Cited by 171Neuroscience and Neuropharmacology ResearchAutism Spectrum Disorder ResearchNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.

Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction

Open access

Bariselli, Sebastiano, Hörnberg, Hanna, Prévost-Solié, Clément, Musardo, Stefano, Hatstatt-Burklé, Laetitia, Scheiffele, Peter, Bellone, Camilla·2018·Nature Communications

DOI 10.1038/s41467-018-05382-3PMC PMC6085391

Published version of a preprint

Open this paper in CoChat — free account Open PDF

Abstract

Atypical habituation and aberrant exploration of novel stimuli have been related to the severity of autism spectrum disorders (ASDs), but the underlying neuronal circuits are unknown. Here we show that chemogenetic inhibition of dopamine (DA) neurons of the ventral tegmental area (VTA) attenuates exploration toward nonfamiliar conspecifics and interferes with the reinforcing properties of nonfamiliar conspecific interaction in mice. Exploration of nonfamiliar stimuli is associated with the insertion of GluA2-lacking AMPA receptors at excitatory synapses on VTA DA neurons. These synaptic adaptations persist upon repeated exposure to social stimuli and sustain conspecific interaction. Global or VTA DA neuron-specific loss of the ASD-associated synaptic adhesion molecule neuroligin 3 alters the behavioral response toward nonfamiliar conspecifics and the reinforcing properties of conspecific interaction. These behavioral deficits are accompanied by an aberrant expression of AMPA receptors and an occlusion of synaptic plasticity. Altogether, these findings link impaired exploration of nonfamiliar conspecifics to VTA DA neuron dysfunction in mice.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41467-018-05382-3

Cites

94 of 94 references verified0 citation errors · 0 not checkable

Statistics

Fig. 1 VTA DA neuron excitability controls exploration of nonfamiliar conspecific. a Representative images (low and high magnification) of immuno-staining experiments against tyrosine hydroxylase (TH) enzyme (in green) performed on midbrain slices of DAT-Cre mice infected with AAV5-DIO-hM4Di-mCherry (red). Scale bar: 1 mm and 100 μm. b Experimental time-course for the habituation/nonfamiliar exploration task. c Time course of time interaction for VTA::DAhM4Di mice treated with vehicle during habituation phase. Friedman test (x2(4) = 32.94, P < 0.0001) followed by Dunn’s test for planned multiple comparisons. d Graph reporting the time interaction at day 4 with s1 and at day 5 with s2 for VTA::DAhM4Di mice treated with vehicle. Wilcoxon test (W = 156). e Time interaction over days during the habituation/nonfamiliar exploration task (s1 and s2 are nonfamiliar conspecific stimuli presented at day 1–4 and 5, respectively) for VTA::DAhM4Di and VTA::DAmCherry mice treated with CNO. Repeated measures (RM) two-way ANOVA (time main effect: F(4,140) = 12.38, P < 0.0001; virus main effect: F(1,35) = 3.13, P = 0.0854; time × drug interaction: F(4,140) = 9.32, P < 0.0001) followed by Bonferroni post hoc test. f Social novelty index calculated from VTA::DAhM4Di treated with vehicle, VTA::DAhM4Di and VTA::DAmCherry both treated with CNO. Kruskal–Wallis test (K(3) = 10.26, P = 0.0059) followed by Dunn’s multiple comparisons test. N indicates number of mice. Error bars report s.e.mCC BY · PubMed Central

Fig. 2 VTA DA neuron excitability controls preference for nonfamiliar conspecific. a Left: experimental time-course. Right: apparatus schematic and occupancy plot. b Time in chamber for vehicle treated VTA::DAhM4Di. RM one-way ANOVA (chamber main effect: F(1.969, 33.48) = 21.79, P < 0.0001, first 5 mins; chamber main effect: F(1.881, 31.98) = 2.825, P = 0.0771, last 5 mins) followed by Holm-Sidak post hoc test. c Time in chamber for CNO treated VTA::DAmCherry. RM one-way ANOVA (chamber main effect: F(1.645, 23.03) = 8.959, P = 0.0022, first 5 mins; chamber main effect: F(1.545, 21.63) = 3.665, P = 0.0527, last 5 mins) followed by Holm-Sidak post hoc test. d Time in chamber for CNO treated VTA::DAhM4Di mice. RM one-way ANOVA (chamber main effect: F(1.494, 25.4) = 5.248, P = 0.0191, first 5 mins; chamber main effect: F(1.663, 28.27) = 5.006, P = 0.0182, last 5 mins) followed by Holm-Sidak post hoc test. e Time sniffing for vehicle treated VTA::DAhM4Di. RM two-way ANOVA (stimulus main effect: F(1,34) = 7.634, P = 0.0092; time main effect: F(1,34) = 9.617, P = 0.0039; time × stimulus interaction: F(1,34) = 18.41, P = 0.0001) followed by Bonferroni post hoc test. f Time sniffing for CNO treated VTA::DAmCherry. RM two-way ANOVA (stimulus main effect: F(1,28) = 13.96, P = 0.0008; time main effect: F(1,28) = 5.028, P = 0.0330; time × stimulus interaction: F(1,28) = 5.629, P = 0.0248) followed by Bonferroni post hoc test. g Time sniffing for CNO treated VTA::DAhM4Di mice. RM two-way ANOVA (stimulus main effect: F(1,34) = 1.458, P = 0.2356; Time main effect: F(1,34) = 4.806, P = 0.0353; time × stimulus interaction: F(1,34) = 0.6434, P = 0.4281) followed by Bonferroni post hoc test. h Distance moved. One-way ANOVA (group main effect: F(2, 48) = 12.86, P < 0.0001, first 5 mins; group main effect: F(2, 48) = 15.01, P < 0.0001, last 5 mins) followed by Bonferroni post hoc test for planned comparisons. i Social novelty index. RM two-way ANOVA (time main effect: F(2,48) = 10.54, P = 0.0021; group main effect: F(2,48) = 35.503, P = 0.0212; time × group interaction: F(2,48) = 6.23, P = 0.0039) followed by Bonferroni post hoc test for planned comparisons. N indicates number of mice. Error bars represent s.e.mCC BY · PubMed Central

