Cited by 571Chemokine receptors and signalingNeutrophil, Myeloperoxidase and Oxidative MechanismsInflammation biomarkers and pathways

The DOI matches its Crossref record; 243 of the 246 references it cites were found in a registry or an index.

Neutrophil chemoattractant receptors in health and disease: double-edged swords

Open access

Metzemaekers, Mieke, Gouwy, Mieke, Proost, Paul·2020·Cellular & Molecular Immunology

DOI 10.1038/s41423-020-0412-0PMC PMC7192912

Open this paper in CoChat — free account Open PDF

Abstract

Neutrophils are frontline cells of the innate immune system. These effector leukocytes are equipped with intriguing antimicrobial machinery and consequently display high cytotoxic potential. Accurate neutrophil recruitment is essential to combat microbes and to restore homeostasis, for inflammation modulation and resolution, wound healing and tissue repair. After fulfilling the appropriate effector functions, however, dampening neutrophil activation and infiltration is crucial to prevent damage to the host. In humans, chemoattractant molecules can be categorized into four biochemical families, i.e., chemotactic lipids, formyl peptides, complement anaphylatoxins and chemokines. They are critically involved in the tight regulation of neutrophil bone marrow storage and egress and in spatial and temporal neutrophil trafficking between organs. Chemoattractants function by activating dedicated heptahelical G protein-coupled receptors (GPCRs). In addition, emerging evidence suggests an important role for atypical chemoattractant receptors (ACKRs) that do not couple to G proteins in fine-tuning neutrophil migratory and functional responses. The expression levels of chemoattractant receptors are dependent on the level of neutrophil maturation and state of activation, with a pivotal modulatory role for the (inflammatory) environment. Here, we provide an overview of chemoattractant receptors expressed by neutrophils in health and disease. Depending on the (patho)physiological context, specific chemoattractant receptors may be up- or downregulated on distinct neutrophil subsets with beneficial or detrimental consequences, thus opening new windows for the identification of disease biomarkers and potential drug targets.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41423-020-0412-0

Cites

243 of 243 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713
Getting to the site of inflammation: the leukocyte adhesion cascade updated
Ley, K., Laudanna, C., Cybulsky, M. I., & Nourshargh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2156 · Cited by 4,354
Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
Fridlender, Z. G., Sun, J., Kim, S., Kapoor, V., Cheng, G., Ling, L. E., Worthen, G. S., & Albelda, S. Μ. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.017 · Cited by 3,470
A guide to chemokines and their receptors
Hughes, C. E., & Nibbs, R. J. B. (2018) · FEBS Journal · doi:10.1111/febs.14466 · Cited by 1,510
The Neutrophil’s Role During Health and Disease
Liew, P. X., & Kubes, P. (2019) · Physiological Reviews · doi:10.1152/physrev.00012.2018 · Cited by 1,237
Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation
McDonald, B., Pittman, K., Menezes, G. B., Hirota, S. A., Slaba, I., Waterhouse, C. C. M., Beck, P. L., Muruve, D. A., & Kubes, P. (2010) · Science · doi:10.1126/science.1195491 · Cited by 1,210
Neutrophil migration in infection and wound repair: going forward in reverse
de Oliveira, S., Rosowski, E. E., & Huttenlocher, A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.49 · Cited by 1,058
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors
Bachelerie, F., Ben‐Baruch, A., Burkhardt, A. M., Combadière, C., Farber, J. M., Graham, G. J., Horuk, R., Sparre‐Ulrich, A. H., Locati, M., Luster, A. D., et al. (2013) · Pharmacological Reviews · doi:10.1124/pr.113.007724 · Cited by 888
CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma
Steele, C. W., Karim, S. A., Leach, J. D. G., Bailey, P. J., Upstill‐Goddard, R., Rishi, L., Foth, M., Bryson, S., McDaid, K., Wilson, Z., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.04.014 · Cited by 857
Neutrophil ageing is regulated by the microbiome
Zhang, D., Chen, G., Manwani, D., Mortha, A., Xu, C., Faith, J. J., Burk, R. D., Kunisaki, Y., Jang, J.-E., Scheiermann, C., et al. (2015) · Nature · doi:10.1038/nature15367 · Cited by 839

