Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease
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Abstract Recent evidence suggests the commensal microbiome regulates host immunity and influences brain function; findings that have ramifications for neurodegenerative diseases. In the context of Alzheimer’s disease (AD), we previously reported that perturbations in microbial diversity induced by life-long combinatorial antibiotic (ABX) selection pressure in the APP SWE /PS1 ΔE9 mouse model of amyloidosis is commensurate with reductions in amyloid-β (Aβ) plaque pathology and plaque-localised gliosis. Considering microbiota-host interactions, specifically during early post-natal development, are critical for immune- and neuro-development we now examine the impact of microbial community perturbations induced by acute ABX exposure exclusively during this period in APP SWE /PS1 ΔE9 mice. We show that early post-natal (P) ABX treatment (P14-P21) results in long-term alterations of gut microbial genera (predominantly Lachnospiraceae and S24-7 ) and reduction in brain Aβ deposition in aged APP SWE /PS1 ΔE9 mice. These mice exhibit elevated levels of blood- and brain-resident Foxp3 + T-regulatory cells and display an alteration in the inflammatory milieu of the serum and cerebrospinal fluid. Finally, we confirm that plaque-localised microglia and astrocytes are reduced in ABX-exposed mice. These findings suggest that ABX-induced microbial diversity perturbations during post-natal stages of development coincide with altered host immunity mechanisms and amyloidosis in a murine model of AD.
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- Authors
- Minter, M. R., Hinterleitner, R., Meisel, M., Zhang, C., Leone, V., Zhang, X., Oyler-Castrillo, P., Zhang, X., Musch, M. W., Shen, X., Jabri, B., Chang, E. B., Tanzi, R. E., & Sisodia, S. S.
- Affiliations
- University of Chicago (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Sisodia, Sangram S.
- ORCID
- Venue
- Scientific Reports
- Published
- 2017-09-05
- Volume
- 7
- Issue
- 1
- Pages
- 10411-10411
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5585265
- OpenAlex
- W2753802402
- Cited by
- 292
- References
- 86
- Citations by year
- 2026: 12 · 2025: 31 · 2024: 45 · 2023: 40 · 2022: 44 · 2021: 41 · 2020: 32 · 2019: 27 · 2018: 20
- FWCI
- 15.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Cure Alzheimer's Fund
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK042086)
- Argonne National Laboratory
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, gut microbiota, antibiotic exposure, postnatal development, amyloid plaques, APPswe/PS1ΔE9 mice, Lachnospiraceae, S24-7, regulatory T cells, Foxp3, neuroinflammation, cerebrospinal fluid, microglia, astrocytes, gliosis, microbiota-host interactions, brain development
- MeSH terms
- Gastrointestinal Microbiome, Alzheimer Disease, Amyloidosis, Animals, Anti-Bacterial Agents, Brain, Disease Models, Animal, Male, Mice, Transgenic, RNA, Ribosomal, 16S, Neuroimmunomodulation, Biomarkers, Amyloid beta-Protein Precursor, Inflammation Mediators, Biodiversity, Mice, Metagenome, Metagenomics, Plaque, Amyloid, Microbiota
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