Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE
Open accessAbstract
Emerging evidence supports that mitochondrial dysfunction contributes to systemic lupus erythematosus (SLE) pathogenesis. Here we show that programmed mitochondrial removal, a hallmark of mammalian erythropoiesis, is defective in SLE. Specifically, we demonstrate that during human erythroid cell maturation, a hypoxia-inducible factor (HIF)-mediated metabolic switch is responsible for the activation of the ubiquitin-proteasome system (UPS), which precedes and is necessary for the autophagic removal of mitochondria. A defect in this pathway leads to accumulation of red blood cells (RBCs) carrying mitochondria (Mito+ RBCs) in SLE patients and in correlation with disease activity. Antibody-mediated internalization of Mito+ RBCs induces type I interferon (IFN) production through activation of cGAS in macrophages. Accordingly, SLE patients carrying both Mito+ RBCs and opsonizing antibodies display the highest levels of blood IFN-stimulated gene (ISG) signatures, a distinctive feature of SLE.
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Abnormal retention of mitochondria in mature erythrocytes in patients with SLE is caused by a defective hypoxia-inducible factor-mediated metabolic switch that impairs activation of the ubiquitin-proteasome system necessary for mitophagy during erythroid maturation.
“Abnormal retention of mitochondria in mature erythrocytes in patients with SLE is caused by a defective hypoxia-inducible factor (HIF)-mediated metabolic switch that leads to impaired activation of the ubiquitin-proteasome system, necessary for the execution of mitophagy during human erythroid cell maturation”
From The role of mitochondria in rheumatic diseases (2022) · cites this paper as [119]
High interferon-stimulated gene signatures in patients with SLE are associated with the presence of mitochondria-containing erythrocytes and opsonizing antibodies.
“high interferon-stimulated gene signatures in patients with SLE are associated with the presence of mitochondria-containing erythrocytes and opsonizing antibodies119”
From The role of mitochondria in rheumatic diseases (2022) · cites this paper as [119]
Phagocytosis of opsonized mitochondria-containing erythrocytes induces activation of the cGAS-STING pathway in macrophages and subsequent production of type I interferons.
“phagocytosis of opsonized mitochondria-containing erythrocytes induces activation of the DNA-sensing cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS–STING) pathway in macrophages and induces subsequent production of type I interferons119”
From The role of mitochondria in rheumatic diseases (2022) · cites this paper as [119]
A proportion of erythrocytes contain mitochondria in SLE, although mitochondria are normally absent in mature erythrocytes.
“a study published in 2021 revealed that a proportion of erythrocytes contain mitochondria in SLE119”
From The role of mitochondria in rheumatic diseases (2022) · cites this paper as [119]
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Lactate metabolism in human health and disease
Li, X., Yang, Y., Zhang, B., Lin, X., Fu, X., An, Y., Zou, Y., Wang, J.-X., Wang, Z., & Yu, T. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01151-3 · Cited by 1,454 · see citing works
Mitochondrial control of inflammation
Marchi, S., Guilbaud, E., Tait, S. W. G., Yamazaki, T., & Galluzzi, L. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-022-00760-x · Cited by 1,027 · see citing works
Mitochondrial DNA Release in Innate Immune Signaling
Newman, L. E., & Shadel, G. S. (2023) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-032620-104401 · Cited by 331 · see citing works
Role of the cGAS–STING pathway in systemic and organ-specific diseases
Skopelja‐Gardner, S., An, J., & Elkon, K. B. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00589-6 · Cited by 315 · see citing works
Systemic Lupus Erythematosus Pathogenesis: Interferon and Beyond
Caielli, S., Wan, Z., & Pascual, V. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101921-042422 · Cited by 221 · see citing works
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The emerging role of protein l-lactylation in metabolic regulation and cell signalling
Ren, H., Tang, Y., & Zhang, D. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01259-0 · Cited by 142 · see citing works
Emerging concepts of type I interferons in SLE pathogenesis and therapy
Psarras, A., Wittmann, M., & Vital, E. M. J. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00826-z · Cited by 134 · see citing works
The immunology of systemic lupus erythematosus
