Antemortem MRI based STructural Abnormality iNDex (STAND)-scores correlate with postmortem Braak neurofibrillary tangle stage
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The clinical diagnosis of Alzheimer's disease (AD) does not exactly match the pathological findings at autopsy in every subject. Therefore, in-vivo imaging measures, such as Magnetic Resonance Imaging (MRI) that reflect underlying pathology, would be clinically useful independent supplementary measures of disease stage. We have developed an algorithm that extracts atrophy information from individual patient's 3D MRI scans and assigns a STructural Abnormality iNDex (STAND)-score to the scan based on the degree of atrophy in comparison to patterns extracted from a large library of clinically well characterized AD and CN (cognitively normal) subject's MRI scans. STAND-scores can be adjusted for demographics to give adjusted-STAND (aSTAND)-scores which are >0 for subjects with brains identified as abnormal by the algorithm. Since histopathological findings are considered to represent the "ground truth", our objective was to assess the sensitivity of aSTAND-scores to pathological AD staging. This was done by comparing antemortem MRI based aSTAND-scores with postmortem grading of disease severity in 101 subjects who had both antemortem MRI and postmortem Braak neurofibrillary tangle (NFT) staging. We found a rank correlation of 0.62 (p<0.0001) between Braak NFT stage and aSTAND-scores. The results show that optimally extracted information from MRI scans such as STAND-scores accurately capture the severity of neuronal pathology and can be used as an independent approximate surrogate marker for in-vivo pathological staging as well as for early identification of AD in individual subjects.
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Antemortem MRI has previously been found to correlate well with measures of cognitive deterioration and post-mortem Braak staging of Alzheimer's disease.
“As well as revealing signs of atrophy, which can inform differential diagnosis of the disease, antemortem MRI has previously been found to correlate well with measures of cognitive deterioration and post-mortem Braak staging of the disease (Csernansky et al., 2004, Jack et al., 2002, Vemuri et al., 2008, Whitwell et al., 2008).”
From In vivo imaging of tau pathology using multi-parametric quantitative MRI (2015) · cites this paper as Vemuri et al., 2008
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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Mild Cognitive Impairment: Clinical Characterization and Outcome
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999) · Archives of Neurology · doi:10.1001/archneur.56.3.303 · Cited by 8,980 · see citing works
Self-citationVoxel-Based Morphometry—The Methods
Ashburner, J., & Friston, K. J. (2000) · NeuroImage · doi:10.1006/nimg.2000.0582 · Cited by 8,676 · see citing works
Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864 · see citing works
Self-citationAshburner, J., & Friston, K. J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.018 · Cited by 7,507 · see citing works
A New Clinical Scale for the Staging of Dementia
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056 · see citing works
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
Gómez-Isla, T., Price, J. L., McKeel Jr., D. W., Morris, J. C., Growdon, J. H., & Hyman, B. T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04491.1996 · Cited by 1,796 · cited 1× · see citing works
“For this reason as well as the fact that degenerative histological changes occur long before the disease is clinically detectable (Gomez-Isla et al., 1996), it would be useful to have additional non-invasive measures to complement the clinical assessment.”
Evans, D. A. (1989) · JAMA · doi:10.1001/jama.262.18.2551 · Cited by 1,627 · see citing works
HYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542 · see citing works
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
Gómez‐Isla, T., Hollister, R., West, H., Mui, S., Growdon, J. H., Petersen, R. C., Parisi, J. E., & Hyman, B. T. (1997) · Annals of Neurology · doi:10.1002/ana.410410106 · Cited by 1,489 · see citing works
Self-citationPrinciples of Behavioral and Cognitive Neurology
(2000) · doi:10.1093/oso/9780195134759.001.0001 · Cited by 1,448 · see citing works
Neuropathology of older persons without cognitive impairment from two community-based studies
Bennett, D. A., Schneider, J. A., Arvanitakis, Z., Kelly, J. F., Aggarwal, N. T., Shah, R. C., & Wilson, R. S. (2006) · Neurology · doi:10.1212/01.wnl.0000219668.47116.e6 · Cited by 1,336 · see citing works
Evans, D. A. (1989) · JAMA · doi:10.1001/jama.1989.03430180093036 · Cited by 1,226 · cited 1× · see citing works
“In addition, old age is the strongest known risk factor for typical late onset AD (Evans et al., 1989).”
Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Preedy, V., & Watson, R. (2010) · Springer eBooks · doi:10.1007/978-0-387-78665-0_5485 · Cited by 1,146 · see citing works
Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease
Jack, C. R., Petersen, R. C., Xu, Y. C., Waring, S. C., O'Brien, P. C., Tangalos, E. G., Smith, G. E., Ivnik, R. J., & Kokmen, E. (1997) · Neurology · doi:10.1212/wnl.49.3.786 · Cited by 1,128 · see citing works
Self-citationMR‐based hippocampal volumetry in the diagnosis of Alzheimer's disease
Jack, C. R., Petersen, R. C., O’Brien, P. C., & Tangalos, E. G. (1992) · Neurology · doi:10.1212/wnl.42.1.183 · Cited by 878 · see citing works
Self-citationIn Vivo Mapping of Gray Matter Loss with Voxel-Based Morphometry in Mild Alzheimer's Disease
Baron, J., Chételat, G., Desgranges, B., Perchey, G., Landeau, B., Sayette, V. D. L., & Eustache, F. (2001) · NeuroImage · doi:10.1006/nimg.2001.0848 · Cited by 683 · see citing works
Neuropathology of Cognitively Normal Elderly
Knopman, D. S., Parisi, J. E., Salviati, A., Floriach-Robert, M., Boeve, B. F., Ivnik, R. J., Smith, G. E., Dickson, D. W., Johnson, K. A., Petersen, L. E., et al. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.11.1087 · Cited by 674 · see citing works
Self-citationRate of medial temporal lobe atrophy in typical aging and Alzheimer's disease
Jack, C. R., Petersen, R. C., Xu, Y., O'Brien, P. C., Smith, G. E., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1998) · Neurology · doi:10.1212/wnl.51.4.993 · Cited by 666 · see citing works
Self-citationPresymptomatic hippocampal atrophy in Alzheimer's disease: A longitudinal MRI study
Fox, N. C., Warrington, E. K., Freeborough, P. A., Hartikainen, P., Kennedy, A. M., Stevens, J. M., & Rossor, M. N. (1996) · Brain · doi:10.1093/brain/119.6.2001 · Cited by 656 · see citing works
Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia
Jack, C. R., Dickson, D. W., Parisi, J. E., Xu, Y. C., Cha, R. H., O’Brien, P. C., Edland, S. D., Smith, G. E., Boeve, B. F., Tangalos, E. G., et al. (2002) · Neurology · doi:10.1212/wnl.58.5.750 · Cited by 610 · see citing works
Self-citationWhitwell, J. L., Przybelski, S. A., Weigand, S. D., Knopman, D. S., Boeve, B. F., Petersen, R. C., & Jack, C. R. (2007) · Brain · doi:10.1093/brain/awm112 · Cited by 607 · see citing works
Self-citationEvans, D. A., Funkenstein, H. H., Albert, M., Scherr, P. A., Cook, N. R., Chown, M. J., Hebert, L. E., Hennekens, C. H., & Taylor, J. O. (1989) · PubMed · Cited by 599 · see citing works
Jack, C. R., Twomey, C. K., Zinsmeister, A. R., Sharbrough, F. W., Petersen, R. C., & Cascino, G. D. (1989) · Radiology · doi:10.1148/radiology.172.2.2748838 · Cited by 592 · see citing works
Self-citationMorris, J. C., & Price, J. L. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:2:101 · Cited by 513 · see citing works
Rose, S. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.4.528 · Cited by 465 · see citing works
Bobinski, M., de Leon, M. J., Wegiel, J., DeSanti, S., Convit, A., Saint Louis, L. A., Rusinek, H., & Wisniewski✠, H. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00476-5 · Cited by 455 · see citing works
Alzheimer's disease diagnosis in individual subjects using structural MR images: Validation studies
Vemuri, P., Gunter, J. L., Senjem, M. L., Whitwell, J. L., Kantarci, K., Knopman, D. S., Boeve, B. F., Petersen, R. C., & Jack, C. R. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.09.073 · Cited by 450 · see citing works
Self-citationMapping gray matter loss with voxel-based morphometry in mild cognitive impairment
Chételat, G., Desgranges, B., de la Sayette, V., Viader, F., Eustache, F., & Baron, J. (2002) · NeuroReport · doi:10.1097/00001756-200210280-00022 · Cited by 405 · see citing works
Neuropathologic Outcome of Mild Cognitive Impairment Following Progression to Clinical Dementia
Jicha, G. A., Parisi, J. E., Dickson, D. W., Johnson, K., Cha, R., Ivnik, R. J., Tangalos, E. G., Boeve, B. F., Knopman, D. S., Braak, H., et al. (2006) · Archives of Neurology · doi:10.1001/archneur.63.5.674 · Cited by 399 · see citing works
Self-citationRiley, K. P., Snowdon, D. A., & Markesbery, W. R. (2002) · Annals of Neurology · doi:10.1002/ana.10161 · Cited by 392 · see citing works
Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry
Frisoni, G. B. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.73.6.657 · Cited by 386 · see citing works
Freeborough, P. A., & Fox, N. C. (1997) · IEEE Transactions on Medical Imaging · doi:10.1109/42.640753 · Cited by 384 · see citing works
“Preclinical” AD revisited: Neuropathology of cognitively normal older adults
Schmitt, F. A., Davis, D. G., Wekstein, D. R., Smith, C. D., Ashford, J. W., & Markesbery, W. R. (2000) · Neurology · doi:10.1212/wnl.55.3.370 · Cited by 369 · see citing works
Hippocampal volume as an index of Alzheimer neuropathology
Gosche, K. M., Mortimer, J. A., Smith, C. D., Markesbery, W. R., & Snowdon, D. A. (2002) · Neurology · doi:10.1212/wnl.58.10.1476 · Cited by 359 · see citing works
Age and gender effects on human brain anatomy: A voxel-based morphometric study in healthy elderly
Smith, C. D., Chebrolu, H., Wekstein, D. R., Schmitt, F. A., & Markesbery, W. R. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.018 · Cited by 319 · see citing works