Fig. 3 VTA DA neuron excitability mediates the reinforcing properties of nonfamiliar conspecific. a Experimental protocol for conditioned place preference with different stimuli. b Representative occupancy plots. c Scatter plot of preference score measured for familiar mouse pairing during CPP. Paired t test (t(9) = 0.2086; mean and s.e.m for Pre-TEST: 0.498 ± 0.0298; mean and s.e.m for Post-TEST: 0.506 ± 0.0562). d Scatter plot of preference score for nonfamiliar conspecific pairing during CPP. Paired t test (t(9) = 4.578; mean and s.e.m for Pre-TEST: 0.497 ± 0.0144; mean and s.e.m for Post-TEST: 0.596 ± 0.0285). e Scatter plot of preference score for novel object pairing during CPP. Paired t test (t(9) = 2.263; mean and s.e.m for Pre-TEST: 0.510 ± 0.0430; mean and s.e.m for Post-TEST: 0.403 ± 0.0455). f Time course of interaction during conditioning blocks with a familiar mouse (f1). Friedman test (P = 0.0150; x2(12) = 23.51). g Time course of interaction during conditioning blocks with a nonfamiliar conspecific (s1). Friedman test (P < 0.0001; x2(12) = 52.71). h Time course of interaction during conditioning blocks with a novel object (o1). Friedman test (P = 0.0008; x2(12) = 31.88). i Cumulative interaction during conditioning sessions at day 1 and day 4, respe–Wallis test (K(6) = 46.09, P < 0.0001) followed by Dunn’s test for planned comparisons. j Left: experimental protocol for VTA::DAhM4Di and VTA::DAmCherry treated with CNO during CPP with nonfamiliar conspecific pairings. Right: representative occupancy plots for CNO treated VTA::DAmCherry and VTA::DAhM4Di. k Scatter plot of preference score for VTA::DAmCherry treated with CNO during conditioning sessions with a nonfamiliar conspecific (mean and s.e.m for Pre-TEST: 0.4808 ± 0.0267; mean and s.e.m for Post-TEST: 0.5836 ± 0.0275), and scatter plot of preference score for VTA::DAhM4Di treated with CNO during conditioning sessions with a nonfamiliar conspecific (mean and s.e.m for Pre-TEST: 0.4903 ± 0.0162; mean and s.e.m for Post-TEST: 0.5091 ± 0.0428). RM two-way ANOVA (time main effect: F(1, 24) = 7.7048, P = 0.0105; virus main effect: F(1,24) = 0.8678, P = 0.3609; time × virus interaction: F(1,24) = 3.2861, P = 0.0824) followed by Bonferroni post hoc test for planned comparisons. N indicates number of mice. Error bars represent s.e.mCC BY · PubMed Central

Fig. 4 Global knockdown of Nlgn3 alters sociability and social reward behaviors. a Experimental time-course for the habituation/nonfamiliar exploration task. b Mean social interaction time for wild type (WT) and Nlgn3KO mice. RM two-way ANOVA (time main effect: F(4, 80) = 20.3, P < 0.0001; genotype main effect: F(1, 20) = 3.629, P = 0.0713; time × genotype interaction: F(4, 80) = 6.071, P = 0.0003) followed by Bonferroni’s post hoc test. c Social novelty index of WT and Nlgn3KO mice. Unpaired t test (t(20) = 2.481). d Mean object interaction of WT and Nlgn3KO mice. RM two-way ANOVA (time main effect: F(4, 80) = 17.07, P < 0.0001; genotype main effect: F(1, 20) = 3.858, P = 0.0636; time × genotype interaction: F(4, 80) = 1.715, P = 0.1547) followed by Bonferroni’s post hoc test. e Dot plot of object novelty index for WT and Nlgn3KO mice. Mann–Whitney U = 30. f Schematic of novel object recognition test. g Time spent investigating a novel and a familiar object. Paired t test (WT: t(7) = 5.494. Mean and s.e.m familiar = 6.841 ± 1.41, mean and s.e.m novel = 14.33 ± 2.617. KO: t(7) = 5.12. Mean and s.e.m familiar = 8.115 ± 1.186, mean and s.e.m novel = 16.63 ± 2.441). h Object discrimination ratio for WT and Nlgn3KO mice. Unpaired t test (t(14) = 0.5314). i Mean velocity of WT and Nlgn3KO mice during a 7 min-open field test. Unpaired t test (t(20) = 3.178). j Number of marbles buried for WT and Nlgn3KO mice. Unpaired t test (t(19) = 5.505). (k) Schematics of the social conditioned place preference (CPP) test. l Scatter plot of preference score measured during the Pre- and Post-TEST for WT (mean and s.e.m for Pre-TEST: 0.4846 ± 0.0209; mean and s.e.m for Post-TEST: 0.5578 ± 0.0158), and Nlgn3KO mice (mean and s.e.m for Pre-TEST: 0.4809 ± 0.0178; mean and s.e.m for Post-TEST: 0.4886 ± 0.0225). RM two-way ANOVA (time main effect: F(1, 30) = 4.422, P = 0.0440; genotype main effect: F(1,30) = 3.492, P = 0.0715; time × genotype interaction: F(1,30) = 2.885, P = 0.0998) followed by Bonferroni post hoc test for planned comparisons. N numbers indicate mice. All error bars are s.e.mCC BY · PubMed Central

