Tuning fatty acid oxidation in skeletal muscle with dietary fat and exercise

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093 · see citing works

Metabolic regulation of gene expression by histone lactylation

Zhang, D., Tang, Z., Huang, H., Zhou, G., Cui, C., Weng, Y., Liu, W., Kim, S., Lee, S., Perez-Neut, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1678-1 · Cited by 4,371 · see citing works

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300 · see citing works

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

Forman, B. M., Chen, J., & Evans, R. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4312 · Cited by 2,116 · see citing works

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084 · see citing works

Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration

Romijn, J. A., Coyle, E. F., Sidossis, L. S., Gastaldelli, A., Horowitz, J. F., Endert, E., & Wolfe, R. R. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.3.e380 · Cited by 1,747 · see citing works

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

Gerhart‐Hines, Z., Rodgers, J. T., Bare, O., Lerin, C., Kim, S., Mostoslavsky, R., Alt, F. W., Wu, Z., & Puigserver, P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601633 · Cited by 1,294 · see citing works

Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans

Burgomaster, K. A., Howarth, K. R., Phillips, S. M., Rakobowchuk, M., MacDonald, M. J., McGee, S. L., & Gibala, M. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.142109 · Cited by 1,257 · see citing works

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253 · see citing works

Fatty Acids, Eicosanoids, and Hypolipidemic Agents Identified as Ligands of Peroxisome Proliferator-Activated Receptors by Coactivator-Dependent Receptor Ligand Assay

Krey, G. D., Braissant, O., L’Horset, F., Kalkhoven, E., Perroud, M., Parker, M. G., & Wahli, W. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.6.0007 · Cited by 1,221 · see citing works

Integrative Biology of Exercise

Hawley, J. A., Hargreaves, M., Joyner, M. J., & Zierath, J. R. (2014) · Cell · doi:10.1016/j.cell.2014.10.029 · Cited by 1,152 · see citing works

Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss

Kelley, D. E., Goodpaster, B., Wing, R. R., & Simoneau, J.-A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.6.e1130 · Cited by 1,096 · see citing works

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

Cantó, C., Jiang, L. Q., Deshmukh, A. S., Mataki, C., Coste, A., Lagouge, M., Zierath, J. R., & Auwerx, J. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.006 · Cited by 921 · see citing works

Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome

Tanaka, T., Yamamoto, J., Iwasaki, S., Asaba, H., Hamura, H., Ikeda, Y., Watanabe, M., Magoori, K., Ioka, R. X., Tachibana, K., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306981100 · Cited by 832 · see citing works

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

Haemmerle, G., Moustafa, T., Wölkart, G., Büttner, S., Schmidt, A. G., van de Weijer, T., Hesselink, M. K. C., Jaeger, D., Kienesberger, P. C., Zierler, K. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2439 · Cited by 767 · see citing works

Lactate as a fulcrum of metabolism

Brooks, G. A. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101454 · Cited by 724 · see citing works

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

Feige, J. N., Lagouge, M., Canto, C., Strehle, A., Houten, S. M., Milne, J. C., Lambert, P. D., Mataki, C., Elliott, P. J., & Auwerx, J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.017 · Cited by 719 · see citing works

Lipid oxidation is reduced in obese human skeletal muscle

Kim, J.-Y., Hickner, R. C., Cortright, R. L., Dohm, G. L., & Houmard, J. A. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1039 · Cited by 634 · see citing works

Maintenance of Skeletal Muscle Mitochondria in Health, Exercise, and Aging

Hood, D. A., Memme, J. M., Oliveira, A. N., & Triolo, M. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114310 · Cited by 567 · see citing works

Differential oxidation of individual dietary fatty acids in humans

DeLany, J. P., Windhauser, M. M., Champagne, C. M., & Bray, G. A. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.4.905 · Cited by 560 · see citing works

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

Hancock, C. R., Han, D.-H., Chen, M., Terada, S., Yasuda, T., Wright, D. C., & Holloszy, J. O. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802057105 · Cited by 538 · see citing works

Metabolic flexibility and insulin resistance

Galgani, J. E., Moro, C., & Ravussin, E. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90558.2008 · Cited by 532 · see citing works

Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle

Turner, N., Bruce, C. R., Beale, S. M., Hoehn, K. L., So, T., Rolph, M. S., & Cooney, G. J. (2007) · Diabetes · doi:10.2337/db07-0093 · Cited by 520 · see citing works

Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss.

Simoneau, J., Veerkamp, J. H., Turcotte, L. P., & Kelley, D. E. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.14.2051 · Cited by 491 · see citing works

Skeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance

Kiens, B. (2006) · Physiological Reviews · doi:10.1152/physrev.00023.2004 · Cited by 478 · see citing works

The ultrastructure of the normal human skeletal muscle

Hoppeler, H. H., L�thi, P., Claassen, H., Weibel, E. R., & HOWALD, H. (1973) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00588462 · Cited by 444 · see citing works

Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training.

Kiens, B., Essen‐Gustavsson, B., Christensen, N. J., & Saltin, B. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019823 · Cited by 444 · see citing works

Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women

Talanian, J. L., Galloway, S. D. R., Heigenhauser, G. J. F., Bonen, A., & Spriet, L. L. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01098.2006 · Cited by 443 · see citing works

Isoform‐specific and exercise intensity‐dependent activation of 5′‐AMP‐activated protein kinase in human skeletal muscle

Wojtaszewski, J. F. P., Nielsen, P., Hansen, B. F., Richter, E. A., & Kiens, B. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00221.x · Cited by 435 · see citing works

Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36

Bonen, A., Parolin, M. L., Steinberg, G. R., Calles‐Escandon, J., Tandon, N. N., Glatz, J. F. C., Luiken, J. J. F. P., Heigenhauser, G. J. F., & Dyck, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1065fje · Cited by 410 · see citing works

Role of triglyceride-fatty acid cycle in controlling fat metabolism in humans during and after exercise

Wolfe, R. R., Klein, S., Carraro, F., & Weber, J. M. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.2.e382 · Cited by 381 · see citing works

Skeletal muscle lipid metabolism with obesity

Hulver, M. W., Berggren, J. R., Cortright, R. N., Dudek, R. W., Thompson, R. P., Pories, W. J., MacDonald, K. G., Cline, G. W., Shulman, G. I., Dohm, G. L., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00514.2002 · Cited by 339 · see citing works

Lipoprotein lipase activity in adipose tissue and skeletal muscle of runners: Relation to serum lipoproteins

Nikkilä, E. A., Taskinen, M., Rehunen, S., & Härkönen, M. (1978) · Metabolism · doi:10.1016/0026-0495(78)90288-3 · Cited by 334 · see citing works

Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content

Bruce, C. R., Thrush, A. B., Mertz, V. A., Bezaire, V., Chabowski, A., Heigenhauser, G. J. F., & Dyck, D. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00587.2005 · Cited by 328 · see citing works

Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats

Dobbins, R. L., Szczepaniak, L. S., Bentley, B., Esser, V., Myhill, J., & McGarry, J. D. (2001) · Diabetes · doi:10.2337/diabetes.50.1.123 · Cited by 315 · see citing works

High-intensity aerobic interval training increases fat and carbohydrate metabolic capacities in human skeletal muscle

Perry, C. G. R., Heigenhauser, G. J. F., Bonen, A., & Spriet, L. L. (2008) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h08-097 · Cited by 309 · see citing works

Exercise training increases lipid metabolism gene expression in human skeletal muscle

Tunstall, R. J., Mehan, K. A., Wadley, G. D., Collier, G. R., Bonen, A., Hargreaves, M., & Cameron-Smith, D. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00475.2001 · Cited by 292 · see citing works

Increased Malonyl-CoA Levels in Muscle From Obese and Type 2 Diabetic Subjects Lead to Decreased Fatty Acid Oxidation and Increased Lipogenesis; Thiazolidinedione Treatment Reverses These Defects

Bandyopadhyay, G. K., Yu, J. G., Ofrecio, J., & Olefsky, J. M. (2006) · Diabetes · doi:10.2337/db06-0062 · Cited by 291 · see citing works

Utilization of skeletal muscle triacylglycerol during postexercise recovery in humans

Kiens, B., & Richter, E. A. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.2.e332 · Cited by 290 · see citing works

Gender differences in substrate utilization during submaximal exercise in endurance-trained subjects

Roepstorff, C., Steffensen, C. H., Madsen, M., Stallknecht, B., Kanstrup, I.-L., Richter, E. A., & Kiens, B. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00266.2001 · Cited by 279 · see citing works

Fatty acid transport proteins, implications in physiology and disease

Kazantzis, M., & Stahl, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.09.010 · Cited by 276 · see citing works

Nutrient balance and energy expenditure during ad libitum feeding of high-fat and high-carbohydrate diets in humans

Thomas, C., Peters, J., Reed, G., Abumrad, N., Sun, M., & Hill, J. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/55.5.934 · Cited by 268 · see citing works

Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle

Garcia-Roves, P., Huss, J. M., Han, D.-H., Hancock, C. R., Iglesias-Gutierrez, E., Chen, M., & Holloszy, J. O. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704024104 · Cited by 246 · see citing works

A short-term, high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle

Cameron-Smith, D., Burke, L. M., Angus, D. J., Tunstall, R. J., Cox, G. R., Bonen, A., Hawley, J. A., & Hargreaves, M. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.2.313 · Cited by 243 · see citing works

III. Arbeitsfähigkeit und Ernährung¹

Christensen, E. H., & Hansen, O. (1939) · Skandinavisches Archiv Für Physiologie · doi:10.1111/j.1748-1716.1939.tb01320.x · Cited by 239 · see citing works

Whole body oxidation of dietary fatty acids: implications for energy utilization

Jones, P., Pencharz, P., & Clandinin, M. T. (1985) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/42.5.769 · Cited by 238 · see citing works

AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity.

Lantier, L., Fentz, J., Mounier, R., Leclerc, J., Treebak, J. T., Pehmøller, C., Sanz, N., Sakakibara, I., Saint‐Amand, E., Rimbaud, S., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-250449 · Cited by 228 · see citing works

Regulation of AMPK Activation by CD36 Links Fatty Acid Uptake to β-Oxidation

Samovski, D., Sun, J., Pietka, T., Gross, R. W., Eckel, R. H., Su, X., Stahl, P. D., & Abumrad, N. A. (2014) · Diabetes · doi:10.2337/db14-0582 · Cited by 218 · see citing works

Lipoprotein metabolism influenced by training-induced changes in human skeletal muscle.

Kiens, B., & Lithell, H. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113918 · Cited by 216 · see citing works

Regulation of Skeletal Muscle Physiology and Metabolism by Peroxisome Proliferator-Activated Receptor δ

Ehrenborg, E., & Krook, A. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001560 · Cited by 213 · see citing works

Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance

Steinberg, G. R., Parolin, M. L., Heigenhauser, G. J. F., & Dyck, D. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00542.2001 · Cited by 207 · see citing works

Evaluation of exercise and training on muscle lipid metabolism

Bergman, B. C., Butterfield, G. E., Wolfel, E. E., Casazza, G. A., Lopaschuk, G. D., & Brooks, G. A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.1.e106 · Cited by 207 · see citing works

TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism

Takahashi, H., Alves, C. R. R., Stanford, K. I., Middelbeek, R. J. W., Nigro, P., Ryan, R. E., Xue, R., Sakaguchi, M., Lynes, M. D., So, K., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0030-7 · Cited by 204 · see citing works

Heterogeneity of pig intestinal<scp>d</scp>-glucose transport systems

Halaihel, N., Gerbaud, D., Vasseur, M., & Alvarado, F. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.277.6.c1130 · Cited by 199 · see citing works

PPARδ Promotes Running Endurance by Preserving Glucose

Fan, W., Waizenegger, W., Lin, C. S., Sorrentino, V., He, M.-X., Wall, C. E., Li, H., Liddle, C., Yu, R. T., Atkins, A. R., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.006 · Cited by 198 · see citing works

Beneficial metabolic adaptations due to endurance exercise training in the fasted state

Van Proeyen, K., Szlufcik, K., Nielens, H., Ramaekers, M., & Hespel, P. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00907.2010 · Cited by 196 · see citing works

Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration

Stellingwerff, T., Spriet, L. L., Watt, M. J., Kimber, N. E., Hargreaves, M., Hawley, J. A., & Burke, L. M. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00268.2005 · Cited by 195 · see citing works

Plasticity in mitochondrial cristae density allows metabolic capacity modulation in human skeletal muscle

Nielsen, J., Gejl, K. D., Hey‐Mogensen, M., Holmberg, H., Suetta, C., Krustrup, P., Elemans, C. P. H., & Ørtenblad, N. (2017) · The Journal of Physiology · doi:10.1113/jp273040 · Cited by 191 · see citing works

Effects of exercise intensity and training on lipid metabolism in young women.

Friedlander, A., Casazza, G., Horning, M., Buddinger, T. F., & Brooks, G. (1998) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.5.e853 · Cited by 182 · see citing works

Three minutes of all-out intermittent exercise per week increases skeletal muscle oxidative capacity and improves cardiometabolic health

Gillen, J. B., Percival, M. E., Skelly, L. E., Martin, B. J., Tan, R. B., Tarnopolsky, M. A., & Gibala, M. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111489 · Cited by 181 · see citing works

Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans

Pesta, D. H., Hoppel, F., Macek, C., Messner, H., Faulhaber, M., Kobel, C., Parson, W., Burtscher, M., Schocke, M. F. H., & Gnaiger, E. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00285.2011 · Cited by 181 · see citing works

Effect of endurance training on lipid metabolism in women: a potential role for PPARα in the metabolic response to training

Horowitz, J. F., Leone, T. C., Feng, W., Kelly, D. P., & Klein, S. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.2.e348 · Cited by 181 · see citing works

Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes

Bruce, C. R., Kriketos, A. D., Cooney, G. J., & Hawley, J. A. (2004) · Diabetologia · doi:10.1007/s00125-003-1265-7 · Cited by 176 · see citing works

Interaction of training and diet on metabolism and endurance during exercise in man.