Tsokos, G. C. (2024) · Nature Immunology · doi:10.1038/s41590-024-01898-7 · Cited by 136 · see citing works
Advances in the management of systemic lupus erythematosus
Morand, E. F., Fernandez‐Ruiz, R., Blazer, A., & Niewold, T. B. (2023) · BMJ · doi:10.1136/bmj-2022-073980 · Cited by 123 · see citing works
Immunopathogenesis of systemic lupus erythematosus: An update
Arnaud, L., Chasset, F., & Martin, T. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103648 · Cited by 116 · see citing works
Mechanisms underlying sex differences in autoimmunity
Fairweather, D., Beetler, D. J., McCabe, E. J., & Lieberman, S. M. (2024) · Journal of Clinical Investigation · doi:10.1172/jci180076 · Cited by 121 · see citing works
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Nonresolving inflammation redux
Nathan, C. (2022) · Immunity · doi:10.1016/j.immuni.2022.03.016 · Cited by 103 · see citing works
Red Blood Cell Metabolism In Vivo and In Vitro
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Wu, H., Huang, H., & Zhao, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1211221 · Cited by 96 · see citing works
Pathogenic cellular and molecular mediators in lupus nephritis
Mohan, C., Zhang, T., & Putterman, C. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00722-z · Cited by 92 · see citing works
The role of mitochondria in rheumatic diseases
Becker, Y. L. C., Duvvuri, B., Fortin, P. R., Lood, C., & Boilard, E. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00834-z · Cited by 81 · see citing works
Huang, N., Winans, T., Wyman, B., Oaks, Z., Faludi, T., Choudhary, G., Lai, Z., Lewis, J., Beckford, M., Duarte, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46441-2 · Cited by 82 · see citing works
An update on autoantibodies in systemic lupus erythematosus
Gómez-Bañuelos, E., Fava, A., & Andrade, F. (2022) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000922 · Cited by 77 · see citing works
A guide to membrane atg8ylation and autophagy with reflections on immunity
Deretic, V. P., & Lazarou, M. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202203083 · Cited by 78 · see citing works
Mitochondrial control of innate immune responses
Chen, S., Liao, Z., & Xu, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1166214 · Cited by 77 · see citing works
Lactylation in health and disease: physiological or pathological?
Zhao, L., Qi, H., Lv, H., Liu, W., Zhang, R., & Yang, A. (2025) · Theranostics · doi:10.7150/thno.105353 · Cited by 72 · see citing works
Mitochondrial DNA signals driving immune responses: Why, How, Where?
Giordano, L., Ware, S. A., Lagranha, C. J., & Kaufman, B. A. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02042-0 · Cited by 77 · see citing works
Moriconi, C., Dzieciątkowska, M., Roy, M. K., D’Alessandro, A., Roingeard, P., Lee, J., Gibb, D. R., Tredicine, M., McGill, M. A., Qiu, A., et al. (2022) · British Journal of Haematology · doi:10.1111/bjh.18287 · Cited by 64 · see citing works
Type I Interferons in Autoimmunity: Implications in Clinical Phenotypes and Treatment Response
Londe, A. C., Fernandez‐Ruiz, R., Júlio, P. R., Appenzeller, S., & Niewold, T. B. (2023) · The Journal of Rheumatology · doi:10.3899/jrheum.2022-0827 · Cited by 64 · see citing works
Type I Interferons in Systemic Lupus Erythematosus: A Journey from Bench to Bedside
Sim, T. M., Ong, S. J., Mak, A., & Tay, S. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052505 · Cited by 63 · see citing works
Chemoproteomic mapping of the glycolytic targetome in cancer cells
Tian, Y., Wan, N., Zhang, H., Shao, C., Ding, M., Bao, Q., Hu, H., Sun, H., Liu, C., Zhou, K., et al. (2023) · Nature Chemical Biology · doi:10.1038/s41589-023-01355-w · Cited by 62 · see citing works
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy
Saunders, T. L., Windley, S. P., Gervinskas, G., Balka, K. R., Rowe, C. L., Lane, R. M., Tailler, M., Nguyen, T. N., Ramm, G., Lazarou, M., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01260-2 · Cited by 63 · see citing works
PANoptosis: Mechanism and Role in Pulmonary Diseases
Chen, S., Jiang, J., Li, T., & Huang, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015343 · Cited by 61 · see citing works
Immunometabolism in systemic lupus erythematosus
Patiño‐Martínez, E., & Kaplan, M. J. (2025) · Nature Reviews Rheumatology · doi:10.1038/s41584-025-01267-0 · Cited by 67 · see citing works
Autophagy pathways in autoimmune diseases
Keller, C. W., Adamopoulos, I. E., & Lünemann, J. D. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103030 · Cited by 58 · see citing works
Non-histone lactylation: unveiling its functional significance
