The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function
Open accessAbstract
Scribble (Scrib) is a key regulator of apicobasal polarity, presynaptic architecture, and short-term synaptic plasticity in Drosophila. In mammals, its homolog Scrib1 has been implicated in cancer, neural tube closure, and planar cell polarity (PCP), but its specific role in the developing and adult nervous system is unclear. Here, we used the circletail mutant, a mouse model for PCP defects, to show that Scrib1 is located in spines where it influences actin cytoskeleton and spine morphing. In the hippocampus of these mutants, we observed an increased synapse pruning associated with an increased number of enlarged spines and postsynaptic density, and a decreased number of perforated synapses. This phenotype was associated with a mislocalization of the signaling pathway downstream of Scrib1, leading to an overall activation of Rac1 and defects in actin dynamic reorganization. Finally, Scrib1-deficient mice exhibit enhanced learning and memory abilities and impaired social behavior, two features relevant to autistic spectrum disorders. Our data identify Scrib1 as a crucial regulator of brain development and spine morphology, and suggest that Scrib1(crc/+) mice might be a model for studying synaptic dysfunction and human psychiatric disorders.
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Mice mutant for the truncated circletail allele have enhanced learning and memory.
“Mice mutant for the truncated circletail allele have enhanced learning and memory (Moreau et al., 2010)”
From Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation (2019) · cites this paper as Moreau et al., 2010
Scribble loss alters synaptic maturation and pruning, with changes in learning, memory, and social behavior.
“Scribble loss alters synaptic maturation and pruning, with changes in learning, memory, and social behavior (Moreau et al., 2010).”
From Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation (2019) · cites this paper as Moreau et al., 2010
Scribble and the cadherin-catenin complex work together to recruit β-PIX, stimulating local actin polymerization and synaptic vesicle recruitment.
“Subsequent work reinforced connections between Scribble and the cadherin–catenin complex, suggesting that they work together to recruit the Rac/Cdc42 guanine nucleotide exchange factor β-PIX, stimulating local actin polymerization and synaptic vesicle recruitment (Fig. 3 A; Moreau et al., 2010; Sun and Bamji, 2011).”
From Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation (2019) · cites this paper as Moreau et al., 2010
Mouse Scribble is enriched at synapses of primary hippocampal neurons and in their spine precursors, where it colocalizes with the cadherin-catenin complex.
“Mouse Scribble is also enriched at synapses of primary hippocampal neurons (Sun et al., 2009) and in their “spine” precursors (Moreau et al., 2010), where it colocalizes with the cadherin–catenin complex.”
From Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation (2019) · cites this paper as Moreau et al., 2010
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Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works
Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-1848.2004.00076.x · Cited by 1,545 · cited 3× · see citing works
“Miceweretestedinatransparentplasticcagedividedintothreechambers (each20 (cid:5) 40 (cid:5) 22 cm) as previously described (Nadler et al., 2004; Jamainetal.,2008).”
InfluentialNMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
Lau, C. G., & Zukin, R. S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2153 · Cited by 1,159 · cited 1× · see citing works
“Many of these proteins belong to families that contain PSD-95/Discs-large/ZO-1 (PDZ) domains (Sheng and Hoogenraad, 2007), and have been implicated in trafficking and anchoring of synaptic proteins (Wenthold et al., 2003; Elias and Nicoll, 2007; Lau and Zukin, 2007; Shepherd and Huganir, 2007).”
The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View
Sheng, M., & Hoogenraad, C. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060805.160029 · Cited by 1,003 · see citing works
A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice
Tabuchi, K., Blundell, J., Etherton, M. R., Hammer, R. E., Liu, X., Powell, C. M., & Südhof, T. C. (2007) · Science · doi:10.1126/science.1146221 · Cited by 997 · see citing works
The cell biology of synaptic plasticity: AMPA receptor trafficking
Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978 · see citing works
Balancing Structure and Function at Hippocampal Dendritic Spines
Bourne, J. N., & Harris, K. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125646 · Cited by 916 · see citing works
Structure-stability-function relationships of dendritic spines
Kasai, H., Matsuzaki, M., Noguchi, J., Yasumatsu, N., & Nakahara, H. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00162-0 · Cited by 847 · see citing works
Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?