Fig. 5 Nlgn3 in VTA DA neurons is required for social exploration and the reinforcing properties of conspecific interaction. a Left: representative image of coronal slice of VTA and SNc from an AAV2 DIO-miRNlgn3-GFP infected DAT-Cre mouse. Right: higher magnification of VTA. Scale bar: 1 mm and 100 μm. b Experimental schematic of behavioral test order in VTA-injected mice. c Experimental schematic of the social-CPP test. d Scatter plot of preference score measured during the Pre- and Post-TEST for VTA::GFP (mean and s.e.m for pre-TEST = 0.4642 ± 0.0247. Mean and s.e.m post-TEST = 0.5526 ± 0.0200), and VTA::DANL3KD mice (mean and s.e.m for Pre-TEST: 0.4434 ± 0.0218; mean and s.e.m for Post-TEST: 0.4548 ± 0.0214). RM two-way ANOVA (time main effect: F(1, 20) = 4.24, P = 0.0527; virus main effect: F(1,20) = 6.103, P = 0.0226; time × virus interaction: F(1,20) = 2.527, P = 0.1276) followed by Bonferroni post hoc test for planned comparisons. e Experimental schematic of the habituation/nonfamiliar exploration task. f Mean social interaction plotted for VTA::GFP and VTA::DANL3KD mice. RM two-way ANOVA (time main effect: F(4, 80) = 8.058, P < 0.0001, virus main effect: F(1, 20) = 9.164, P = 0.0067; time × virus interaction: F(4, 80) = 3.179, P = 0.0178) followed by Bonferroni’s post hoc test. g Social novelty index for VTA::GFP and VTA::DANL3KD mice. Unpaired t test (t(20) = 2.908). h Experimental schematic of novel object recognition test. i Time spent investigating a novel and a familiar object. Paired t test (VTA::GFP: t(13) = 3.763. Mean and s.e.m familiar = 6.199 ± 0.805, mean and s.e.m novel = 14.03 ± 2.188. VTA::DANL3KD: t(7) = 6.518. Mean familiar = 8.226, s.e.m ± 1.069, mean novel = 16.2, s.e.m ± 1.582). j Discrimination ratio for object discrimination plotted for VTA::GFP and VTA::DANL3KD. Unpaired t test (t(20) = 0.1627). k Mean velocity of VTA::GFP and VTA::DANL3KD mice during a 7 min open field test. Mann–Whitney U = 47. l Number of marbles buried plotted for VTA::GFP and VTA::DANL3KD. Mann–Whitney U = 49.5. N numbers indicate mice. All error bars are s.e.mCC BY · PubMed Central

Fig. 6 Novelty-induced synaptic plasticity. a Top: experimental paradigm. Bottom: scatter plot of rectification index and AMPAR-EPSCs example traces (−60, 0, and 40 mV) recorded from VTA DA neurons at baseline (B, homecage), or 24 h after 15 min of novel context (Nc), nonfamiliar conspecific (s1) or novel object (o1) exposure. One-way ANOVA (F(3, 39) = 4.153, P = 0.0120) followed by Bonferroni post hoc test for planned comparisons. b Top: experimental paradigm. Bottom: scatter plot and example traces of AMPA/NMDA ratio recorded from VTA DA neurons at baseline (B, homecage), or 24 h after 15 min of novel context (Nc), nonfamiliar conspecific (s1) or novel object (o1) exposure. One-way ANOVA (F(3, 42) = 0.0287, P = 0.9933). c Top: experimental paradigm. Bottom: scatter plot and example traces of rectification index recorded from VTA DA neurons at baseline (B), 24 h after four repeated exposures to either a novel mouse (s1) or a novel object (o1) and ten repeated exposures to a nonfamiliar conspecific (s1, bold purple). One-way ANOVA (F(3, 64) = 5.149, P = 0.0030) followed by Bonferroni post hoc test for planned multiple comparisons. d Top: experimental paradigm. Bottom: scatter plot and example traces of AMPA/NMDA ratio recorded from VTA DA neurons at baseline (b), 24 h after four repeated exposures to either a nonfamiliar conspecific (s1) or a novel object (o1) and ten repeated exposures to a nonfamiliar conspecific (s1, bold purple). One-way ANOVA (F(3,46) = 4.4939, P = 0.0076) followed by Bonferroni post hoc test for planned multiple comparisons. n,N indicates number of cells and mice respectively. Scale bars: 20 msec, 20 pA. Error bars report s.e.mCC BY · PubMed Central

Fig. 7 GluA2-lacking AMPAR function controls habituation to nonfamiliar conspecific. a Schema of the experimental paradigm. b Representative image of cannula placement for NASPM or vehicle infusion (green: TH; blue: DAPI; white arrow indicates cannula tip). c Time course of time interaction with a nonfamiliar conspecific (s1) for vehicle or NASPM infused mice at day 2, day 3, and day 4. RM two-way ANOVA (time main effect: F(3, 24) = 17.57, P < 0.0001; drug main effect: F(1, 8) = 16.48, P = 0.0036; time × drug interaction: F(3, 24) = 3.141, P = 0.0439). d Time course of time interaction with a novel object (o1) over 4 days for Vehicle and NASPM groups. RM two-way ANOVA (time main effect: F(3, 33) = 24.71, P < 0.0001; drug main effect: F(1,11) = 0.00005, P = 0.9942; time × drug interaction: F(3, 33) = 1.109, P = 0.3595). e Experimental paradigm for noncontingent optogenetic stimulation. f Representative image of optic fiber placement for DIO-ChR2 expressing mice (red: TH, green: AAV-DIO-ChR2-eYFP, blue: DAPI; white arrow indicates fiber optic tip). g Left: example traces of a photocurrent negative (IChR2−) and a photocurrent positive (IChR2+) VTA DA neuron. Scale bars: 20 msec, 1 nA. Middle: scatter plot of RI recorded from photocurrent negative (IChR−) and photocurrent positive (IChR2+) VTA DA neurons and AMPAR-EPSCs example traces (−60, 0, and 40 mV) recorded from VTA DA neurons. Mann−Whitney test (U = 6). Scale bars: 20 msec, 20 pA. h Time course over 4 days of time interaction with a nonfamiliar conspecific (s1) for VTA::DAChR2 and VTA::DAeYFP mice with noncontingent optical stimulation. RM two-way ANOVA (time main effect: F(3, 18) = 2.9966, P = 0.0386; virus main effect: F(1, 18) = 7.9034, P = 0.0116; time × virus interaction: F(3, 18) = 1.9532, P = 0.1320). N indicates number of mice. Error bars represent s.e.mCC BY · PubMed Central

