High-Fiber Cereal Reduces Postprandial Insulin Responses in Hyperinsulinemic but not Normoinsulinemic Subjects
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OBJECTIVE—The objective of this study was to compare the plasma glucose and insulin responses elicited by two ready-to-eat breakfast cereals (one being high and the other being low in cereal fiber) and to see if the differences in response depended on subjects’ fasting plasma insulin. RESEARCH DESIGN AND METHODS—Nondiabetic men (n = 77) were studied on two occasions after 10- to 14-h overnight fasts. They consumed 25 g of available carbohydrate from high- or low-fiber breakfast cereals in random order with blood taken at intervals for 2 h. Data from the 42 men with high fasting plasma insulin (FPI) on screening (>40 pmol/l) were compared with those from the 35 men with normal FPI (≤40 pmol/l). RESULTS—Hyperinsulinemic men had significantly higher waist circumference and BMI, lower HDL cholesterol, and a trend toward higher triglycerides (P = 0.07) than control subjects. In all 77 subjects, the incremental area under the glucose response curve (AUC) after high-fiber cereal was 11.8 ± 5.5% (P = 0.036) less than after low-fiber cereal with the reductions being equivalent in the hyperinsulinemic (12.6 ± 8.3%) and control (10.9 ± 9.1%) groups. However, insulin peak rise was reduced by the high-fiber cereal only in hyperinsulinemic men (351 ± 29 vs. 485 ± 55 pmol/l) but not in control subjects (211 ± 20 vs. 220 ± 20 pmol/l; cereal × group interaction P = 0.044). Insulin AUC after the high-fiber cereal, expressed as a percentage of that after low-fiber cereal, was negatively related to FPI (P = 0.009) but not to age, BMI, or waist circumference. CONCLUSIONS—The high-fiber cereal reduced glucose responses to the same extent in normal and hyperinsulinemic men, but reduced insulin responses only in hyperinsulinemic subjects.
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An insulin index is likely to be influenced by the pathophysiological status of the test subject.
“Moreover, an insulin index is likely to be influenced by the pathophysiological status of the test subject (Wolever et al. 2004).”
From Glycaemic index methodology (2005) · cites this paper as Wolever et al. 2004
In an interlaboratory GI study, laboratories using venous blood returned CI of 50%, compared with 30% in laboratories using capillary blood.
“This has been confirmed directly in the interlaboratory study of GI, in which laboratories taking venous blood returned CI of .50 %, compared with , 30 % in all laboratories using capillary blood (Wolever et al. 2002(Wolever et al. , 2004)).”
From Glycaemic index methodology (2005) · cites this paper as Wolever et al. 2004
The Research Design and Methods passages (page not supplied) describe a single study comparing responses to high- and low-fiber cereals, not an interlaboratory GI study. Searches for venous versus capillary blood and the claimed 50% versus 30% confidence intervals found no passage addressing that comparison in our copy. (LLM, conf=0.75)
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Self-citationArabinoxylan-enriched meal increases serum ghrelin levels in healthy humans
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Continuous Glucose Monitoring in Gastroparesis
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- Authors
- Wolever, T. M. S., Campbell, J. E., Geleva, D., & Anderson, G. H.
- Affiliations
- St. Michael's Hospital (CA)
- University of Toronto (CA)
- General Mills (United States) (US)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2004-06-01
- Volume
- 27
- Issue
- 6
- Pages
- 1281-1285
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2118573223
- Cited by
- 44
- References
- 9
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- General Mills
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- dietary fiber, postprandial insulin response, hyperinsulinemia, fasting insulin, plasma glucose response, insulin sensitivity, dyslipidemia, waist circumference
- MeSH terms
- Insulin Secretion, Adult, Aged, Edible Grain, Dietary Fiber, Fasting, Humans, Hyperinsulinism, Insulin, Kinetics, Male, Middle Aged, Reference Values, Postprandial Period
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