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The Cell Biology of Ferroptosis

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Iron Homeostasis and Ferroptosis in Human Diseases: Mechanisms and Therapeutic Prospects

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GPX4, ferroptosis, and diseases

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An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis

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Exploiting ferroptosis vulnerabilities in cancer

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Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes

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Therapeutic inhibition of ferroptosis in neurodegenerative disease

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Research on ferroptosis as a therapeutic target for the treatment of neurodegenerative diseases

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A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer's disease

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Apolipoprotein E in Alzheimer’s disease: molecular insights and therapeutic opportunities

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The link between amyloid β and ferroptosis pathway in Alzheimer’s disease progression

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Selenoproteins and tRNA-Sec: regulators of cancer redox homeostasis

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A Concise Review on Oxidative Stress-Mediated Ferroptosis and Cuproptosis in Alzheimer’s Disease

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Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer’s disease

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Inhibition of ferroptosis through regulating neuronal calcium homeostasis: An emerging therapeutic target for Alzheimer’s disease

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Ferroptosis: Emerging Role in Diseases and Potential Implication of Bioactive Compounds

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Striking a NRF2: The Rusty and Rancid Vulnerabilities Toward Ferroptosis in Alzheimer's Disease

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Neuroinflammation in Age-Related Neurodegenerative Diseases: Role of Mitochondrial Oxidative Stress

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Fluorescent probes for lighting up ferroptotic cell death: A review

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Multi-Target Neuroprotection of Thiazolidinediones on Alzheimer’s Disease via Neuroinflammation and Ferroptosis

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Natural Flavonoids and Ferroptosis: Potential Therapeutic Opportunities for Human Diseases

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Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration?

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Secreted Apoe rewires melanoma cell state vulnerability to ferroptosis

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Improving understanding of ferroptosis: Molecular mechanisms, connection with cellular senescence and implications for aging

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Ferroptosis and cognitive impairment: Unraveling the link and potential therapeutic targets

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Roles of Ubiquitin Ligases and Deubiquitylases in Alzheimer’s Disease

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Ferroptosis in Alzheimer's Disease: The Regulatory Role of Glial Cells.

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COVID-19 and Alzheimer's Disease: Neuroinflammation, Oxidative Stress, Ferroptosis, and Mechanisms Involved

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The crystal structure of human ferroptosis suppressive protein 1 in complex with flavin adenine dinucleotide and nicotinamide adenine nucleotide

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Iron on trial: recasting the role of iron in neurodegeneration

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CRISPR screen reveals a simultaneous targeted mechanism to reduce cancer cell selenium and increase lipid oxidation to induce ferroptosis

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Ferroptosis: A new strategy for targeting Alzheimer’s disease

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MiR-7a–Klf4 axis as a regulator and therapeutic target of neuroinflammation and ferroptosis in Alzheimer’s disease

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Symphony of regulated cell death: Unveiling therapeutic horizons in sarcopenia

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Ferroptosis in Alzheimer’s disease: molecular mechanisms and advances in therapeutic strategies

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Targeting the Gut-Brain-Ferroptosis Axis: Molecular Mechanisms and Therapeutic Potential in Alzheimer’s Disease and Epilepsy

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Programmed Cell Death Pathways in Cholangiocarcinoma: Opportunities for Targeted Therapy

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Targeting Metals in Alzheimer’s Disease: An Update

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Exploring the association between aging, ferroptosis, and common age-related diseases

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Ferroptosis-Regulated Cell Death as a Therapeutic Strategy for Neurodegenerative Diseases: Current Status and Future Prospects

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TXNIP promotes ferroptosis through NCOA4 mediated ferritinophagy

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Alzheimer’s disease induced neurons bearing PSEN1 mutations exhibit reduced excitability

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Anti-NOTCH1 therapy with OMP-52 M51 inhibits salivary adenoid cystic carcinoma by depressing epithelial-mesenchymal transition (EMT) process and inducing ferroptosis

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Ferroptosis and Alzheimer’s disease: a new insight into neurodegeneration

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Origins of nervous tissue susceptibility to ferroptosis

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The metabolic code of ferroptosis: nutritional regulators of cell death

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Regulation of apoptosis, ferroptosis, and pyroptosis mediated by acetylation

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Iron metabolism: An emerging therapeutic target underlying the anti-Alzheimer's disease effect of ginseng

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Engineering acyclovir-induced RNA nanodevices for reversible and tunable control of aptamer function

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Oxidized phospholipids in ferroptosis, immunity and inflammation

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A perspective on autophagy and transcription factor EB in Alcohol-Associated Alzheimer’s disease

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Regulated neuronal death in Alzheimer's disease: Crosstalk and convergence of apoptosis, pyroptosis, senescence, and ferroptosis

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Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

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Familial Alzheimer’s Disease Neurons Bearing Mutations in PSEN1 Display Increased Calcium Responses to AMPA as an Early Calcium Dysregulation Phenotype

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Emerging roles and therapeutic potentials of ferroptosis: from the perspective of 11 human body organ systems

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β-Glucan nanotubes loaded with iron diselenide for enhanced photothermal and photodynamic therapy in hepatocellular carcinoma

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EOGT knockdown promotes ferroptosis and inhibits hepatocellular carcinoma proliferation by regulating SLC7A11 via HEY1

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miR-21-5p ameliorates Busulfan-induced testicular dysfunction and maintains spermatogenesis

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Integrated bioinformatics, network pharmacology, molecular docking, and molecular dynamics simulation to explore the potential pharmacological mechanism of Erigeron breviscapus (Vant.) Hand-Mazz regulating ferroptosis for the treatment of Alzheimer's disease

Xu, B., Sun, G., & Zhang, Y. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.138698 · Cited by 3 · see citing works

Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases

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Exploring the co‐morbid relationship between Alzheimer's disease and lung cancer in the 5xFAD transgenic mouse model

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ACSL4 in Alzheimer's disease: Pathogenetic mechanisms and potential therapeutic targets

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Presenilin mutations disrupt iron homeostasis to promote ferroptosis mediated neurodegeneration in Caenorhabditis elegans

Ryan, K. C., Laboy, J. T., Ashraf, R., Ashkavand, Z., Jayasinghe, I., & Norman, K. R. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103910 · Cited by 2 · see citing works

Redundant or resilient? A systems view of ferroptosis surveillance mechanisms

Liang, D., & Jiang, X. (2026) · Cell chemical biology · doi:10.1016/j.chembiol.2025.11.013 · Cited by 2 · see citing works

Constructing a prognostic risk model for Alzheimer’s disease based on ferroptosis

Wang, X., Zhai, R.-Q., Li, Z., Li, H.-Q., Lei, Y.-T., Zhao, F.-F., Hao, X.-X., Wang, S., & Wu, Y. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1168840 · Cited by 1 · see citing works

MicroRNA-124a promoted the differentiation of bone marrow mesenchymal stem cells into neurons through Notch signal pathway

Wang, D., Jing, L., Zhao, Z., Huang, S., Xie, L., Hu, S., Liang, H., Chen, Y., & Zhao, E. (2024) · European journal of medical research · doi:10.1186/s40001-024-02061-6 · Cited by 1 · see citing works

Proteomic Investigation of Neurotrophic trans-Banglene Reveals Potential Link to Iron Homeostasis

Gunawardana, P. B. W., Gohil, K., Moon, K., Foster, L. J., & Williams, F. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04772-1 · Cited by 2 · see citing works

Integrated multi-omics analysis reveals the bioactive components and mechanism of selenium-enriched rapeseed in enhancing male reproductive function

Lu, Y., Fang, X., Dun, X., Wang, X., Jiang, L., Wang, H., & Chen, Z. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107450 · Cited by 1 · see citing works

Pre-activation of T cell immunity potentiates ferroptotic cell death through arachidonic acid hybridized nanovesicles

Lyu, Q., Liu, C., Li, S., Shan, D., Han, H., Wang, L., & Xu, H. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03797-x · Cited by 1 · see citing works

Methylmercury induces ferroptosis by suppressing GPX4 protein levels in C17.2 mouse neural stem cells

Yamashita, N., Nozuki, H., Yamashita, T., Tsubaki, K., Fukushima, R., Yamagata, R., & Hwang, G. (2026) · The Journal of Toxicological Sciences · doi:10.2131/jts.51.101 · Cited by 1 · see citing works

Decoding the key mechanisms of ferroptosis and inflammation: Emerging therapeutic targets for Alzheimer's disease

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Proteomic Investigation of Neurotrophic trans -Banglene Reveals Potential Link to Iron HomeostasisPreprint

Gunawardana, P. B. W., Gohil, K., Moon, K., Foster, L. J., & Williams, F. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.04.611284 · Cited by 1 · see citing works

The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosisPreprint

Mahoney‐Sanchez, L., Clarke, H., Penverne, A., Evans, J. R., D’Sa, K., Strohbuecker, S., Lopez-Garcia, P., Cosker, K., Šoltić, D., O’Callaghan, B., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.13.682089 · Cited by 1 · see citing works

