Assembly and activation of the Hippo signalome by FAT1 tumor suppressor
Open accessAbstract
Dysregulation of the Hippo signaling pathway and the consequent YAP1 activation is a frequent event in human malignancies, yet the underlying molecular mechanisms are still poorly understood. A pancancer analysis of core Hippo kinases and their candidate regulating molecules revealed few alterations in the canonical Hippo pathway, but very frequent genetic alterations in the FAT family of atypical cadherins. By focusing on head and neck squamous cell carcinoma (HNSCC), which displays frequent FAT1 alterations (29.8%), we provide evidence that FAT1 functional loss results in YAP1 activation. Mechanistically, we found that FAT1 assembles a multimeric Hippo signaling complex (signalome), resulting in activation of core Hippo kinases by TAOKs and consequent YAP1 inactivation. We also show that unrestrained YAP1 acts as an oncogenic driver in HNSCC, and that targeting YAP1 may represent an attractive precision therapeutic option for cancers harboring genomic alterations in the FAT1 tumor suppressor genes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
FAT1 interacts with Hippo signaling components such as NF2, MST1/2, and LATS1/2, leading to inactivation of YAP.
“FAT1 interacts with Hippo signaling components such as NF2, MST1/2, and LATS1/2, leading to inactivation of YAP (50).”
From Targeting eIF4A-dependent translation in genetically complex sarcoma (2026) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
Chen, E. Y., Tan, C. M., Kou, Y., Duan, Q., Wang, Z., Meirelles, G. V., Clark, N. R., & Ma’ayan, A. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-128 · Cited by 7,814 · see citing works
Self-citationMutational heterogeneity in cancer and the search for new cancer-associated genes
Lawrence, M. S., Stojanov, P., Polak, P., Kryukov, G. V., Cibulskis, K., Sivachenko, A., Carter, S. L., Stewart, C., Mermel, C. H., Roberts, S. A., et al. (2013) · Nature · doi:10.1038/nature12213 · Cited by 5,461 · see citing works
Comprehensive genomic characterization of head and neck squamous cell carcinomas
The Cancer Genome Atlas Network (2015) · Nature · doi:10.1038/nature14129 · Cited by 4,063 · see citing works
Mermel, C. H., Schumacher, S. E., Hill, B., Meyerson, M. M., Beroukhim, R., & Getz, G. A. (2011) · Genome biology · doi:10.1186/gb-2011-12-4-r41 · Cited by 3,469 · see citing works
TEAD mediates YAP-dependent gene induction and growth control
Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1664408 · Cited by 2,498 · see citing works
Self-citationThe Hippo Signaling Pathway in Development and Cancer
Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.011 · Cited by 2,274 · see citing works
The Hippo pathway and human cancer
Harvey, K. F., Zhang, X., & Thomas, D. M. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3458 · Cited by 1,852 · see citing works
Liu-Chittenden, Y., Huang, B., Shim, J. S., Chen, Q., Lee, S.-J., Anders, R. A., Liu, J. O., & Pan, D. (2012) · Genes & Development · doi:10.1101/gad.192856.112 · Cited by 1,452 · see citing works
Rouleau, G. A., Merel, P., Lutchman, M., Sanson, M., Zucman‐Rossi, J., Marineau, C., Hoang‐Xuan, K., Demczuk, S., Desmaze, C., Plougastel-Douglas, B., et al. (1993) · Nature · doi:10.1038/363515a0 · Cited by 1,398 · see citing works
The emerging roles of YAP and TAZ in cancer
Moroishi, T., Hansen, C. G., & Guan, K. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3876 · Cited by 1,156 · see citing works
Self-citationYAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response
Azzolin, L., Panciera, T., Soligo, S., Enzo, E., Bicciato, S., Dupont, S., Bresolin, S., Frasson, C., Basso, G., Guzzardo, V., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.013 · Cited by 1,094 · see citing works
Yap1 acts downstream of α-catenin to control epidermal proliferation
Schlegelmilch, K., Mohseni, M., Kirak, O., Pruszak, J., Rodriguez, J. R., Zhou, D., Kreger, B. T., Vasioukhin, V., Avruch, J., Brummelkamp, T. R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.031 · Cited by 1,036 · see citing works
Feng, X., Degese, M. S., Iglesias‐Bartolomé, R., Vaque, J. P., Molinolo, A., Rodrigues, M. W., Zaidi, M. R., Ksander, B. R., Merlino, G. T., Sodhi, A., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.016 · Cited by 559 · see citing works
Self-citationGMAP and GSNAP for Genomic Sequence Alignment: Enhancements to Speed, Accuracy, and Functionality
Wu, T. D., Reeder, J., Lawrence, M. F., Becker, G., & Brauer, M. J. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3578-9_15 · Cited by 419 · see citing works