HULETTE, C. M., WELSH-BOHMER, K. A., MURRAY, M. G., SAUNDERS, A. M., MASH, D. C., & MCINTYRE, L. M. (1998) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199812000-00009 · Cited by 311 · see citing works
Changes in premorbid brain volume predict Alzheimer’s disease pathology
Silbert, L. C., Quinn, J. F., Moore, M. M., Corbridge, E., Ball, M. J., MURDOCH, G. H., Sexton, G. J., & Kaye, J. A. (2003) · Neurology · doi:10.1212/01.wnl.0000079053.77227.14 · Cited by 280 · see citing works
Age- and sex-related effects on the neuroanatomy of healthy elderly
Lemaître, H., Crivello, F., Grassiot, B., Alpérovitch, A., Tzourio, C., & Mazoyer, B. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.042 · Cited by 280 · see citing works
Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia
Zarow, C., Vinters, H. V., Ellis, W. G., Weiner, M. W., Mungas, D., White, L., & Chui, H. C. (2005) · Annals of Neurology · doi:10.1002/ana.20503 · Cited by 241 · see citing works
Neuroimaging in Alzheimer disease: an evidence-based review
Kantarci, K., & Jack, C. R. (2003) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(03)00025-x · Cited by 227 · see citing works
Self-citationβ‐amyloid burden is not associated with rates of brain atrophy
Josephs, K. A., Whitwell, J. L., Ahmed, Z., Shiung, M. M., Weigand, S. D., Knopman, D. S., Boeve, B. F., Parisi, J. E., Petersen, R. C., Dickson, D. W., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21223 · Cited by 224 · see citing works
Self-citationPihlajam�ki, M., Tanila, H., H�nninen, T., Könönen, M., Laakso, M. P., Partanen, K. P. L., Soininen, H. S., & Aronen, H. J. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200004)47:4 · Cited by 210 · see citing works
Braak, H., & Braak, E. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90032-9 · Cited by 181 · see citing works
Unbiased whole-brain analysis of gray matter loss in Alzheimer's disease
Rombouts, S. A. R. B., Barkhof, F., Witter, M. P., & Scheltens, P. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01067-3 · Cited by 168 · see citing works
Measuring atrophy in Alzheimer disease
Schott, J. M., Price, S. L., Frost, C. D., Whitwell, J. L., Rossor, M. N., & Fox, N. C. (2005) · Neurology · doi:10.1212/01.wnl.0000167542.89697.0f · Cited by 162 · see citing works
Self-citationPathological markers associated with normal aging and dementia in the elderly
Crystal, H. A., Dickson, D. W., Sliwinski, M. J., Lipton, R. B., Grober, E., Marks‐Nelson, H., & Antis, P. (1993) · Annals of Neurology · doi:10.1002/ana.410340410 · Cited by 161 · see citing works
Self-citationShiino, A., Watanabe, T., Maeda, K., Kotani, E., Akiguchi, I., & Matsuda, M. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.06.010 · Cited by 147 · see citing works
(2004) · PubMed · Cited by 127 · see citing works
Spatial, Temporal and Numeric Analysis of Alzheimer Changes in the Nucleus Coeruleus
Busch, C., Bohl, J. R. E., & Ohm, T. G. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00035-3 · Cited by 105 · see citing works
Argyrophilic grains: A distinct disease or an additive pathology?
Josephs, K. A., Whitwell, J. L., Parisi, J. E., Knopman, D. S., Boeve, B. F., Geda, Y. E., Jack, C. R., Petersen, R. C., & Dickson, D. W. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.10.032 · Cited by 97 · see citing works
Self-citationNagy, Z., Hindley, N., Braak, H., Braak, E., Yilmazer‐Hanke, D., Schultz, C., Barnetson, L. P. D., Jobst, K. A., & Smith, A. D. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017110 · Cited by 49 · see citing works
Stoub, T. R., deToledo‐Morrell, L., Stebbins, G. T., Leurgans, S. E., Bennett, D. A., & Shah, R. C. (2005) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2005.06.175 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 60 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Killiany RJ, Gomez-Isla T, Moss M, Kikinis R, Sandor T, Jolesz F, Tanzi R, Jones K, Hyman BT, Albert MS. Use of structural magnetic resonance imaging to predict who will get Alzheimer’s disease. Ann Neurol. 2000;47:430–439. [PubMed] [Google Scholar]
Cited by
Sorted by citations
Jack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70291-0 · Cited by 4,396 · see citing works
Self-citationThe clinical use of structural MRI in Alzheimer disease
Frisoni, G. B., Fox, N. C., Jack, C. R., Scheltens, P., & Thompson, P. M. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.215 · Cited by 2,113 · see citing works
Self-citationRevising the definition of Alzheimer's disease: a new lexicon
Dubois, B., Feldman, H. H., Jacova, C., Cummings, J. L., DeKosky, S. T., Barberger-Gateau, P., Delacourte, A., Frisoni, G., Fox, N. C., Galasko, D., et al. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70223-4 · Cited by 1,869 · see citing works
Jack, C. R., Lowe, V. J., Weigand, S. D., Wiste, H. J., Senjem, M. L., Knopman, D. S., Shiung, M. M., Gunter, J. L., Boeve, B. F., Kemp, B. J., et al. (2009) · Brain · doi:10.1093/brain/awp062 · Cited by 1,099 · see citing works
Self-citationBiomarker Modeling of Alzheimer’s Disease
Jack, C. R., & Holtzman, D. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.12.003 · Cited by 1,002 · see citing works
