The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response
Open accessAbstract
Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric UC patients receiving standardised therapy. We validate our key findings in adult and paediatric UC cohorts of 408 participants. We observe a marked suppression of mitochondrial genes and function across cohorts in active UC, and that increasing disease severity is notable for enrichment of adenoma/adenocarcinoma and innate immune genes. A subset of severity genes improves prediction of corticosteroid-induced remission in the discovery cohort; this gene signature is also associated with response to anti-TNFα and anti-α 4 β 7 integrin in adults. The severity and therapeutic response gene signatures were in turn associated with shifts in microbes previously implicated in mucosal homeostasis. Our data provide insights into UC pathogenesis, and may prioritise future therapies for nonresponders to current approaches.
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Cited by
Friedrich, M., Pohin, M., Jackson, M. A., Korsunsky, I., Bullers, S. J., Rue-Albrecht, K., Christoforidou, Z., Sathananthan, D., Thomas, T., Ravindran, R., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01520-5 · Cited by 303
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The emerging role of oxidative stress in inflammatory bowel disease
Muro, P., Zhang, L., Li, S., Zhao, Z., Jin, T., Mao, F., & Mao, Z. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1390351 · Cited by 279
Grey, M. J., De Luca, H., Ward, D. V., Kreulen, I. A. M., Bugda Gwilt, K., Foley, S. E., Thiagarajah, J. R., McCormick, B. A., Turner, J. R., & Lencer, W. I. (2022) · Journal of Clinical Investigation · doi:10.1172/jci153519 · Cited by 65
Metadata
- Authors
- Haberman, Y., Karns, R., Dexheimer, P. J., Schirmer, M., Somekh, J., Jurickova, I., Braun, T., Novak, E., Bauman, L., Collins, M. H., Mo, A., Rosen, M. J., Bonkowski, E., Gotman, N., Marquis, A., Nistel, M., Rufo, P. A., Baker, S. S., Sauer, C. G., Markowitz, J., Pfefferkorn, M. D., Rosh, J. R., Boyle, B. M., Mack, D. R., Baldassano, R. N., Shah, S., Leleiko, N. S., Heyman, M. B., Grifiths, A. M., Patel, A. S., Noe, J. D., Aronow, B. J., Kugathasan, S., Walters, T. D., Gibson, G., Thomas, S. D., Mollen, K., Shen-Orr, S., Huttenhower, C., Xavier, R. J., Hyams, J. S., & Denson, L. A.
- Venue
- Nature Communications
- Published
- 2019-01-03
- Volume
- 10
- Issue
- 1
- Pages
- 38-38
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2907177946
- Cited by
- 371
- References
- 59
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- gold
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- Haberman, Y., Karns, R., Dexheimer, P. J., Schirmer, M., Somekh, J., Jurickova, I., Braun, T., Novak, E., Bauman, L., Collins, M. H., Mo, A., Rosen, M. J., Bonkowski, E., Gotman, N., Marquis, A., Nistel, M., Rufo, P. A., Baker, S. S., Sauer, C. G., . . . Denson, L. A. (2019). Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response. Nature Communications. https://doi.org/10.1038/s41467-018-07841-3
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