A modified decision tree improves generalization across multiple brains proteomic data sets and reveals the role of ferroptosis in Alzheimer’s diseasePreprint

Ivanov, M. V., Kopeykina, A. S., Kazakova, E. M., Tarasova, I. A., Sun, Z., Postoenko, V. I., Yang, J.-H., & Gorshkov, M. V. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.07.606974

リポタンパク質受容体ApoER2によるがん細胞のフェロトーシス制御

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Iron Dyshomeostasis in Schizophrenia and Potential Treatments to Mitigate Its Effects

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Modified Decision Tree with Custom Splitting Logic Improves Generalization across Multiple Brains’ Proteomic Data Sets of Alzheimer’s Disease

Ivanov, M. V., Kopeykina, A. S., Kazakova, E. M., Tarasova, I. A., Sun, Z., Postoenko, V. I., Yang, J.-H., & Gorshkov, M. V. (2025) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c00677 · Cited by 1 · see citing works

The protective role of vitamins against neurotoxicity associated with ferroptosis

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Interactions between the gut microbiome and ferroptosis in degenerative diseases: Novel mechanisms and potential therapeutic strategies

Chen, Y., Wei, X., Yi, X., & Jiang, D. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.01.020

Natural Products for Alzheimer’s Disease: A New Twist Impacting Ferroptosis

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Microfluidic compartmentalization reveals that ferrostatin-1 restores directional mitochondrial transport in Aβ-challenged neurons

Majerníková, N., Corci, B., Zhang, Y., Chen, T., van Koeveringe, M., Mensinga, D., Mulder, P. P. M. F. A., Verpoorte, E. M. J., Mattarei, A., Pendin, D., et al. (2026) · Lab on a Chip · doi:10.1039/d5lc00834d

Based on Bioinformatics Analysis of Ferroptosis-Immune Interaction Core Genes and Immune Infiltration Characteristics in Alzheimer’s Disease

Ma, J., Li, Y., Zheng, R., & Jian, C. (2026) · Open Journal of Internal Medicine · doi:10.4236/ojim.2026.162024

Advances in nano-TCM for Alzheimer’s disease: lipid-based carriers integrated with innovative delivery strategies

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MDM2/Notch-Ferroptosis crosstalk in cancer: metabolic rewiring, immune evasion, and organ-specific metastasis

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Notch-1 suppressed ocular trauma injury in ganglion cells via modulating NICD/YAP/EZH2 signaling induced ferroptosis

Miao, H., Jiang, X., & Liu, X. (2026) · Scientific Reports · doi:10.1038/s41598-026-64030-9

The Substrate-Engine Model of Ferroptosis: Stage-Specific Targeting of Acyl-CoA Synthetase Long-Chain Family Member 4 and 5-Lipoxygenase in Alzheimer’s Disease

Mondal, A., Acharya, R., & Jain, S. (2026) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.6c00163

Metal Ions and Protein Aggregation: Unraveling Molecular Interactions and Theranostic Prospects in Proteinopathies

Milardi, D., Han, J., Lee, H. J., Ding, F., Miller, Y., Faller, P., Bush, A. I., Crouch, P. J., Finkelstein, D. I., Double, K. L., et al. (2026) · Chemical Reviews · doi:10.1021/acs.chemrev.5c00420

Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease

Bao, W.-D., Pang, P., Zhou, X.-T., Hu, F., Xiong, W., Chen, K., Wang, J., Wang, F., Xie, D., Ya⁃zhuo, H. U., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-020-00685-9 · Cited by 679 · see citing works

Ferroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer's disease

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Iron dyshomeostasis and ferroptosis in Alzheimer’s disease: Molecular mechanisms of cell death and novel therapeutic drugs and targets for AD

Zhang, Y., Wang, M., & Chang, W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.983623 · Cited by 67 · see citing works

Enhanced defense against ferroptosis ameliorates cognitive impairment and reduces neurodegeneration in 5xFAD mice

Chen, L., Dar, N. J., Na, R., McLane, K. D., Yoo, K., Han, X., & Ran, Q. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.01.002 · Cited by 80 · see citing works

Presenilin Deficiency Increases Susceptibility to Oxidative Damage in Fibroblasts

Zou, K., Islam, S., Sun, Y., Gao, Y., Nakamura, T., Komano, H., Tomita, T., & Michikawa, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.902525 · Cited by 3 · see citing works