Fiala, J. C., Spacek, J., & Harris, K. M. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00158-3 · Cited by 811 · see citing works
Automated apparatus for quantitation of social approach behaviors in mice
Nadler, J. J., Moy, S. S., Dold, G., Trang, D., Simmons, N., Perez, A., Young, N. B., Barbaro, R. P., Piven, J., Magnuson, T. R., et al. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2004.00071.x · Cited by 775 · see citing works
Usui, T., Shima, Y., Shimada, Y., Hirano, S., Burgess, R. W., Schwarz, T. L., Takeichi, M., & Uemura, T. (1999) · Cell · doi:10.1016/s0092-8674(00)80046-x · Cited by 721 · see citing works
Identification of Vangl2 and Scrb1 as planar polarity genes in mammals
Montcouquiol, M., Rachel, R. A., Lanford, P. J., Copeland, N. G., Jenkins, N. A., & Kelley, M. W. (2003) · Nature · doi:10.1038/nature01618 · Cited by 705 · see citing works
Self-citationDani, V. S., Chang, Q., Maffei, A., Turrigiano, G. G., Jaenisch, R., & Nelson, S. B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506071102 · Cited by 639 · see citing works
Bourgeron, T. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.06.003 · Cited by 637 · cited 5× · see citing works
“These results show that Scrib1 plays a crucial role in regulating higher brain functions that might be relevant to ASD.”
InfluentialJamain, S., Radyushkin, K., Hammerschmidt, K., Granon, S., Boretius, S., Varoqueaux, F., Ramanantsoa, N., Gallego, J., Ronnenberg, A., Winter, D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711555105 · Cited by 556 · see citing works
A developmental change in NMDA receptor-associated proteins at hippocampal synapses
Sans, N., Petralia, R. S., Wang, Y.-X., Blahos, J., Hell, J. W., & Wenthold, R. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-03-01260.2000 · Cited by 537 · see citing works
Self-citationAssémat, E., Bazellières, E., Pallesi‐Pocachard, E., Bivic, A. L., & Massey‐Harroche, D. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.029 · Cited by 471 · see citing works
Tissue/planar cell polarity in vertebrates: new insights and new questions
Wang, Y., & Nathans, J. (2007) · Development · doi:10.1242/dev.02772 · Cited by 442 · see citing works
Behavioral phenotyping strategies for mutant mice
Crawley, J. N. (2008) · Neuron · doi:10.1016/j.neuron.2008.03.001 · Cited by 439 · see citing works
Zhan, L., Rosenberg, A., Bergami, K. C., Yu, M., Xuan, Z., Jaffe, A. B., Allred, C., & Muthuswamy, S. K. (2008) · Cell · doi:10.1016/j.cell.2008.09.045 · Cited by 436 · see citing works
Hikida, T., Jaaro-Peled, H., Seshadri, S., Oishi, K., Hookway, C., Kong, S., Wu, D., Xue, R., Andradé, M., Tankou, S. K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704774104 · Cited by 417 · see citing works
Wenthold, R. J., Prybylowski, K., Standley, S., Sans, N., & Petralia, R. S. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135803 · Cited by 363 · see citing works
Self-citationA GIT1/PIX/Rac/PAK Signaling Module Regulates Spine Morphogenesis and Synapse Formation through MLC
Zhang, H., Webb, D. J., Asmussen, H., Niu, S., & Horwitz, A. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3553-04.2005 · Cited by 354 · see citing works
Hung, A. Y., Futai, K., Sala, C., Valtschanoff, J. G., Ryu, J., Woodworth, M. A., Kidd, F. L., Sung, C. C., Miyakawa, T., Bear, M. F., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3032-07.2008 · Cited by 350 · see citing works
NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex
Sans, N., Prybylowski, K., Petralia, R. S., Chang, K., Wang, Y.-X., Racca, C., Vicini, S., & Wenthold, R. J. (2003) · Nature Cell Biology · doi:10.1038/ncb990 · Cited by 327 · see citing works
Self-citationMontcouquiol, M., Sans, N., Huss, D., Kach, J., Dickman, J. D., Forge, A., Rachel, R. A., Copeland, N. G., Jenkins, N. A., Bogani, D., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4680-05.2006 · Cited by 322 · see citing works
