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Black Tea drinks with inulin and dextrin reduced postprandial plasma glucose fluctuations in patients with type 2 diabetes: an acute, randomized, placebo-controlled, single-blind crossover study

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Chen, Si, Peng, Danfeng, Shan, Yingyi, Liu, Fengjing, Du, Ronghui, Bao, Yuqian, Yu, Haoyong, Tu, Yinfang·2024·Nutrition & Diabetes
DOI 10.1038/s41387-024-00351-wPMC PMC11608310
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Abstract

BACKGROUND: This study evaluated the effects of black tea drinks with inulin and dextrin (BTID) on postprandial plasma glucose (PG) in patients with type 2 diabetes mellitus (T2DM). METHODS: An acute, randomized, double-blind, placebo-controlled, crossover clinical trial was carried out on T2DM patients. The subjects were randomly assigned to groups consuming placebo black tea powder or BTID (identically packaged) followed by a mixed meal tolerance test (MMTT). Afterwards, individuals who initially consumed BTID were given the placebo and those who initially consumed the placebo were given BTID. RESULTS: A total of 35 patients were included in the study, and 32 completed the study. Compared to placebo, BTID significantly reduced the change in glycaemia at 30 min, 1, 2, and 3 h during the MMTT. In the analysis of PG fluctuations at 2 h during the MMTT, the proportion of patients with minor PG fluctuations (< 2.8 mmol/L) in the BTID group was 53.1%, significantly higher than the 28.1% in the placebo group. Binary logistic regression analysis revealed that the risk of significant PG fluctuations decreased by 65.5% after consuming BTID, with a corresponding odds ratio of 0.345 (P = 0.044, 95% CI 0.122-0.974). In addition, the areas under the curve for PG and insulin secretion after BTID administration were significantly smaller than that for placebo. CONCLUSIONS: Compared to placebo, BTID significantly reduced the change in PG levels during the MMTT and decreased the risk of large PG fluctuations by 65.5%. These effects were associated to a significant reduction in postprandial insulin secretion and may help to improved insulin sensitivity and a lower β-cell burden.

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  • Comparable studies examining postprandial glucose dynamics observed favorable responses with prebiotic beverages independent of available CHO content.

    “Thus, it is worthwhile to note that comparable studies examining postprandial glucose dynamics observed favorable responses with prebiotic beverages independent of available CHO content (21,22).”

    From Prebiotic soda lowers postprandial glucose compared to traditional soda pop: a randomized controlled trial (2025) · cites this paper as [22]

    The Discussion (page unavailable) reports smaller postprandial plasma-glucose increases with black tea containing inulin and resistant dextrin than with placebo black tea. The Methods describe the same mixed meal in both conditions, and the Introduction calls the added fibres nondigestible. However, the paper does not establish that the favorable response was independent of available carbohydrate (CHO) content; the Discussion also notes that the study lacked controls needed to rule out other factors. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • The prebiotic blend reduced mixed-meal postprandial glucose and insulin AUC compared to the non-prebiotic tea beverage control.

    “The prebiotic blend reduced mixed-meal postprandial glucose and insulin AUC compared to the non-prebiotic tea beverage control.”

    From Prebiotic soda lowers postprandial glucose compared to traditional soda pop: a randomized controlled trial (2025) · cites this paper as [22]

  • A recent study measured the 0-3 h postprandial glucose response to an inulin-dextrin tea supplement paired with a standardized mixed meal in adults with type 2 diabetes.

    “Specifically, a recent study measured the 0-3 h postprandial glucose response to an inulin-dextrin tea supplement paired with a standardized mixed meal in adults with type 2 diabetes (22).”

    From Prebiotic soda lowers postprandial glucose compared to traditional soda pop: a randomized controlled trial (2025) · cites this paper as [22]

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Cited by

Sorted by citations

Authors
Chen, S., Peng, D., Shan, Y., Liu, F., Du, R., Bao, Y., Yu, H., & Tu, Y.
Affiliations
Shanghai Jiao Tong University (CN)
Corresponding author
  • Yu, Haoyong
  • Tu, Yinfang
ORCID
Venue
Nutrition & Diabetes
Publisher
Springer Science and Business Media LLC
Published
2024-11-30
Volume
14
Issue
1
Pages
95-95
ISSN
2044-4052 (ISSN-L)
DOI
10.1038/s41387-024-00351-w
PMC
PMC11608310
OpenAlex
W4404880877
Cited by
8
References
1
Citations by year
2026: 7 · 2025: 1
FWCI
2.35
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrition and Diabetes (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (822MS207)
  • Science and Technology Commission of Shanghai Municipality (21Y11910900)
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
black tea, inulin, dextrin, type 2 diabetes, postprandial blood glucose, glucose fluctuations, mixed meal tolerance test, postprandial insulin secretion, insulin sensitivity, functional foods
MeSH terms
Adult, Aged, Blood Glucose, Dextrins, Diabetes Mellitus, Type 2, Double-Blind Method, Female, Humans, Insulin, Inulin, Male, Middle Aged, Tea, Single-Blind Method, Cross-Over Studies, Postprandial Period

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