Self-citationBuilding better biomarkers: brain models in translational neuroimaging
Woo, C.-W., Chang, L. J., Lindquist, M. A., & Wager, T. D. (2017) · Nature Neuroscience · doi:10.1038/nn.4478 · Cited by 1,056 · see citing works
Brain atrophy in Alzheimer’s Disease and aging
Pini, L., Pievani, M., Bocchetta, M., Altomare, D., Bosco, P., Cavedo, E., Galluzzi, S., Marizzoni, M., & Frisoni, G. B. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.01.002 · Cited by 874 · see citing works
Jack, C. R., Knopman, D. S., Weigand, S. D., Wiste, H. J., Vemuri, P., Lowe, V., Kantarci, K., Gunter, J. L., Senjem, M. L., Ivnik, R. J., et al. (2012) · Annals of Neurology · doi:10.1002/ana.22628 · Cited by 602 · see citing works
Self-citationJack, C. R., Wiste, H. J., Vemuri, P., Weigand, S. D., Senjem, M. L., Zeng, G., Bernstein, M. A., Gunter, J. L., Pankratz, V. S., Aisen, P. S., et al. (2010) · Brain · doi:10.1093/brain/awq277 · Cited by 531 · see citing works
Self-citationBrain β-amyloid load approaches a plateau
Jack, C. R., Wiste, H. J., Lesnick, T. G., Weigand, S. D., Knopman, D. S., Vemuri, P., Pankratz, V. S., Senjem, M. L., Gunter, J. L., Mielke, M. M., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e3182840bbe · Cited by 406 · see citing works
Self-citationMRI and CSF biomarkers in normal, MCI, and AD subjects
Vemuri, P., Wiste, H. J., Weigand, S. D., Shaw, L. M. J., Trojanowski, J. Q., Weiner, M. W., Knopman, D. S., Petersen, R. C., & Jack, C. R. (2009) · Neurology · doi:10.1212/wnl.0b013e3181af79fb · Cited by 398 · see citing works
Self-citationPathogenesis, diagnostics, and therapeutics for Alzheimer's disease: Breaking the memory barrier
Tryphena, K. P., Shukla, R., Khatri, D. K., & Vora, L. K. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102481 · Cited by 418 · see citing works
Curtis, C., Gamez, J. E., Singh, U., Sadowsky, C. H., Villena, T., Sabbagh, M. N., Beach, T. G., Duara, R., Fleisher, A. S., Frey, K. A., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2014.4144 · Cited by 332 · see citing works
Amyloid‐β associated cortical thinning in clinically normal elderly
Becker, J. A., Hedden, T., Carmasin, J., Maye, J., Rentz, D. M., Putcha, D., Fischl, B., Greve, D. N., Marshall, G. A., Salloway, S., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22333 · Cited by 342 · see citing works
Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology
Schmitz, T. W., Spreng, R. N., Initiative, T. A. D. N., Weiner, M. W., Aisen, P. S. S., Petersen, R. C., Jack, C. R., Jagust, W. J., Trojanowki, J. Q., Toga, A. W., et al. (2016) · Nature Communications · doi:10.1038/ncomms13249 · Cited by 335 · see citing works
Self-citationWidespread brain tau and its association with ageing, Braak stage and Alzheimer’s dementia
Lowe, V. J., Wiste, H. J., Senjem, M. L., Weigand, S. D., Therneau, T. M., Boeve, B. F., Josephs, K. A., Fang, P., Pandey, M. K., Murray, M. E., et al. (2017) · Brain · doi:10.1093/brain/awx320 · Cited by 302 · see citing works
Self-citationWang, L. Y., Benzinger, T. L. S., Su, Y., Christensen, J. J., Friedrichsen, K. A., Aldea, P., McConathy, J., Cairns, N. J., Fagan, A. M., Morris, J. C., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.2078 · Cited by 295 · see citing works
Diagnostic neuroimaging across diseases
Klöppel, S., Abdulkadir, A., Jack, C. R., Koutsouleris, N., Mourão-Miranda, J., & Vemuri, P. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.002 · Cited by 279 · see citing works
Self-citationEskildsen, S. F., Coupé, P., García-Lorenzo, D., Fonov, V., Pruessner, J. C., & Collins, D. L. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.09.058 · Cited by 269 · see citing works
Mild cognitive impairment due to Alzheimer disease in the community
Petersen, R. C., Aisen, P., Boeve, B. F., Geda, Y. E., Ivnik, R. J., Knopman, D. S., Mielke, M., Pankratz, V. S., Roberts, R., Rocca, W. A., et al. (2013) · Annals of Neurology · doi:10.1002/ana.23931 · Cited by 265 · see citing works
Self-citationJack, C. R., Wiste, H. J., Weigand, S. D., Knopman, D. S., Mielke, M. M., Vemuri, P., Lowe, V. J., Senjem, M. L., Gunter, J. L., Reyes, D. A., et al. (2015) · Brain · doi:10.1093/brain/awv283 · Cited by 252 · see citing works
Self-citationMRI and CSF biomarkers in normal, MCI, and AD subjects
Vemuri, P., Wiste, H. J., Weigand, S. D., Shaw, L. M. J., Trojanowski, J. Q., Weiner, M. W., Knopman, D. S., Petersen, R. C., & Jack, C. R. (2009) · Neurology · doi:10.1212/wnl.0b013e3181af79e5 · Cited by 246 · see citing works
Self-citationSex and age differences in atrophic rates: an ADNI study with n=1368 MRI scans
Hua, X., Hibar, D. P., Lee, S., Toga, A. W., Jack, C. R., Weiner, M. W., & Thompson, P. M. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.04.033 · Cited by 234 · see citing works
Self-citationThurfjell, L., Lilja, J., Lundqvist, R., Buckley, C. J., Smith, A. P. L., Vandenberghe, R. R., & Sherwin, P. F. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.114.142109 · Cited by 224 · see citing works
Evidence for Ordering of Alzheimer Disease Biomarkers
Jack, C. R. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.183 · Cited by 221 · see citing works
Self-citationAlzheimer disease: new concepts on its neurobiology and the clinical role imaging will play