Fig. 8 Aberrant increase of GluA2-lacking AMPARs in Nlgn3-deficient VTA DA neurons. a Top: experimental paradigm. Bottom: scatter plot of rectification index and example traces of AMPAR-EPSCs (−60, 0, and 40 mV) measured from adolescent WT, Nlgn3KO and VTA::DANL3KD. One-way ANOVA (F(2, 23) = 8.363, P = 0.0019) followed by Bonferroni post hoc test. b Top: experimental paradigm. Bottom: scatter plot of rectification index and example traces of AMPAR-EPSCs (−60, 0, and 40 mV) measured from VTA::DANLKD mice at baseline (B) or 24 h after 15 min exposure to a nonfamiliar conspecific (s1). Unpaired t test (t(16) = 0.7536). n, N indicates number of cells and mice respectively. Scale bars: 20 msec, 20 pA. Error bars represent s.e.mCC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388
Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
The social motivation theory of autism
Chevallier, C., Kohls, G., Troiani, V., Brodkin, E. S., & Schultz, R. T. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.02.007 · Cited by 2,072
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
Study, P. A. R. I. S., Jamain, S., Quach, H., Betancur, C., Råstam, M., Colineaux, C., Gillberg, I. C., Soderstrom, H., Giros, B., Leboyer, M., et al. (2003) · Nature Genetics · doi:10.1038/ng1136 · Cited by 1,851
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice
Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-1848.2004.00076.x · Cited by 1,522
Natural neural projection dynamics underlying social behavior
Gunaydin, L. A., Grosenick, L., Finkelstein, J. C., Kauvar, I. V., Fenno, L. E., Adhikari, A., Lammel, S., Mirzabekov, J. J., Airan, R. D., Zalocusky, K. A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.017 · Cited by 1,389
Neuron-type-specific signals for reward and punishment in the ventral tegmental area
Cohen, J. Y., Haesler, S., Vong, L., Lowell, B. B., & Uchida, N. (2012) · Nature · doi:10.1038/nature10754 · Cited by 1,318
Input-specific control of reward and aversion in the ventral tegmental area
Lammel, S., Lim, B. K., Ran, C., Huang, K. W., Betley, M. J., Tye, K. M., Deisseroth, K., & Malenka, R. C. (2012) · Nature · doi:10.1038/nature11527 · Cited by 1,300