Montaner, S., Sodhi, A., Molinolo, A. A., Bugge, T. H., Sawai, E. T., Yunsheng, H., Li, Y., Ray, P. E., & Gutkind, J. S. (2003) · Cancer Cell · doi:10.1016/s1535-6108(02)00237-4 · Cited by 372 · see citing works
Self-citationA YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasisPreprint
Moroishi, T., Park, H. W., Qin, B., Chen, Q., Meng, Z., Plouffe, S. W., Taniguchi, K., Yu, F., Karin, M., Pan, D., et al. (2015) · Genes & Development · doi:10.1101/gad.262816.115 · Cited by 367 · see citing works
Self-citationRecurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation
Morris, L. G. T., Kaufman, A., Gong, Y., Ramaswami, D., Walsh, L. A., Turcan, Ş., Eng, S., Kannan, K. S., Zou, Y., Peng, L., et al. (2013) · Nature Genetics · doi:10.1038/ng.2538 · Cited by 366 · see citing works
Praskova, M. D., KHOKLATCHEV, A., Ortiz-Vega, S., & Avruch, J. (2004) · Biochemical Journal · doi:10.1042/bj20040025 · Cited by 342 · see citing works
Iglesias-Bartolome, R., Patel, V., Cotrim, A., Leelahavanichkul, K., Molinolo, A. A., Mitchell, J. B., & Gutkind, J. S. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.06.007 · Cited by 284 · see citing works
Self-citationLATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma
Murakami, H., Mizuno, T., Taniguchi, T., Fujii, M., Ishiguro, F., Fukui, T., Akatsuka, S., Horio, Y., Hida, T., Kondo, Y., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2164 · Cited by 260 · see citing works
Ciani, L., Patel, A., Allen, N. D., & ffrench‐Constant, C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.10.3575-3582.2003 · Cited by 255 · see citing works
Tao-1 Phosphorylates Hippo/MST Kinases to Regulate the Hippo-Salvador-Warts Tumor Suppressor Pathway
Boggiano, J. C., Vanderzalm, P. J., & Fehon, R. G. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.08.028 · Cited by 249 · see citing works
Poon, C. L. C., Lin, J. I., Zhang, X., & Harvey, K. F. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.09.012 · Cited by 227 · see citing works
Barry, E. R., & Camargo, F. D. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.12.006 · Cited by 214 · see citing works
Martı́n, D., Abba, M. C., Molinolo, A., Vitale-Cross, L. A., Wang, Z., Zaida, M., Delic, N. C., Samuels, Y., Lyons, J. G., & Gutkind, J. S. (2014) · Oncotarget · doi:10.18632/oncotarget.2417 · Cited by 202 · see citing works
Self-citationSeparating the adhesive and signaling functions of the Fat and Dachsous protocadherins
Matakatsu, H., & Blair, S. S. (2006) · Development · doi:10.1242/dev.02401 · Cited by 189 · see citing works
Vitale-Cross, L. A., Molinolo, A., Martı́n, D., Younis, R. H., Maruyama, T., Patel, V., Chen, W., Schneider, A., & Gutkind, J. S. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0502 · Cited by 143 · see citing works
Self-citationInhibition of Autophagosome Formation by the Benzoporphyrin Derivative Verteporfin
Donohue, E., Tovey, A. N., Vogl, A. W., Arns, S., Sternberg, E. D., Young, R. N., & Roberge, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.139915 · Cited by 138 · see citing works
A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma
Hiemer, S. E., Zhang, L., Kartha, V. K., Packer, T. S., Almershed, M., Noonan, V. L., Kukuruzinska, M. A., Bais, M. V., Monti, S., & Varelas, X. (2015) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0580 · Cited by 136 · see citing works
Sleeping Giants: Emerging Roles for the Fat Cadherins in Health and Disease
Sadeqzadeh, E., de Bock, C. E., & Thorne, R. F. (2013) · Medicinal Research Reviews · doi:10.1002/med.21286 · Cited by 131 · see citing works
Self-citationChikumi, H., Barac, A., Behbahani, B., Gao, Y., Teramoto, H., Zheng, Y., & Gutkind, J. S. (2004) · Oncogene · doi:10.1038/sj.onc.1207012 · Cited by 128 · see citing works
Self-citationIglesias‐Bartolomé, R., Martı́n, D., & Gutkind, J. S. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0239 · Cited by 117 · see citing works
Self-citationAn evolutionary shift in the regulation of the Hippo pathway between mice and flies
Bossuyt, W., Chen, C.-L., Chen, Q., Sudol, M., McNeill, H., Pan, D., Kopp, A., & Halder, G. A. (2013) · Oncogene · doi:10.1038/onc.2013.82 · Cited by 110 · see citing works
Characterizing genomic alterations in cancer by complementary functional associations
Kim, J. W., Botvinnik, O. B., Abudayyeh, O. O., Birger, C., Rosenbluh, J., Shrestha, Y., Abazeed, M. E., Hammerman, P. S., DiCara, D., Konieczkowski, D. J., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3527 · Cited by 97 · see citing works
Self-citationComparative integromics on FAT1, FAT2, FAT3 and FAT4