Jack, C. R. (2012) · Radiology · doi:10.1148/radiol.12110433 · Cited by 211 · see citing works
Self-citationEffect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease
Vemuri, P., Wiste, H. J., Weigand, S. D., Knopman, D. S., Shaw, L. M., Trojanowski, J. Q., Aisen, P. S., Weiner, M., Petersen, R. C., Jack, C. R., et al. (2010) · Annals of Neurology · doi:10.1002/ana.21953 · Cited by 195 · see citing works
Self-citationDiffusion tensor imaging and cognitive function in older adults with no dementia
Kantarci, K., Senjem, M. L., Avula, R., Zhang, B., Samikoglu, A. R., Weigand, S. D., Przybelski, S. A., Edmonson, H. A., Vemuri, P., Knopman, D. S., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31822313dc · Cited by 182 · see citing works
Self-citationToward a unified framework for interpreting machine-learning models in neuroimaging
Kohoutová, L., Heo, J., Cha, S., Lee, S., Moon, T., Wager, T. D., & Woo, C. (2020) · Nature Protocols · doi:10.1038/s41596-019-0289-5 · Cited by 168 · see citing works
Multimodality imaging characteristics of dementia with Lewy bodies
Kantarci, K., Lowe, V. J., Boeve, B. F., Weigand, S. D., Senjem, M. L., Przybelski, S. A., Dickson, D. W., Parisi, J. E., Knopman, D. S., Smith, G. E., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.024 · Cited by 175 · see citing works
Self-citationClinical prediction from structural brain MRI scans: A large-scale empirical study
Initiative, F. T. A. D. N., Sabuncu, M. R., & Konukoglu, E. (2015) · Neuroinformatics · doi:10.1007/s12021-014-9238-1 · Cited by 161 · see citing works
APOE modifies the association between Aβ load and cognition in cognitively normal older adults
Kantarci, K., Lowe, V. J., Przybelski, S. A., Weigand, S. D., Senjem, M. L., Ivnik, R. J., Preboske, G. M., Roberts, R. O., Geda, Y. E., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31824365ab · Cited by 159 · see citing works
Self-citation[<sup>18</sup>F]AV‐1451 tau positron emission tomography in progressive supranuclear palsy
Whitwell, J. L., Lowe, V. J., Tosakulwong, N., Weigand, S. D., Senjem, M. L., Schwarz, C. G., Spychalla, A. J., Petersen, R. C., Jack, C. R., & Josephs, K. A. (2017) · Movement Disorders · doi:10.1002/mds.26834 · Cited by 159 · see citing works
Self-citationPattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies
Nedelska, Z., Ferman, T. J., Boeve, B. F., Przybelski, S. A., Lesnick, T. G., Murray, M. E., Gunter, J. L., Senjem, M. L., Vemuri, P., Smith, G. E., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.005 · Cited by 155 · see citing works
Self-citationGrothe, M. J., Teipel, S. J., & Initiative, F. T. A. D. N. (2016) · Human Brain Mapping · doi:10.1002/hbm.23018 · Cited by 150 · see citing works
Townley, R. A., Graff-Radford, J., Mantyh, W. G., Botha, H., Polsinelli, A. J., Przybelski, S. A., Machulda, M. M., Makhlouf, A. T., Senjem, M. L., Murray, M. E., et al. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa068 · Cited by 145 · see citing works
Self-citationShapes of the Trajectories of 5 Major Biomarkers of Alzheimer Disease
Jack, C. R., Vemuri, P., Wiste, H. J., Weigand, S. D., Lesnick, T. G., Lowe, V., Kantarci, K., Bernstein, M. A., Senjem, M. L., Gunter, J. L., et al. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.3405 · Cited by 145 · see citing works
Self-citationStructural imaging biomarkers of Alzheimer's disease: predicting disease progression
Eskildsen, S. F., Coupé, P., Fonov, V., Pruessner, J. C., & Collins, D. L. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.04.034 · Cited by 129 · see citing works
Rates of β-amyloid accumulation are independent of hippocampal neurodegeneration
Jack, C. R., Wiste, H. J., Knopman, D. S., Vemuri, P., Mielke, M. M., Weigand, S. D., Senjem, M. L., Gunter, J. L., Lowe, V. J., Gregg, B. E., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000386 · Cited by 124 · see citing works
Self-citationBiomarkers in Alzheimer's disease drug development
Cummings, J. L. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.06.004 · Cited by 121 · see citing works
Soares, H. D., Chen, Y., Sabbagh, M. N., Rohrer, A., Schrijvers, E. M. C., & Breteler, M. M. B. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05066.x · Cited by 114 · see citing works
Physical exercise alleviates debilities of normal aging and Alzheimer’s disease
Archer, T. (2010) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2010.01412.x · Cited by 109 · see citing works
Antemortem differential diagnosis of dementia pathology using structural MRI: Differential-STAND
Vemuri, P., Simon, G., Kantarci, K., Whitwell, J. L., Senjem, M. L., Przybelski, S. A., Gunter, J. L., Josephs, K. A., Knopman, D. S., Boeve, B. F., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.12.073 · Cited by 108 · see citing works
Self-citationTosun, D., Landau, S. M., Aisen, P. S. S., Petersen, R. C., Mintun, M. A., Jagust, W., Weiner, M. W., & Initiative, A. D. N. (2017) · Brain · doi:10.1093/brain/awx046 · Cited by 107 · see citing works
Self-citationBiomarkers in Sporadic and Familial Alzheimer’s Disease
Lista, S., O’Bryant, S. E., Blennow, K., Dubois, B., Hugon, J., Zetterberg, H., & Hampel, H. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-143006 · Cited by 106 · see citing works