Show all 94 references

Sorted by citations

Dissecting the contribution of host genetics and the microbiome in complex behaviors
Buffington, S. A., Dooling, S. W., Sgritta, M., Noecker, C. A., Murillo, O. D., Felice, D., Turnbaugh, P. J., & Costa‐Mattioli, M. (2021) · Cell · doi:10.1016/j.cell.2021.02.009 · Cited by 214
VTA dopamine neuron activity encodes social interaction and promotes reinforcement learning through social prediction error
Solié, C., Girard, B., Righetti, B., Tapparel, M., & Bellone, C. (2022) · Nature Neuroscience · doi:10.1038/s41593-021-00972-9 · Cited by 186
Self-citation
Responses and functions of dopamine in nucleus accumbens core during social behaviors
Dai, B., Sun, F., Tong, X., Ding, Y., Kuang, A., Osakada, T., Li, Y., & Lin, D. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111246 · Cited by 187
Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement
Corre, J., van Zessen, R., Loureiro, M., Patriarchi, T., Tian, L., Pascoli, V., & Lüscher, C. (2018) · eLife · doi:10.7554/elife.39945 · Cited by 178
The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota
Bermudez-Martin, P., Becker, J. A. J., Caramello, N., Fernández, S. P., Campos, R. C., Canaguier, J., Barbosa, S., Martínez-Gili, L., Myridakis, A., Dumas, M., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01103-z · Cited by 166
Rescue of oxytocin response and social behaviour in a mouse model of autism
Hörnberg, H., Pérez-Garci, E., Schreiner, D., Hatstatt-Burklé, L., Magara, F., Baudouin, S., Matter, A., Nacro, K., Pecho-Vrieseling, E., & Scheiffele, P. (2020) · Nature · doi:10.1038/s41586-020-2563-7 · Cited by 154
Self-citation
Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex
Sacai, H., Sakoori, K., Konno, K., Nagahama, K., Suzuki, H., Watanabe, T., Watanabe, M., Uesaka, N., & Kano, M. (2020) · Nature Communications · doi:10.1038/s41467-020-18861-3 · Cited by 148
NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model
Qi, G., Zhang, P., Li, T., Li, M., Zhang, Q., He, F., Zhang, L., Cai, H., Lv, X., Qiao, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28190-2 · Cited by 151
5-HT modulation of a medial septal circuit tunes social memory stability
Wu, X., Morishita, W., Beier, K. T., Heifets, B. D., & Malenka, R. C. (2021) · Nature · doi:10.1038/s41586-021-03956-8 · Cited by 116
Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice
Park, G., Ryu, C., Kim, S., Jeong, S. J., Koo, J. W., Lee, Y., & Kim, S. J. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109104 · Cited by 109
Adolescent sleep shapes social novelty preference in mice
Bian, W.-J., Brewer, C. L., Kauer, J. A., & de Lecea, L. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01076-8 · Cited by 99
Dual action of ketamine confines addiction liability
Simmler, L. D., Li, Y., Hadjas, L. C., Hiver, A., van Zessen, R., & Lüscher, C. (2022) · Nature · doi:10.1038/s41586-022-04993-7 · Cited by 95
Cerebellar dopamine D2 receptors regulate social behaviors
Cutando, L., Puighermanal, E., Castell, L., Tarot, P., Belle, M., Bertaso, F., Arango-Lievano, M., Ango, F., Rubinstein, M., Quintana, A., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01092-8 · Cited by 78
Neuroligin-3: A Circuit-Specific Synapse Organizer That Shapes Normal Function and Autism Spectrum Disorder-Associated Dysfunction
Uchigashima, M., Cheung, A., & Futai, K. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.749164 · Cited by 95
Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity
Elias, L. J., Succi, I. K., Schaffler, M. D., Foster, W., Gradwell, M. A., Bohic, M., Fushiki, A., Upadhyay, A., Ejoh, L. L., Schwark, R., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.034 · Cited by 85
Hypothalamic control of innate social behaviors
Mei, L., Osakada, T., & Lin, D. (2023) · Science · doi:10.1126/science.adh8489 · Cited by 94
The Dopamine Hypothesis of Autism Spectrum Disorder Revisited: Current Status and Future Prospects
Pavăl, D., & Micluția, I. (2021) · Developmental Neuroscience · doi:10.1159/000515751 · Cited by 81
Oxytocin neurons mediate the effect of social isolation via the VTA circuits
Musardo, S., Contestabile, A., Knoop, M., Baud, O., & Bellone, C. (2022) · eLife · doi:10.7554/elife.73421 · Cited by 77
Self-citation
Dopamine Circuit Mechanisms of Addiction-Like Behaviors
Poisson, C. L., Engel, L., & Saunders, B. T. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.752420 · Cited by 75
Maternal gut microbiota mediate intergenerational effects of high-fat diet on descendant social behavior
Gesù, C. M. D., Matz, L. M., Bolding, I. J., Fultz, R., Hoffman, K. L., Marino, A., Petrosino, J. F., & Buffington, S. A. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111461 · Cited by 74
Systematic phenomics analysis of autism-associated genes reveals parallel networks underlying reversible impairments in habituation
McDiarmid, T. A., Belmadani, M., Liang, J., Meili, F., Mathews, E., Mullen, G. P., Hendi, A., Wong, W.-R., Rand, J. B., Mizumoto, K., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1912049116 · Cited by 69
Midbrain circuits of novelty processing
Tapper, A. R., & Molas, S. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107323 · Cited by 74
Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice
Solié, C., Contestabile, A., Espinosa, P., Musardo, S., Bariselli, S., Huber, C., Carleton, A., & Bellone, C. (2022) · Nature Communications · doi:10.1038/s41467-022-28512-4 · Cited by 58
Self-citation
A Systematic Review of Brainstem Contributions to Autism Spectrum Disorder
Seif, A., Shea, C., Schmid, S., & Stevenson, R. A. (2021) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2021.760116 · Cited by 56
Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3
Hong, N., Kim, H. J., Kang, K., Park, J. O., Mun, S., Kim, H., Kang, B. H., Chung, P., Lee, M. Y., & Ahn, J. (2023) · Cell & Bioscience · doi:10.1186/s13578-022-00949-6 · Cited by 52
Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species
Rappeneau, V., & Castillo Díaz, F. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105675 · Cited by 51
“Dopaminergic neurons of the VTA, which extend their projections to the nucleus accumbens (NAc), play a pivotal role in regulating both social cues and reward processing in both humans and rodents (Bariselli et al., 2018; Gunaydin et al., 2014, 2014; Kawamichi et al., 2016).”
Background
Mechanisms Underlying Circuit Dysfunction in Neurodevelopmental Disorders
Exposito-Alonso, D., & Rico, B. (2022) · Annual Review of Genetics · doi:10.1146/annurev-genet-072820-023642 · Cited by 49
Possible Implication of the CA2 Hippocampal Circuit in Social Cognition Deficits Observed in the Neuroligin 3 Knock-Out Mouse, a Non-Syndromic Animal Model of Autism
Modi, B., Pimpinella, D., Pazienti, A., Zacchi, P., Cherubini, E., & Griguoli, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00513 · Cited by 57
Post-weaning social isolation of mice: A putative animal model of developmental disorders
Matsumoto, K., Fujiwara, H., Araki, R., & Yabe, T. (2019) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2019.10.002 · Cited by 48
Inhibition of Trpv4 rescues circuit and social deficits unmasked by acute inflammatory response in a Shank3 mouse model of Autism
Tzanoulinou, S., Musardo, S., Contestabile, A., Bariselli, S., Casarotto, G., Magrinelli, E., Jiang, Y., Jabaudon, D., & Bellone, C. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01427-0 · Cited by 43
Self-citation
The Role of Synaptic Cell Adhesion Molecules and Associated Scaffolding Proteins in Social Affiliative Behaviors
Taylor, S. C., Ferri, S. L., Grewal, M., Smernoff, Z., Bućan, M., Weiner, J. A., Abel, T. G., & Brodkin, E. S. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.02.012 · Cited by 45
Overlapping representations of food and social stimuli in mouse VTA dopamine neurons
Willmore, L., Minerva, A. R., Engelhard, B., Murugan, M., McMannon, B., Oak, N., Thiberge, S. Y., Peña, C. J., & Witten, I. B. (2023) · Neuron · doi:10.1016/j.neuron.2023.08.003 · Cited by 45
Advancing social behavioral neuroscience by integrating ethology and comparative psychology methods through machine learning
Bordes, J., Miranda, L., Müller‐Myhsok, B., & Schmidt, M. V. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105243 · Cited by 45
Deconstructing the contribution of sensory cues in social approach
Contestabile, A., Casarotto, G., Girard, B. J. T., Tzanoulinou, S., & Bellone, C. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15179 · Cited by 36
Self-citation
The neurochemistry of social reward during development: What have we learned from rodent models?