Katoh, Y., & Katoh, M. (2006) · International Journal of Molecular Medicine · doi:10.3892/ijmm.18.3.523 · Cited by 84 · see citing works
Belzacq, A.-S., Jacotot, E. D., Vieira, H. L. A., Mistro, D., Granville, D. J., Xie, Z., Reed, J. C., Kroemer, G., & Brenner, C. (2001) · PubMed · Cited by 78 · see citing works
Miyazaki, T. (2011) · Oncology Reports · doi:10.3892/or.2011.1324 · Cited by 69 · see citing works
Bernkopf, D. B., Hadjihannas, M. V., & Behrens, J. (2014) · Journal of Cell Science · doi:10.1242/jcs.159145 · Cited by 61 · see citing works
Dual Processing of FAT1 Cadherin Protein by Human Melanoma Cells Generates Distinct Protein Products
Sadeqzadeh, E., de Bock, C. E., Zhang, X. D., Shipman, K. L., Scott, N. M., Song, C., Yeadon, T. M., Oliveira, C. S., Jin, B., Hersey, P., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.234419 · Cited by 56 · see citing works
Self-citationFAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation
Ahmed, A. F., de Bock, C. E., Lincz, L. F., Pundavela, J., Zouikr, I., Sontag, E., Hondermarck, H., & Thorne, R. F. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1955-6 · Cited by 53 · see citing works
Self-citationZlatic, S. A., Ryder, P. V., Salazar, G., & Faúndez, V. (2010) · Journal of Visualized Experiments · doi:10.3791/1855 · Cited by 35 · see citing works
Exploiting the mTOR paradox for disease prevention
Iglesias‐Bartolomé, R., & Gutkind, J. S. (2012) · Oncotarget · doi:10.18632/oncotarget.712 · Cited by 30 · see citing works
Self-citationXie-Zukauskas, H., Das, J. R., Short, B. L., Gutkind, J. S., & Ray, P. E. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.12.003 · Cited by 14 · see citing works
Self-citationOral and Pharyngeal Epithelial Keratinocyte Culture
Leelahavanichkul, K., & Gutkind, J. S. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-125-7_5 · Cited by 14 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Pan-cancer single-cell landscape of tumor-infiltrating T cells
Zheng, L., Qin, S., Si, W., Wang, A., Xing, B., Gao, R., Ren, X., Wang, L., Wu, X., Zhang, J., et al. (2021) · Science · doi:10.1126/science.abe6474 · Cited by 1,402 · see citing works
The Hippo Pathway: Biology and Pathophysiology
Ma, S., Meng, Z., Chen, R., & Guan, K.-L. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111829 · Cited by 1,387 · see citing works
Self-citationThe Hippo Signaling Pathway in Development and Disease
Zheng, Y., & Pan, D. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.06.003 · Cited by 867 · see citing works
Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway
Li, Z., Razavi, P., Li, Q., Toy, W., Liu, B., Ping, C., Hsieh, W., Sanchez-Vega, F., Brown, D. N., Da Cruz Paula, A. F., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.11.006 · Cited by 508 · see citing works
Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis
Pastushenko, I., Mauri, F., Song, Y., de Cock, F., Meeusen, B., Swedlund, B., Impens, F., Haver, D. V., Opitz, M., Théry, M., et al. (2020) · Nature · doi:10.1038/s41586-020-03046-1 · Cited by 431 · see citing works
Huang, C. L., Chen, L., Savage, S. R., Eguez, R. V., Dou, Y., Li, Y., Leprevost, F. D. V., Jaehnig, E. J., Lei, J. T., Wen, B., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2020.12.007 · Cited by 354 · see citing works
Translational genomics and recent advances in oral squamous cell carcinoma
Chai, A. W. Y., Lim, K. P., & Cheong, S. C. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.09.011 · Cited by 300 · see citing works
Self-citationYAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches
Piccolo, S., Panciera, T., Contessotto, P., & Cordenonsi, M. (2022) · Nature Cancer · doi:10.1038/s43018-022-00473-z · Cited by 250 · see citing works
Feng, X., Arang, N., Rigiracciolo, D. C., Lee, J. S., Yeerna, H., Wang, Z., Lubrano, S., Kishore, A., Pachter, J. A., König, G. M., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.01.009 · Cited by 237 · see citing works
Self-citationBreast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments
Testa, U., Castelli, G., & Pelosi, E. (2020) · Medical Sciences · doi:10.3390/medsci8010018 · Cited by 226 · see citing works
Insights into recent findings and clinical application of YAP and TAZ in cancer
Franklin, J. M., Wu, Z., & Guan, K.-L. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-023-00579-1 · Cited by 213 · see citing works
Self-citationFang, W., Ma, Y., Yin, J. C., Hong, S., Zhou, H., Wang, A., Wang, F., Bao, H., Wu, X., Yang, Y., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0585 · Cited by 204 · see citing works
YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma
Omori, H., Nishio, M., Masuda, M., Miyachi, Y., Ueda, F., Nakano, T., Sato, K., Mimori, K., Taguchi, K., Hikasa, H., et al. (2020) · Science Advances · doi:10.1126/sciadv.aay3324 · Cited by 116 · see citing works
Messina, B., Sardo, F. L., Scalera, S., Memeo, L., Colarossi, C., Mare, M., Blandino, G., Ciliberto, G., Maugeri‐Saccà, M., & Bon, G. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05568-8 · Cited by 112 · see citing works
Major Molecular Signaling Pathways in Oral Cancer Associated With Therapeutic Resistance
Usman, S., Jamal, A., Teh, M., & Waseem, A. (2021) · Frontiers in Oral Health · doi:10.3389/froh.2020.603160 · Cited by 91 · see citing works
The Emerging Role of YAP/TAZ in Tumor Immunity
Pan, Z., Tian, Y., Cao, C., & Niu, G. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0375 · Cited by 95 · see citing works
The two sides of Hippo pathway in cancer
Li, F., & Guan, K. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.07.006 · Cited by 92 · see citing works
Self-citationYAP/TAZ: Molecular pathway and disease therapy
Wei, Y., Hui, V. L. Z., Chen, Y., Han, R., Han, X., & Guo, Y. (2023) · MedComm · doi:10.1002/mco2.340 · Cited by 93 · see citing works
New insights into the ambivalent role of YAP/TAZ in human cancers
Luo, J., Deng, L., Zou, H., Guo, Y., Tong, T., Huang, M., Ling, G., & Li, P. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02704-2 · Cited by 83 · see citing works
Wang, Z., Goto, Y., Allevato, M. M., Wu, V. H., Saddawi‐Konefka, R., Gilardi, M., Alvarado, D., Yung, B. S., O’Farrell, A., Molinolo, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22619-w · Cited by 80 · see citing works
Self-citationGlaviano, A., Wander, S. A., Baird, R. D., Yap, K. C.-Y., Lam, H. Y., Toi, M., Carbone, D., Geoerger, B., Serra, V., Jones, R. H., et al. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101103 · Cited by 85 · see citing works
Xu, J., Tang, Y., Sheng, X., Tian, Y., Deng, M., Du, S., Lv, C., Li, G., Pan, Y., Song, Y., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019103255 · Cited by 75 · see citing works
The role of Hippo‐YAP signaling in squamous cell carcinomas
Maehama, T., Nishio, M., Otani, J., Mak, T. W., & Suzuki, A. (2020) · Cancer Science · doi:10.1111/cas.14725 · Cited by 71 · see citing works
The diverse functions of FAT1 in cancer progression: good, bad, or ugly?
Chen, Z. G., Saba, N. F., & Teng, Y. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02461-8 · Cited by 70 · see citing works
EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1
Ando, T., Arang, N., Wang, Z., Costea, D. E., Feng, X., Goto, Y., Izumi, H., Gilardi, M., Ando, K., & Gutkind, J. S. (2021) · Communications Biology · doi:10.1038/s42003-021-02744-4 · Cited by 67 · see citing works
Self-citationRole of FAT1 in health and disease (Review)
Peng, Z., Gong, Y., & Liang, X. (2021) · Oncology Letters · doi:10.3892/ol.2021.12659 · Cited by 66 · see citing works
Laginestra, M. A., Cascione, L., Motta, G., Fuligni, F., Agostinelli, C., Rossi, M., Sapienza, M. R., Righi, S., Broccoli, A., Indio, V., et al. (2019) · Modern Pathology · doi:10.1038/s41379-019-0279-8 · Cited by 65 · see citing works
Fat/Dachsous family cadherins in cell and tissue organisation
Fulford, A. D., & McNeill, H. (2019) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2019.10.006 · Cited by 65 · see citing works
Targeting the Hippo pathway in cancer
Harvey, K. F., & Tang, T. T.-L. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01234-0 · Cited by 65 · see citing works
Wang, Y., Safi, M., Hirsch, F. R., Lu, S., Peters, S., Govindan, R., Rosell, R., Park, K., & Zhang, J. J. (2025) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00979-8 · Cited by 65 · see citing works
Mechanisms of Cisplatin Resistance in HPV Negative Head and Neck Squamous Cell Carcinomas
Griso-Acevedo, A. B., Acero-Riaguas, L., Castelo, B., Carretero, J. L. C., & Sastre-Perona, A. (2022) · Cells · doi:10.3390/cells11030561 · Cited by 61 · see citing works
New Insights into YAP/TAZ-TEAD-Mediated Gene Regulation and Biological Processes in Cancer
Zhao, Y., Sheldon, M., Sun, Y., & Ma, L. (2023) · Cancers · doi:10.3390/cancers15235497 · Cited by 59 · see citing works
Crosstalk between CAFs and tumour cells in head and neck cancer
Li, X., González-Maroto, C., & Tavassoli, M. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02053-9 · Cited by 58 · see citing works
STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells
Kim, J. W., Berrios, C. J., Kim, M., Schade, A. E., Adelmant, G., Yeerna, H., Damato, E., Iniguez, A. B., Swanson, S. K., Florens, L. A., et al. (2020) · eLife · doi:10.7554/elife.53003 · Cited by 54 · see citing works
Self-citationGenome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway
Chai, A. W. Y., Yee, P. S., Price, S., Yee, S. M., Lee, H. M., Tiong, V. K., Gonçalves, E., Behan, F. M., Bateson, J., Gilbert, J. G. R., et al. (2020) · eLife · doi:10.7554/elife.57761 · Cited by 53 · see citing works
Self-citationShin, Y. Y., Seo, Y., Oh, S., Ahn, J., Song, M., Kang, M., Oh, J., Lee, D., Kim, Y. H., Sung, E., et al. (2021) · Journal of Pineal Research · doi:10.1111/jpi.12779 · Cited by 47 · see citing works
Lippman, S. M., Abate-Shen, C. T., Maresso, K. C., Colditz, G. A., Dannenberg, A. J., Davidson, N. E., Disis, M. L., DuBois, R. N., Szabo, E. M., Giuliano, A. R., et al. (2018) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-18-0421 · Cited by 47 · see citing works
Self-citationHippo Pathway and YAP Signaling Alterations in Squamous Cancer of the Head and Neck
Santos-de-Frutos, K., Segrelles, C., & Lorz, C. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122131 · Cited by 47 · see citing works
Gong, M., Liu, H., Sun, N., Xie, Y., Yan, F., & Cai, L. (2020) · Nanomedicine · doi:10.2217/nnm-2019-0218 · Cited by 45 · see citing works
Chen, N., Golczer, G., Ghose, S., Lin, B., Langenbucher, A., Webb, J., Bhanot, H., Abt, N. B., Lin, D. T., Varvares, M. A., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110970 · Cited by 45 · see citing works
GPR39 Overexpression in OSCC Promotes YAP-Sustained Malignant Progression
Jiang, Y., Li, T., Wu, Y., Xu, H., Xie, C., Dong, Y., Zhong, L., Wang, Z., Zhao, H., Zhou, Y., et al. (2020) · Journal of Dental Research · doi:10.1177/0022034520915877 · Cited by 44 · see citing works
Self-citationPark, J. C., Krishnakumar, H. N., & Saladi, S. V. (2022) · Current Oncology · doi:10.3390/curroncol29060334 · Cited by 42 · see citing works
Dchs1-Fat4 regulation of osteogenic differentiation in mouse
Crespo‐Enríquez, I., Hodgson, T., Zakaria, S., Cadoni, E., Shah, M., Allen, S., Al-Khishali, A., Mao, Y., Yiu, A., Petzold, J., et al. (2019) · Development · doi:10.1242/dev.176776 · Cited by 42 · see citing works
Meng, P., Zhang, Y., Zhang, W., Chen, X., Xu, T., Hu, S., Liang, X., Feng, M., Yang, X., & Ho, M. (2021) · Scientific Reports · doi:10.1038/s41598-020-79524-3 · Cited by 42 · see citing works
Islam, S. S., Qassem, K., Islam, S., Parag, R. R., Rahman, M. Z., Farhat, W. A., Yeger, H., Aboussekhra, A., Karakas, B., & Noman, A. S. M. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05126-8 · Cited by 41 · see citing works
Islam, S. S., Uddin, M. J., Noman, A. S. M., Akter, H., Dity, N. J., Basiruzzman, M., Uddin, K. M. F., Ahsan, J., Annoor, S., Alaiya, A. A., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.04.061 · Cited by 40 · see citing works
The potential role of YAP in head and neck squamous cell carcinoma
Shin, E., & Kim, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00492-9 · Cited by 40 · see citing works
Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2
Li, R., Shao, J., Jin, Y., Kawase, H., Ong, Y. T., Troidl, K., Quan, Q., Wang, L., Bonnavion, R., Wietelmann, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37671-x · Cited by 39 · see citing works
Chakravarthy, A., Reddin, I. G., Henderson, S. R., Dong, C., Kirkwood, N. K., Jeyakumar, M., Rothschild-Rodriguez, D., Gonzalez-Martinez, N., McDermott, J. R., Su, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33544-x · Cited by 39 · see citing works
Lahrouchi, N., George, A., Ratbi, I., Schneider, R., Elalaoui, S. C., Moosa, S., Bharti, S., Sharma, R., Abu-Asab, M. S., Onojafe, F., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08547-w · Cited by 38 · see citing works
Faraji, F., Ramirez, S. I., Quiroz, P. Y. A., Mendez-Molina, A. N., & Gutkind, J. S. (2022) · Cells · doi:10.3390/cells11081370 · Cited by 40 · see citing works
Self-citationChen, Z., Zhang, C., Chen, J., Wang, D., Tu, J., Waes, C. V., Saba, N. F., Chen, Z. G., & Chen, Z. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3659 · Cited by 35 · see citing works
Paul, A., Annunziato, S., Lu, B., Sun, T., Evrova, O., Planas‐Paz, L., Orsini, V., Terracciano, L., Charlat, O., Yang, Z., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28567-3 · Cited by 35 · see citing works
Mann, J. E., Kulkarni, A., Birkeland, A. C., Kafelghazal, J., Eisenberg, J. C., Jewell, B. M., Ludwig, M., Spector, M. E., Jiang, H., Carey, T. E., et al. (2019) · Head & Neck · doi:10.1002/hed.25803 · Cited by 34 · see citing works