Show all 246 references

Sorted by citations

Items 301–400 of 571

Interleukin 17A in the fibrotic-related processes in endometrosis in the mare
Sadowska, A., Wójtowicz, A., Molcan, T., Drzewiecka, E. M., Kaczmarek, M. M., Słyszewska, M., Ferreira-Dias, G. M., & Szóstek-Mioduchowska, A. Z. (2025) · Theriogenology · doi:10.1016/j.theriogenology.2025.117680 · Cited by 4
Endothelial activation during the diapedesis of cancer cells: between the kiss of death and therapeutic breakthrough
Piwowarczyk, K., Madeja, Z., Siedlar, M., & Czyż, J. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00797-5 · Cited by 5
“For instance, CSF-1 and MCP-1 act as chemoattractants for monocytes/ macrophages [62, 63], whereas CXCL1–CXCL-3, CXCL5–CXCL8, chemotactic lipids, complement anaphylatoxins, and formyl peptides induce the chemotaxis of neutrophiles [64].”
The role of neutrophils in the pathophysiology of inflammatory bowel diseases
Steffens, J. P., Yay, E., de Molon, R. S., Stoica, V., Rimmer, P. J., Hirschfeld, J., Iqbal, A. J., Iqbal, T. H., & Chapple, I. (2025) · Periodontology 2000 · doi:10.1111/prd.70037 · Cited by 4
“20,133 One of the key consequences of excessive neutrophilic infiltration in the gut mucosa is the disruption of the epithelial barrier.”
A meta-analysis of chemokines in alopecia areata: recruiting immune cells toward the hair follicle
Caelenberg, E. V., Belpaire, A., van Geel, N., & Speeckaert, R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1648868 · Cited by 4
“CCL8 is a pleiotropic chemokine activating many different immune cells (57).”
Arntl deficiency in myeloid cells reduces neutrophil recruitment and delays skeletal muscle repair
Watanabe, A., Koike, H., Kumagami, N., Shimba, S., Manabe, I., & Oishi, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-33830-8 · Cited by 3
Neutrophil-Related Gene Expression Signatures in Idiopathic Pulmonary Fibrosis: Implications for Disease Characteristic and Identification of Diagnostic Hub Genes
Lin, Y., Lai, X., Lei, T., Qiu, Y., Deng, Q., Liu, Q., Wang, Z., & Huang, W. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s414734 · Cited by 4
“As a key defense against invading pathogens, neutrophils play a crucial role in protecting the body from infections by rapidly recruiting to the site of infection and phagocytosing the pathogens.(27,28) Additionally, neutrophils modulate both innate and adaptive immune responses,(29) involved in many pathophysiologica…”
Background
Modulation of Macrophage Redox and Apoptotic Processes to Leishmania infantum during Coinfection with the Tick-Borne Bacteria Borrelia burgdorferi
Pessôa-Pereira, D., Scorza, B. M., Cyndari, K. I., Beasley, E. A., & Petersen, C. A. (2023) · Pathogens · doi:10.3390/pathogens12091128 · Cited by 4
“We also found increased IL-8, CXCL1, and CCL2 chemokines associated with neutrophilic and monocytic recruitment downstream of IL-17 signaling [48,65].”
Background
Temporal patterns of gene expression in response to inoculation with a virulent Anaplasma phagocytophilum strain in sheep
Eskeland, S., Granquist, E. G., Stuen, S., Lybeck, K. R., Wilhelmsson, P., Lindgren, P., & Makvandi‐Nejad, S. (2023) · Scientific Reports · doi:10.1038/s41598-023-47801-6 · Cited by 4
“Low levels of CXCR1 and CXCR2 expression are characteristic for activated neutrophil granulocytes as reviewed in 78 , suggesting that the neutrophil granulocytes are activated from 8 dpi and onwards (Fig.”
Background
Effect of nonsteroidal anti‐inflammatory drugs (aspirin and naproxen) on inflammation‐associated proteomic profiles in mouse plasma and prostate during TMPRSS2‐ERG (fusion)‐driven prostate carcinogenesis
Prasad, R. R., Mishra, N., Kant, R., Fox, J. T., Shoemaker, R. H., Agarwal, C., Raina, K., & Agarwal, R. (2024) · Molecular Carcinogenesis · doi:10.1002/mc.23718 · Cited by 4
Visualising Neutrophil Actin Dynamics in Zebrafish in Response to Laser Wounding Using Two-Photon Microscopy
Williantarra, I., Georgantzoglou, A., & Sarris, M. (2024) · BIO-PROTOCOL · doi:10.21769/bioprotoc.4997 · Cited by 4
Chelerythrine ameliorates Aspergillus fumigatus keratitis through suppressing the LOX-1/p38 MAPK signaling pathway
Liu, W., Qi, Y., Diao, W., Lin, J., Zhang, L., Wang, Q., Gu, L., Feng, Z., Chi, M., Wang, Y., et al. (2024) · Cytokine · doi:10.1016/j.cyto.2024.156717 · Cited by 4
The granulocyte colony-stimulating factor produced during Streptococcus suis infection controls neutrophil recruitment in the blood without affecting bacterial clearance
Bleuzé, M., Lehoux, M., Auger, J.-P., Gottschalk, M. G., & Segura, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1403789 · Cited by 5
“This state can be visualized by changes in surface marker expression, including an enhanced expression of the integrin CD11b, the shedding of the L-selectin CD62L and the modulation of the CXC motif chemokine receptor 2 (CXCR2) (11 – 13).”
Background
Mice inflammatory responses to inhaled aerosolized LPS: effects of various forms of human alpha1-antitrypsin
Sivaraman, K., Wrenger, S., Liu, B., Schaudien, D., Hesse, C., Gómez‐Mariano, G., Pérez-Luz, S., Sewald, K., DeLuca, D. S., Wurm, M. J., et al. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiac004 · Cited by 4
Integrative profiling of gene expression and chromatin accessibility elucidates specific transcriptional networks in porcine neutrophils
Herrera-Uribe, J., Lim, K., Byrne, K. A., Daharsh, L., Liu, H., Corbett, R. J., Marco, G., Schroyen, M., Koltes, J. E., Loving, C. L., et al. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1107462 · Cited by 4
Neutrophils are atypical antigen-presenting cells
Vorobjeva, N. V. (2023) · Vestnik Moskovskogo universiteta Seria 16 Biologia · doi:10.55959/msu0137-0952-16-78-2-8 · Cited by 6
TRAIL-induced cytokine production via NFKB2 pathway promotes neutrophil chemotaxis and immune suppression in triple negative breast cancersPreprint
Kundu, M., Greer, Y. E., Lobanov, A. V., Ridnour, L. A., Donahue, R. N., Ng, Y., Ratnayake, S., Voeller, D. M., Weltz, S., Chen, Q., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.19.604341 · Cited by 4
Targeting Neutrophil Function as Therapy for Hidradenitis Suppurativa
