The reductive glycine pathway allows autotrophic growth of Desulfovibrio desulfuricans
Open accessAbstract
Six CO 2 fixation pathways are known to operate in photoautotrophic and chemoautotrophic microorganisms. Here, we describe chemolithoautotrophic growth of the sulphate-reducing bacterium Desulfovibrio desulfuricans (strain G11) with hydrogen and sulphate as energy substrates. Genomic, transcriptomic, proteomic and metabolomic analyses reveal that D. desulfuricans assimilates CO 2 via the reductive glycine pathway, a seventh CO 2 fixation pathway. In this pathway, CO 2 is first reduced to formate, which is reduced and condensed with a second CO 2 to generate glycine. Glycine is further reduced in D. desulfuricans by glycine reductase to acetyl-P, and then to acetyl-CoA, which is condensed with another CO 2 to form pyruvate. Ammonia is involved in the operation of the pathway, which is reflected in the dependence of the autotrophic growth rate on the ammonia concentration. Our study demonstrates microbial autotrophic growth fully supported by this highly ATP-efficient CO 2 fixation pathway.
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It is distinct from the H2-dependent glycine reductase pathway of autotrophic CO2 fixation used by Desulfovibrio desulfuricans.
“It is distinct from the H2-dependent glycine reductase pathway of autotrophic CO2 fixation used by Desulfovibrio desulfuricans (Sánchez-Andrea et al., 2020).”
From Serpentinization as the source of energy, electrons, organics, catalysts, nutrients and pH gradients for the origin of LUCA and life (2023) · cites this paper as Sánchez-Andrea et al., 2020
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- Authors
- Sánchez-Andrea, I., Guedes, I. A., Hornung, B., Boeren, S., Lawson, C. E., Sousa, D. Z., Bar-Even, A., Claassens, N. J., & Stams, A. J. M.
- Affiliations
- Leiden University Medical Center (NL)
- Wageningen University & Research (NL)
- University of Wisconsin–Madison (US)
- Max Planck Institute of Molecular Plant Physiology (DE)
- Corresponding author
- Claassens, Nico J.
- Stams, Alfons J. M.
- ORCID
- Venue
- Nature Communications
- Published
- 2020-10-09
- Volume
- 11
- Issue
- 1
- Pages
- 5090-5090
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC7547702
- OpenAlex
- W3092013556
- Cited by
- 306
- References
- 84
- Citations by year
- 2026: 39 · 2025: 57 · 2024: 54 · 2023: 58 · 2022: 50 · 2021: 42 · 2020: 5
- FWCI
- 12.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion, cc-by)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (024.002.002, Gravitation Grant 024.002.002, SIAM Gravitation Grant 024.002.002, 019.163LW.035, VI.Veni.192.156)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Metalloenzymes and iron-sulfur proteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- reductive glycine pathway, Desulfovibrio desulfuricans, chemolithoautotrophic growth, CO2 fixation, sulfate reduction, glycine reductase, acetyl-CoA, sulfate-reducing bacteria
- MeSH terms
- Adenosine Triphosphate, Ammonia, Bacterial Proteins, Carbon Dioxide, Glycine, Genome, Bacterial, Gene Expression Profiling, Desulfovibrio desulfuricans, Autotrophic Processes, Metabolomics
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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