Helge, J. W., Richter, E. A., & Kiens, B. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021309 · Cited by 175 · see citing works

Mitochondrial Lactate Oxidation Complex and an Adaptive Role for Lactate Production

Hashimoto, T., & Brooks, G. A. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31815fcb04 · Cited by 174 · see citing works

Lactate as a Signaling Molecule That Regulates Exercise-Induced Adaptations

Nalbandian, M., & Takeda, M. (2016) · Biology · doi:10.3390/biology5040038 · Cited by 174 · see citing works

Sirtuin 1-mediated Effects of Exercise and Resveratrol on Mitochondrial Biogenesis

Menzies, K. J., Singh, K., Saleem, A., & Hood, D. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.431155 · Cited by 167 · see citing works

Exercise training increases sarcolemmal and mitochondrial fatty acid transport proteins in human skeletal muscle

Talanian, J. L., Holloway, G. P., Snook, L. A., Heigenhauser, G. J. F., Bonen, A., & Spriet, L. L. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00073.2010 · Cited by 167 · see citing works

Fiber type-specific expression of GLUT4 in human skeletal muscle: influence of exercise training.

Daugaard, J. R., Nielsen, J., Kristiansen, S., Andersen, J. L., Hargreaves, M., & Richter, E. A. (2000) · Diabetes · doi:10.2337/diabetes.49.7.1092 · Cited by 166 · see citing works

Dietary fat content alters insulin-mediated glucose metabolism in healthy men

Bisschop, P. H. L. T., de Metz, J., Ackermans, M. T., Endert, E., Pijl, H., Kuipers, F., Meijer, A. J., Sauerwein, H. P., & Romijn, J. A. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.3.554 · Cited by 163 · see citing works

Unravelling the mechanisms regulating muscle mitochondrial biogenesis

Hood, D. A., Tryon, L. D., Carter, H. N., Kim, Y., & Chen, C. C. W. (2016) · Biochemical Journal · doi:10.1042/bcj20160009 · Cited by 159 · see citing works

Molecular Regulation of Fatty Acid Oxidation in Skeletal Muscle during Aerobic Exercise

Lundsgaard, A., Fritzen, A. M., & Kiens, B. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.10.011 · Cited by 155 · see citing works

Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise

Pilegaard, H., Osada, T., Andersen, L. T., Helge, J. W., Saltin, B., & Neufer, P. D. (2005) · Metabolism · doi:10.1016/j.metabol.2005.03.008 · Cited by 154 · see citing works

Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet

Peters, S. J., Harris, R. A., Wu, P., Pehleman, T. L., Heigenhauser, G. J. F., & Spriet, L. L. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.6.e1151 · Cited by 154 · see citing works

Metabolic adaptations to a high-fat diet in endurance cyclists

Goedecke, J. H., Christie, C., Wilson, G., Dennis, S. C., Noakes, T. D., Hopkins, W. G., & Lambert, E. V. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90238-x · Cited by 153 · see citing works

Comparison of the effects on insulin sensitivity of high carbohydrate and high fat diets in normal subjects.

Borkman, M., Campbell, L. V., Chisholm, D. J., & Storlien, L. (1991) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem-72-2-432 · Cited by 151 · see citing works

Skeletal muscle lipid oxidation and obesity: influence of weight loss and exercise.

Berggren, J. R., Boyle, K. E., Chapman, W. H., & Houmard, J. A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00354.2007 · Cited by 151 · see citing works

Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women.

Holloway, G. P., Thrush, A. B., Heigenhauser, G. J. F., Tandon, N. N., Dyck, D. J., Bonen, A., & Spriet, L. L. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00639.2006 · Cited by 147 · see citing works

Lipid-binding proteins and lipoprotein lipase activity in human skeletal muscle: influence of physical activity and gender

Kiens, B., Roepstorff, C., Glatz, J. F. C., Bonen, A., Schjerling, P., Knudsen, J., & Nielsen, J. N. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01278.2003 · Cited by 143 · see citing works

Membrane Associated Fatty Acid Binding Protein (FABPpm) in Human Skeletal Muscle Is Increased by Endurance Training

Kiens, B., Kristiansen, S., Jensen, P. B., Richter, E. A., & Turcotte, L. P. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6118 · Cited by 143 · see citing works

Human Forearm Muscle Metabolism during Exercise II Uptake, release and oxidation of individual FFA and glycerol

Hagenfeldt, L., & Wahren, J. (1968) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365516809076994 · Cited by 138 · see citing works

Sedentary behaviour is a key determinant of metabolic inflexibility

Rynders, C. A., Blanc, S., DeJong, N., Bessesen, D. H., & Bergouignan, A. (2018) · The Journal of Physiology · doi:10.1113/jp273282 · Cited by 137 · see citing works

Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling

Høeg, L. D., Sjøberg, K. A., Jeppesen, J., Jensen, T. E., Frøsig, C., Birk, J. B., Bisiani, B., Hiscock, N., Pilegaard, H., Wojtaszewski, J. F. P., et al. (2011) · Diabetes · doi:10.2337/db10-0698 · Cited by 136 · see citing works

Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training

Alsted, T. J., Nybo, L., Schweiger, M., Fledelius, C., Jacobsen, P., Zimmermann, R., Zechner, R., & Kiens, B. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90912.2008 · Cited by 135 · see citing works

Lipoprotein lipase activity and intramuscular triglyceride stores after long‐term high‐fat and high‐carbohydrate diets in physically trained men

Kiens, B., Essén-Gustavsson, B., Gad, P., & Lithell, H. (1987) · Clinical Physiology · doi:10.1111/j.1475-097x.1987.tb00628.x · Cited by 134 · see citing works

Sensitivity of CPT I to malonyl-CoA in trained and untrained human skeletal muscle

Starritt, E. C., Howlett, R. A., Heigenhauser, G. J. F., & Spriet, L. L. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.3.e462 · Cited by 130 · see citing works

Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: historical advances, current knowledge, and future challenges

Perry, C. G. R., & Hawley, J. A. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029686 · Cited by 130 · see citing works

High-intensity interval training increases SIRT1 activity in human skeletal muscle

Gurd, B. J., Perry, C. G. R., Heigenhauser, G. J. F., Spriet, L. L., & Bonen, A. (2010) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h10-030 · Cited by 128 · see citing works

Inhibition of Carnitine Palmitoyltransferase-1 Activity Alleviates Insulin Resistance in Diet-Induced Obese Mice

