Proscription supports robust perceptual integration by suppression in human visual cortex
Open accessAbstract
Perception relies on integrating information within and between the senses, but how does the brain decide which pieces of information should be integrated and which kept separate? Here we demonstrate how proscription can be used to solve this problem: certain neurons respond best to unrealistic combinations of features to provide ‘what not’ information that drives suppression of unlikely perceptual interpretations. First, we present a model that captures both improved perception when signals are consistent (and thus should be integrated) and robust estimation when signals are conflicting. Second, we test for signatures of proscription in the human brain. We show that concentrations of inhibitory neurotransmitter GABA in a brain region intricately involved in integrating cues (V3B/KO) correlate with robust integration. Finally, we show that perturbing excitation/inhibition impairs integration. These results highlight the role of proscription in robust perception and demonstrate the functional purpose of ‘what not’ sensors in supporting sensory estimation.
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Previous theoretical modeling work indicated that opposite neurons in macaque MSTd may be involved in segregating sensory cues.
“Previous theoretical modeling work has indicated that opposite neurons in macaque MSTd may be involved in segregating sensory cues (22, 32, 33).”
From How multisensory neurons solve causal inference. (2021) · cites this paper as [22]
The Results (Derivation of the proscriptive integration model; page unavailable) model incongruent-cue units, and the Discussion says such signals can account for cases of complete cue scission. The paper cites evidence that similar neurons exist in primates, including a macaque MSTd study, but it does not model MSTd neurons specifically or establish their role in segregating cues. (LLM, conf=0.85)
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How multisensory neurons solve causal inference.
Rideaux, R., Storrs, K. R., Maiello, G., & Welchman, A. E. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2106235118 · Cited by 65 · see citing works
“Previous theoretical modeling work has indicated that opposite neurons in macaque MSTd may be involved in segregating sensory cues (22, 32, 33).”
Self-citationZhang, W.-H., Wang, H., Chen, A., Gu, Y., Lee, T. S., Wong, K. M., & Wu, S. (2019) · eLife · doi:10.7554/elife.43753 · Cited by 45 · see citing works
- Authors
- Rideaux, R., & Welchman, A. E.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Welchman, Andrew E.
- Venue
- Nature Communications
- Published
- 2018-04-17
- Volume
- 9
- Issue
- 1
- Pages
- 1502-1502
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5904115
- OpenAlex
- W2791175239
- Cited by
- 27
- References
- 76
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 1
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Apollo (cc-by)
- Funders
- Wellcome Trust (095183, 095183/Z/10/Z)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- proscription, perceptual integration, sensory integration, GABA, excitation-inhibition balance, visual cortex, robust perception, neural suppression
- MeSH terms
- Adult, Cues, Electric Stimulation, Evoked Potentials, Visual, Female, gamma-Aminobutyric Acid, Humans, Male, Models, Neurological, Neurons, Photic Stimulation, Visual Cortex, Visual Perception, Young Adult, Functional Neuroimaging
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