Meldrum, E., & Ingram, J. R. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27042076 · Cited by 3
“Neutrophil migration from the circulation to sites of inflammation involves slow rolling, enhanced endothelial adhesion and intraluminal crawling prior to trans-endothelial migration and chemotaxis toward an increasing concentration gradient of chemoattractants within inflamed tissue [34].”
Effects of amber LED on inflammatory and regulatory monocytes and lymphocytes
Sousa, K. D. B., Malavazzi, T. C. D. S., Rodrigues, M. F. S. D., Silva, T., Andreo, L., Deana, A. M., Nunes, F. D., Bussadori, S. K., Mesquita‐Ferrari, R. A., & Fernandes, K. P. S. (2024) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2024.112848 · Cited by 3
Neutrophil-Mediated Effects on Hemostasis and Thrombosis: Unraveling Their Complex Interaction in Thrombotic Events
Hassani, S., Fazeli, A., Dorgalaleh, A., Tabibian, S., Lomei, J., Alipour, M., Zadeh, M. K., & Shams, M. (2025) · Seminars in Thrombosis and Hemostasis · doi:10.1055/a-2605-8019 · Cited by 3
“96 Therefore, TAFIa could prevent C5a-induced neutrophil recruitment and activation by inactivation of C5a.”
Bacterial Infections Shape Cardiac Macrophages’ Response to Ischemia
Geißen, S., Hof, A., Philip, E. S., Wagner, E., Schreiber, C., Singgih, K., Narayan, S., Nemade, H., Hohendorff, L. M., Roever, N. A., et al. (2025) · Circulation Research · doi:10.1161/circresaha.124.325147 · Cited by 3
CD45 and CD148 Are Critically Involved in Neutrophil Recruitment and Function During Inflammatory Arthritis in Mice
Heming, J.-N., Margraf, A., Najder, K., Germena, G., Richter, M., Cappenberg, A., Henke, K., Bardel, B., Schemmelmann, L., Oguama, M., et al. (2025) · Cells · doi:10.3390/cells14151169 · Cited by 3
“…7 days after K/BxN serum injection and performed targeted proteomic analyses for the detection of cytokines/chemokines paralleled by individual ELISA assays for the lipid mediator LTB4 and glycoprotein C5a, both acting as chemoat-tractants [52] (hereafter summarized as chemokine/cytokine profile).”
Neutrophil-chemoattractant CXCL5 increases lung barrier permeability in acute lung injury
Berger, S., Goekeri, C., Pennitz, P., Gutbier, B., Michalick, L., Hoffmann, K., López-Rodríguez, E., Gluhovic, V., Wienhold, S.-M., Behrendt, U., et al. (2025) · Mucosal Immunology · doi:10.1016/j.mucimm.2025.10.003 · Cited by 3
Effects of Advanced Glycation End Products (AGEs) on Human Lung Macrophages: Implications for Pulmonary Inflammation
Palestra, F., Memoli, G., Cristinziano, L., Ferrara, A. L., Carucci, L., Rocca, A. L., Illiano, A., Modestino, L., Poto, R., Galdiero, M. R., et al. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s531689 · Cited by 6
Diesel exhaust particles exaggerate chronic intermittent hypoxia-induced lung neutrophil infiltration through CXCL5 and CCL5 in mice
Sun, Y., Zhang, M., Li, S., Huang, H., & Wu, X. (2025) · Respiratory Medicine · doi:10.1016/j.rmed.2025.108548 · Cited by 3
BDKRB1 activation induces CXCR2 desensitization in neutrophils during severe sepsis and exacerbates disease severity
Arifa, R. D. D. N., Mascarenhas, C., Rossi, L. C. R., Silva, M. E. F., Lucas, L. M. B., Barbosa, J. P. P., Boff, D., Resende, B. G., Tavares, L. D., Reis, A. C., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.185743 · Cited by 3
“On the other hand, CCR2 is upregulated during sepsis, promoting inappropriate migration of neutrophils to remote organs, such as lung, increasing the tissue injury in these organs (2, 13, 14).”
Structural Basis of Chemokine CXCL8 Monomer and Dimer Binding to Chondroitin Sulfate: Insights into Specificity and Plasticity
Mahler, B. P., Nagarajan, B., Sankaranarayanan, N. V., Joseph, P. R. B., Desai, U. R., & Rajarathnam, K. (2026) · Biomolecules · doi:10.3390/biom16010124 · Cited by 3
“A hallmark of the host immune response is the recruitment of circulating neutrophils to sites of infection [1,2].”
Mechanistic understanding of crosstalk between blood vessels and immunity and inflammation in diseases
Cao, Y. (2026) · Immunity & Inflammation · doi:10.1007/s44466-025-00021-1 · Cited by 5
“Fully differentiated neutrophils are equipped with pathogen-recognition machineries, chemotactic receptors, adhesion molecules, and FcRs to accomplish their immune surveillance functions [76].”
Divergent roles for complement components C3 and C4 in controlling Klebsiella pneumoniae gut colonization and systemic dissemination
Valencia‐Bacca, J. D., Jennings‐Gee, J. E., Nutter, N. A., Adams-Sims, A. E., Hegarty, A. A., Nzuki, H. L., Nagpal, R., Zafar, M. A., & Haas, K. M. (2026) · mBio · doi:10.1128/mbio.03416-25 · Cited by 3
“The extent to which local C3a-responsive cells, such as mast cells and/or epithelial cells, as well as Kpn LPS-induced upregulation of C3aR on these and other cell types (57), are involved in eliciting signals that may be required for myeloid cell recruitment requires further study.”
Spatial transcriptomics maps early B-cell and T-cell activation in hidradenitis suppurativa
Lee, J., Ham, S., Lee, J., Krueger, J. G., Lee, Y. I., & Kim, J. (2026) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2026.01.041 · Cited by 3
The glia-neutrophil axis: an understudied crosstalk in bacteria-induced neuroinflammation
Dunphy, A. M., & Marriott, I. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1765892 · Cited by 3
The Role of Neutrophils and NETosis in Diseases: The Implications for Therapy
Ma, Z., Wang, Q., Zhang, Y., Li, Y., Wu, H., Yang, H., & Li, X. (2026) · MedComm · doi:10.1002/mco2.70770 · Cited by 3
Neutrophil immunometabolism in ACLF and sepsis: mechanisms, dysfunction, and therapeutic opportunities
Mukherjee, S., Malemnganba, T., & Acharya, P. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1828801 · Cited by 3
“One aspect we must take cognizance of, however, is that chemokine receptor signaling does not operate in isolation but is highly sensitive to the metabolic state of neutrophils (90).”
Neutrophil accumulation raises defence against Streptococcus equi ssp. zooepidemicus in the absence of Gasdermin D
Li, Y., Lin, Z., Yu, J., Liu, Y., Li, S., Huang, Y., Oladejo, A. O., & Fu, Q. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111891 · Cited by 3
