The microbiome: A target for Alzheimer disease?
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The AppNL-F and AppNL-G-F alleles impact the gut microbiome in ways that link to cognitive performance.
“Collectively, these results suggest that the AppNL-F and AppNL-G-F alleles impact the gut microbiome in ways that link to cognitive performance, and support the hypothesis that AD risk alleles may elicit their impact on cognition at least in part by altering the microbiome’s contribution to neurophysiology49–52.”
From Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in AppNL-G-F, AppNL-F, and wild type mice (2021) · cites this paper as [49]
The main text (pp. 779–780) links gut-microbiome changes with cognitive impairment in 5xFAD and APP/PS1 mouse models. It does not discuss the AppNL-F or AppNL-G-F alleles, so it does not support the allele-specific claim. (LLM, conf=0.86)
Experimental — accuracy not yet measuredAD risk alleles may elicit their impact on cognition at least in part by altering the microbiome's contribution to neurophysiology.
“Collectively, these results suggest that the AppNL-F and AppNL-G-F alleles impact the gut microbiome in ways that link to cognitive performance, and support the hypothesis that AD risk alleles may elicit their impact on cognition at least in part by altering the microbiome’s contribution to neurophysiology49–52.”
From Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in AppNL-G-F, AppNL-F, and wild type mice (2021) · cites this paper as [49]
The main text (pp. 779–780) reports microbiome changes and cognitive impairment in 5xFAD mice, and says that modulating the gut microbiota partly improved cognition in APP/PS1 mice. This supports a possible microbiome–cognition link, but the paper does not test the AppNL-F or AppNL-G-F alleles or establish that AD risk alleles generally affect cognition through the microbiome. (LLM, conf=0.84)
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Research Advances and Perspectives on Gut Microbiota Regulating Alzheimer’s Disease
Zhu, F., & Shao, X. (2026) · Biology · doi:10.3390/biology15201893
- Authors
- Seo, D.-O., Boros, B. D., & Holtzman, D. M.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Holtzman, David M.
- Venue
- Cell Research
- Published
- 2019-09-06
- Volume
- 29
- Issue
- 10
- Pages
- 779-780
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- PMC
- PMC6796832
- OpenAlex
- W2971579341
- Cited by
- 56
- References
- 10
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 9 · 2023: 8 · 2022: 9 · 2021: 11 · 2020: 5 · 2019: 2
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, gut microbiota, microbiome, peripheral immune cells, amyloidosis, mouse model, behavior change, neuroinflammation, gut-brain axis
- MeSH terms
- Gastrointestinal Microbiome, Alzheimer Disease, Amino Acids, Humans, Sodium, Disease Progression, Microbiota
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