

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Koob, G. F., & Vendruscolo, L. F. (2023) · Current topics in behavioral neurosciences · doi:10.1007/7854_2023_424 · Cited by 44 · see citing works

Behavioral and slice electrophysiological assessment of DREADD ligand, deschloroclozapine (DCZ) in rats

Nentwig, T. B., Obray, J. D., Vaughan, D. T., & Chandler, L. J. (2022) · Scientific Reports · doi:10.1038/s41598-022-10668-0 · Cited by 41 · see citing works

A balancing act: the role of pro‐ and anti‐stress peptides within the central amygdala in anxiety and alcohol use disorders

Walker, L. C. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15301 · Cited by 37 · see citing works

Chemogenetics as a neuromodulatory approach to treating neuropsychiatric diseases and disorders

Song, J., Patel, R. V., Sharif, M. S., Ashokan, A., & Michaelides, M. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.11.019 · Cited by 33 · see citing works

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Haun, H. L., Lebonville, C. L., Solomon, M. G., Griffin, W. C., Lopez, M. F., & Becker, H. C. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.01.002 · Cited by 33 · see citing works

Dynorphin/kappa opioid receptor system regulation on amygdaloid circuitry: Implications for neuropsychiatric disorders

Limoges, A., Yarur, H. E., & Tejeda, H. A. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.963691 · Cited by 33 · see citing works

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Estave, P. M., Spodnick, M. B., & Karkhanis, A. N. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2020_421 · Cited by 30 · see citing works

Kappa opioid receptors in the bed nucleus of the stria terminalis regulate binge-like alcohol consumption in male and female mice

Haun, H. L., Griffin, W. C., Lopez, M. F., & Becker, H. C. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.107984 · Cited by 30 · see citing works

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Peters, C., He, S., Fermani, F., Lim, H., Ding, W., Mayer, C., & Klein, R. (2023) · Science Advances · doi:10.1126/sciadv.adf6521 · Cited by 29 · see citing works

κ Opioid Receptor-Dynorphin Signaling in the Central Amygdala Regulates Conditioned Threat Discrimination and Anxiety

Baird, M. A., Hsu, T. Y., Wang, R., Juarez, B., & Zweifel, L. S. (2020) · eNeuro · doi:10.1523/eneuro.0370-20.2020 · Cited by 28 · see citing works

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Heilig, M. A., Witkiewitz, K. A., Ray, L. A., & Leggio, L. (2024) · Journal of Clinical Investigation · doi:10.1172/jci172889 · Cited by 27 · see citing works

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Herman, M. A., & Quadir, S. G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00170-5 · Cited by 26 · see citing works

Central nucleus of the amygdala projections onto the nucleus accumbens core regulate binge-like alcohol drinking in a CRF-dependent manner

Borrego, M. B., Grigsby, K. B., Townsley, K. G., Chan, A. E., Firsick, E. J., Tran, A., Savarese, A. M., & Ozburn, A. R. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108874 · Cited by 24 · see citing works

NOP Receptor Antagonists Decrease Alcohol Drinking in the Dark in C57BL/6J Mice

Brunori, G., Weger, M., Schoch, J., Targowska‐Duda, K. M., Barnes, M., Borruto, A. M., Rorick‐Kehn, L. M., Zaveri, N. T., Pintar, J. E., Ciccocioppo, R., et al. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14165 · Cited by 21 · see citing works

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King, C. E., Griffin, W. C., Lopez, M. F., & Becker, H. C. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01046-x · Cited by 21 · see citing works

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Cameron, C. M., Nieto, S. J., Bosler, L., Wong, M. H., Bishop, I., Mooney, L. J., & Cahill, C. M. (2021) · Advances in Drug and Alcohol Research · doi:10.3389/adar.2021.10009 · Cited by 20 · see citing works

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Lorente, J. D., Cuitavi, J., Campos‐Jurado, Y., Montón-Molina, R., González-Romero, J. L., & Hipólito, L. (2021) · Pain · doi:10.1097/j.pain.0000000000002332 · Cited by 19 · see citing works

Neuropeptides and Neurotransmission

Gantait, A. M., Bataineh, Y. A., Surchi, H. S., Gantait, A., Rani, G. T., Paul, P., Kokaz, S. F., Al-Jaidi, B. A., Kumar, P., Karan, S., et al. (2020) · Springer eBooks · doi:10.1007/978-981-15-3556-7_16 · Cited by 18 · see citing works

Differential regulation of alcohol consumption and reward by the transcriptional cofactor LMO4

