The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases
Open accessAbstract
Reactive oxygen species (ROS) are generated and consumed in living organism for normal metabolism. Paradoxically, the overproduction and/or mismanagement of ROS have been involved in pathogenesis and progression of various human diseases. Here, we reported a two-dimensional (2D) vanadium carbide (V 2 C) MXene nanoenzyme (MXenzyme) that can mimic up to six naturally-occurring enzymes, including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione peroxidase (GPx), thiol peroxidase (TPx) and haloperoxidase (HPO). Based on these enzyme-mimicking properties, the constructed 2D V 2 C MXenzyme not only possesses high biocompatibility but also exhibits robust in vitro cytoprotection against oxidative stress. Importantly, 2D V 2 C MXenzyme rebuilds the redox homeostasis without perturbing the endogenous antioxidant status and relieves ROS-induced damage with benign in vivo therapeutic effects, as demonstrated in both inflammation and neurodegeneration animal models. These findings open an avenue to enable the use of MXenzyme as a remedial nanoplatform to treat ROS-mediated inflammatory and neurodegenerative diseases.
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Cites
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Self-citationSynthesis of Copper Peroxide Nanodots for H2O2 Self-Supplying Chemodynamic Therapy
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Cited by
Dong, C., Dai, X., Wang, X., Lu, Q., Chen, L., Song, X., Ding, L., Huang, H., Feng, W., Chen, Y., et al. (2022) · Advanced Materials · doi:10.1002/adma.202205680 · Cited by 130
Self-citationWu, M., Zhang, Z., Li, D., Ruan, X., Yang, J., Chen, S., Li, X., & Ling, W. (2025) · Theranostics · doi:10.7150/thno.102977 · Cited by 21
Li, Q., Xiao, X., Yan, T., Song, D., Li, L., Chen, Z., Zhong, Y., Deng, W., Liu, X., Song, Y., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c15715 · Cited by 20
Che, H., Xu, J., Wu, D., Chen, S., Liu, C., Zhao, C., & Peng, K. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.11.002 · Cited by 19
Metadata
- Authors
- Feng, W., Han, X., Hu, H., Chang, M., Ding, L., Xiang, H., Chen, Y., & Li, Y.
- Venue
- Nature Communications
- Published
- 2021-04-13
- Volume
- 12
- Issue
- 1
- Pages
- 2203-2203
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3156145557
- Cited by
- 517
- References
- 54
- FWCI
- 23.65
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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