The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing
Open accessAbstract
Laminin, as a key component of the basement membrane extracellular matrix (ECM), regulates tissue morphogenesis. Here, we show that multiple laminin isoforms promiscuously bind to growth factors (GFs) with high affinity, through their heparin-binding domains (HBDs) located in the α chain laminin-type G (LG) domains. These domains also bind to syndecan cell-surface receptors, promoting attachment of fibroblasts and endothelial cells. We explore the application of these multifunctional laminin HBDs in wound healing in the type-2 diabetic mouse. We demonstrate that covalent incorporation of laminin HBDs into fibrin matrices improves retention of GFs and significantly enhances the efficacy of vascular endothelial cell growth factor (VEGF-A165) and platelet-derived growth factor (PDGF-BB) in promoting wound healing in vivo, under conditions where the GFs alone in fibrin are inefficacious. This laminin HBD peptide may be clinically useful by improving biomaterial matrices as both GF reservoirs and cell scaffolds, leading to effective tissue regeneration.
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Tonnesen, M. G., Feng, X., & Clark, R. A. F. (2000) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1046/j.1087-0024.2000.00014.x · Cited by 1,463
Neutrophils and Wound Repair: Positive Actions and Negative Reactions
Wilgus, T. A., Roy, S., & McDaniel, J. C. (2013) · Advances in Wound Care · doi:10.1089/wound.2012.0383 · Cited by 616
Extracellular Matrix: Functions in the Nervous System
Barros, C. S., Franco, S. J., & Muller, U. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005108 · Cited by 506
Martino, M. M., Tortelli, F., Mochizuki, M., Traub, S., Ben-David, D., Kuhn, G. A., Müller, R., Livne, E., Eming, S. A., & Hubbell, J. A. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002614 · Cited by 459
Self-citationHsieh, P. C. H. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25878 · Cited by 357
Laminins: Roles and Utility in Wound Repair
Iorio, V., Troughton, L. D., & Hamill, K. J. (2015) · Advances in Wound Care · doi:10.1089/wound.2014.0533 · Cited by 169
Cited by
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Veith, A. P., Henderson, K., Spencer, A., Sligar, A. D., & Baker, A. B. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.09.010 · Cited by 1,021
Alavi, M., & Nokhodchi, A. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115349 · Cited by 311
Targeted Drug Delivery via the Use of ECM-Mimetic Materials
Hwang, J., Sullivan, M. O., & Kiick, K. L. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00069 · Cited by 76
Extracellular matrix-inspired biomaterials for wound healing
Hosty, L., Heatherington, T., Quondamatteo, F., & Browne, S. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09750-9 · Cited by 63
Density-Based High-Quality Fat: Characterization and Correlation with Different Body Fat Ratio
Wang, X., Guan, J., Chen, Y., Li, Y., Lu, F., & Dong, Z. (2022) · Aesthetic Plastic Surgery · doi:10.1007/s00266-022-02973-w · Cited by 8
Metadata
- Authors
- Ishihara, J., Ishihara, A., Fukunaga, K., Sasaki, K., White, M. J. V., Briquez, P. S., & Hubbell, J. A.
- Venue
- Nature Communications
- Published
- 2018-06-04
- Volume
- 9
- Issue
- 1
- Pages
- 2163-2163
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2805260639
- Cited by
- 233
- References
- 6
- FWCI
- 16.39
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ishihara, J., Ishihara, A., Fukunaga, K., Sasaki, K., White, M. J. V., Briquez, P. S., & Hubbell, J. A. (2018). Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing. Nature Communications. https://doi.org/10.1038/s41467-018-04525-w
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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