Self-citationDisruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse
Murdoch, J. N. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg014 · Cited by 308 · see citing works
Local protein synthesis, actin dynamics, and LTP consolidation
Bramham, C. R. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.09.013 · Cited by 301 · see citing works
Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized
Bienvenu, T., & Chelly, J. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1878 · Cited by 289 · see citing works
Synaptic trafficking of glutamate receptors by MAGUK scaffolding proteins
Elias, G. M., & Nicoll, R. A. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.07.005 · Cited by 288 · see citing works
Qin, Y., Capaldo, C., Gumbiner, B. M., & Macara, I. G. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200506094 · Cited by 285 · see citing works
Hayashi, M. L., Choi, S.-Y., Rao, B. S. S., Jung, H.-Y., Lee, H.-K., Zhang, D., Chattarji, S., Kirkwood, A., & Tonegawa, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.003 · Cited by 280 · see citing works
Protocadherin Celsr3 is crucial in axonal tract development
Tissir, F., Bar, I., Jossin, Y., Backer, O. D., & Goffinet, A. M. (2005) · Nature Neuroscience · doi:10.1038/nn1428 · Cited by 257 · see citing works
Tashiro, A., & Yuste, R. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.04.001 · Cited by 253 · see citing works
Targeting and activation of Rac1 are mediated by the exchange factor β-Pix
ten Klooster, J. P., Jaffer, Z. M., Chernoff, J., & Hordijk, P. L. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200509096 · Cited by 250 · see citing works
Junctional recruitment of mammalian Scribble relies on E-cadherin engagement
Navarro, C., Nola, S., Audebert, S., Santoni, M.-J., Arsanto, J.-P., Ginestier, C., Marchetto, S., Jacquemier, J., Isnardon, D., Le Bivic, A., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208632 · Cited by 237 · see citing works
Saneyoshi, T., Wayman, G. A., Fortin, D. A., Davare, M. A., Hoshi, N., Nozaki, N., Natsume, T., & Soderling, T. R. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.016 · Cited by 228 · see citing works
Mammalian Scribble Forms a Tight Complex with the βPIX Exchange Factor
Audebert, S., Navarro, C., Nourry, C., Chasserot-Golaz, S., Lécine, P., Bellaiche, Y., Dupont, J.-L., Premont, R. T., Sempéré, C., Strub, J.-M., et al. (2004) · Current Biology · doi:10.1016/j.cub.2004.05.051 · Cited by 218 · see citing works
NONCANONICAL WNT SIGNALING AND NEURAL POLARITY
Montcouquiol, M., Crenshaw, E. B., & Kelley, M. W. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112933 · Cited by 191 · see citing works
Self-citationEssential Role for the PKC Target MARCKS in Maintaining Dendritic Spine Morphology
Calabrese, B., & Halpain, S. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.027 · Cited by 187 · see citing works
Hines, R. M., Wu, L., Hines, D. J., Steenland, H. W., Mansour, S., Dahlhaus, R., Singaraja, R. R., Cao, X., Sammler, E. M., Hormuzdi, S. G., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0032-08.2008 · Cited by 177 · see citing works
Early Forebrain Wiring: Genetic Dissection Using Conditional Celsr3 Mutant Mice
Zhou, L., Bar, I., Achouri, Y., Campbell, K., Backer, O. D., Hébert, J. M., Jones, K. R., Kessaris, N., de Rouvroit, C. L., O’Leary, D. D. M., et al. (2008) · Science · doi:10.1126/science.1155244 · Cited by 175 · see citing works
Opposing roles in neurite growth control by two seven-pass transmembrane cadherins
Shima, Y., Kawaguchi, S., Kosaka, K., Nakayama, M., Hoshino, M., Nabeshima, Y., Hirano, T., & Uemura, T. (2007) · Nature Neuroscience · doi:10.1038/nn1933 · Cited by 154 · see citing works
The Scribble and Par complexes in polarity and migration: friends or foes?