Maiya, R., Pomrenze, M. B., Tran, T. N. A., Tiwari, G. R., Beckham, A., Paul, M. T., Mayfield, R. D., & Messing, R. O. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0706-8 · Cited by 17 · see citing works

Stress‐related neuropeptide systems as targets for treatment of alcohol addiction: A clinical perspective

Heilig, M. A. (2023) · Journal of Internal Medicine · doi:10.1111/joim.13636 · Cited by 17 · see citing works

Intra-dorsolateral striatal AMPA receptor antagonism reduces binge-like alcohol drinking in male and female C57BL/6J mice

Bauer, M. R., McVey, M. M., Germano, D. M., Zhang, Y., & Boehm, S. L. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113631 · Cited by 13 · see citing works

The Dynorphin/-Opioid Receptor System at the Interface of Hyperalgesia/Hyperkatifeia and Addiction

Marchette, R. C. N., Vendruscolo, L. F., & Koob, G. F. (2025) · Current Addiction Reports · doi:10.1007/s40429-025-00618-x · Cited by 13 · see citing works

Gut Microbiome-Liver-Brain axis in Alcohol Use Disorder. The role of gut dysbiosis and stress in alcohol-related cognitive impairment progression: possible therapeutic approaches

Pich, E. M., Tarnanas, I., Brigidi, P., & Collo, G. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100713 · Cited by 13 · see citing works

A critical review of effects on ethanol intake of the dynorphin/kappa opioid receptor system in the extended amygdala: From inhibition to stimulation

Pirino, B. E., Kelley, A. M., Karkhanis, A. N., & Barson, J. R. (2023) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15078 · Cited by 13 · see citing works

Naloxone-induced analgesia mediated by central kappa opioid system in chronic inflammatory pain

Lee, G. J., Kim, S. A., Kim, Y. J., & Oh, S. B. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147445 · Cited by 12 · see citing works

Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms

Özkan-Kotiloğlu, S., Kaya-Akyüzlü, D., Yurdakul, R., Yıldırım, M. A., & İlhan, İ. Ö. (2023) · Alcohol and Alcoholism · doi:10.1093/alcalc/agad036 · Cited by 12 · see citing works

Regulation of alcohol drinking by ventral striatum and extended amygdala circuitry

Borrego, M. B., Chan, A. E., & Ozburn, A. R. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109074 · Cited by 11 · see citing works

Self-Administration of Entactogen Psychostimulants Dysregulates Gamma-Aminobutyric Acid (GABA) and Kappa Opioid Receptor Signaling in the Central Nucleus of the Amygdala of Female Wistar Rats

Khom, S., Nguyen, J. D., Vandewater, S. A., Grant, Y., Roberto, M., & Taffe, M. A. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.780500 · Cited by 10 · see citing works

Insula Dynorphin and Kappa Opioid Receptor Systems Regulate Alcohol Drinking in a Sex-Specific Manner in Mice

Pina, M. M., Pati, D., Neira, S., Taxier, L. R., Stanhope, C. M., Mahoney, A. A., D’Ambrosio, S., Kash, T. L., & Navarro, M. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0406-22.2023 · Cited by 10 · see citing works

Kappa-opioid receptor stimulation in the nucleus accumbens shell and ethanol drinking: Differential effects by rostro-caudal location and level of drinking

Pirino, B. E., Hawks, A., Carpenter, B. A., Candelas, P. G., Gargiulo, A. T., Curtis, G. R., Karkhanis, A. N., & Barson, J. R. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01850-1 · Cited by 10 · see citing works

Subregional Differences in Alcohol Modulation of Central Amygdala Neurocircuitry

Melkumyan, M., & Silberman, Y. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.888345 · Cited by 9 · see citing works

Acute and chronic alcohol modulation of extended amygdala calcium dynamics

Roland, A. V., Chao, T.-H. H., Hon, O. J., Machinski, S. N., Sides, T. R., Lee, S. I., Shih, Y. I., & Kash, T. L. (2024) · Alcohol · doi:10.1016/j.alcohol.2024.02.004 · Cited by 9 · see citing works

The pharmacological stressor yohimbine, but not U50,488, increases responding for conditioned reinforcers paired with ethanol or sucrose

Tabbara, R. I., Rahbarnia, A., Lê, A. D., & Fletcher, P. J. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05647-0 · Cited by 9 · see citing works

Emerging medications and pharmacological treatment approaches for substance use disorders

Raymond, J. S., Athanasopoulos, A. G., Badolato, C. J., Doolan, T. M., Scicluna, R. L., Everett, N. A., Bowen, M. T., & James, M. H. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173952 · Cited by 8 · see citing works

Leveraging Neural Networks in Preclinical Alcohol Research

Smith, L. C., & Kimbrough, A. (2020) · Brain Sciences · doi:10.3390/brainsci10090578 · Cited by 8 · see citing works

Voluntary Exercise Ameliorates Chronic Ethanol Withdrawal-Induced Adaptations of Opioid Receptor Expression in the Nucleus Accumbens, Dopamine Release, and Ethanol Consumption

Nelson, C. A., Brundage, J., Williams, B. M., Baldridge, J., Stockard, A. L., Bassett, C. H., Burger, B. J., Gunter, B. T., Payne, A. J., Yorgason, J. T., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12071593 · Cited by 6 · see citing works

Kappa-opioid receptor activation reinstates nicotine self-administration in mice

Gowrishankar, R., Gomez, A. M., Walicki, M. C., & Bruchas, M. R. (2022) · Addiction Neuroscience · doi:10.1016/j.addicn.2022.100017 · Cited by 6 · see citing works

Dynamic regulation of CeA gene expression during acute and protracted abstinence from chronic binge drinking of male and female C57BL/6J mice

Méndez, H. G., Neira, S., Flanigan, M. E., Haun, H. L., Boyt, K. M., Thiele, T. E., & Kash, T. L. (2024) · Alcohol · doi:10.1016/j.alcohol.2024.06.005 · Cited by 5 · see citing works

Activation of the dorsal septum increases alcohol consumption in male C57BL/6J mice

Haun, H. L., D’Ambrosio, S., Pati, D., Taxier, L. R., & Kash, T. L. (2022) · Addiction Neuroscience · doi:10.1016/j.addicn.2022.100023 · Cited by 5 · see citing works

Diastereoselective synthesis of conformationally restricted KOR agonists

Ilari, D., Maskri, S., Schepmann, D., Köhler, J., Daniliuc, C. G., Koch, O., & Wünsch, B. (2021) · Organic & Biomolecular Chemistry · doi:10.1039/d1ob00398d · Cited by 5 · see citing works

The Role of the Dynorphin/Kappa Opioid Receptor System in the Actions of Alcohol

Sureshkumar, K., Go, J., Tran, M., Malhotra, S., Ahmad, S. M., & Lutfy, K. (2022) · Psychoactives · doi:10.3390/psychoactives1020006 · Cited by 5 · see citing works

Acute Wheel-Running Increases Markers of Stress and Aversion-Related Signaling in the Basolateral Amygdala of Male Rats

Grigsby, K. B., Kerr, N. R., Kelty, T. J., Mao, X., Childs, T. E., & Booth, F. W. (2022) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk8010006 · Cited by 5 · see citing works

Binge ethanol consumption can be attenuated by systemic administration of minocycline and is associated with enhanced neuroinflammation in the central amygdala

Schrank, S., Sevigny, J. P., Yunus, N. I., Vetter, K., Aguilar, O. D., Ily, V., Valchinova, M., Keinath, A. T., & Sparta, D. R. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110174 · Cited by 4 · see citing works

Epigenetic and Transcriptional Control of the Opioid Prodynorphine Gene: In-Depth Analysis in the Human Brain

Nosova, O., Bazov, I., Karpyak, V. M., Hallberg, M., & Bakalkin, G. Y. (2021) · Molecules · doi:10.3390/molecules26113458 · Cited by 4 · see citing works

Manipulations of central amygdala neurotensin neurons alter the consumption of ethanol and sweet fluids in micePreprint

Torruella-Suárez, M. L., Vandenberg, J. R., Cogan, E. S., Tipton, G. J., Teklezghi, A., Dange, K., Patel, G. K., McHenry, J. A., Hardaway, J. A., Kantak, P. A., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/245274 · Cited by 4 · see citing works

Alcohol drinking is associated with greater calcium activity in mouse central amygdala dynorphin-expressing neurons

Lebonville, C. L., Rinker, J. A., O’Hara, K., McMahan, C. S., Hoffman, M., Becker, H. C., & Mulholland, P. J. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111445 · Cited by 3 · see citing works

Imaging Kappa Opioid Receptors in the Living Brain with Positron Emission Tomography

Placzek, M. S. (2021) · Handbook of experimental pharmacology · doi:10.1007/164_2021_498 · Cited by 3 · see citing works

Acute and chronic alcohol modulation of extended amygdala calcium dynamicsPreprint

Roland, A. V., Chao, T.-H. H., Hon, O. J., Machinski, S. N., Sides, T. R., Lee, S. I., Shih, Y. I., & Kash, T. L. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.10.561741 · Cited by 2 · see citing works

Kappa opioid receptor antagonism in neuropsychiatry: from molecular mechanisms to clinical prospects

Wang, H., Ji, Y., Huang, J., Yang, S., Zhang, Q., Hu, S., Xu, X., & Yang, C. (2026) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-026-02216-y · Cited by 1 · see citing works

Repeated cycles of binge‐like ethanol consumption and abstinence alter neuropeptide m RNA in prefrontal and insular cortex, amygdala, and lateral hypothalamus of male and female C 57 BL /6 J mice

Dankert, A. M., Kash, T. L., & Thiele, T. E. (2025) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15536 · Cited by 1 · see citing works

Alcohol

(2021) · Elsevier eBooks · doi:10.1016/b978-0-12-816793-9.00001-3

Salvia divinorum: un estudio fenomenológico y cognitivo de la experiencia en usuarios de Latinoamérica y España.

Nava-Gomez, L. J., & González-González, J. C. (2022) · Revista Iberoamericana ConCiencia. · doi:10.32654/concienciaepg/eds.especial-9

Comorbidities Are Complex: The Dynorphin/Kappa Opioid Receptor System in a Preclinical Model of Stress and Alcohol

Conway, S. M., & Al‐Hasani, R. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.04.005

Evaluating the molecular drivers of physical inactivity and muscle atrophy as initiating factors in cognitive impairment

Kerr, N. R. (2023) · doi:10.32469/10355/97056

BLA KOR inputs to the BNST regulate social stress-escalated alcohol consumptionPreprint

Paliarin, F., Duplantis, C., Doré, E., Basavanhalli, S., Weiser, E., Jones, T. W., & Maiya, R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.07.622470

Proteomic analysis of central amygdala systems regulated by mifepristone in the context of alcohol dependence

Lee, S., Romero, L. M., Lammons, J. W., Klein, J. M., Edwards, K. N., Guidry, J. J., & Edwards, S. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110728

Divergent ethanol drinking phenotypes are linked to region-specific dysregulation of serotonin systems in the mouse brainPreprint

George, B. E., Vidrascu, E., Neira, S., Devine, M. P., & Kash, T. L. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.30.702832

G9a inhibition reduces stress‐potentiated alcohol drinking in both male and female mice: Implications for safe and effective pharmacological therapeutics for alcohol use disorder

Holmes, D., Lopez, M. F., Becker, H. C., Cowan, C. W., & Anderson, E. M. (2026) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.70277

Voluntary cocaine or sugar intake induce neuroadaptations of the endocannabinoid system in reward-related brain regions

Nogueira, D. D. S. (2019) · theses.fr (ABES) · doi:10.70675/d429d5dbz5001z4e60z9622z4f636e667f17

A dorsolateral BNST–parabrachial nucleus pathway regulates adolescent alcohol-induced negative affect in females

Albrechet‐Souza, L., & Wills, T. A. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111760

Kappa opioid receptor and dynorphin signaling in the central amygdala regulates alcohol intake

Bloodgood, D. W., Hardaway, J. A., Stanhope, C. M., Pati, D., Pina, M. M., Neira, S., Desai, S., Boyt, K. M., Palmiter, R. D., & Kash, T. L. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0690-z · Cited by 71 · see citing works

Dynorphin/Kappa Opioid Receptor Activity Within the Extended Amygdala Contributes to Stress-Enhanced Alcohol Drinking in Mice

Haun, H. L., Lebonville, C. L., Solomon, M. G., Griffin, W. C., Lopez, M. F., & Becker, H. C. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.01.002 · Cited by 33 · see citing works

A critical review of effects on ethanol intake of the dynorphin/kappa opioid receptor system in the extended amygdala: From inhibition to stimulation

Pirino, B. E., Kelley, A. M., Karkhanis, A. N., & Barson, J. R. (2023) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15078 · Cited by 13 · see citing works

ASSA14-04-01 Long-Term efficiency of percutaneous transluminal septal myocardial ablation for hypertrophic obstractive cardiomyopathy

Xiaozeng, W., Xing-Xing, L., Jie, D., Gu, R., & Yaling, H. (2014) · Heart · doi:10.1136/heartjnl-2014-307109.67

Kappa opioid receptors in the bed nucleus of the stria terminalis regulate binge-like alcohol consumption in male and female mice

Haun, H. L., Griffin, W. C., Lopez, M. F., & Becker, H. C. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.107984 · Cited by 30 · see citing works