Manduca, A., Carbone, E., Schiavi, S., Cacchione, C., Buzzelli, V., Campolongo, P., & Trezza, V. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15321 · Cited by 34
Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders
Risi, M. D., Tufano, M., Alvino, F. G., Ferraro, M. G., Torromino, G., Gigante, Y., Monfregola, J., Marrocco, E., Pulcrano, S., Tunisi, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23903-5 · Cited by 34
NMDA receptor hypofunction underlies deficits in parvalbumin interneurons and social behavior in neuroligin 3 R451C knockin mice
Cao, W., Li, J., Shen, L., Xia, Q.-Q., Du, Y.-L., Yang, Q., Ye, Y.-Z., Zeng, L., Li, X., Xu, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111771 · Cited by 31
Presynaptic PTPσ regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms
Kim, K., Shin, W., Kang, M., Lee, S., Kim, D., Kang, R., Jung, Y., Cho, Y., Yang, E., Kim, H., et al. (2020) · eLife · doi:10.7554/elife.54224 · Cited by 29
Altered baseline and amphetamine-mediated behavioral profiles in dopamine transporter Cre (DAT-Ires-Cre) mice compared to tyrosine hydroxylase Cre (TH-Cre) mice
Chohan, M. O., Esses, S., Haft, J., Ahmari, S. E., & Veenstra-VanderWeele, J. M. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05635-4 · Cited by 30
Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder
Kaiser, F. M. P., Gruenbacher, S., Oyaga, M. R., Nio, E., Jaritz, M., Sun, Q., van der Zwaag, W., Kreidl, E., Zopf, L. M., Dalm, V. A. S. H., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220498 · Cited by 31
Dopamine control of social novelty preference is constrained by an interpeduncular-tegmentum circuit
Molas, S., Freels, T. G., Zhao-Shea, R., Lee, T., Giménez‐Gómez, P., Barbini, M., Martin, G. E., & Tapper, A. R. (2024) · Nature Communications · doi:10.1038/s41467-024-47255-y · Cited by 31
The Effect of Limosilactobacillus reuteri on Social Behavior Is Independent of the Adaptive Immune System
Dooling, S. W., Sgritta, M., Wang, I.-C., Duque, A. L. R. F., & Costa‐Mattioli, M. (2022) · mSystems · doi:10.1128/msystems.00358-22 · Cited by 30
SHANK3 Downregulation in the Ventral Tegmental Area Accelerates the Extinction of Contextual Associations Induced by Juvenile Non-familiar Conspecific Interaction
Bariselli, S., Contestabile, A., Tzanoulinou, S., Musardo, S., & Bellone, C. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00360 · Cited by 28
Self-citation
Species-typical group size differentially influences social reward neural circuitry during nonreproductive social interactions
Abreu, J. A. G., Rosenberg, A. E., Fricker, B. A., Wallace, K. J., Seifert, A. W., & Kelly, A. M. (2022) · iScience · doi:10.1016/j.isci.2022.104230 · Cited by 26
Reduction in the activity of VTA/SNc dopaminergic neurons underlies aging-related decline in novelty seeking
Shan, Q., Tian, Y., Chen, H., Lin, X., & Tian, Y. (2023) · Communications Biology · doi:10.1038/s42003-023-05571-x · Cited by 25
Postpartum changes in affect-related behavior and VTA dopamine neuron activity in rats
Rincón‐Cortés, M., & Grace, A. A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109768 · Cited by 26
Interconnected neural circuits mediating social reward
Isaac, J., & Murugan, M. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.10.004 · Cited by 26
Morphine reduces the interest for natural rewards
Piccin, A., Courtand, G., & Contarino, A. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06131-7 · Cited by 27
Impaired synaptic plasticity in an animal model of autism exhibiting early hippocampal GABAergic-BDNF/TrkB signaling alterations
Sgritta, M., Vignoli, B., Pimpinella, D., Griguoli, M., Santi, S., Bialowas, A., Wiera, G., Zacchi, P., Malerba, F., Marchetti, C., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105728 · Cited by 24
Autism-associated mutations in K V 7 channels induce gating pore current
El-Din, T. M. G., Lantin, T., Tschumi, C. W., Juarez, B., Quinlan, M. A., Hayano, J. H., Li, J., Zweifel, L. S., & Catterall, W. A. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2112666118 · Cited by 22
Synaptic ensembles between raphe and D 1 R-containing accumbens shell neurons underlie postisolation sociability in males
Choi, J. E., Choi, D. I., Lee, J., Kim, J., Kim, M. J., Hong, I., Jung, H., Sung, Y., Kim, J., Kim, T., et al. (2022) · Science Advances · doi:10.1126/sciadv.abo7527 · Cited by 23
Pharmacology profile of F17464, a dopamine D3 receptor preferential antagonist
Cosi, C., Martel, J., Auclair, A. L., Collo, G., Cavalleri, L., Heusler, P., Leriche, L., Gaudoux, F., Sokoloff, P., Moser, P. C., et al. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173635 · Cited by 23
Representation of sex-specific social memory in ventral CA1 neurons
Watarai, A., Tao, K., & Okuyama, T. (2025) · Science · doi:10.1126/science.adp3814 · Cited by 25
Genetics, molecular control and clinical relevance of habituation learning
Blok, L. E. R., Boon, M., van Reijmersdal, B., Höffler, K. D., Fencková, M., & Schenck, A. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104883 · Cited by 23
Increase in neuropeptide Y activity impairs social behaviour in association with glutamatergic dysregulation in diabetic mice
Ueda, D., Yonemochi, N., Kamata, T., Shibasaki, M., Kamei, J., Waddington, J. L., & Ikeda, H. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15326 · Cited by 21
Role of dopamine neurons in familiarity
Fleury, S., Kolaric, R., Espera, J., Ha, Q. H., Tomaio, J. N., Gether, U., Sørensen, A. T., & Mingote, S. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16326 · Cited by 21
Chemogenetic manipulation of the bed nucleus of the stria terminalis counteracts social behavioral deficits induced by early life stress in C57BL/6J mice
Emmons, R., Sadok, T., Rovero, N. G., Belnap, M. A., Henderson, H. J. M., Quan, A., Toro, N. J. D., & Halladay, L. R. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24644 · Cited by 21
Striatal increase of dopamine receptor 2 density in idiopathic and syndromic mouse models of autism spectrum disorder
Chhabra, S., Nardi, L., Leukel, P., Sommer, C. J., & Schmeißer, M. J. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1110525 · Cited by 23
A ventral hippocampal-lateral septum pathway regulates social novelty preference
Rashid, M., Thomas, S., Isaac, J., Karkare, S. C., Klein, H., & Murugan, M. (2024) · eLife · doi:10.7554/elife.97259.2 · Cited by 24
Adult hippocampal neurogenesis and social behavioural deficits in the R451C Neuroligin3 mouse model of autism are reverted by the antidepressant fluoxetine
Gioia, R., Seri, T., Diamanti, T., Fimmanò, S., Vitale, M., Ahlenius, H., Kokaia, Z., Tirone, F., Micheli, L., Biagioni, S., et al. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15753 · Cited by 20
Viral Tracing Confirms Paranigral Ventral Tegmental Area Dopaminergic Inputs to the Interpeduncular Nucleus Where Dopamine Release Encodes Motivated Exploration
Molas, S., Zhao-Shea, R., Freels, T. G., & Tapper, A. R. (2023) · eNeuro · doi:10.1523/eneuro.0282-22.2022 · Cited by 26
Modeling the mechanics of growing epithelia with a bilayer plate theory
Ackermann, J., Qu, P.-Q., LeGoff, L., & Amar, M. B. (2021) · The European Physical Journal Plus · doi:10.1140/epjp/s13360-021-02205-1 · Cited by 19
Drug-Evoked Synaptic Plasticity of Excitatory Transmission in the Ventral Tegmental AreaPreprint
Bellone, C., Loureiro, M., & Lüscher, C. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039701 · Cited by 18
Self-citation
IRSp53 Deletion in Glutamatergic and GABAergic Neurons and in Male and Female Mice Leads to Distinct Electrophysiological and Behavioral Phenotypes
Kim, Y., Noh, Y. W., Kim, K., Yang, E., Kim, H., & Kim, E. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00023 · Cited by 18
Hearing, touching, and multisensory integration during mate choice
Lenschow, C., Mendes, A. R. P., & Lima, S. Q. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.943888 · Cited by 17
RAB39B-mediated trafficking of the GluA2-AMPAR subunit controls dendritic spine maturation and intellectual disability-related behaviour
Mignogna, M. L., Musardo, S., Ranieri, G., Gelmini, S., Espinosa, P., Marra, P., Belloli, S., Murtaj, V., Moresco, R. M., Bellone, C., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01155-5 · Cited by 19
Self-citation
Evidence for a Contribution of the Nlgn3/Cyfip1/Fmr1 Pathway in the Pathophysiology of Autism Spectrum Disorders
Śledziowska, M., Galloway, J., & Baudouin, S. J. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.10.011 · Cited by 16
Dopamine, Psychosis, and Symptom Fluctuation: A Narrative Review