The neonatal liver hosts a spontaneously occurring neutrophil population, exhibiting distinct spatial and functional characteristics from adults
Júnior, W. F. D. S., Lopes, M. A. F., Antunes, M. M., Costa, K. M. D. O., Diniz, A. B., Nakagaki, B. N., de Miranda, C. D. M., Oliveira, H. M. D. C., Reis, A. C., Libreros, S., et al. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae082 · Cited by 3
Causal relationship between circulating cytokines and follicular lymphoma: a two-sample Mendelian randomization study
Sun, C. (2024) · American Journal of Cancer Research · doi:10.62347/jckd6973 · Cited by 3
Associated factors and prognostic implications of neutropenia in individuals with HIV/AIDS
Li, P., Lv, X., Shen, H., Fang, J., Wei, M., Liu, X., & Zhou, F. (2025) · Virology Journal · doi:10.1186/s12985-025-02624-x · Cited by 4
“These cells are equipped with an extensive arsenal of defense strategies, including the phagocytosis and destruction of foreign entities, the release of protein hydrolases, the generation of reactive oxygen species, and the formation of neutrophil extracellular traps (NETs) [2].”
High-dimensional spectral flow cytometry of activation and phagocytosis by peripheral human polymorphonuclear leukocytes
Lamb, E. R., Glomski, I. J., Harper, T. A., Solga, M. D., & Criss, A. K. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf025 · Cited by 3
Heme-induced lung injury in human precision cut lung slices: a new model for acute lung injury
Kewalramani, N., Machahua, C., Marti, T. M., Zandbergen, C., Chortarea, S., Beretta-Piccoli, J., von Garnier, C., Dorn, P., Fytianos, K., & Funke-Chambour, M. (2025) · Respiratory Research · doi:10.1186/s12931-025-03191-z · Cited by 3
CLIC2 regulates immunosuppression and macrophage differentiation in genomically stable gastric cancer
Longo, V., Mazzone, P., Calice, G., Zoppoli, P., Paola, G. D., Cesta, G., Luongo, M., Sabato, C., Russi, S., Laurino, S., et al. (2025) · Biology Direct · doi:10.1186/s13062-025-00666-3 · Cited by 3
“5) [19], with CCL8 being statistically significant ( p = 0.0126).”
Influential
Enhanced neuroprotection in Parkinson's disease by neutrophil-biomimetic nanovesicles through autophagy inhibition and apoptosis antagonism
Li, S., Ren, Y., Xiao, X. R., Chen, Y., Zhao, W. D., Liu, H., Ding, Z., Xu, Y., Xin, H., & Guo, Y. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.166832 · Cited by 3
Peripheral Ulcerative Keratitis: Pathogenesis, Diagnosis, and Multimodal Management
Guerrero-Acosta, J. C., Ortiz-Morales, G., Vera-Duarte, G. R., Navas, A., Graue-Hernández, E. O., & Ramírez-Miranda, A. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15031264 · Cited by 3
“In ANCA-associated vasculitis, neutrophils are primed through Fc-independent mechanisms and interact with complement (C5a–C5aR axis) to produce a self-amplifying neutrophil-complement loop; ophthalmic series document the same neutrophil-rich, melt-prone phenotype at the limbus [21,31,41,42].”
Accelerated wound healing and its promoting effects of topical codeine on the healing of full-thickness cutaneous wound, evidences for modulating cytokines involved in pain, inflammation and collagen biosynthesis
Mahmoudi, Z., & Farahpour, M. R. (2022) · European Journal of Trauma and Emergency Surgery · doi:10.1007/s00068-022-01999-8 · Cited by 3
“Neutrophil and monocyte are used in inflamed tissues and are frequently directed by CXC (C-X-C motif) chemokine subfamilies [14].”
Background
Polysialylation controls immune function of myeloid cells in murine model of pneumococcal pneumonia
Shinde, P., Kiepas, A., Zhang, L., Sudhir, S., Κωνσταντόπουλος, Κ., & Stamatos, N. M. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112648 · Cited by 3
“32,33 The small molecular weight of fMLP makes a significant polySia-induced conformational change unlikely.”
Peripheral Ulcerative Keratitis Associated with Autoimmune Diseases
Świerczyńska, M., Tronina, A., & Mrukwa–Kominek, E. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.112140 · Cited by 3
Clonal and Scalable Endothelial Progenitor Cell Lines from Human Pluripotent Stem Cells
Lee, J., Sternberg, H., Bignone, P. A., Murai, J., Malik, N. N., West, M. D., & Larocca, D. (2023) · Biomedicines · doi:10.3390/biomedicines11102777 · Cited by 3
“CXCL1 was only expressed by old osteoblasts but not young cells [66] and was known to be produced mainly by TNF-stimulated endothelial cells (ECs) as a potent chemoattractant receptor of innate immune system [45].”
Background
Nasopharyngeal neutrophilic‐retention signatures could predict disease progression in early SARS‐CoV‐2 infection
Qi, F., Cao, Y., Shen, Y., Wang, H., Li, D., Yang, Q., Li, Z., & Zhang, Z. (2023) · Journal of Medical Virology · doi:10.1002/jmv.29328 · Cited by 3
Intrathecal Drug Delivery Systems: Functional Characteristics and Tissue Reactivity
Hayek, S. M., Yaksh, T. L., & Sharan, A. D. (2023) · Springer eBooks · doi:10.1007/978-3-031-39558-1_38 · Cited by 3
A study on expression of GRP78 and CHOP in neutrophil endoplasmic reticulum and their relationship with neutrophil apoptosis in the development of sepsis
Zhao, J., Yang, P., Lü, L., Yi, T., Li, Y., Mao, W., Zhou, Q., & Lin, K. (2024) · Journal of Biosciences · doi:10.1007/s12038-023-00409-4 · Cited by 3
“It has been found that the necrotic response of PMNs is ampliﬁed while the apoptotic response is signiﬁcantly delayed in sepsis patients (Metzemaekers et al. 2020; Xie et al. 2020; Qi et al. 2021).”
Aerosolized Harmful Algal Bloom Toxin Microcystin-LR Induces Type 1/Type 17 Inflammation of Murine Airways
Breidenbach, J. D., French, B. W., Stanoszek, L. M., Lavik, J., Maddipati, K. R., Premathilaka, S. H., Baliu-Rodriguez, D., Timalsina, B., Aradhyula, V., Patel, S., et al. (2024) · Toxins · doi:10.3390/toxins16110470 · Cited by 3
Dual roles of GM-CSF in breast cancer: Immunomodulation and therapeutic implications
Guo, Y., Hu, Y., Huang, D., Yang, J., Fu, S., Deng, X., Long, J., Wang, J., & Wang, Y. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104804 · Cited by 3
PI3K Isoforms in Cell Signalling and Innate Immune Cell Responses