Humbert, P. O., Dow, L. E., & Russell, S. M. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.10.005 · Cited by 153 · see citing works
mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression
Sans, N., Wang, P. Y., Du, Q., Petralia, R. S., Wang, Y., Nakka, S., Blumer, J., Macara, I. G., & Wenthold, R. J. (2005) · Nature Cell Biology · doi:10.1038/ncb1325 · Cited by 126 · see citing works
Self-citationSfakianos, M. K., Eisman, A. S., Gourley, S. L., Bradley, W. D., Scheetz, A. J., Settleman, J. E., Taylor, J. R., Greer, C. A., Williamson, A., & Koleske, A. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0793-07.2007 · Cited by 126 · see citing works
Polarity Regulators and the Control of Epithelial Architecture, Cell Migration, and Tumorigenesis
Dow, L. E., & Humbert, P. O. (2007) · International review of cytology · doi:10.1016/s0074-7696(07)62006-3 · Cited by 121 · see citing works
Scrib regulates PAK activity during the cell migration process
Nola, S., Sebbagh, M., Marchetto, S., Osmani, N., Nourry, C., Audebert, S., Navarro, C., Rachel, R. A., Montcouquiol, M., Sans, N., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn248 · Cited by 108 · see citing works
Self-citationGant, J. C., Thibault, O., Blalock, E. M., Yang, J., Bachstetter, A. D., Kotick, J. D., Schauwecker, P. E., Hauser, K. F., Smith, G. M., Mervis, R., et al. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01725.x · Cited by 106 · see citing works
Scribble Interacts with β-Catenin to Localize Synaptic Vesicles to Synapses
Sun, Y., Aiga, M., Yoshida, E., Humbert, P. O., & Bamji, S. X. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1172 · Cited by 93 · see citing works
Thyrotropin receptor trafficking relies on the hScrib–βPIX–GIT1–ARF6 pathway
Lahuna, O., Quellari, M., Achard, C. S., Nola, S., Méduri, G., Navarro, C., Vitale, N., Borg, J., & Misrahi, M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600616 · Cited by 81 · see citing works
NOS1AP associates with Scribble and regulates dendritic spine development
Richier, L., Williton, K., Clattenburg, L., Colwill, K., O'Brien, M., Tsang, C., Kolar, A., Zinck, N., Metalnikov, P., Trimble, W. S., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3726-09.2010 · Cited by 81 · see citing works
Driver, J. E., Racca, C., Cunningham, M. O., Towers, S. K., Davies, C. H., Whittington, M. A., & LeBeau, F. E. N. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05705.x · Cited by 80 · see citing works
Self-citationNMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
Lau, C. G., & Zukin, R. S. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2171 · Cited by 73 · see citing works
The Plane Facts of PCP in the CNS
Goodrich, L. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.003 · Cited by 68 · see citing works
Mata, I. F., Pérez‐Iglesias, R., Roiz‐Santiáñez, R., Tordesillas‐Gutiérrez, D., González‐Mandly, A., Vázquez‐Barquero, J. L., & Crespo‐Facorro, B. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.020 · Cited by 65 · see citing works
Rubio, M. E. (2006) · Hearing Research · doi:10.1016/j.heares.2006.03.007 · Cited by 53 · see citing works
Self-citationBrünig, I., Kaech, S., Brinkhaus, H., Oertner, T. G., & Matus, A. I. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.038 · Cited by 51 · see citing works
Association of the neuropilin‐2 (NRP2) gene polymorphisms with autism in Chinese Han population
Wu, S., Yue, W., Jia, M., Ruan, Y., Lu, T., Gong, X., Mei, S., Liu, J., Yang, X., & Zhang, D. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30495 · Cited by 46 · see citing works
Molecular mechanisms of dendritic spine development and maintenance [Review]
Sala, C., Cambianica, I., & Rossi, F. (2008) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2008-1696 · Cited by 45 · see citing works
Retinal axon misrouting at the optic chiasm in mice with neural tube closure defects
Rachel, R. A., Murdoch, J. N., Beermann, F., Copp, A. J., & Mason, C. A. (2000) · genesis · doi:10.1002/1526-968x(200005)27:1 · Cited by 37 · see citing works
Mouse models for dissecting vertebrate planar cell polarity signaling in the inner ear
Chacon-Heszele, M. F., & Chen, P. (2009) · Brain Research · doi:10.1016/j.brainres.2009.02.004 · Cited by 20 · see citing works
Valtschanoff, J. G., Sala, C., Futai, K., et al. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/tv51-8s03 · Cited by 18 · see citing works
Tashiro, A. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(04)00085-5 · Cited by 16 · see citing works
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Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation
Bonello, T. T., & Peifer, M. (2019) · Journal of Cell Biology · doi:10.1083/jcb.201810103 · Cited by 127 · see citing works
“The effects on learning and memory are striking: Mice mutant for the truncated circletail allele have enhanced learning and memory (Moreau et al., 2010), and in Drosophila Scribble plays an important role in “active forgetting” (Cervantes-Sandoval et al.”