Multi-Functional Regulation by YAP/TAZ Signaling Networks in Tumor Progression and Metastasis
Thrash, H. L., & Pendergast, A. M. (2023) · Cancers · doi:10.3390/cancers15194701 · Cited by 33 · see citing works
Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice
Nishio, M., To, Y., Maehama, T., Aono, Y., Otani, J., Hikasa, H., Kitagawa, A., Mimori, K., Sasaki, T., Nishina, H., et al. (2020) · Cancer Science · doi:10.1111/cas.14581 · Cited by 32 · see citing works
Fransson, S. M., Martinez‐Monleon, A., Johansson, M., Sjöberg, R., Björklund, C., Ljungman, G., Ek, T., Kogner, P., & Martinsson, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-78370-7 · Cited by 33 · see citing works
Creb5 coordinates synovial joint formation with the genesis of articular cartilage
Zhang, C., Gao, Y., Hung, H.-H. K., Zhu, Z., Grodzinsky, A. J., & Lassar, A. B. (2022) · Nature Communications · doi:10.1038/s41467-022-35010-0 · Cited by 33 · see citing works
MK5 Regulates YAP Stability and Is a Molecular Target in YAP-Driven Cancers
Seo, J., Kim, M. H., Hong, H., Cho, H., Park, S., Kim, S. K., & Kim, J. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1339 · Cited by 35 · see citing works
The critical role of the Hippo signaling pathway in kidney diseases
Sun, Y.-T., Jin, D., Zhang, Z.-W., Jin, D., Xue, J., Duan, L.-Y., Zhang, Y.-Q., Kang, X.-M., & Lian, F.-M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.988175 · Cited by 30 · see citing works
Zhang, W., Tang, Y., Guo, Y., Kong, Y., Shi, F., Sheng, C., Wang, S., & Wang, Q. (2022) · npj Precision Oncology · doi:10.1038/s41698-022-00292-6 · Cited by 32 · see citing works
Ca2+ signaling and the Hippo pathway: Intersections in cellular regulation
Sayedyahossein, S., Thines, L., & Sacks, D. B. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110846 · Cited by 29 · see citing works
Targeting YAP/TAZ-TEAD signaling as a therapeutic approach in head and neck squamous cell carcinoma
Sato, K., Faraji, F., Cervantes‐Villagrana, R. D., Wu, X., Koshizuka, K., Ishikawa, T., Iglesias‐Bartolomé, R., Chen, L., de Marval, P. L. M., Gwaltney, S. L., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217467 · Cited by 29 · see citing works
Self-citationLan, T., Ge, Q., Zheng, K., Huang, L., Yan, Y., Zheng, L., Lu, Y., & Zheng, D. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.870055 · Cited by 29 · see citing works
Amanda, B., Pragasta, R., Cakrasana, H., Mustika, A., Faizah, Z., & Oceandy, D. (2024) · Cells · doi:10.3390/cells13221868 · Cited by 28 · see citing works
Wen, F., Han, Y., Zhang, H., Zhao, Z., Wang, W., Chen, F., Qin, W., Ju, J., An, L., Yan, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54850-6 · Cited by 28 · see citing works
Membrane potential mediates the cellular response to mechanical pressure
Mukherjee, A., Huang, Y., Elgeti, J., Oh, S., Abreu, J. G., Ammar, L., Nelliat, A. R., Schüttler, J., Su, D., Dupré, C., et al. (2025) · Cell · doi:10.1016/j.cell.2025.11.004 · Cited by 27 · see citing works
Posttranslational modifications of YAP/TAZ: molecular mechanisms and therapeutic opportunities
Zhang, Z., He, P., Li, Y., Gong, J., Qin, R., & Min, W. Z. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00760-4 · Cited by 29 · see citing works
Howard, A., Bojko, J., Flynn, B. P., Bowen, S., Jungwirth, U., & Walko, G. (2022) · Experimental Dermatology · doi:10.1111/exd.14655 · Cited by 26 · see citing works
YAP-driven malignant reprogramming of oral epithelial stem cells at single cell resolution
Faraji, F., Ramirez, S. I., Clubb, L. M., Sato, K., Burghi, V., Hoang, T. S., Officer, A., Quiroz, P. Y. A., Galloway, W. M. G., Mikulski, Z., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55660-6 · Cited by 26 · see citing works
Self-citationThe Hippo signaling pathway in gastric cancer
Cao, Z., An, L., Han, Y., Jiao, S., & Zhou, Z. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023038 · Cited by 25 · see citing works
Germline variants in DNA repair genes are associated with young-onset head and neck cancer
Cury, S. S., de Miranda, P. M., Marchi, F. A., do Canto, L. M., Chulam, T. C., Petersen, A. H., Aagaard, M. M., Pinto, C. A. L., Kowalski, L. P., & Rogatto, S. R. (2021) · Oral Oncology · doi:10.1016/j.oraloncology.2021.105545 · Cited by 25 · see citing works
Sibai, M., Altuntaş, E., Süzek, B. E., Şahin, B., Parlayan, C., Öztürk, G., Baykal, A. T., & Demircan, T. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.11.118 · Cited by 24 · see citing works
FAT1 inhibits the proliferation and metastasis of cervical cancer cells by binding β-catenin.