Galvão, I., Sousa, L. P., Teixeira, M. M., & Pinho, V. (2022) · Current topics in microbiology and immunology · doi:10.1007/978-3-031-06566-8_6 · Cited by 3
Immunological Evaluation of Individuals Infected with Acinetobacter baumannii.
Ahmed, S., Yaseen, K. H., & Mahmood, M. M. (2022) · PubMed Central · doi:10.22092/ari.2022.357980.2126 · Cited by 3
Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in ChildrenPreprint
Boribong, B. P., LaSalle, T. J., Bartsch, Y. C., Ellett, F. E., Loiselle, M., Davis, J. P., Gonye, A. L. K., Hajizadeh, S., Kreuzer, J., Pillai, S. S., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4066809 · Cited by 3
Anti-Inflammatory Effects of Calcium Hydroxide Combined with Ellagic Acid as Pulp Capping Material: In Vivo Study
Sari, A. F., Nirwana, I., Yuliati, A., Meizarini, A., Rahayu, R. P., Palupi, R., Alexandra, M. F., Nuraida, T. B., Surboyo, M. D. C., & Shariff, K. A. (2024) · European Journal of Dentistry · doi:10.1055/s-0044-1791243 · Cited by 2
“19 The mechanical trauma that is created in the teeth activates the in ﬂ ammation response by the odon-toblast cell.”
CXCR1 Expression in MDA-PCa-2b Cell Upregulates ITM2A to Inhibit Tumor Growth
Adekoya, T. O., Smith, N., Kothari, P., Dacanay, M. A., Li, Y., & Richardson, R. M. (2024) · Cancers · doi:10.3390/cancers16244138 · Cited by 2
“CXCR1 and CXCR2 are expressed in various cell types including immune cells, fibroblasts, endothelial cells, osteoclasts, and cancer cells [14–16].”
Clustering analyses of murine bone marrow-derived neutrophils reveal a phenotypic heterogeneity that can respond differentially to stimulation
Silva, P. H., Peñaloza, H. F., Cordero, J., Kalergis, A. M., Barrera, N. P., & Bueno, S. M. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e42227 · Cited by 2
“…and CD64 (FCGR1A) seem to be involved in specific effects of neutrophil functions such as “ aggregation of neutrophils ” , “ binding of leukocytes ” , and “ accumulation of neutrophils ” , which could be related to the fine regulation of these cells depending on the biological context [27,36].”
The N-terminal ELR+ motif of the neutrophil attractant CXCL8 confers susceptibility to degradation by the Group A streptococcal protease, SpyCEP
Giblin, S. P., McKenna, S., Matthews, S., Sriskandan, S., & Pease, J. E. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108448 · Cited by 2
“Neutrophils are the ﬁ rst immune cells to respond to GAS infections and are speci ﬁ cally recruited to sites of bacterial infection by chemoattractants acting on cell-surface receptors (2), notably the CXC subset of chemokines of which CXCL8 is a principal member (3).”
Regulated Release of Small Extracellular Vesicles Directs Neutrophil Recruitment in Cutaneous Wound Healing
Choi, W., Park, D. J., Dorschner, R. A., Pool, K., Sayeed, S., Kezios, J., Lee, J., Adlawan, S., & Eliceiri, B. P. (2025) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2025.08.034 · Cited by 2
Transcriptome‐Based Identification of Biomarkers Associated With Sphingosine‐1‐Phosphate Signaling Pathway in Aortic Dissection
Li, A., Chen, X., Huang, W., Ni, L., Zhu, L., & Shao, G. (2025) · International Journal of Hypertension · doi:10.1155/ijhy/8882980 · Cited by 2
“CXCL5 promotes neutrophil migration and activates infammatory responses through chemokine C-X-C motif receptor 2 (CXCR2) [38].”
Assessment of neutrophil percentage to albumin ratio as a diagnostic biomarker for osteoarthritis: A cross-sectional study utilizing NHANES data
Lian, Q., Liu, Y., Tian, F., Hu, Y., Li, H., Ding, H., & Zhang, L. (2025) · Medicine · doi:10.1097/md.0000000000045681 · Cited by 2
Targeted nuclear degranulation of neutrophils in the shock stage of severe burns drives rapid neutrophil extracellular trap release during infection to mediate acute lung injury
Xie, C., Gao, X., Li, L., Wei, X., Li, D., Yu, J., & Shao, Y. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.12.003 · Cited by 2
Albumin Nanoparticles Harness Activated Neutrophils to Cross Vascular Barriers for Targeted Subcutaneous and Orthotopic Colon Cancer Therapy
Luo, Z., Dong, L., Zhang, Y., & Zhang, M. (2026) · Journal of Functional Biomaterials · doi:10.3390/jfb17010036 · Cited by 2
“The rationale for employing neutrophils as cellular carriers stems from their innate ability to migrate toward inflammatory and tumor microenvironments [30].”
Association between endo-histological outcomes and colonic mucosal transcriptomic profiles in patients with ulcerative colitis receiving filgotinib
Magro, F., Rogler, G., Feagan, B. G., Peyrin‐Biroulet, L., Oortwijn, A. F., Cougnaud, L., Faes, M., Bauer, Y., Randall, M. J., Rudolph, C., et al. (2026) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaf228 · Cited by 2
Mechanistic insights into neutrophil involvement in liver transplant ischemia-reperfusion injury and rejection
She, Z., Cai, H., Li, X., Jh, C., Chen, Y., Cai, J., & Wu, B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1754165 · Cited by 2
In situ spatial transcriptomics reveals novel markers of the limbal stem cell niche and ocular surface epithelia
Nureen, L., Salerno, A., D’Agostino, S., Barbaro, V., Ferrari, S., Ponzin, D., Vittorio, O., & Girolamo, N. D. (2026) · Stem Cell Reports · doi:10.1016/j.stemcr.2026.102792 · Cited by 2
Identification of prognostic factors and development of a prognostic model in patients with acute diquat (200 g/L) poisoning
Ren, Y., Guo, F., Liu, Y., & Wang, L. (2026) · Clinical Toxicology · doi:10.1080/15563650.2026.2621060 · Cited by 2
“Meanwhile, they also regulate multiple processes, including acute injury repair, carcinogenesis, autoimmunity, and chronic inflammation [38,39]. in our cohort, participants in the non-survival group exhibited significantly higher neutrophil counts and inflammatory indices than their counterparts in…”
Neutrophil-mediated delivery of antibiotics across the tympanic membrane for otitis media treatment in a preclinical model
Tang, W., Ma, X., Marlowe, C., Liu, S. S., Park, K.-W., Chen, P., Shu, H., & Yang, R. (2026) · Science Translational Medicine · doi:10.1126/scitranslmed.adu9186 · Cited by 2