BackgroundInfluentialStephens, R., Lim, K., Portela, M., Kvansakul, M., Humbert, P. O., & Richardson, H. E. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.01.011 · Cited by 132 · see citing works
Scribble Scaffolds a Signalosome for Active Forgetting
Cervantes-Sandoval, I., Chakraborty, M., MacMullen, C., & Davis, R. L. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.010 · Cited by 100 · see citing works
Lohia, M., Qin, Y., & Macara, I. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051130 · Cited by 64 · see citing works
The Scribble family in cancer: twentieth anniversary
Santoni, M.-J., Kashyap, R., Camoin, L., & Borg, J.-P. (2020) · Oncogene · doi:10.1038/s41388-020-01478-7 · Cited by 62 · see citing works
The polarity protein Scrib is essential for directed endothelial cell migration
Michaelis, U. R., Chavakis, E., Kruse, C., Jungblut, B., Kaluza, D., Wandzioch, K., Manavski, Y., Heide, H., Santoni, M.-J., Potente, M., et al. (2013) · Circulation Research · doi:10.1161/circresaha.112.300592 · Cited by 57 · see citing works
Scribble1/AP2 complex coordinates NMDA receptor endocytic recycling
Piguel, N. H., Fievre, S., Blanc, J.-M., Carta, M., Moreau, M. M., Moutin, E., Pinheiro, V. L., Medina, C., Ezan, J., Lasvaux, L., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.017 · Cited by 52 · see citing works
Self-citationRui, M., Qian, J., Liu, L., Cai, Y., Lv, H., Han, J., Jia, Z., & Xie, W. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.794040 · Cited by 37 · see citing works
Hilal, M. L., Moreau, M. M., Racca, C., Pinheiro, V. L., Piguel, N. H., Santoni, M.-J., Dos Santos Carvalho, S., Blanc, J.-M., Abada, Y.-S. K., Peyroutou, R., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhw333 · Cited by 20 · see citing works
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- Authors
- Moreau, M. M., Piguel, N., Papouin, T., Koehl, M., Durand, C. M., Rubio, M. E., Loll, F., Richard, E. M., Mazzocco, C., Racca, C., Oliet, S. H. R., Nora Abrous, D., Montcouquiol, M., & Sans, N.
- Affiliations
- Université de Bordeaux (FR)
- University of Connecticut (US)
- Newcastle University (GB)
- ORCID
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-07-21
- Volume
- 30
- Issue
- 29
- Pages
- 9738-9752
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6632828
- OpenAlex
- W1970675321
- Cited by
- 69
- References
- 64
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 1 · 2022: 6 · 2021: 6 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 10 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 5
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- European Commission (2003227)
- Agence Nationale de la Recherche (ANR-07-NEUR-0031, ANR-07-NEUR-031-01)
- Institut National de la Santé et de la Recherche Médicale
- Université de Bordeaux
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- planar cell polarity, dendritic spine morphology, synaptic pruning, hippocampus, actin cytoskeleton, Rac1, perforated synapses, postsynaptic density, learning and memory, social behavior, autism spectrum disorder, neuroplasticity, brain development
- MeSH terms
- Animals, Brain, Cells, Cultured, Chlorocebus aethiops, Female, Hippocampus, Learning, Male, Memory, Motor Activity, Mutation, Synaptic Transmission, Neuronal Plasticity, Social Behavior, Synapses, Patch-Clamp Techniques, COS Cells, Models, Animal, Intracellular Signaling Peptides and Proteins, Dendritic Spines, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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