The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Exosomes and cancer - Diagnostic and prognostic biomarkers and therapeutic vehicle
Open accessAbstract
Exosomes belong to a subpopulation of extracellular vesicles secreted by the dynamic multistep endocytosis process and carry diverse functional molecular cargoes, including proteins, lipids, nucleic acids (DNA, messenger and noncoding RNA), and metabolites to promote intercellular communication. Proteins and noncoding RNA are among the most abundant contents in exosomes; they have biological functions and are selectively packaged into exosomes. Exosomes derived from tumor, stromal and immune cells contribute to the multiple stages of cancer progression as well as resistance to therapy. In this review, we will discuss the biogenesis of exosomes and their roles in cancer development. Since specific contents within exosomes originate from their cells of origin, this property allows exosomes to function as valuable biomarkers. We will also discuss the potential use of exosomes as diagnostic and prognostic biomarkers or predictors for different therapeutic strategies for multiple cancers. Furthermore, the applications of exosomes as direct therapeutic targets or engineered vehicles for drugs are an important field of exosome study. Better understanding of exosome biology may pave the way to promising exosome-based clinical applications.
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Cites
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BackgroundInfluentialTumour exosome integrins determine organotropic metastasis
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Cited by
Exosome-Based Drug Delivery: Translation from Bench to Clinic
Koh, H. B., Kim, H. J., Kang, S.-W., & Yoo, T.-H. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082042 · Cited by 259
Bahadorani, M., Nasiri, M., Dellinger, K., Aravamudhan, S., & Zadegan, R. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s464249 · Cited by 121
Tiwari, P., Shukla, R. P., Yadav, K., Singh, N., Marwaha, D., Gautam, S., Bakshi, A. K., Rai, N., Kumar, A., Sharma, D., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.11.005 · Cited by 90
Metadata
- Authors
- Wang, X., Tian, L., Lu, J., & Ng, I. O.-L.
- Venue
- Oncogenesis
- Published
- 2022-09-15
- Volume
- 11
- Issue
- 1
- Pages
- 54-54
- ISSN
- 2157-9024 (ISSN-L)
- OpenAlex
- W4295945085
- Cited by
- 275
- References
- 10
- FWCI
- 14.78
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wang, X., Tian, L., Lu, J., & Ng, I. O.-L. (2022). Exosomes and cancer - Diagnostic and prognostic biomarkers and therapeutic vehicle. Oncogenesis. https://doi.org/10.1038/s41389-022-00431-5
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