Carvalho, D. Z., Louis, E. K. S., Boeve, B. F., Mielke, M. M., Przybelski, S. A., Knopman, D. S., Machulda, M. M., Roberts, R. O., Geda, Y. E., Petersen, R. C., et al. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2016.08.023 · Cited by 102 · see citing works
Self-citationBrain structure and cognition 3 years after the end of an early menopausal hormone therapy trial
Kantarci, K., Tosakulwong, N., Lesnick, T. G., Zuk, S. M., Lowe, V. J., Fields, J. A., Gunter, J. L., Senjem, M. L., Settell, M. L., Gleason, C. E., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000005325 · Cited by 104 · see citing works
Self-citationFocal atrophy on MRI and neuropathologic classification of dementia with Lewy bodies
Kantarci, K., Ferman, T. J., Boeve, B. F., Weigand, S. D., Przybelski, S. A., Vemuri, P., Murray, M. E., Senjem, M. L., Smith, G. E., Knopman, D. S., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e31826357a5 · Cited by 101 · see citing works
Self-citationPost-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection
Ikonomović, M. D., Buckley, C. J., Heurling, K., Sherwin, P. F., Jones, P. A., Zanette, M., Mathis, C. A., Klunk, W. E., Chakrabarty, A., Ironside, J. W., et al. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0399-z · Cited by 98 · see citing works
In vivo imaging of tau pathology using multi-parametric quantitative MRI
Wells, J. A., O'Callaghan, J. M., Holmes, H. E., Powell, N. M., Johnson, R. A., Siow, B., Torrealdea, F., Ismail, O., Walker-Samuel, S., Golay, X., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.02.023 · Cited by 93 · see citing works
Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease
Lowe, V. J., Lundt, E. S., Albertson, S. M., Przybelski, S. A., Senjem, M. L., Parisi, J. E., Kantarci, K., Boeve, B., Jones, D. T., Knopman, D., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.03.016 · Cited by 90 · see citing works
Self-citationQuantitative structural MRI for early detection of Alzheimer's disease
McEvoy, L. K., & Brewer, J. B. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.162 · Cited by 90 · see citing works
Amyloid-β deposition and regional grey matter atrophy rates in dementia with Lewy bodies
Sarro, L., Senjem, M. L., Lundt, E. S., Przybelski, S. A., Lesnick, T. G., Graff-Radford, J., Boeve, B. F., Lowe, V. J., Ferman, T. J., Knopman, D. S., et al. (2016) · Brain · doi:10.1093/brain/aww193 · Cited by 89 · see citing works
Self-citationSalloway, S., Gamez, J. E., Singh, U., Sadowsky, C. H., Villena, T., Sabbagh, M. N., Beach, T. G., Duara, R., Fleisher, A. S., Frey, K. A., et al. (2017) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2017.06.001 · Cited by 87 · see citing works
Selective Disruption of the Cerebral Neocortex in Alzheimer's Disease
Desikan, R. S., Sabuncu, M. R., Schmansky, N. J., Reuter, M., Cabral, H., Hess, C. P., Weiner, M. W., Biffi, A., Anderson, C. D., Rosand, J. M., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012853 · Cited by 83 · see citing works
Unbiased comparison of sample size estimates from longitudinal structural measures in ADNI
Holland, D., McEvoy, L. K., Dale, A. M., & Initiative, T. A. D. N. (2011) · Human Brain Mapping · doi:10.1002/hbm.21386 · Cited by 83 · see citing works
Multi-cohort and longitudinal Bayesian clustering study of stage and subtype in Alzheimer’s disease
Poulakis, K., Pereira, J. B., Muehlboeck, J., Wahlund, L., Smedby, Ö., Volpe, G., Masters, C. L., Ames, D. J., Niimi, Y., Iwatsubo, T., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32202-6 · Cited by 84 · see citing works
Hua, X., Lee, S., Hibar, D. P., Yanovsky, I., Leow, A., Toga, A. W., Jack, C. R., Bernstein, M. A., Reiman, E. M., Harvey, D. J., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.104 · Cited by 84 · see citing works
Self-citationSpatially distinct atrophy is linked to β-amyloid and tau in preclinical Alzheimer disease
Wang, L. Y., Benzinger, T. L. S., Hassenstab, J. J., Blazey, T., Owen, C., Liu, J., Fagan, A. M., Morris, J. C., & Ances, B. M. (2015) · Neurology · doi:10.1212/wnl.0000000000001401 · Cited by 79 · see citing works
A computational model of neurodegeneration in Alzheimer’s disease
Jones, D., Lowe, V., Graff-Radford, J., Botha, H., Barnard, L., Wiepert, D., Murphy, M. C., Murray, M., Senjem, M., Gunter, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29047-4 · Cited by 78 · see citing works
Self-citationApplying tensor-based morphometry to parametric surfaces can improve MRI-based disease diagnosis
Wang, Y., Yuan, L., Shi, J., Greve, A., Ye, J., Toga, A. W., Reiss, A. L., & Thompson, P. M. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.02.011 · Cited by 72 · see citing works
Magnetic resonance imaging of Huntington's disease: preparing for clinical trials
Klöppel, S., Henley, S. M. D., Hobbs, N. Z., Wolf, R. C., Kassubek, J., Tabrizi, S. J., & Frackowiak, R. S. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.01.045 · Cited by 71 · see citing works
Shi, J., Leporé, N., Gutman, B. A., Thompson, P. M., Baxter, L. C., Caselli, R. J., Wang, Y., & Initiative, A. D. N. (2014) · Human Brain Mapping · doi:10.1002/hbm.22447 · Cited by 72 · see citing works
Enrichment and Stratification for Predementia Alzheimer Disease Clinical Trials