Chen, M., Sun, X., Wang, Y., Ling, K., Chen, C., Cai, X., Liang, X., & Liang, Z. (2019) · Europe PMC (PubMed Central) · Cited by 23 · see citing works
Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma
Brandt, A. P., Thiele, B., Schultheiß, C., Daetwyler, E., & Binder, M. (2023) · Cancers · doi:10.3390/cancers15072051 · Cited by 20 · see citing works
Somatic genetic aberrations in benign breast disease and the risk of subsequent breast cancer
Zeng, Z., Vo, A. H., Li, X., Shidfar, A., Saldana, P., Blanco, L. Z., Xuei, X., Luo, Y., Khan, S. A., & Clare, S. E. (2020) · npj Breast Cancer · doi:10.1038/s41523-020-0165-z · Cited by 18 · see citing works
Yang, M. G., Han, Y., Han, Q., Rong, X., Liu, X., & Lin, X. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16883 · Cited by 19 · see citing works
Sutural fibroblasts exhibit the function of vascular endothelial cells upon mechanical strain
Guan, L., Liang, W., Ding, P., & Zhao, Z. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.109046 · Cited by 19 · see citing works
Inactivation of Hippo pathway characterizes a poor-prognosis subtype of esophageal cancer
Mai, Z., Yuan, J., Yang, H., Fang, S., Xie, X., Wang, X., Xie, J., Wen, J., & Fu, J. (2022) · JCI Insight · doi:10.1172/jci.insight.155218 · Cited by 19 · see citing works
Oncogenic signaling-mediated regulation of chromatin during tumorigenesis
Alam, J., Huda, M. N., Tackett, A. J., & Miah, S. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10104-3 · Cited by 20 · see citing works
FAT1 cadherin controls neuritogenesis during NTera2 cell differentiation
Ahmed, A. F., de Bock, C. E., Sontag, E., Hondermarck, H., Lincz, L. F., & Thorne, R. F. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.04.197 · Cited by 19 · see citing works
Self-citationNano-Photosensitizer Directed Targeted Phototherapy Effective Against Oral Cancer in Animal Model
Yu, L., Zhu, G., Zhang, Z., Xu, Z., Peng, W., Zeng, L., Yu, Y., Wang, S., Lin, Z., Zhang, X., et al. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s434917 · Cited by 18 · see citing works
Wang, F., Liu, P., An, H., & Zhang, Y. L. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4665 · Cited by 18 · see citing works
Expanding the Spectrum of FAT1 Nephropathies by Novel Mutations That Affect Hippo Signaling
Fabretti, F., Tschernoster, N., Erger, F., Hedergott, A. M., Buescher, A. K., Dafinger, C., Reusch, B., Köntges, V. K., Kohl, S., Bartram, M. P., et al. (2021) · Kidney International Reports · doi:10.1016/j.ekir.2021.01.023 · Cited by 18 · see citing works
Li, M., Zhong, Y., & Wang, M. (2021) · Environmental Toxicology · doi:10.1002/tox.23347 · Cited by 18 · see citing works
Bai, Y., Boath, J., White, G. R., Kariyawasam, U. G. I. U., Farah, C. S., & Darido, C. (2021) · Cancers · doi:10.3390/cancers13205123 · Cited by 18 · see citing works
Cyclin-dependent kinase 4 and 6 inhibitors in breast cancer treatment
Guo, Z., Dong, R. W., Wu, Y., Dong, S., & Alahari, S. K. (2025) · Oncogene · doi:10.1038/s41388-025-03378-0 · Cited by 17 · see citing works
Mutations and Copy Number Abnormalities of Hippo Pathway Components in Human Cancers
He, Z., Li, R., & Jiang, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.661718 · Cited by 17 · see citing works
Extrinsic induction of apoptosis and tumor suppression via the p53–Reprimo–Hippo–YAP/TAZ–p73 pathway
Takikawa, M., Nakano, A., Krishnaraj, J., Tabata, Y., Watanabe, Y., Okabe, A., Sakaguchi, Y., Fujiki, R., Mochizuki, A., Tajima, T., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2413126122 · Cited by 16 · see citing works
Li, Y. R., Kandyba, E. E., Halliwill, K. D., Delrosario, R., Tran, Q., Bayani, N., Wu, D., Mirzoeva, O. K., Reeves, M. Q., Islam, S. M. A., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-1379 · Cited by 16 · see citing works
Rong, X., Han, Q., Lin, X., Kremerskothen, J., & Wang, E. (2019) · Cancer Management and Research · doi:10.2147/cmar.s194512 · Cited by 16 · see citing works
da Silva, J. L., Oliveira, L. J. D. C., de Resende, C. A. A., Reinert, T., de Albuquerque, L. Z., Leite, L. F., & Mano, M. S. (2025) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359251353623 · Cited by 17 · see citing works