Shi, P., Ma, Y., & Zhang, S. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1535611 · Cited by 59 · see citing works
Sun, W., Li, P., Wang, M., Xu, Y., Shen, D., Zhang, X., & Liu, Y. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109660 · Cited by 54 · see citing works
Mitochondrial impairment and repair in the pathogenesis of systemic lupus erythematosus
Zhao, L., Hu, X., Xiao, F., Zhang, X., Zhao, L., & Wang, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.929520 · Cited by 52 · see citing works
Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature
Natarelli, N., Gahoonia, N., Aflatooni, S., Bhatia, S., & Sivamani, R. K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063303 · Cited by 55 · see citing works
Type I IFN drives unconventional IL-1β secretion in lupus monocytes
Caielli, S., Balasubramanian, P., Rodríguez-Alcázar, J. F., Balaji, U., Robinson, L. A., Wan, Z., Baisch, J. M., Smitherman, C., Walters, L., Sparagana, P. R., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.09.004 · Cited by 53 · see citing works
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Metabolic alterations of the immune system in the pathogenesis of autoimmune diseases
Blanco, L. P., & Kaplan, M. J. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002084 · Cited by 54 · see citing works
Innate virus-sensing pathways in B cell systemic autoimmunity
Vinuesa, C. G., Grenov, A., & Kassiotis, G. (2023) · Science · doi:10.1126/science.adg6427 · Cited by 52 · see citing works
Ontogeny and Function of Plasmacytoid Dendritic Cells
Adams, N. M., Das, A., Yun, T. J., & Reizis, B. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-090122-041105 · Cited by 48 · see citing works
Zhang, J., Ji, H., Liu, M., Zheng, M., Wen, Z., & Shen, H. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2300758 · Cited by 48 · see citing works
Mitochondria in the Pathogenesis of Systemic Lupus Erythematosus
Chen, P.-M., & Tsokos, G. C. (2022) · Current Rheumatology Reports · doi:10.1007/s11926-022-01063-9 · Cited by 46 · see citing works
Goldbach‐Mansky, R. T., Alehashemi, S., & de Jesus, A. A. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01184-8 · Cited by 47 · see citing works
Self-citationDysregulation of the cGAS-STING Pathway in Monogenic Autoinflammation and Lupus
Wobma, H., Shin, D. S., Chou, J. S., & Dedeoğlu, F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.905109 · Cited by 41 · see citing works
The role of hypoxic microenvironment in autoimmune diseases
Gong, X., Yang, S.-Y., Wang, Z.-Y., & Tang, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1435306 · Cited by 40 · see citing works
Substrate and Functional Diversity of Protein Lysine Post-translational Modifications
Hao, B., Chen, K., Zhai, L., Liu, M., Liu, B., & Tan, M. (2024) · Genomics Proteomics & Bioinformatics · doi:10.1093/gpbjnl/qzae019 · Cited by 39 · see citing works
Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
Do, B. T., Hsu, P. P., Vermeulen, S. Y., Wang, Z., Hirz, T., Abbott, K. L., Aziz, N., Replogle, J. M., Bjelosevic, S., Paolino, J. D., et al. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.05.010 · Cited by 36 · see citing works
Wang, H., Shen, M., Ma, Y., Lan, L., Xue, J., Cen, X., Guo, G., Zhou, Q., Yuan, M., Chen, J., et al. (2024) · Kidney International · doi:10.1016/j.kint.2023.12.017 · Cited by 36 · see citing works
Mitochondrial Dysfunction in Systemic Lupus Erythematosus with a Focus on Lupus Nephritis
Halfon, M., Tankeu, A. T., & Ribi, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116162 · Cited by 36 · see citing works
NETosis promotes chronic inflammation and fibrosis in systemic lupus erythematosus and COVID-19
Lin, H., Liu, J., Li, N., Zhang, B., Nguyen, V. D., Yao, P., Feng, J., Liu, Q., Chen, Y. Z., Li, G., et al. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109687 · Cited by 35 · see citing works
Metabolic regulation of erythrocyte development and disorders
Lyu, J., Ni, M., Weiss, M. J., & Xu, J. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104153 · Cited by 33 · see citing works
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Reticulocytes in donor blood units enhance red blood cell alloimmunization
Thomas, T. A., Qiu, A., Kim, C. Y., Gordy, D. E., Miller, A., Tredicine, M., Dzieciątkowska, M., Zotti, F. D., Hod, E. A., D’Alessandro, A., et al. (2023) · Haematologica · doi:10.3324/haematol.2023.282815 · Cited by 33 · see citing works
Targeting Interferon Signalling in Systemic Lupus Erythematosus: Lessons Learned
Jones, S. A., & Morand, E. F. (2024) · Drugs · doi:10.1007/s40265-024-02043-2 · Cited by 33 · see citing works
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Mitochondria as a key player in systemic lupus erythematosus