Holland, D., McEvoy, L. K., Desikan, R. S., Dale, A. M., & Initiative, A. D. N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047739 · Cited by 70 · see citing works
Neuroimaging in frontotemporal lobar degeneration—predicting molecular pathology
Whitwell, J. L., & Josephs, K. A. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.7 · Cited by 70 · see citing works
Self-citationImaging and Molecular Mechanisms of Alzheimer’s Disease: A Review
Femminella, G. D., Thayanandan, T., Calsolaro, V., Komici, K., Rengo, G., Corbi, G., & Ferrara, N. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123702 · Cited by 68 · see citing works
Applying Automated MR-Based Diagnostic Methods to the Memory Clinic: A Prospective Study
Klöppel, S., Peter, J., Ludl, A., Pilatus, A., Maier, S., Mader, I., Heimbach, B., Frings, L., Egger, K., Dukart, J., et al. (2015) · Journal of Alzheimer’s Disease · doi:10.3233/jad-150334 · Cited by 69 · see citing works
Dallaire‐Théroux, C., Callahan, B. L., Potvin, O., Saïkali, S., & Duchesne, S. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161028 · Cited by 68 · see citing works
Advances in MRI Biomarkers for the Diagnosis of Alzheimer’s Disease
Kehoe, E. G., McNulty, J. P., Mullins, P. G., & Bokde, A. L. W. (2014) · Biomarkers in Medicine · doi:10.2217/bmm.14.42 · Cited by 65 · see citing works
Alliance for aging research AD biomarkers work group: structural MRI
Jack, C. R. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.011 · Cited by 64 · see citing works
Self-citationHänggi, J., Streffer, J. R., Jäncke, L., & Höck, C. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101260 · Cited by 62 · see citing works
Longitudinal structural and molecular neuroimaging in agrammatic primary progressive aphasia
Tetzloff, K. A., Duffy, J. R., Clark, H. M., Strand, E. A., Machulda, M. M., Schwarz, C. G., Senjem, M. L., Reid, R. I., Spychalla, A. J., Tosakulwong, N., et al. (2017) · Brain · doi:10.1093/brain/awx293 · Cited by 62 · see citing works
Self-citationA comparison of three brain atlases for MCI prediction
Ota, K., Oishi, N., Ito, K., & Fukuyama, H. (2013) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2013.10.003 · Cited by 58 · see citing works
Crescenzi, R. L., DeBrosse, C., Nanga, R. P. R., Byrne, M. D., Krishnamoorthy, G., D’Aquilla, K., Nath, H., Morales, K. H., Iba, M., Hariharan, H., et al. (2016) · Hippocampus · doi:10.1002/hipo.22693 · Cited by 55 · see citing works
Role of hippocampal CA1 atrophy in memory encoding deficits in amnestic Mild Cognitive Impairment
Fouquet, M., Desgranges, B., Joie, R. L., Rivière, D., Mangin, J., Landeau, B., Mézenge, F., Pèlerin, A., Sayette, V. D. L., Viader, F., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.036 · Cited by 56 · see citing works
Cortical atrophy in presymptomatic Alzheimer's disease presenilin 1 mutation carriers
Quiroz, Y. T., Stern, C. E., Reiman, E. M., Brickhouse, M. J., Ruiz‐Rizzo, A. L., Sperling, R. A., Lopera, F. J., & Dickerson, B. C. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-303299 · Cited by 50 · see citing works
Shi, J., Stonnington, C. M., Thompson, P. M., Chen, K., Gutman, B. A., Reschke, C., Baxter, L. C., Reiman, E. M., Caselli, R. J., & Wang, Y. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.09.062 · Cited by 49 · see citing works
Diagnostic value of cerebrospinal fluid Aβ ratios in preclinical Alzheimer’s disease
Adamczuk, K., Schaeverbeke, J. M., Vanderstichele, H., Lilja, J., Nelissen, N., Laere, K. V., Dupont, P. J., Hilven, K., Poesen, K., & Vandenberghe, R. R. (2015) · Alzheimer s Research & Therapy · doi:10.1186/s13195-015-0159-5 · Cited by 49 · see citing works
Effects of age on the glucose metabolic changes in mild cognitive impairment
Kantarci, K., Senjem, M. L., Lowe, V. J., Wiste, H. J., Weigand, S. D., Kemp, B. J., Frank, A. R., Shiung, M. M., Boeve, B. F., Knopman, D. S., et al. (2010) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2070 · Cited by 47 · see citing works
Self-citationLeoni, V., & Caccia, C. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.03.015 · Cited by 47 · see citing works
Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?
Whitwell, J. L., Tosakulwong, N., Weigand, S. D., Senjem, M. L., Lowe, V. J., Gunter, J. L., Boeve, B. F., Knopman, D. S., Dickerson, B. C., Petersen, R. C., et al. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.01.006 · Cited by 47 · see citing works
Self-citationLeinonen, V., Rinne, J. O., Virtanen, K. A., Eskola, O., Rummukainen, J., Huttunen, J., zu Fraunberg, M. V. U., Nerg, O., Koivisto, A. M., Rinne, J., et al. (2013) · European Journal of Neurology · doi:10.1111/ene.12102 · Cited by 43 · see citing works
Clinical Diagnosis of Alzheimer’s Disease
Khan, T. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804832-0.00002-x · Cited by 41 · see citing works
Yu, P., Initiative, A. D. N., Dean, R. A., Hall, S. D., Qi, Y., Sethuraman, G., Willis, B. A., Siemers, E., Martényi, F., Tauscher, J. T., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120832 · Cited by 39 · see citing works
Bonifacio, G., & Zamboni, G. (2016) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2015-133759 · Cited by 40 · see citing works
CSF beta‐amyloid 1–42 – what are we measuring in Alzheimer's disease?
Hu, W. T., Watts, K. D., Shaw, L. M. J., Howell, J. C., Trojanowski, J. Q., Basra, S. S., Glass, J. D., Lah, J. J., & Levey, A. I. (2014) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.160 · Cited by 37 · see citing works
The neurobiology of Alzheimer disease defined by neuroimaging
Masdeu, J. C., Kreisl, W. C., & Berman, K. F. (2012) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3283557b36 · Cited by 36 · see citing works
Giulietti, G., Torso, M., Serra, L., Spanò, B., Marra, C., Caltagirone, C., Cercignani, M., Bozzali, M., & (ADNI), T. A. D. N. I. (2018) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25947 · Cited by 37 · see citing works
Using Structural and Diffusion Magnetic Resonance Imaging To Differentiate the Dementias
Suri, S., Topiwala, A., Mackay, C. E., Ebmeier, K. P., & Filippini, N. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0475-3 · Cited by 34 · see citing works
Using Biomarkers to Improve Detection of Alzheimer’s Disease
Biagioni, M. C., & Galvin, J. E. (2011) · Neurodegenerative Disease Management · doi:10.2217/nmt.11.11 · Cited by 34 · see citing works
Staging Neurodegenerative Disorders: Structural, Regional, Biomarker, and Functional Progressions
Archer, T., Kostrzewa, R. M., Beninger, R. J., & Palomo, T. (2011) · Neurotoxicity Research · doi:10.1007/s12640-010-9190-2 · Cited by 34 · see citing works
Tracking the development of agrammatic aphasia: A tensor-based morphometry study
Whitwell, J. L., Duffy, J. R., Machulda, M. M., Clark, H. M., Strand, E. A., Senjem, M. L., Gunter, J. L., Spychalla, A. J., Petersen, R. C., Jack, C. R., et al. (2016) · Cortex · doi:10.1016/j.cortex.2016.09.017 · Cited by 31 · see citing works
Self-citationde Souza, L. C., Lehéricy, S., Dubois, B., Stella, F., & Sarazin, M. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328357b9ab · Cited by 29 · see citing works
Rates of lobar atrophy in asymptomatic <i>MAPT</i> mutation carriers
Chen, Q., Boeve, B. F., Senjem, M., Tosakulwong, N., Lesnick, T. G., Brushaber, D., Dheel, C., Fields, J., Forsberg, L., Gavrilova, R., et al. (2019) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2019.05.010 · Cited by 28 · see citing works
Self-citationRaj, A., Tora, V., Gao, X., Cho, H., Choi, J. Y., Ryu, Y. H., Lyoo, C. H., & Franchi, B. (2021) · Brain Connectivity · doi:10.1089/brain.2020.0841 · Cited by 26 · see citing works
Posterior cortical atrophy phenotypic heterogeneity revealed by decoding 18F-FDG-PET
Townley, R. A., Botha, H., Graff‐Radford, J., Whitwell, J. L., Boeve, B. F., Machulda, M. M., Fields, J. A., Drubach, D. A., Savica, R., Petersen, R. C., et al. (2021) · Brain Communications · doi:10.1093/braincomms/fcab182 · Cited by 26 · see citing works
Self-citationValkanova, V., & Ebmeier, K. P. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.02.016 · Cited by 24 · see citing works
Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia
Petroi, D., Duffy, J. R., Borgert, A. J., Strand, E. A., Machulda, M. M., Senjem, M. L., Jack, C. R., Josephs, K. A., & Whitwell, J. L. (2020) · Brain and Language · doi:10.1016/j.bandl.2020.104773 · Cited by 23 · see citing works
Self-citationNeuroimaging in Neurodegenerative Dementias
McGinnis, S. M. (2013) · Seminars in Neurology · doi:10.1055/s-0032-1331808 · Cited by 21 · see citing works
Voxel-wise deviations from healthy aging for the detection of region-specific atrophy
Klöppel, S., Yang, S., Kellner, E., Reisert, M., Heimbach, B., Urbach, H., Linn, J., Weidauer, S., Andres, T., Bröse, M., et al. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.09.013 · Cited by 21 · see citing works
- Authors
- Vemuri, P., Whitwell, J. L., Kantarci, K., Josephs, K. A., Parisi, J. E., Shiung, M. S., Knopman, D. S., Boeve, B. F., Petersen, R. C., Dickson, D. W., & Jack, C. R.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Jack, Clifford R.
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 42
- Issue
- 2
- Pages
- 559-567
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3097053
- OpenAlex
- W1990502495
- Cited by
- 172
- References
- 60
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 14 · 2015: 11 · 2014: 16 · 2013: 15 · 2012: 13
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG11378, K23AG030935, P50‐AG16574, R01 AG06786, U01AG006786, R01AG011378, P50AG016574)
- National Center for Research Resources (KL2RR024151, K12RR24151, C06RR018898)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- Alzheimer's disease, neurofibrillary tangles, Braak staging, brain atrophy, postmortem neuropathology, disease staging, early detection of Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Brain, Diagnosis, Female, Humans, Magnetic Resonance Imaging, Male, Sensitivity and Specificity, Severity of Illness Index, Statistics as Topic, Reproducibility of Results, Neurofibrillary Tangles, Imaging, Three-Dimensional
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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