Cited by 58Olfactory and Sensory Function StudiesNeuroscience and Neuropharmacology ResearchNeurobiology and Insect Physiology Research

Layer- and cell type-selective co-transmission by a basal forebrain cholinergic projection to the olfactory bulb

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Case, Daniel T., Burton, Shawn D., Gedeon, Jeremy Y., Williams, Sean-Paul G., Urban, Nathaniel N., Seal, Rebecca P.·2017·Nature Communications

Abstract

Abstract Cholinergic neurons in the basal forebrain project heavily to the main olfactory bulb, the first processing station in the olfactory pathway. The projections innervate multiple layers of the main olfactory bulb and strongly influence odor discrimination, detection, and learning. The precise underlying circuitry of this cholinergic input to the main olfactory bulb remains unclear, however. Here, we identify a specific basal forebrain cholinergic projection that innervates select neurons concentrated in the internal plexiform layer of the main olfactory bulb. Optogenetic activation of this projection elicits monosynaptic nicotinic and GABAergic currents in glomerular layer-projecting interneurons. Additionally, we show that the projection co-expresses markers for GABAergic neurotransmission. The data thus implicate neurotransmitter co-transmission in the basal forebrain regulation of this inhibitory olfactory microcircuit.

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  • Olfactory-bulb-projecting cholinergic neurons from the basal forebrain cotransmit GABA and Ach onto deep short axon cells within the internal plexiform layer, reinforcing pervasive GABA cotransmission from this population.

    “More recently, olfactorybulb-projecting cholinergic neurons from the basal forebrain were also shown to cotransmit GABA and Ach onto deep, short axon cells within the internal plexiform layer of the bulb, reinforcing the pervasive nature of GABA cotransmission from this population of cholinergic neurons throughout the brain.91”

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Authors
Case, D. T., Burton, S. D., Gedeon, J. Y., Williams, S.-P. G., Urban, N. N., & Seal, R. P.
Affiliations
  • University of Pittsburgh (US)
  • University of Utah (US)
Corresponding author
Seal, Rebecca P.
Venue
Nature Communications
Published
2017-09-21
Volume
8
Issue
1
Pages
652-652
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2755396562
Cited by
58
References
43
Citations by year
2026: 1 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 9 · 2020: 6 · 2019: 10 · 2018: 4 · 2017: 1
FWCI
3.59
Type
journal article
Language
en
Open access
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Pennsylvania Department of Health
  • National Institutes of Health (5r01dc005798-10)
  • National Institute on Deafness and Other Communication Disorders (R01-DC-005798, R01DC011184, F31DC013490)
  • National Institute of Neurological Disorders and Stroke (R01NS082650)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords
cholinergic projections, main olfactory bulb, basal forebrain, nicotinic acetylcholine receptors, GABAergic neurotransmission, optogenetic stimulation, olfactory processing
MeSH terms
Animals, Female, gamma-Aminobutyric Acid, Male, Mice, Inbred C57BL, Mice, Transgenic, Synaptic Transmission, Olfactory Bulb, Prosencephalon, Diagonal Band of Broca, Amino Acid Transport Systems, Acidic, Cholinergic Neurons

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