Integrated analysis of deregulation microRNA expression in head and neck squamous cell carcinoma
Qi, C., Sheng, J., Huang, M., Zou, Y., Wang, Y., Wang, F., Zeng, F., Hua, Q., & Chen, S. (2021) · Medicine · doi:10.1097/md.0000000000024618 · Cited by 15 · see citing works
The Distinctive Features behind the Aggressiveness of Oral and Cutaneous Squamous Cell Carcinomas
Alonso-Juarranz, M., Mascaraque, M., Carrasco, E., Gracia-Cazaña, T., de la Sen, Ó., Gilaberte, Y., González, S., Juarranz, Á., & Falahat, F. (2023) · Cancers · doi:10.3390/cancers15123227 · Cited by 11 · see citing works
Zhong, W., Jiang, H., Zou, Y., Ren, J., Li, Z., He, K., Zhao, J., Zhou, X., Mou, D., & Cai, Y. (2020) · Pediatric Research · doi:10.1038/s41390-020-0863-0 · Cited by 14 · see citing works
Targeting YAP/TAZ–TEAD and their protein-protein interaction for precision cancer therapy
Chen, F., Su, J., Liu, Y., Zhang, Z., Li, S., Yuan, Y., & Lai, J. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118330 · Cited by 15 · see citing works
Lu, W.-T., Zalmas, L., Bailey, C., Black, J. R., Martínez‐Ruiz, C., Pich, O., Gimeno-Valiente, F., Usaite, I., Magness, A. J., Thol, K., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01558-w · Cited by 13 · see citing works
Ferrari, P., Schiavone, M. L., Scatena, C., & Nicolini, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073438 · Cited by 13 · see citing works
Huang, W., & Wang, H. (2021) · Translational Breast Cancer Research · doi:10.21037/tbcr-20-52 · Cited by 12 · see citing works
Immunotherapy for hepatobiliary cancers: Emerging targets and translational advances.
Li, D., Lin, S., Hong, J., & Ho, M. (2022) · Advances in Cancer Research · doi:10.1016/bs.acr.2022.01.013 · Cited by 11 · see citing works
- Authors
- Martin, D., Degese, M. S., Vitale-Cross, L., Iglesias-Bartolome, R., Valera, J. L. C., Wang, Z., Feng, X., Yeerna, H., Vadmal, V., Moroishi, T., Thorne, R. F., Zaida, M., Siegele, B., Cheong, S. C., Molinolo, A. A., Samuels, Y., Tamayo, P., Guan, K. L., Lippman, S. M., Lyons, J. G., & Gutkind, J. S.
- Affiliations
- National Institutes of Health (US)
- University of California San Diego (US)
- Hunter Cancer Research Alliance (AU)
- University of Colorado Anschutz (US)
- University of Malaya (MY)
- Weizmann Institute of Science (IL)
- The University of Sydney (AU)
- Corresponding author
- Lippman, Scott M.
- Gutkind, J. Silvio
- ORCID
- Venue
- Nature Communications
- Published
- 2018-07-09
- Volume
- 9
- Issue
- 1
- Pages
- 2372-2372
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6037762
- OpenAlex
- W2808390504
- Cited by
- 174
- References
- 44
- Citations by year
- 2026: 14 · 2025: 25 · 2024: 22 · 2023: 25 · 2022: 27 · 2021: 20 · 2020: 17 · 2019: 21 · 2018: 3
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- The University of Malaya Research Repository (University of Malaya) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- NOVA (University of Newcastle Australia) (submittedVersion)
- Funders
- Israel Science Foundation (877/13)
- National Health and Medical Research Council (1026232)
- Cancer Council NSW
- Japan Society for the Promotion of Science (18H02438)
- National Human Genome Research Institute (R01HG009285)
- National Cancer Institute (R35CA196878, U24CA194107, U01CA217885, P30CA023100, U24CA248457)
- National Institute of Dental and Craniofacial Research (R01DE026870, R01DE026644)
- FP7 Ideas: European Research Council (335377)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- Hippo signaling pathway, FAT1, atypical cadherin, head and neck squamous cell carcinoma, tumor suppressor
- MeSH terms
- Squamous Cell Carcinoma of Head and Neck, Hippo Signaling Pathway, YAP-Signaling Proteins, Head and Neck Neoplasms, Humans, Phosphoproteins, Proto-Oncogene Proteins, Transcription Factors, Signal Transduction, Cadherins, Hepatocyte Growth Factor, Protein Serine-Threonine Kinases, Adaptor Proteins, Signal Transducing, Gene Knockdown Techniques, HEK293 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