Quintero-González, D. C., Muñoz-Urbano, M., & Vásquez, G. M. (2022) · Autoimmunity · doi:10.1080/08916934.2022.2112181 · Cited by 31 · see citing works
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Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115
Zhang, Z.-D., Shi, C.-R., Li, F., Gan, H., Wei, Y., Zhang, Q., Shuai, X., Chen, M., Lin, Y., Xiong, T.-C., et al. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01131-3 · Cited by 30 · see citing works
Modulation of plasmacytoid dendritic cells response in inflammation and autoimmunity
Kioon, M. D. A., Laurent, P., Chaudhary, V., Du, Y., Crow, M. K., & Barrat, F. J. (2024) · Immunological Reviews · doi:10.1111/imr.13331 · Cited by 28 · see citing works
Role of mitochondrial dysfunction in kidney disease: Insights from the cGAS-STING signaling pathway
Li, L., Liu, F., Feng, C., Chen, Z., Zhang, N., & Mao, J. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003022 · Cited by 27 · see citing works
Emerging dimensions of cellular cGAS-STING signaling
Guey, B., & Ablasser, A. (2022) · Current Opinion in Immunology · doi:10.1016/j.coi.2022.01.004 · Cited by 26 · see citing works
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Role of novel protein acylation modifications in immunity and its related diseases
Li, X., Yu, T., Li, X., He, X., Zhang, B., & Yang, Y. (2024) · Immunology · doi:10.1111/imm.13822 · Cited by 25 · see citing works
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Yennemadi, A. S., Keane, J., & Leisching, G. R. (2023) · Lupus · doi:10.1177/09612033231164635 · Cited by 22 · see citing works
Enhanced lactate accumulation upregulates PD‐L1 expression to delay neutrophil apoptosis in sepsis
Fei, M., Zhang, H., Meng, F., An, G., Tang, J., Tong, J., Xiong, L., Liu, Q., & Li, C. (2023) · Open Research (University of Surrey) · doi:10.1002/viw.20230053 · Cited by 22 · see citing works
Therapeutic landscape in systemic lupus erythematosus: mtDNA activation of the cGAS-STING pathway
Gu, X., Chen, Y., Cao, K., Tu, M., Liu, W., & Ju, J. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112114 · Cited by 21 · see citing works
The role of lactate metabolism and lactylation in pulmonary arterial hypertension
Peng, T.-Y., Lu, J., Zheng, X.-L., Zeng, C. C., & He, Y. (2025) · Respiratory Research · doi:10.1186/s12931-025-03163-3 · Cited by 24 · see citing works
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The in vivo drug delivery pattern of the organelle-targeting small molecules
Fang, Z., & Chen, H. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115020 · Cited by 21 · see citing works
The Roles of Lactate and Lactylation in Diseases Related to Mitochondrial Dysfunction
Ma, F., & Yu, W. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157149 · Cited by 20 · see citing works
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Mitochondrial regulation of erythropoiesis in homeostasis and disease
Menon, V., Slavinsky, M., Hermine, O., & Ghaffari, S. (2024) · British Journal of Haematology · doi:10.1111/bjh.19600 · Cited by 19 · see citing works
Metabolic reprogramming shapes post-translational modification in macrophages
Han, Z., Shen, Y., Yan, Y., Bin, P., Zhang, M., & Gan, Z. (2025) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2025.101338 · Cited by 19 · see citing works
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Defective Lamtor5 Leads to Autoimmunity by Deregulating v‐ATPase and Lysosomal Acidification
Zhang, W. K., Sha, Z., Tang, Y., Jin, C., Gao, W., Chen, C., Yu, L., Lv, N., Liu, S., Xu, F., et al. (2024) · Advanced Science · doi:10.1002/advs.202400446 · Cited by 16 · see citing works
Chen, H., Li, H., Jiang, X., Wang, Y., Bian, Y., Ma, S., & Liu, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1025688 · Cited by 17 · see citing works
Expansion and differentiation of ex vivo cultured erythroblasts in scalable stirred bioreactors
Gallego‐Murillo, J. S., Iacono, G., van der Wielen, L. A. M., van den Akker, E., Lindern, M. V., & Wahl, A. (2022) · Biotechnology and Bioengineering · doi:10.1002/bit.28193 · Cited by 14 · see citing works
Type I interferons in health and disease: molecular aspects and clinical implications
Mavragani, C. P., & Crow, M. K. (2025) · Physiological Reviews · doi:10.1152/physrev.00047.2024 · Cited by 15 · see citing works
The cGAS-STING pathway: Mechanism and medical implications
Hooftman, A., Keller, A., & Ablasser, A. (2026) · Cell · doi:10.1016/j.cell.2026.06.001 · Cited by 20 · see citing works
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Immunometabolic alterations in lupus: where do they come from and where do we go from there?