Keung, W., Ussher, J. R., Jaswal, J. S., Raubenheimer, M., Lam, V. H., Wagg, C. S., & Lopaschuk, G. D. (2012) · Diabetes · doi:10.2337/db12-0259 · Cited by 128 · see citing works

Three weeks on a high-fat diet increases intrahepatic lipid accumulation and decreases metabolic flexibility in healthy overweight men

van Herpen, N. A., Schrauwen-Hinderling, V. B., Schaart, G., Mensink, R. P., & Schrauwen, P. (2011) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2010-2243 · Cited by 124 · see citing works

Fatty acids stimulate AMP‐activated protein kinase and enhance fatty acid oxidation in L6 myotubes

Watt, M. J., Steinberg, G. R., Chen, Z., Kemp, B. E., & Febbraio, M. A. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.107318 · Cited by 120 · see citing works

Effects of Dietary Fat on Muscle Substrates, Metabolism, and Performance in Athletes

VOGT, M., PUNTSCHART, A., HOWALD, H., MUELLER, B., MANNHART, C., GFELLER-TUESCHER, L., MULLIS, P., & HOPPELER, H. (2003) · Medicine &amp; Science in Sports &amp; Exercise · doi:10.1249/01.mss.0000069336.30649.bd · Cited by 120 · see citing works

Human Skeletal Muscle Fatty Acid and Glycerol Metabolism During Rest, Exercise and Recovery

van Hall, G., Sacchetti, M., Rådegran, G., & Saltin, B. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.023796 · Cited by 119 · see citing works

Skeletal muscle fat and carbohydrate metabolism during recovery from glycogen-depleting exercise in humans

Kimber, N. E., Heigenhauser, G. J. F., Spriet, L. L., & Dyck, D. J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.031179 · Cited by 107 · see citing works

Human skeletal muscle carnitine palmitoyltransferase I activity determined in isolated intact mitochondria

Berthon, P. M., Howlett, R. A., Heigenhauser, G. J. F., & Spriet, L. L. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.1.148 · Cited by 107 · see citing works

Additive effects of training and high-fat diet on energy metabolism during exercise

Simi, B., Sempore, B., Mayet, M. H., & Favier, R. J. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.71.1.197 · Cited by 107 · see citing works

Evidence for concerted action of FAT/CD36 and FABPpm to increase fatty acid transport across the plasma membrane

Chabowski, A., Górski, J., Luiken, J. J. F. P., Glatz, J. F. C., & Bonen, A. (2007) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2007.10.017 · Cited by 106 · see citing works

Exercise Alleviates Lipid-Induced Insulin Resistance in Human Skeletal Muscle–Signaling Interaction at the Level of TBC1 Domain Family Member 4

Pehmøller, C. K., Brandt, N., Birk, J. B., Høeg, L. D., Sjøberg, K. A., Goodyear, L. J., Kiens, B., Richter, E. A., & Wojtaszewski, J. F. P. (2012) · Diabetes · doi:10.2337/db11-1572 · Cited by 103 · see citing works

Postprandial lipemia and chylomicron clearance in athletes and in sedentary men

Cohen, J. C., Noakes, T. D., & Benadé, A. J. S. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/49.3.443 · Cited by 97 · see citing works

Fat Oxidation before and after a High Fat Load in the Obese Insulin-Resistant State

Blaak, E. E., Hul, G., Verdich, C., Stich, V., Martinez, A., Petersen, M., Feskens, E. F. M., Patel, K., Oppert, J. M., Barbe, P., et al. (2006) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2005-1598 · Cited by 97 · see citing works

The relationship between skeletal muscle mitochondrial citrate synthase activity and whole body oxygen uptake adaptations in response to exercise training.

Vigelsø, A., Andersen, N. B., & Dela, F. (2014) · Europe PMC (PubMed Central) · Cited by 96 · see citing works

Organ-specific dietary fatty acid uptake in humans using positron emission tomography coupled to computed tomography

Labbé, S. M., Grenier–Larouche, T., Croteau, É., Normand-Lauzière, F., Frisch, F., Ouellet, R., Guérin, B., Turcotte, É. E., & Carpentier, A. C. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00579.2010 · Cited by 90 · see citing works

Effect of exercise on recovery changes in plasma levels of FFA, glycerol, glucose and catecholamines

Bahr, R., Høstmark, A. T., Newsholme, E. A., Grønnerød, O., & Sejersted, O. M. (1991) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1991.tb09205.x · Cited by 87 · see citing works

Lactate administration increases mRNA expression of PGC-1α and UCP3 in mouse skeletal muscle

Kitaoka, Y., Takeda, K., Tamura, Y., & Hatta, H. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0016 · Cited by 85 · see citing works

Mechanisms Preserving Insulin Action during High Dietary Fat Intake

Lundsgaard, A., Holm, J. B., Sjøberg, K. A., Bojsen-Møller, K. N., Myrmel, L. S., Fjære, E., Jensen, B. A. H., Nicolaisen, T. S., Hingst, J. R., Hansen, S. L., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.022 · Cited by 85 · see citing works

Muscle enzyme activity in humans: role of substrate availability and training

Helge, J. W., & Kiens, B. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.5.r1620 · Cited by 84 · see citing works

Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells

Garcia‐Martínez, C., Marotta, M., Moore‐Carrasco, R., Guitart, M., Camps, M., Busquets, S., Montell, E., & Gómèz‐Foix, A. M. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00271.2004 · Cited by 83 · see citing works

Regulation of metabolic genes in human skeletal muscle by short-term exercise and diet manipulation

Arkinstall, M. J., Tunstall, R. J., Cameron‐Smith, D., & Hawley, J. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00557.2003 · Cited by 83 · see citing works

Basic disturbances in skeletal muscle fatty acid metabolism in obesity and type 2 diabetes mellitus

Blaak, E. E. (2004) · Proceedings of the Nutrition Society · doi:10.1079/pns2004361 · Cited by 83 · see citing works

A high-fat, high-saturated fat diet decreases insulin sensitivity without changing intra-abdominal fat in weight-stable overweight and obese adults

von Frankenberg, A. D., Marina, A. L., Song, X., Callahan, H. S., Kratz, M., & Utzschneider, K. M. (2015) · Zeitschrift für Ernährungswissenschaft · doi:10.1007/s00394-015-1108-6 · Cited by 83 · see citing works

Glucose uptake is increased in trained vs. untrained muscle during heavy exercise

Kristiansen, S., Gade, J., Wojtaszewski, J. F. P., Kiens, B., & Richter, E. A. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.3.1151 · Cited by 82 · see citing works

AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice

Fentz, J., Kjøbsted, R., Birk, J. B., Jordy, A. B., Jeppesen, J. F., Thorsen, K., Schjerling, P., Kiens, B., Jessen, N., Viollet, B., et al. (2015) · The FASEB Journal · doi:10.1096/fj.14-266650 · Cited by 82 · see citing works

Endurance Training Modulates Intramyocellular Lipid Compartmentalization and Morphology in Skeletal Muscle of Lean and Obese Women

Devries, M. C., Samjoo, I. A., Hamadeh, M. J., McCready, C., Raha, S., Watt, M. J., Steinberg, G. R., & Tarnopolsky, M. A. (2013) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2013-2044 · Cited by 82 · see citing works

Influence of 12 weeks of training by brisk walking on postprandial lipemia and insulinemia in sedentary middle-aged women

Aldred, H. E., Hardman, A. E., & Taylor, S. (1995) · Metabolism · doi:10.1016/0026-0495(95)90172-8 · Cited by 82 · see citing works

High-Fat/Low-Carbohydrate Diet Reduces Insulin-Stimulated Carbohydrate Oxidation but Stimulates Nonoxidative Glucose Disposal in Humans: An Important Role for Skeletal Muscle Pyruvate Dehydrogenase Kinase 4

Chokkalingam, K., Jewell, K., Norton, L., Littlewood, J. J., van Loon, L. J. C., Mansell, P., Macdonald, I. A., & Tsintzas, K. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1592 · Cited by 81 · see citing works

Augmenting muscle diacylglycerol and triacylglycerol content by blocking fatty acid oxidation does not impede insulin sensitivity

Timmers, S., Nabben, M., Bosma, M., van Bree, B., Lenaers, E., van Beurden, D., Schaart, G., Westerterp-Plantenga, M. S., Langhans, W., Hesselink, M. K. C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206868109 · Cited by 80 · see citing works

LKB1 Regulates Lipid Oxidation During Exercise Independently of AMPK

Jeppesen, J. F., Maarbjerg, S., Jordy, A. B., Fritzen, A. M., Pehmøller, C. K., Sylow, L., Serup, A. K., Jessen, N., Thorsen, K., Prats, C., et al. (2013) · Diabetes · doi:10.2337/db12-1160 · Cited by 80 · see citing works

Exercise training, postprandial hypertriglyceridemia, and LDL subfraction distribution

ZIOGAS, G. G., THOMAS, T. R., & HARRIS, W. S. (1997) · Medicine &amp;amp Science in Sports &amp;amp Exercise · doi:10.1097/00005768-199708000-00002 · Cited by 79 · see citing works

A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals

Boyle, K. E., Canham, J. P., Consitt, L. A., Zheng, D., Koves, T. R., Gavin, T. P., Holbert, D., Neufer, P. D., Ilkayeva, O., Muoio, D. M., et al. (2011) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2010-2253 · Cited by 79 · see citing works

Endurance Exercise Training Up-Regulates Lipolytic Proteins and Reduces Triglyceride Content in Skeletal Muscle of Obese Subjects

Louche, K., Badin, P.-M., Montastier, É., Laurens, C., Bourlier, V., de Glisezinski, I., Thalamas, C., Viguerie, N., Langin, D., & Moro, C. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2058 · Cited by 78 · see citing works

A systematic analytical chemistry/cell assay approach to isolate activators of orphan nuclear receptors from biological extracts: characterization of peroxisome proliferator-activated receptor activators in plasma

Banner, C. D., Göttlicher, M., Widmark, E., Sjövall, J., Jj, R., & Gustafsson, J. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)36951-0 · Cited by 76 · see citing works

Lactate administration activates the ERK1/2, mTORC1, and AMPK pathways differentially according to skeletal muscle type in mouse

Cerda‐Kohler, H., Henríquez‐Olguín, C., Casas, M., Jensen, T. E., Llanos, P., & Jaimovich, E. (2018) · Physiological Reports · doi:10.14814/phy2.13800 · Cited by 76 · see citing works

The effect of 13 weeks of running training followed by 9 d of detraining on postprandial lipaemia

Herd, S. L., Hardman, A. E., Boobis, L., & Cairns, C. J. (1998) · British Journal Of Nutrition · doi:10.1017/s0007114598001779 · Cited by 75 · see citing works

High-Intensity Interval Training Improves Markers of Oxidative Metabolism in Skeletal Muscle of Individuals With Obesity and Insulin Resistance

Matos, M. A. D., Vieira, D. V., Pinhal, K. C., Lopes, J. F., Dias-Peixoto, M. F., Pauli, J. R., Castro Magalhães, F. D., Little, J. P., Rocha-Vieira, E., & Amorim, F. T. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01451 · Cited by 75 · see citing works

Effect of exercise training on metabolic flexibility in response to a high-fat diet in obese individuals

Battaglia, G. M., Zheng, D., Hickner, R. C., & Houmard, J. A. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00355.2012 · Cited by 74 · see citing works

Human skeletal muscle pyruvate dehydrogenase kinase activity increases after a low-carbohydrate diet

Peters, S. J., Amand, T. A. S., Howlett, R. A., Heigenhauser, G. J. F., & Spriet, L. L. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.6.e980 · Cited by 74 · see citing works

Fat adaptation followed by carbohydrate restoration increases ampk activity in skeletal muscle from trained humans

Yeo, W. K., Lessard, S. J., Chen, Z.-P., Garnham, A. P., Burke, L. M., Rivas, D. A., Kemp, B. E., & Hawley, J. A. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90540.2008 · Cited by 73 · see citing works

The Importance of Fatty Acids as Nutrients during Post-Exercise Recovery

Lundsgaard, A.-M., Fritzen, A. M., & Kiens, B. (2020) · Nutrients · doi:10.3390/nu12020280 · Cited by 72 · see citing works

Effects of aerobic training on pyruvate dehydrogenase and pyruvate dehydrogenase kinase in human skeletal muscle

LeBlanc, P. J., Peters, S. J., Tunstall, R. J., Cameron‐Smith, D., & Heigenhauser, G. J. F. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.058263 · Cited by 69 · see citing works

High‐intensity exercise training enhances mitochondrial oxidative phosphorylation efficiency in a temperature‐dependent manner in human skeletal muscle: implications for exercise performance

Fiorenza, M., Lemminger, A. K., Marker, M., Eibye, K., Iaia, F. M., Bangsbo, J., & Hostrup, M. (2019) · The FASEB Journal · doi:10.1096/fj.201900106rrr · Cited by 69 · see citing works

Enzymatic regulation of glucose disposal in human skeletal muscle after a high-fat, low-carbohydrate diet

Pehleman, T. L., Peters, S. J., Heigenhauser, G. J. F., & Spriet, L. L. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00686.2004 · Cited by 68 · see citing works

PPARδ agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle

Constantin, D., Constantin‐Teodosiu, D., Layfield, R., Tsintzas, K., Bennett, A. J., & Greenhaff, P. L. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.135459 · Cited by 67 · see citing works

Long- and medium-chain fatty acid oxidation is increased in exercise-trained human skeletal muscle

Jong-Yeon, K., Hickner, R. C., Dohm, G. L., & Houmard, J. A. (2002) · Metabolism · doi:10.1053/meta.2002.31326 · Cited by 66 · see citing works

Dietary fat oxidation as a function of body fat

Westerterp, K. R., Smeets, A. J. P. G., Lejeune, M. P. G. M., Wouters-Adriaens, M. P. E., & Westerterp‐Plantenga, M. S. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.132 · Cited by 66 · see citing works

PDC activity and acetyl group accumulation in skeletal muscle during prolonged exercise

Constantin‐Teodosiu, D., Cederblad, G., & Hultman, E. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.6.2403 · Cited by 66 · see citing works

Effect of dietary macronutrient composition on tissue-specific lipoprotein lipase activity and insulin action in normal-weight subjects

Yost, T. J., Jensen, D. R., Haugen, B. R., & Eckel, R. H. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.2.296 · Cited by 65 · see citing works

Enhanced Fatty Acid Oxidation and FATP4 Protein Expression after Endurance Exercise Training in Human Skeletal Muscle

Jeppesen, J. F., Jordy, A. B., Sjøberg, K. A., Füllekrug, J., Stahl, A., Nybo, L., & Kiens, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029391 · Cited by 63 · see citing works

Hyperlipemic response of young trained and untrained men after a high fat meal.

Merrill, J. R., Holly, R. G., Anderson, R. L., Rifai, N., King, M. E., & DeMeersman, R. E. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.2.217 · Cited by 63 · see citing works

High-intensity interval training changes mitochondrial respiratory capacity differently in adipose tissue and skeletal muscle

Dohlmann, T. L., HINDSØ, M. G., Dela, F., Helge, J. W., & Larsen, S. (2018) · Physiological Reports · doi:10.14814/phy2.13857 · Cited by 62 · see citing works

Interaction Between Dietary Lipids and Physical Inactivity on Insulin Sensitivity and on Intramyocellular Lipids in Healthy Men

Stettler, R., Ith, M., Acheson, K. J., Décombaz, J., Boesch, C., Tappy, L., & Binnert, C. (2005) · Diabetes Care · doi:10.2337/diacare.28.6.1404 · Cited by 61 · see citing works

Hormone-sensitive lipase activity and fatty acyl-CoA content in human skeletal muscle during prolonged exercise

Watt, M. J., Heigenhauser, G. J. F., O'Neill, M., & Spriet, L. L. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01181.2002 · Cited by 60 · see citing works

Opposite Regulation of Insulin Sensitivity by Dietary Lipid Versus Carbohydrate Excess

Lundsgaard, A., Sjøberg, K. A., Høeg, L. D., Jeppesen, J. F., Jordy, A. B., Serup, A. K., Fritzen, A. M., Pilegaard, H., Myrmel, L. S., Madsen, L., et al. (2017) · Diabetes · doi:10.2337/db17-0046 · Cited by 59 · see citing works

High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans

Leckey, J. J., Hoffman, N. J., Parr, E. B., Devlin, B. L., Trewin, A. J., Stepto, N. K., Morton, J. P., Burke, L. M., & Hawley, J. A. (2018) · The FASEB Journal · doi:10.1096/fj.201700993r · Cited by 59 · see citing works

Enhanced insulin signaling in human skeletal muscle and adipose tissue following gastric bypass surgery

Albers, P. H., Bojsen-Møller, K. N., Dirksen, C., Serup, A. K., Steenberg, D. E., Frystyk, J., Clausen, T. R., Kiens, B., Richter, E. A., Madsbad, S., et al. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00228.2014 · Cited by 58 · see citing works

AN EVALUATION OF EXERCISE AND TRAINING ON MUSCLE LIPID METABOLISM

Bergman, B. C., Butterfield, G. E., Wolfel, E. E., Casazza, G. A., & Brooks, G. A. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199805001-01745 · Cited by 57 · see citing works

Studies of plasma membrane fatty acid-binding protein and other lipid-binding proteins in human skeletal muscle

Roepstorff, C., Wulff Helge, J., Vistisen, B., & Kiens, B. (2004) · Proceedings of the Nutrition Society · doi:10.1079/pns2004332 · Cited by 54 · see citing works

Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise

Hingst, J. R., Kjøbsted, R., Birk, J. B., Eskesen, N. O., Larsen, M. R., Kido, K., Larsen, J. K., Kjeldsen, S. A. S., Fentz, J., Frøsig, C., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101028 · Cited by 54 · see citing works

Muscle Structure with Low- and High-Fat Diets in Well-Trained Male Runners

Hoppeler, Billeter, Horváth, Leddy, & Pendergast (1999) · International Journal of Sports Medicine · doi:10.1055/s-1999-8838 · Cited by 52 · see citing works

Effect of Dietary Macronutrient Composition on AMPK and SIRT1 Expression and Activity in Human Skeletal Muscle

Draznin, B., Wang, C., Adochio, R., Leitner, J. W., & Cornier, M. (2012) · Hormone and Metabolic Research · doi:10.1055/s-0032-1312656 · Cited by 51 · see citing works

Increased mitochondrial content rescues in vivo muscle oxidative capacity in long‐term high‐fat‐diet‐fed rats

van den Broek, N. M. A., Čiapaitė, J., Feyter, H. M. M. L. D., Houten, S. M., Wanders, R. J. A., Jeneson, J. A. L., Nicolay, K., & Prompers, J. J. (2009) · The FASEB Journal · doi:10.1096/fj.09-143842 · Cited by 50 · see citing works

Fractional oxidation of chylomicron-derived oleate is greater than that of palmitate in healthy adults fed frequent small meals

Schmidt, D. E., Allred, J. B., & Kien, C. L. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32107-6 · Cited by 48 · see citing works

Effects of lactate administration on mitochondrial enzyme activity and monocarboxylate transporters in mouse skeletal muscle

Takahashi, K., Kitaoka, Y., Matsunaga, Y., & Hatta, H. (2019) · Physiological Reports · doi:10.14814/phy2.14224 · Cited by 48 · see citing works

Lipid sensing and lipid sensors

Wolfrum, C. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7279-4 · Cited by 46 · see citing works

Decrease of lipoprotein lipase activity in skeletal muscle in man during a short-term carbohydrate-rich dietary regime. With special reference to HDL-cholesterol, apolipoprotein and insulin concentrations

Lithell, H., Jacobs, I. A., Vessby, B., Hellsing, K., & Karlsson, J. (1982) · Metabolism · doi:10.1016/0026-0495(82)90141-x · Cited by 46 · see citing works

Weight Reduction and the Impaired Plasma-Derived Free Fatty Acid Oxidation in Type 2 Diabetic Subjects1

Blaak, E. E., Wolffenbuttel, B. H. R., Saris, W. H. M., Pelsers, M. M. A. L., & Wagenmakers, A. J. M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.4.7397 · Cited by 46 · see citing works

A Low-Carbohydrate/High-Fat Diet Improves Glucoregulation in Type 2 Diabetes Mellitus by Reducing Postabsorptive Glycogenolysis

Allick, G., Bisschop, P. H. L. T., Ackermans, M. T., Endert, E., Meijer, A. J., Kuipers, F., Sauerwein, H. P., & Romijn, J. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1041 · Cited by 46 · see citing works

Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training

Kleinert, M., Parker, B. L., Jensen, T. E., Raun, S. H., Pham, T. C. P., Han, X., James, D. E., Richter, E. A., & Sylow, L. (2018) · Scientific Reports · doi:10.1038/s41598-018-28540-5 · Cited by 46 · see citing works

5′‐AMP activated protein kinase α2 controls substrate metabolism during post‐exercise recovery via regulation of pyruvate dehydrogenase kinase 4

Fritzen, A. M., Lundsgaard, A., Jeppesen, J. F., Christiansen, M. L. B., Biensø, R. S., Dyck, J. R. B., Pilegaard, H., & Kiens, B. (2015) · The Journal of Physiology · doi:10.1113/jp270821 · Cited by 45 · see citing works

Active middle-aged men have lower fasting inflammatory markers but the postprandial inflammatory response is minimal and unaffected by physical activity status

Dixon, N. C., HURST, T. L., Talbot, D. C. S., Tyrrell, R. M., & Thompson, D. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91532.2008 · Cited by 45 · see citing works

Lipoprotein lipase activity and plasma triglyceride clearance are elevated in endurance-trained women

Podl, T. R., Zmuda, J. M., Yurgalevitch, S. M., Fahrenbach, M. C., Bausserman, L., Terry, R. B., & Thompson, P. D. (1994) · Metabolism · doi:10.1016/0026-0495(94)90258-5 · Cited by 44 · see citing works

Pyruvate overrides inhibition of PDH during exercise after a low-carbohydrate diet

Amand, T. A. S., Spriet, L. L., Jones, N. L., & Heigenhauser, G. J. F. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.2.e275 · Cited by 41 · see citing works

AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle

Fentz, J., Kjøbsted, R., Kristensen, C. M., Hingst, J. R., Birk, J. B., Gudiksen, A., Foretz, M., Schjerling, P., Viollet, B., Pilegaard, H., et al. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00157.2015 · Cited by 40 · see citing works

Unraveling the Complexities of SIRT1-Mediated Mitochondrial Regulation in Skeletal Muscle

Philp, A., & Schenk, S. (2013) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3182956803 · Cited by 39 · see citing works

Low-carbohydrate diet alters intracellular glucose metabolism but not overall glucose disposal in exercise-trained subjects

Cutler, D. L., Gray, C. G., Park, S. W., Hickman, M. G., Bell, J., & Kolterman, O. (1995) · Metabolism · doi:10.1016/0026-0495(95)90027-6 · Cited by 39 · see citing works

Effects of the carnitine-acyltransferase inhibitor etomoxir on insulin sensitivity, energy expenditure and substrate oxidation in NIDDM

Hübinger, A., Knode, O., Susanto, F., Reinauer, H., & Gries, F. (1997) · Hormone and Metabolic Research · doi:10.1055/s-2007-979072 · Cited by 38 · see citing works

Effects of decreased lactate accumulation after dichloroacetate administration on exercise training-induced mitochondrial adaptations in mouse skeletal muscle

Hoshino, D., Tamura, Y., Masuda, H., Matsunaga, Y., & Hatta, H. (2015) · Physiological Reports · doi:10.14814/phy2.12555 · Cited by 38 · see citing works

Palmitic acid follows a different metabolic pathway than oleic acid in human skeletal muscle cells; lower lipolysis rate despite an increased level of adipose triglyceride lipase

Bakke, S. S., Moro, C., Nikolić, N., Hessvik, N. P., Badin, P.-M., Lauvhaug, L., Fredriksson, K., Hesselink, M. K. C., Boekschoten, M. V., Kersten, S., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.07.001 · Cited by 38 · see citing works

Exercise training improves fat metabolism independent of total energy expenditure in sedentary overweight men, but does not restore lean metabolic phenotype

Lefai, É., Blanc, S., Momken, I., Antoun, E., Chery, I., Zahariev, A., Gabert, L., Bergouignan, A., & Simon, C. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.151 · Cited by 38 · see citing works

Adaptations in Mitochondrial Enzymatic Activity Occurs Independent of Genomic Dosage in Response to Aerobic Exercise Training and Deconditioning in Human Skeletal Muscle

Fritzen, A. M., Thøgersen, F. B., Thybo, K., Vissing, C. R., Krag, T. O. B., Ruiz‐Ruiz, C., Risom, L., Wibrand, F., Høeg, L. D., Kiens, B., et al. (2019) · Cells · doi:10.3390/cells8030237 · Cited by 38 · see citing works

Increasing Dietary Fat Elicits Similar Changes in Fat Oxidation and Markers of Muscle Oxidative Capacity in Lean and Obese Humans

Bergouignan, A., Gozansky, W. S., Barry, D. W., Leitner, W., MacLean, P. S., Hill, J. O., Draznin, B., & Melanson, E. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030164 · Cited by 36 · see citing works

Increase in skeletal muscle lipoprotein lipase following endurance training in man

Svedenhag, J., Lithell, H., JUHLIN‐DANNFELT, A., & Henriksson, J. (1983) · Atherosclerosis · doi:10.1016/0021-9150(83)90198-3 · Cited by 36 · see citing works

Early skeletal muscle adaptations to short‐term high‐fat diet in humans before changes in insulin sensitivity

Anderson, A. S., Haynie, K. R., McMillan, R. P., Osterberg, K. L., Boutagy, N. E., Frisard, M. I., Davy, B. M., Davy, K. P., & Hulver, M. W. (2015) · Obesity · doi:10.1002/oby.21031 · Cited by 35 · see citing works

Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents

Turner, N., Bruce, N., Beale, N., Hoehn, N., So, N., Rolph, M. S., & Cooney, N. (2007) · Figshare · Cited by 34 · see citing works

Glucometabolic consequences of acute and prolonged inhibition of fatty acid oxidation

Lundsgaard, A., Fritzen, A. M., Nicolaisen, T. S., Carl, C. S., Sjøberg, K. A., Raun, S. H., Klein, A. B., Sanchez-Quant, E., Langer, J., Ørskov, C., et al. (2019) · Journal of Lipid Research · doi:10.1194/jlr.ra119000177 · Cited by 33 · see citing works

PPARδ agonism inhibits skeletal muscle PDC activity, mitochondrial ATP production and force generation during prolonged contraction

Constantin‐Teodosiu, D., Baker, D. J., Constantin, D., & Greenhaff, P. L. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.164210 · Cited by 27 · see citing works

Impaired insulin sensitivity is accompanied by disturbances in skeletal muscle fatty acid handling in subjects with impaired glucose metabolism

Moors, C. C. M., van der Zijl, N. J., Diamant, M., Blaak, E. E., & Goossens, G. H. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.123 · Cited by 25 · see citing works

Turnover of free fatty acids during recovery from exercise

Hagenfeldt, L., & Wahren, J. (1975) · Journal of Applied Physiology · doi:10.1152/jappl.1975.39.2.247 · Cited by 25 · see citing works

Elevated n-3 fatty acids in a high-fat diet attenuate the increase in PDH kinase activity but not PDH activity in human skeletal muscle

Turvey, E. A., Heigenhauser, G. J. F., Parolin, M. L., & Peters, S. J. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00604.2004 · Cited by 24 · see citing works

High-fat/low-carbohydrate diets regulate glucose metabolism via a long-term transcriptional loop

Sparks, L. M., Xie, H., Koza, R. A., Mynatt, R. L., Bray, G. A., & Smith, S. R. (2006) · Metabolism · doi:10.1016/j.metabol.2006.07.003 · Cited by 21 · see citing works

High-fat feeding inhibits exercise-induced increase in mitochondrial respiratory flux in skeletal muscle

Skovbro, M., Boushel, R., HANSEN, C. N., Helge, J. W., & Dela, F. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01341.2010 · Cited by 20 · see citing works

Overexpression of SIRT1 in Rat Skeletal Muscle Does Not Alter Glucose Induced Insulin Resistance

Brandon, A. E., Tid-Ang, J. D., Wright, L. E., Stuart, E., Suryana, E., Bentley, N. L., Turner, N. A., Cooney, G. J., Ruderman, N. B., & Kraegen, E. W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121959 · Cited by 18 · see citing works

Fluxing the Mitochondria to Insulin Resistance

Watt, M. J., & Hevener, A. L. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.12.002 · Cited by 16 · see citing works

Mechanisms Preserving Insulin Action during High Dietary Fat Intake

Lundsgaard, A., Holm, J. B., Sjøberg, K. A., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.002 · Cited by 14 · see citing works

Four weeks one-leg training and high fat diet does not alter PPARα protein or mRNA expression in human skeletal muscle

Helge, J. W., Bentley, D. J., Schjerling, P., Willer, M., Gibala, M. J., Franch, J., Tapia-Laliena, M. Á., Daugaard, J. R., & Andersen, J. L. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0479-7 · Cited by 12 · see citing works

Insulin sensitivity is independent of lipid binding protein trafficking at the plasma membrane in human skeletal muscle: effect of a 3-day, high-fat diet.

Jordy, A. B., Serup, A., Karstoft, K., Pilegaard, H., Kiens, B., & Jeppesen, J. (2014) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00124.2014 · Cited by 12 · see citing works

AAV-mediated Sirt1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance

Vil, L., Roca, C., Elias, I., Casellas, A., Lage, R., Franckhauser, S., & Bosch, F. (2016) · Molecular Therapy — Methods & Clinical Development · doi:10.1038/mtm.2016.72 · Cited by 11 · see citing works

Effect of a 1-week, eucaloric, moderately high-fat diet on peripheral insulin sensitivity in healthy premenopausal women

Branis, N. M., Etesami, M., Walker, R. W., Berk, E. S., & Albu, J. (2015) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2015-000100 · Cited by 10 · see citing works

Fatty acid type–specific regulation of SIRT1 does not affect insulin sensitivity in human skeletal muscle

Fritzen, A. M., Lundsgaard, A., Jeppesen, J. F., Sjøberg, K. A., Høeg, L. D., Deleuran, H. H., Wojtaszewski, J. F. P., Richter, E. A., & Kiens, B. (2019) · The FASEB Journal · doi:10.1096/fj.201801950r · Cited by 10 · see citing works

Training state and fasting-induced PDH regulation in human skeletal muscle

Gudiksen, A., Bertholdt, L., Stankiewicz, T., Villesen, I. F., Bangsbo, J., Plomgaard, P., & Pilegaard, H. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2164-6 · Cited by 9 · see citing works

The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia

Sylow, L., Tokarz, V. L., Richter, E. A., & Klip, A. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.03.020 · Cited by 366 · see citing works

Skeletal muscle energy metabolism in obesity

Mengeste, A. M., Rustan, A. C., & Lund, J. (2021) · Obesity · doi:10.1002/oby.23227 · Cited by 141 · see citing works

Interactions between insulin and exercise

Richter, E. A., Sylow, L., & Hargreaves, M. (2021) · Biochemical Journal · doi:10.1042/bcj20210185 · Cited by 99 · see citing works

Physiological significance of elevated levels of lactate by exercise training in the brain and body

Lee, S., Choi, Y., Jeong, E., Park, J., Kim, J., Tanaka, M., & Choi, J. (2023) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2022.12.001 · Cited by 67 · see citing works

Metabolic syndrome and its association with nonalcoholic steatohepatitis

Bril, F., Sanyal, A., & Cusi, K. (2023) · Clinics in Liver Disease · doi:10.1016/j.cld.2023.01.002 · Cited by 52 · see citing works

Epigenetics in obesity: Mechanisms and advances in therapies based on natural products

Chen, P., Wang, Y., Chen, F., & Zhou, B. (2024) · Pharmacology Research &amp; Perspectives · doi:10.1002/prp2.1171 · Cited by 27 · see citing works

Obesity and Exercise: New Insights and Perspectives

James, N. M., & Stanford, K. I. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf017 · Cited by 20 · see citing works

Targeting Intramyocellular Lipids to Improve Aging Muscle Function

Russ, D. W., Manickam, R., & Tipparaju, S. M. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02622-6 · Cited by 15 · see citing works

472: Oxidative stress impairs fatty acid oxidation in the human term placenta

Thomas, M. M., Haghiac, M., Minium, J., et al. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.11.207 · Cited by 1 · see citing works

Molecular Changes in Fatty Acid Oxidation in the Failing Heart

Jaswal, J. S., Keung, W., Wang, W., Ussher, J. R., & Lopaschuk, G. D. (2011) · Springer eBooks · doi:10.1007/978-1-4419-7130-2_12 · Cited by 2 · see citing works

CYTOKINES INHIBIT FATTY ACID OXIDATION IN ISOLATED RAT HEPATOCYTES

Nachiappan, V., Curtiss, D., Corkey, B. E., & Kilpatrick, L. E. (1994) · Shock · doi:10.1097/00024382-199402000-00007 · Cited by 76 · see citing works

Medium-Chain Fatty Acid Feeding Reduces Oxidation and Causes Panacinar Steatosis in Livers of Neonatal Pigs

Gerrard, S. D., Yonke, J. A., McMillan, R. P., Sunny, N. E., & El‐Kadi, S. W. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.01.023 · Cited by 7 · see citing works

Effects of 2[5(4-chlorphenyl)pentyl]oxirane-2- carboxylate on fatty acid synthesis and fatty acid oxidation in isolated rat hepatocytes

Agius, L., Pillay, D., George, K., et al. (1985) · Biochemical Pharmacology · doi:10.1016/0006-2952(85)90562-3 · Cited by 15 · see citing works