Nanomedicine-based therapeutic strategies for cerebral ischemia–reperfusion injury: from blood–brain barrier penetration to precision targeting
Guo, X., Liu, G., Liu, Y., Jin, M., Zihao, Y. O. N. G., Li, F., Tang, S., Xie, L., Huang, C., Mu, Q., et al. (2026) · European journal of medical research · doi:10.1186/s40001-026-04073-w · Cited by 2
Single-cell spatiotemporal mapping reveals a spleen-to-lung neutrophil axis in antiviral defense
Yang, Z., Cong, B., Wang, B., Liu, S., Liu, Y., Ren, X., & Cao, X. (2026) · Immunity & Inflammation · doi:10.1007/s44466-026-00030-8 · Cited by 2
“We found that a variety of well-characterized chemokines with neutrophil chemotactic potential [12] were highly expressed in the distinct lung cell subpopulations: Cxcl5 was prominently expressed in the LU_Epi_Club; Cxcl12 was highly enriched in LU_Mac_Spp1_Il10, LU_Mac_Spp1_Il10_Mki67 and…”
Heterozygous NFKB1 variant causes inflammatory dysregulation shaped by broader genetic context in common variable immunodeficiency
Hayes, K. M., Boldt, K., Schnorr, P. J., Bawa, P., Abyazi, M. L., Ware, M. S., Gyimesi, G., James, M. F., Ko, H., Cunningham‐Rundles, C., et al. (2026) · JCI Insight · doi:10.1172/jci.insight.198703 · Cited by 2
“…chemoattractant chemokines, and we did see reduction of CXCL1 in the plasma over time upon initiating treatment with infliximab as well as increased mRNA expression of the neutrophil chemoattractants CXCL2 and CXCL3 due to the 1377delT heterozygous NFKB1 variant in CA01-derived iMONOs (48–50).”
Plasma Extracellular Vesicles (EVs)-Mediated Immune Dysregulation and Chronic Inflammation in Autism Spectrum Disorder
Moussa, H. Y. A., Thomas, R., Albatarni, R., Shin, K. C., Nour‐Eldine, W., Alshaban, F. A. W., Abdulla, S. A., Al‐Shammari, A. R., Decock, J. V., & Park, Y. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01723-9 · Cited by 2
“Chemokines such as Gro-alpha (CXCL1) and RANTES (CCL5) were downregulated, whereas pro - inflammatory cytokines including IFN-γ, stem cell growth factor (SCGF-beta), and IL-15 were upregulated in ASD EVs, suggesting that several chemokines and cytokines are dysregulated in ASD EVs compared with HC EVs.”
Influential
Helix 8 in chemotactic receptors of the complement system
Wiśniewski, S., Dragan, P., Makal, A., & Latek, D. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009994 · Cited by 2
“We also performed homology modeling to characterize conformations of another subtype of C5aR recep-tors—C5aR2 and explain its lack of ability to couple with G proteins and affect chemotaxis through the classical G protein-mediated pathway like C5aR1 [16,19].”
AKT2 inhibition accelerates the acquisition of phagocytic ability in induced pluripotent stem cell–derived neutrophils
Hino, T., Nakahara, F., Miyauchi, M., Ito, Y., Masamoto, Y., Morita, K., Kagoya, Y., Kojima, H., & Kurokawa, M. (2023) · Experimental Hematology · doi:10.1016/j.exphem.2023.104137 · Cited by 2
Protective effects of mouthwash formulations of Syzygium polyantha (L.) and Piper betel (L.) on oral microbiota-induced gingivitis
Putri, M. H., Nurjanah, N., Laela, D. S., & Sukmasari, S. (2023) · Healthcare in Low-resource Settings · doi:10.4081/hls.2023.11768 · Cited by 2
Label-Free Dynamic Mass Redistribution Assay To Characterize Holistic Chemokine Receptor Pharmacology in Neutrophils
Thomsen, A. R. B. (2024) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.123.001976 · Cited by 2
CXCR2 perturbation promotes Staphylococcus aureus implant-associated infection
Akaraphanth, M., Nordgren, T. M., & Gries, C. M. (2024) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001821 · Cited by 2
“The regulation of CXCR2 expression and its role during disease is notably complicated and is often situation-dependent [38].”
Background
ATP and Formyl Peptides Facilitate Chemoattractant Leukotriene-B4 Synthesis and Drive Calcium Fluxes, Which May Contribute to Neutrophil Swarming at Sites of Cell Damage and Pathogens Invasion
Golenkina, E. A., Viryasova, G. M., Galkina, S. I., Iakushkina, I. V., Gaponova, T. V., Romanova, Y. M., & Sud’ina, G. F. (2024) · Biomedicines · doi:10.3390/biomedicines12061184 · Cited by 2
“End-target chemoattractants formyl peptides collaborate with intermediate-target chemoattractants (lipid leukotriene B4 and chemokines, e.g., CXCL8) to navigate neutrophil trafficking [30].”
Background
Phagocytosis: A Practical Approach for Evaluating Neutrophil Function in Health and Disease
Rojas-Espinosa, O., Arce‐Paredes, P., Islas-Trujillo, S., Becerril-Villanueva, L. E., & Ponce-Regalado, M. D. (2024) · Modern Research in Inflammation · doi:10.4236/mri.2024.132002 · Cited by 2
Distinctive features and prognostic utility of neutrophil in severe patients with Klebsiella pneumoniae infection
Du, C., Lu, M., Zheng, J., Liu, C., Yang, P., Yi, J., Zhu, L., & Shen, N. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1406168 · Cited by 2
“However, the role of neutrophils during infectious diseases is intricate (Koenderman et al., 2022; Metzemaekers et al., 2020).”
Background
ECRG4 mediates host response to cutaneous infection by regulating neutrophil recruitment and adhesion receptor expression
Pool, K., Hemmat, G. J., & Dorschner, R. A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0310810 · Cited by 2
Adenosine accumulation in the blood of newborn mice weakens antimicrobial host defenses
Ledderose, C., Valsami, E., Elevado, M., Stevenson, A., Abutabikh, R., Curatolo, J., & Junger, W. G. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf003 · Cited by 2
Formyl peptide receptor modulators: a patent review and potential applications for inflammatory diseases (2021–2024)
Tsai, Y.-F., Yang, S.-C., & Hwang, T. (2025) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2025.2515882 · Cited by 2
“FPR1 mainly drives pro-inflammatory responses, whereas FPR2 shows biased agonism with dual functionality, mediating both pro-and anti-inflammatory activities depending on the bound ligand [14].”
Placental inflammation-driven T cell memory formation promotes allergic responses in offspring via endogenous glucocorticoids
Kwon, M. S., Park, W. H., La, J., Kim, C. W., & Lee, H. K. (2025) · Mucosal Immunology · doi:10.1016/j.mucimm.2025.06.006 · Cited by 2