Novak, G., & Seeman, M. (2022) · Healthcare · doi:10.3390/healthcare10091713 · Cited by 17
Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neurons
Chen, Y., Kuang, J., Niu, Y., Zhu, H., Chen, X., So, K., Xu, A., & Shi, L. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.378203 · Cited by 14
Prefrontal cortical circuits in social behaviors: an overview
Cao, W., Li, H., & Luo, J. (2024) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2300743 · Cited by 14
Control of Behavioral Arousal and Defense by a Glutamatergic Midbrain-Amygdala Pathway in Mice
Chen, S.-Y., Yao, J., Hu, Y., Chen, H., Liu, P.-C., Wang, W., Zeng, Y.-H., Zhuang, C.-W., Zeng, S.-X., Li, Y., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.850193 · Cited by 14
The emergence of electrical activity in human brain organoids
Mancinelli, S., Bariselli, S., & Lodato, S. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102632 · Cited by 16
Self-citation
Neuroligins in neurodevelopmental conditions: how mouse models ofde novomutations can help us link synaptic function to social behavior
Pohl, T. T., & Hörnberg, H. (2022) · Neuronal Signaling · doi:10.1042/ns20210030 · Cited by 13
Self-citation
Sex differences in autism‐like behavior and dopaminergic neurons in substantia nigra of juvenile mice prenatally exposed to valproate
Zárate-López, D., Garzón‐Partida, A. P., González-Pérez, Ó., & Gálvez‐Contreras, A. Y. (2024) · Developmental Psychobiology · doi:10.1002/dev.22469 · Cited by 12
Short-term social isolation acts on hypothalamic neurons to promote social behavior in a sex- and context-dependent manner
Zhao, X., Chae, Y. C., Smith, D., Chen, V., DeFelipe, D., Sokol, J. W., Sadangi, A., & Tschida, K. (2024) · eLife · doi:10.7554/elife.94924.3 · Cited by 13
Systematic Input–Output Mapping Reveals Structural Plasticity of VTA Dopamine Neurons-Zona Incerta Loop Underlying the Social Buffering Effects in Learned Helplessness
Cai, H., Zhang, P., Qi, G., Zhang, L., Li, T., Li, M., Lv, X., Lei, J., Ming, J., & Tian, B. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02614-4 · Cited by 12
A glutamatergic basal forebrain to midbrain circuit mediates wakefulness and defensive behavior
Cai, P., Chen, H., Tang, W.-T., Hu, Y., Chen, S.-Y., Lu, J., Lin, Z., Huang, S., Hu, L., Su, W.-K., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.108979 · Cited by 15
The PFC-LH-VTA pathway contributes to social deficits in IRSp53-mutant mice
Noh, Y. W., Kim, Y., Lee, S., Kim, Y., Shin, J. J., Kang, H., Kim, I. H., & Kim, E. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02257-y · Cited by 11
Parenting behaviors in mice: Olfactory mechanisms and features in models of autism spectrum disorders
Dudas, A., Nakahara, T. S., Pellissier, L. P., & Chamero, P. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105686 · Cited by 11
Complex Interactions between Genes and Social Environment Cause Phenotypes Associated with Autism Spectrum Disorders in Mice
Śledziowska, M., Kalbassi, S., & Baudouin, S. J. (2020) · eNeuro · doi:10.1523/eneuro.0124-20.2020 · Cited by 10
Transient nicotine exposure in early adolescent male mice freezes their dopamine circuits in an immature state
Reynolds, L. M., Gulmez, A., Fayad, S. L., Campos, R. C., Rigoni, D., Nguyen, C., Le Borgne, T., Topilko, T., Rajot, D., Franco, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53327-w · Cited by 10
“Totestthispossibility, weused a chemogenetic approachto exclusively decrease the excitability of VTA DA neurons of mice exposed to NIC in adolescence 49 , by expressing an inhibitory DREADD (hM4D(G i )) in a projection-and neurotransmitter-speci ﬁ c manner (Fig.”
Background
Embryonic Valproate Exposure Alters Mesencephalic Dopaminergic Neurons Distribution and Septal Dopaminergic Gene Expression in Domestic Chicks
Adiletta, A., Pross, A., Taricco, N., & Sgadó, P. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.804881 · Cited by 9
The microbial metabolite p -Cresol induces autistic-like behaviors in mice by remodeling the gut microbiotaPreprint
Bermudez-Martin, P., Becker, J. A. J., Caramello, N., Fernandez, S. P., Campos, R. C., Canaguier, J., Barbosa, S., Martinez-Gili, L., Myridakis, A., Dumas, M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.18.101147 · Cited by 10
Identification of touch neurons underlying dopaminergic pleasurable touch and sexual receptivityPreprint
Elias, L. J., Schaffler, M. D., Succi, I., Foster, W., Gradwell, M. A., Bohic, M., Ejoh, L. L., Abraira, V. E., & Abdus-Saboor, I. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.22.461355 · Cited by 10
Salience to remember: VTA-IC dopaminergic pathway activity is necessary for object recognition memory formation
Ramírez-Mejía, G., Gil-Lievana, E., Urrego-Morales, O., Gálvez-Márquez, D. K., Hernández-Ortiz, E., Carrillo-Lorenzo, J. A., & Bermúdez‐Rattoni, F. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109464 · Cited by 9
AST-001 Improves Social Deficits and Restores Dopamine Neuron Activity in a Mouse Model of Autism
Um, K. B., Kwak, S., Cheon, S.-H., Kim, J., & Hwang, S. (2023) · Biomedicines · doi:10.3390/biomedicines11123283 · Cited by 9
VTA multifaceted modulation of CA1 local circuits
Adeyelu, T. T., & Ogundele, O. M. (2023) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2023.107760 · Cited by 10
Optogenetic and chemogenetic approaches reveal differences in neuronal circuits that mediate initiation and maintenance of social interaction
Rojek-Sito, K., Meyza, K. Z., Ziegart-Sadowska, K., Nazaruk, K., Puścian, A., Hamed, A., Kiełbiński, M., Solecki, W., & Knapska, E. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002343 · Cited by 12
Transcriptional Profiling of Xenogeneic Transplants: Examining Human Pluripotent Stem Cell-Derived Grafts in the Rodent Brain
Bye, C. R., Penna, V., de Luzy, I. R., Gantner, C. W., Hunt, C. J., Thompson, L. H., & Parish, C. L. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.10.001 · Cited by 9
Cerebellar contributions to fear-based emotional processing: relevance to understanding the neural circuits involved in autism
Couto-Ovejero, S., Ye, J., Kind, P. C., Till, S. M., & Watson, T. C. (2023) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2023.1229627 · Cited by 10
Roles of AMPA receptors in social behaviors
Xu, Q. W., Larosa, A., & Wong, T. P. (2024) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2024.1405510 · Cited by 6
Social environment enrichment alleviates anxiety-like behavior in mice: Involvement of the dopamine system
Wang, Q., Wang, Y., Tian, Y., Li, Y., Han, J., Tai, F., & Jia, R. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114687 · Cited by 10
Neuroligin-3 Regulates Excitatory Synaptic Transmission and EPSP-Spike Coupling in the Dentate Gyrus In Vivo
Muellerleile, J., Vnencak, M., Ippolito, A., Krueger‐Burg, D., Jungenitz, T., Schwarzacher, S. W., & Jedlička, P. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02663-9 · Cited by 8
Adolescent sleep defects and dopaminergic hyperactivity in mice with a schizophrenia-linked Shank3 mutation
Bian, W.-J., Gonzalez, O. C., & de Lecea, L. (2023) · SLEEP · doi:10.1093/sleep/zsad131 · Cited by 9
Circuits underlying social function and dysfunction
Wang, Z., Yueh, H., Chau, M., Veenstra-VanderWeele, J. M., & O’Reilly, K. C. (2023) · Autism Research · doi:10.1002/aur.2978 · Cited by 9
Recovery from social isolation requires dopamine in males, but not the autism-related gene nlg3 in either sex
Yost, R. T., Scott, A. M., Kurbaj, J. M., Walshe‐Roussel, B., Dukas, R., & Simon, A. F. (2024) · Royal Society Open Science · doi:10.1098/rsos.240604 · Cited by 10
The Cerebellum–Ventral Tegmental Area Microcircuit and Its Implications for Autism Spectrum Disorder: A Narrative Review
Zhou, P., Peng, S., Wen, S., Lan, Q., Zhuang, Y., Li, X., Shi, M., & Zhang, C. (2024) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s485487 · Cited by 7
Oxytocin and dopamine in psychostimulant-induced changes in social behaviour
Díaz, F. C., Neumann, I. D., & Rappeneau, V. (2025) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2025.101200 · Cited by 8
Sex-dependent and ontogenetic effects of low dose ethanol on social behavioral deficits induced by mouse maternal separation
Henderson, H. J. M., Etem, G., Bjorni, M., Belnap, M. A., Rosellini, B., & Halladay, L. R. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113241 · Cited by 6
Blockade of orexin receptor 1 attenuates morphine protracted abstinence-induced anxiety-like behaviors in male mice
Ye, H., Cao, T., Shu, Q., Chen, Y., Lu, Y., He, Z., & Li, Z. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106080 · Cited by 7

Authors: Bariselli, S., Hörnberg, H., Prévost-Solié, C., Musardo, S., Hatstatt-Burklé, L., Scheiffele, P., & Bellone, C.
Affiliations: University of Geneva (CH)
University of Basel (CH)
Corresponding author: Bellone, Camilla
ORCID: Bariselli, Sebastiano
Hörnberg, Hanna
Musardo, Stefano
Scheiffele, Peter
Bellone, Camilla
Venue: Nature Communications
Publisher: Springer Science and Business Media LLC
Published: 2018-08-09
Volume: 9
Issue: 1
Pages: 3173-3173
ISSN: 2041-1723 (ISSN-L)
DOI: 10.1038/s41467-018-05382-3
PMC: PMC6085391
OpenAlex: W2886986075
Cited by: 171
References: 94
Citations by year: 2026: 12 · 2025: 20 · 2024: 27 · 2023: 27 · 2022: 31 · 2021: 23 · 2020: 18 · 2019: 9 · 2018: 3
FWCI: 6.04
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Nature Communications (publishedVersion, cc-by)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
edoc (University of Basel) (submittedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders: National Science Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (150704)
Fondation Pierre Mercier
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: ventral tegmental area, dopaminergic neurons, neuroligin-3, autism spectrum disorder, sociability, habituation, synaptic plasticity, chemogenetic inhibition, social reinforcement, synaptic adhesion molecules
MeSH terms: Animals, Behavior, Animal, Female, Male, Membrane Proteins, Mice, Inbred C57BL, Mice, Transgenic, Nerve Tissue Proteins, Neuronal Plasticity, Neurons, Social Behavior, Synapses, Cell Adhesion Molecules, Neuronal, Ventral Tegmental Area, Receptors, AMPA, Mice, Dopaminergic Neurons

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks