The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Patient derived organoids to model rare prostate cancer phenotypes
Open accessAbstract
A major hurdle in the study of rare tumors is a lack of existing preclinical models. Neuroendocrine prostate cancer is an uncommon and aggressive histologic variant of prostate cancer that may arise de novo or as a mechanism of treatment resistance in patients with pre-existing castration-resistant prostate cancer. There are few available models to study neuroendocrine prostate cancer. Here, we report the generation and characterization of tumor organoids derived from needle biopsies of metastatic lesions from four patients. We demonstrate genomic, transcriptomic, and epigenomic concordance between organoids and their corresponding patient tumors. We utilize these organoids to understand the biologic role of the epigenetic modifier EZH2 in driving molecular programs associated with neuroendocrine prostate cancer progression. High-throughput organoid drug screening nominated single agents and drug combinations suggesting repurposing opportunities. This proof of principle study represents a strategy for the study of rare cancer phenotypes.
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Self-citationAbiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer
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Self-citationAbiraterone for prostate cancer not previously treated with hormone therapy
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Self-citationOrganoid Cultures Derived from Patients with Advanced Prostate Cancer
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Yao, Y., Xu, X., Yang, L., Zhu, J., Wan, J., Shen, L., Xia, F., Fu, G., Deng, Y., Pan, M., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.10.010 · Cited by 755
Tumor organoids: Opportunities and challenges to guide precision medicine
Veninga, V., & Voest, E. E. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.07.020 · Cited by 339
Tumor organoids: applications in cancer modeling and potentials in precision medicine
Xu, H., Jiao, D., Liu, A., & Wu, K. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01278-4 · Cited by 286
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Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets
Tang, F., Xu, D., Wang, S., Wong, C. K., Martinez-Fundichely, A., Lee, C. J., Cohen, S., Park, J., Hill, C. E., Eng, K., et al. (2022) · Science · doi:10.1126/science.abe1505 · Cited by 268
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Metadata
- Authors
- Puca, L., Bareja, R., Prandi, D., Shaw, R., Benelli, M., Karthaus, W. R., Hess, J., Sigouros, M., Donoghue, A., Kossai, M., Gao, D., Cyrta, J., Sailer, V., Vosoughi, A., Pauli, C., Churakova, Y., Cheung, C., Deonarine, L. D., McNary, T. J., Rosati, R., Tagawa, S. T., Nanus, D. M., Mosquera, J. M., Sawyers, C. L., Chen, Y., Inghirami, G., Rao, R. A., Grandori, C., Elemento, O., Sboner, A., Demichelis, F., Rubin, M. A., & Beltran, H.
- Venue
- Nature Communications
- Published
- 2018-06-19
- Volume
- 9
- Issue
- 1
- Pages
- 2404-2404
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2808350668
- Cited by
- 361
- References
- 50
- FWCI
- 25.53
- Type
- journal article
- Language
- en
- Open access
- gold
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- Puca, L., Bareja, R., Prandi, D., Shaw, R., Benelli, M., Karthaus, W. R., Hess, J., Sigouros, M., Donoghue, A., Kossai, M., Gao, D., Cyrta, J., Sailer, V., Vosoughi, A., Pauli, C., Churakova, Y., Cheung, C., Deonarine, L. D., McNary, T. J., . . . Beltran, H. (2018). Patient derived organoids to model rare prostate cancer phenotypes. Nature Communications. https://doi.org/10.1038/s41467-018-04495-z
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