Ferroptosis-related genes MDM2 and CDKN1A as potential biomarkers for COPD
Shi, R., Wang, L., Bai, C., Wang, F., Li, C., Xiao, C., Chen, A. F., & Yang, W. (2025) · Journal of Inflammation · doi:10.1186/s12950-025-00468-4 · Cited by 2
“Meanwhile, senescent neutrophils (CXCR4 high CXCR1/2 low ) in tissues can also return of the cell to the bone marrow [30].”
Assessment of the Functional Activities of Casein Phosphopeptides on Circulating Blood Leukocytes
Mezzomo, T. R., Martins, C. A. F., Marcondes, D. B. D. S., Mischiatti, K. L., & Weffort‐Santos, A. M. (2021) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-021-10166-3 · Cited by 2
Targeting Molecular and Cellular Mechanisms in Chronic Obstructive Pulmonary Disease
Bhatt, S., Kanoujia, J., Nagappa, A. N., & Pai, K. S. R. (2021) · Springer eBooks · doi:10.1007/978-981-33-6827-9_5 · Cited by 2
Screening of Neutrophil Activating Factors from a Metagenome Library of Sponge-Associated Bacteria
Okamura, Y., Takahashi, H., Shiida, A., Hirata, Y., Takeyama, H., & Suzuki, K. (2021) · Marine Drugs · doi:10.3390/md19080427 · Cited by 2
“, leukotriene B4 or LTB4), and formyl peptides [3].”
Background
MAPK activated kinase 2 inhibition shifts the chemokine signature in arthritis synovial fluid mononuclear cells from CXCR3 to CXCR2
Kragstrup, T. W., Sørensen, A. S., Brüner, M., Lomholt, S., Nielsen, M. A., Schafer, P. H., & Deleuran, B. W. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109267 · Cited by 2
Investigating the evolution process of lung adenocarcinoma via random walk and dynamic network analysis
Chen, B., Zhang, J., Wang, T., Shao, C., Miao, L., Zhang, S., & Shang, X. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.953801 · Cited by 2
“Furthermore, the biological functions of neutrophil chemotaxis, peptidoglycan binding, and oligosaccharide binding are associated with some diseases, but there is no direct evidence that they are strongly associated with LUAD (Metzemaekers et al., 2020; Cui et al., 2022; Rye and Bovin, 1997).”
Background
Bioinformatic Analyses of Peripheral Blood Transcriptome Identify Altered Neutrophil-Related Pathway and Different Transcriptomic Profiles for Acute Pancreatitis in Patients with and without Chylomicronemia Syndrome
Liu, C.-L., & Dai, Y.-H. (2023) · Biomolecules · doi:10.3390/biom13020284 · Cited by 2
“This gene encodes CXCR2, which is a major chemokine receptor involved in neutrophil trafficking [81].”
Background
Enhancement of neutrophil chemotaxis by trans-anethole-treated Staphylococcus aureus strains
Kwiatkowski, P. A., Tabiś, A., Sobolewski, P., Płaziński, W., Pruss, A., Sienkiewicz, M., Dołęgowska, B., & Wojciechowska‐Koszko, I. (2023) · PLoS ONE · doi:10.1371/journal.pone.0284042 · Cited by 2
“…peptides (e.g., N-formyl-L-methionyl-L-leucyl-phenylalanine known as fMLP), leukotriene B4, platelet-activating factor, chemokines (e.g., interleukin-8 –IL-8 known as CXCL8) and released through subsequent cascades of complement system reactions–complement components 3a and 5a (C5a) [2–4].”
Background
Indoleamine 2, 3-dioxygenase 1 mediated alterations in the functionality of immune cells, deciphers the pregnancy outcomes in crossbred dairy cows
Mohapatra, S. K., Chaudhary, D., Panda, B. S. K., Somagond, Y. M., Kamboj, A., Kapila, R., & Dang, A. K. (2023) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2023.103972 · Cited by 2
Differences in expression of tumor suppressor, innate immune, inflammasome, and potassium/gap junction channel host genes significantly predict viral reservoir size during treated HIV infectionPreprint
Dwivedi, A. K., Siegel, D. A., Thanh, C., Hoh, R., Hobbs, K. S., Pan, T., Gibson, E. A., Martin, J. N., Hecht, F. M., Pilcher, C. D., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.10.523535 · Cited by 2
Mouse gingival single-cell transcriptomic atlas: An activated fibroblast subpopulation guides oral barrier immunity in periodontitisPreprint
Kondo, T., Gleason, A., Okawa, H., Hokugo, A., & Nishimura, I. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.13.536751 · Cited by 2
“In addition, 363 neutrophils can respond to various chemo-attractants that modulate and finetune various cellular 364 behaviors, such as migration direction, adhesion strength, and functional heterogeneity [70].”
Background
Neutrophils actively swell to potentiate rapid migrationPreprint
Nagy, T. L., Strickland, E., & Weiner, O. D. (2023) · eLife · doi:10.7554/elife.90551.1 · Cited by 2
Infiltrative classical monocyte-derived and SPP1 lipid-associated macrophages mediate inflammation and fibrosis in ANCA-associated glomerulonephritisPreprint
Vegting, Y., Jongejan, A., Neele, A. E., Claessen, N., Sela, G., Prange, K. H. M., Kers, J., Roelofs, J. J. T. H., van der Heijden, J. W., de Boer, O. J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.13.584866 · Cited by 2
Physiological bias governs neutrophil inflammatory threat perceptionPreprint
Pajonczyk, D., Pauli, L., Pünt, C., Sternschulte, M. F., Fehler, O., Vogl, T., Soehnlein, O., Bermúdez, M., Raabe, C. A., & Rescher, U. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.05.588243 · Cited by 2
Neutrophils actively swell to potentiate rapid migrationPreprint
Nagy, T. L., Strickland, E., & Weiner, O. D. (2024) · eLife · doi:10.7554/elife.90551.2 · Cited by 3
Single-cell transcriptomics identifies altered neutrophil dynamics and accentuated T-cell cytotoxicity in tobacco-flavored e-cigarette-exposed mouse lungsPreprint
Kaur, G., Lamb, T. W., Tjitropranoto, A., & Rahman, I. (2025) · eLife · doi:10.7554/elife.106380 · Cited by 2
A nomogram for predicting ischaemic muscle sequelae after revascularization in patients with traumatic femoral-popliteal artery injuries: a retrospective cohort study
Jia, H., Zhang, H., Jin, L., Wang, H., Dong, Q., Chen, W., Zhang, Y., Liu, L., & Hou, Z. (2025) · International Orthopaedics · doi:10.1007/s00264-025-06470-y · Cited by 1
“During reperfusion, the reoxygenation of ischaemic tissues leads to a substantial accumulation of inflammatory cells and the release of large amounts of reactive oxygen species (ROS), hydroxyl radicals, and cytokines, resulting in tissue damage [23].”

