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Cited by 208Multisensory perception and integrationVisual perception and processing mechanismsMotor Control and Adaptation

Multisensory Integration in Macaque Visual Cortex Depends on Cue Reliability

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Morgan, Michael L., DeAngelis, Gregory C., Angelaki, Dora E.·2008·Neuron
DOI 10.1016/j.neuron.2008.06.024PMC PMC2601653
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Abstract

Responses of multisensory neurons to combinations of sensory cues are generally enhanced or depressed relative to single cues presented alone, but the rules that govern these interactions have remained unclear. We examined integration of visual and vestibular self-motion cues in macaque area MSTd in response to unimodal as well as congruent and conflicting bimodal stimuli in order to evaluate hypothetical combination rules employed by multisensory neurons. Bimodal responses were well fit by weighted linear sums of unimodal responses, with weights typically less than one (subadditive). Surprisingly, our results indicate that weights change with the relative reliabilities of the two cues: visual weights decrease and vestibular weights increase when visual stimuli are degraded. Moreover, both modulation depth and neuronal discrimination thresholds improve for matched bimodal compared to unimodal stimuli, which might allow for increased neural sensitivity during multisensory stimulation. These findings establish important new constraints for neural models of cue integration.

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  • Congruent neuron activity is highly predictive of behavioral choice on vestibular-visual combination tasks.

    “Congruent neurons appear to combine vestibular–visual signals in a way that assumes a common cause, and their activity is highly predictive of behavioral choice on vestibular–visual combination tasks (8–10).”

    From How multisensory neurons solve causal inference. (2021) · cites this paper as [10]

    The Discussion’s “Modulation depth and discrimination threshold” section reports improved neural discriminability for congruent cells under aligned visual–vestibular stimulation, but explicitly says that a parallel improvement in behavioral sensitivity during multimodal discrimination remains to be demonstrated. It does not establish that their activity is highly predictive of behavioral choice. The indexed passages provide no page numbers. (LLM, conf=0.86)

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  • Congruent neurons combine vestibular-visual signals in a way that assumes a common cause.

    “Congruent neurons appear to combine vestibular–visual signals in a way that assumes a common cause, and their activity is highly predictive of behavioral choice on vestibular–visual combination tasks (8–10).”

    From How multisensory neurons solve causal inference. (2021) · cites this paper as [10]

    The Results describe congruent MSTd neurons combining visual and vestibular inputs, and the Discussion reports that weighted linear sums describe bimodal responses. The paper does not establish that these neurons assume a common cause; its Results also say the monkeys only maintained fixation, so it does not test whether neural activity predicts behavioral choice. (LLM, conf=0.84)

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  • When a small conflict is introduced between two cues, an observer's judgment incorporates both signals but depends more on the more reliable signal.

    “In particular, if a small conflict is introduced between two cues, an observer’s judgment will incorporate both signals but depend more on the signal that is more reliable (i.e., has the lowest estimator variance) (9, 10, 21).”

    From How multisensory neurons solve causal inference. (2021) · cites this paper as [10]

    The Introduction (page not provided) says humans often combine cue estimates with weights proportional to their relative reliabilities. The Results report cue-conflict stimuli, but the monkeys only maintained fixation; the paper measures neuronal responses, not observers’ judgments under a small cue conflict. That specific condition is not established by this paper’s findings. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Asymmetries in sensitivity to different cues are common among macaque MSTd neurons.

    “We found that this was made possible by asymmetries in sensitivity to different cues, which are also common among macaque MSTd neurons (6, 8, 10, 11).”

    From How multisensory neurons solve causal inference. (2021) · cites this paper as [10]

  • Vestibular and visual signals are combined in macaque MSTd.

    “Neurophysiological work in macaque monkeys indicates that vestibular and visual signals are combined on the dorsal subdivision of the medial superior temporal area (MSTd) (6–11) and in the ventral intraparietal area (VIP) (12, 13).”

    From How multisensory neurons solve causal inference. (2021) · cites this paper as [10]

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Research works printed but not linked: 4

  1. Gattass R Gross CG Visual topography of striate projection zone (MT) in posterior superior temporal sulcus of the macaque J Neurophysiol 1981 46 621 638 7299437
  2. Kadunce DC Vaughan JW Wallace MT Benedek G Stein BE Mechanisms of within- and cross-modality suppression in the superior colliculus J Neurophysiol 1997 78 2834 2847 9405504
  3. Robinson DA A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field IEEE Trans Biomed Eng 1963 10 137 145 14121113
  4. Zeki SM Functional organization of a visual area in the posterior bank of the superior temporal sulcus of the rhesus monkey J Physiol 1974 236 549 573 4207129 PMC1350849

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Authors
Morgan, M. L., DeAngelis, G. C., & Angelaki, D. E.
Affiliations
  • Washington University in St. Louis (US)
  • University of Rochester (US)
Corresponding author
Angelaki, Dora E.
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2008-08
Volume
59
Issue
4
Pages
662-673
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2008.06.024
PMC
PMC2601653
OpenAlex
W2122904188
Cited by
208
References
48
Citations by year
2026: 7 · 2025: 16 · 2024: 5 · 2023: 8 · 2022: 11 · 2021: 9 · 2020: 10 · 2019: 11 · 2018: 15 · 2017: 17 · 2016: 15 · 2015: 13 · 2014: 11 · 2013: 10 · 2012: 12
FWCI
17.24
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Eye Institute (R01EY017866, EY-017866, EY-016178, R01EY016178)
  • National Institute on Deafness and Other Communication Disorders (DC04260., R01DC004260)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Keywords
multisensory integration, cue reliability, visual-vestibular integration, self-motion perception, macaque visual cortex, bimodal stimuli, cue weighting, stimulus degradation
MeSH terms
Analysis of Variance, Animals, Cues, Discrimination, Psychological, Evoked Potentials, Kinesthesis, Macaca mulatta, Male, Mental Processes, Models, Neurological, Motion Perception, Neurons, Sensory Thresholds, Temporal Lobe, Vestibule, Labyrinth, Visual Cortex

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