Ma, L., Roach, T., & Morel, L. M. (2022) · Current Opinion in Immunology · doi:10.1016/j.coi.2022.102245 · Cited by 15 · see citing works
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Abnormal energy metabolism in the pathogenesis of systemic lupus erythematosus
Cao, S., Jiang, J., Yin, H., Wang, L., & Lu, Q. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112149 · Cited by 16 · see citing works
Roles of lactylation in lipid metabolism and related diseases
Zhao, B. T., Lan, Z., Li, C., & Wang, H. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02705-4 · Cited by 14 · see citing works
cGAS–STING signaling pathway as a therapeutic target in human diseases
Xiao, Y., Ma, Y., Zhao, J., Zhang, X., Gan, C., Gao, J., & Huang, Z. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003904 · Cited by 15 · see citing works
Rafael‐Vidal, C., Martínez-Ramos, S., Malvar‐Fernández, B., Altabás‐González, I., Mouriño, C., Veale, D. J., Floudas, A., Fearon, U., Pego‐Reigosa, J. M., & García, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1277267 · Cited by 14 · see citing works
Immunoregulation role of the erythroid cells
Niu, C., & Zhang, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1466669 · Cited by 14 · see citing works
Animal models of systemic lupus erythematosus and their applications in drug discovery
Xin, Y., Zhang, B., Zhao, J., Liu, Q., Yin, H., & Lu, Q. (2022) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2022.2050691 · Cited by 13 · see citing works
Zhu, Z., Huang, C., Chen, J., Wan, L., Zhang, C., & Wang, J. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07498-9 · Cited by 14 · see citing works
Intracellular Sensing of DNA in Autoinflammation and Autoimmunity
MacLauchlan, S., Fitzgerald, K. A., & Gravallese, E. M. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42256 · Cited by 12 · see citing works
Metabolite to Modifier: Lactate and Lactylation in the Evolution of Tumors
Zhao, L., Cui, H., Li, Y., Ye, Y., & Shen, Z. (2025) · MedComm · doi:10.1002/mco2.70413 · Cited by 11 · see citing works
Human TLR8 induces inflammatory bone marrow erythromyeloblastic islands and anemia in SLE-prone mice
Maria, N. I., Papoin, J., Raparia, C., Sun, Z., Josselsohn, R., Lu, A., Katerji, H., Syeda, M. M., Polsky, D., Paulson, R. F., et al. (2023) · Life Science Alliance · doi:10.26508/lsa.202302241 · Cited by 11 · see citing works
- Authors
- Caielli, S., Cardenas, J., de Jesus, A. A., Baisch, J., Walters, L., Blanck, J. P., Balasubramanian, P., Stagnar, C., Ohouo, M., Hong, S., Nassi, L., Stewart, K., Fuller, J., Gu, J., Banchereau, J. F., Wright, T., Goldbach-Mansky, R., & Pascual, V.
- Affiliations
- Weill Cornell Medicine (US)
- Texas Scottish Rite Hospital for Children (US)
- The Jackson Laboratory for Genomic Medicine (US)
- Corresponding author
- Caielli, Simone
- Pascual, Virginia
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 184
- Issue
- 17
- Pages
- 4464-4479.e19
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC8380737
- OpenAlex
- W3189265697
- Cited by
- 228
- References
- 88
- Citations by year
- 2026: 36 · 2025: 53 · 2024: 60 · 2023: 40 · 2022: 33 · 2021: 6
- FWCI
- 26.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 384 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- NIH (U19 AI082715)
- Sanofi
- AstraZeneca
- Weill Cornell Medical College
- National Institute of Allergy and Infectious Diseases
- Lupus Research Alliance
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- systemic lupus erythematosus, erythropoiesis, autophagy, hypoxia-inducible factor, ubiquitin-proteasome system, mitochondrial dysfunction, type I interferon, cGAS, macrophages, opsonic antibodies, interferon-stimulated genes, disease activity
- MeSH terms
- Endothelial PAS Domain-Containing Protein 1, Adolescent, Child, Child, Preschool, Erythroblasts, Erythrocytes, Erythropoiesis, Humans, Interferon Type I, Lupus Erythematosus, Systemic, Mitochondria, Myeloid Cells, Ubiquitin, Proteasome Endopeptidase Complex, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Mitophagy
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