Authors: Metzemaekers, M., Gouwy, M., & Proost, P.
Affiliations: KU Leuven (BE)
Corresponding author: Proost, Paul
ORCID: Metzemaekers, Mieke
Gouwy, Mieke
Proost, Paul
Venue: Cellular & Molecular Immunology
Publisher: Springer Science and Business Media LLC
Published: 2020-04-01
Volume: 17
Issue: 5
Pages: 433-450
ISSN: 1672-7681 (ISSN-L)
2042-0226
DOI: 10.1038/s41423-020-0412-0
PMC: PMC7192912
OpenAlex: W3014824156
Cited by: 570
References: 246
Citations by year: 2026: 75 · 2025: 124 · 2024: 115 · 2023: 110 · 2022: 94 · 2021: 43 · 2020: 9
FWCI: 6.87
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Cellular and Molecular Immunology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Lirias (submittedVersion, other-oa)
Funders: Onderzoeksraad, KU Leuven (C16/17/010)
Fonds Wetenschappelijk Onderzoek (G.0808.18N)
EC | Horizon 2020 Framework Programme (779295)
Rega Foundation
M.M. obtained a PhD fellowship supported by the L’Oréal-UNESCO for Women in Science initiative and the FWO-Vlaanderen
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: neutrophils, chemoattractant receptors, G protein-coupled receptors, atypical chemokine receptors, formyl peptides, anaphylatoxins, chemokines, neutrophil trafficking, neutrophil maturation, inflammation resolution, tissue repair, disease biomarkers, therapeutic target
MeSH terms: Animals, Chemotactic Factors, Disease, Health, Humans, Neutrophils, Signal Transduction, Receptors, Formyl Peptide

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neutrophil chemoattractant receptors in health and disease: double-edged swords

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks