Exploring a blue-light-sensing transcription factor to double the peak productivity of oil in Nannochloropsis oceanica
Open accessAbstract
Oleaginous microalgae can produce triacylglycerol (TAG) under stress, yet the underlying mechanism remains largely unknown. Here, we show that, in Nannochloropsis oceanica, a bZIP-family regulator NobZIP77 represses the transcription of a type-2 diacylgycerol acyltransferase encoding gene NoDGAT2B under nitrogen-repletion (N+), while nitrogen-depletion (N−) relieves such inhibition and activates NoDGAT2B expression and synthesis of TAG preferably from C16:1. Intriguingly, NobZIP77 is a sensor of blue light (BL), which reduces binding of NobZIP77 to the NoDGAT2B-promoter, unleashes NoDGAT2B and elevates TAG under N−. Under N+ and white light, NobZIP77 knockout fully preserves cell growth rate and nearly triples TAG productivity. Moreover, exposing the NobZIP77-knockout line to BL under N− can double the peak productivity of TAG. These results underscore the potential of coupling light quality to oil synthesis in feedstock or bioprocess development.
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Several studies have investigated the impact of LED light on the enhancement of lipids in microalgae, highlighting the significant role of blue light.
“Several studies have specifically investigated the impact of LED light on the enhancement of lipids in microalgae, highlighting the significant role of blue light in this process [137, 145, 146].”
From Microalgae biofuels: illuminating the path to a sustainable future amidst challenges and opportunities (2024) · cites this paper as [145]
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MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0
Tamura, K., Dudley, J. T., Nei, M., & Kumar, S. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm092 · Cited by 28,734 · see citing works
MUSCLE: a multiple sequence alignment method with reduced time and space complexity
Edgar, R. C. (2004) · BMC Bioinformatics · doi:10.1186/1471-2105-5-113 · Cited by 8,879 · see citing works
MYB transcription factors in Arabidopsis
Dubos, C., Stracke, R., Erich Grotewold, A., Weißhaar, B., Martin, C. R., & Lepiniec, L. (2010) · Trends in Plant Science · doi:10.1016/j.tplants.2010.06.005 · Cited by 4,885 · see citing works
Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances
Hu, Q., Sommerfeld, M., Jarvis, E., Ghirardi, M., Posewitz, M., Seibert, M., & Darzins, A. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03492.x · Cited by 3,745 · see citing works
Self-citationRodolfi, L., Chini Zittelli, G., Bassi, N., Padovani, G., Biondi, N., Bonini, G., & Tredici, M. R. (2009) · Biotechnology and Bioengineering · doi:10.1002/bit.22033 · Cited by 2,879 · see citing works
An outlook on microalgal biofuels
Wijffels, R. H., & Barbosa, M. J. (2010) · Science · doi:10.1126/science.1189003 · Cited by 1,886 · see citing works
bZIP transcription factors in Arabidopsis
Jakoby, M. J., Weißhaar, B., Dröge‐Laser, W., Vicente‐Carbajosa, J., Tiedemann, J., Kroj, T., & Parcy, F. (2002) · Trends in Plant Science · doi:10.1016/s1360-1385(01)02223-3 · Cited by 1,862 · see citing works
The development and application of optogenetics
Fenno, L., Yizhar, O., & Deisseroth, K. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113817 · Cited by 1,822 · see citing works
Ritchie, R. J. (2006) · Photosynthesis Research · doi:10.1007/s11120-006-9065-9 · Cited by 1,323 · see citing works
Keane, T., Creevey, C. J., Pentony, M. M., Naughton, T. J., & Mclnerney, J. O. (2006) · BMC Evolutionary Biology · doi:10.1186/1471-2148-6-29 · Cited by 1,070 · see citing works
Ajjawi, I., Verruto, J., Aqui, M., Soriaga, L. B., Coppersmith, J. L., Kwok, K., Peach, L., Orchard, E. D., Kalb, R., Xu, W., et al. (2017) · Nature Biotechnology · doi:10.1038/nbt.3865 · Cited by 472 · see citing works
Genomic footprints of a cryptic plastid endosymbiosis in diatoms
Moustafa, A., Beszteri, B., Maier, U. G., Bowler, C., Valentin, K., & Bhattacharya, D. (2009) · Science · doi:10.1126/science.1172983 · Cited by 422 · see citing works
Li, J., Han, D., Wang, D., Ning, K., Jia, J., Wei, L., Jing, X., Huang, S., Chen, J., Li, Y., et al. (2014) · The Plant Cell · doi:10.1105/tpc.113.121418 · Cited by 412 · see citing works
Self-citationSimionato, D., Block, M. A., Rocca, N. L., Jouhet, J., Maréchal, É., Finazzi, G., & Morosinotto, T. (2013) · Eukaryotic Cell · doi:10.1128/ec.00363-12 · Cited by 366 · see citing works
Genome editing of model oleaginous microalgae <i>Nannochloropsis</i> spp. by <scp>CRISPR</scp> /Cas9
Wang, Q., Lu, Y., Xin, Y., Wei, L., Huang, S., & Xu, J. (2016) · The Plant Journal · doi:10.1111/tpj.13307 · Cited by 312 · see citing works
Self-citationAUREOCHROME, a photoreceptor required for photomorphogenesis in stramenopiles
Takahashi, F., Yamagata, D., Ishikawa, M., Fukamatsu, Y., Ogura, Y., Kasahara, M., Kiyosue, T., Kikuyama, M., Wada, M., & Kataoka, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707692104 · Cited by 263 · see citing works
Jia, J., Han, D., Gerken, H. G., Li, Y., Sommerfeld, M. R., Hu, Q., & Xu, J. (2014) · Algal Research · doi:10.1016/j.algal.2014.11.005 · Cited by 239 · see citing works
Self-citationSun, X. L., Cao, Y., Xu, H., Liu, Y., Sun, J., Qiao, D., & Cao, Y. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2013.12.109 · Cited by 223 · see citing works
Gonçalves, E., Wilkie, A. C., Kirst, M., & Rathinasabapathi, B. (2016) · Plant Biotechnology Journal · doi:10.1111/pbi.12523 · Cited by 212 · see citing works
Advances in microalgae engineering and synthetic biology applications for biofuel production
Gimpel, J. A., Specht, E. A., Georgianna, D. R., & Mayfield, S. P. (2013) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2013.03.038 · Cited by 193 · see citing works
Shan, W., Kuang, J., Lu, W., & Chen, J. (2014) · Plant Cell & Environment · doi:10.1111/pce.12303 · Cited by 163 · see citing works
Wei, H., Shi, Y., Ma, X., Pan, Y., Hu, H., Li, Y., Luo, M., Gerken, H. G., & Liu, J. (2017) · Biotechnology for Biofuels · doi:10.1186/s13068-017-0858-1 · Cited by 154 · see citing works
Self-citationPoliner, E., Takeuchi, T., Du, Z., Christoph Benning, A., & Farré, E. M. (2018) · ACS Synthetic Biology · doi:10.1021/acssynbio.7b00362 · Cited by 150 · see citing works
Yi, X., Lu, Y., Lee, Y., Wei, L., Jia, J., Wang, Q., Wang, D., Bai, F., Hu, H., Hu, Q., et al. (2017) · Molecular Plant · doi:10.1016/j.molp.2017.10.011 · Cited by 148 · see citing works
Self-citationTriacylglycerol Accumulation in Photosynthetic Cells in Plants and Algae
Du, Z., & Christoph Benning, A. (2016) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-319-25979-6_8 · Cited by 141 · see citing works
Wang, W., Lu, X., Li, L., Lian, H., Mao, Z., Xu, P., Guo, T., Xu, F., Du, S., Cao, X., et al. (2018) · The Plant Cell · doi:10.1105/tpc.17.00994 · Cited by 135 · see citing works
The Coevolution of Blue-Light Photoreception and Circadian Rhythms
Gehring, W., & Rosbash, M. (2003) · Journal of Molecular Evolution · doi:10.1007/s00239-003-0038-8 · Cited by 132 · see citing works
Zhang, Q., Chieu, H. K., Low, C. P., Zhang, S., Heng, C., & Yang, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306998200 · Cited by 126 · see citing works
Zienkiewicz, K., Zienkiewicz, A., Poliner, E., Du, Z., Vollheyde, K., Herrfurth, C., Marmon, S. K., Farré, E. M., Feußner, I., & Christoph Benning, A. (2017) · Biotechnology for Biofuels · doi:10.1186/s13068-016-0686-8 · Cited by 126 · see citing works
Kwon, S., Kang, N. K., Koh, H. G., Shin, S., Lee, B., Jeong, B., & Chang, Y. K. (2017) · Biotechnology and Bioengineering · doi:10.1002/bit.26465 · Cited by 122 · see citing works
Kang, N. K., Kim, E. K., Kim, Y. U., Lee, B., Jeong, W.-J., Jeong, B., & Chang, Y. K. (2017) · Biotechnology for Biofuels · doi:10.1186/s13068-017-0919-5 · Cited by 119 · see citing works
Lin, X., Tirichine, L., & Bowler, C. (2012) · Plant Methods · doi:10.1186/1746-4811-8-48 · Cited by 114 · see citing works
Biosynthesis of Triacylglycerol Molecules with a Tailored PUFA Profile in Industrial Microalgae
Xin, Y., Shen, C., She, Y., Chen, H., Wang, C., Wei, L., Yoon, K., Han, D., Hu, Q., & Xu, J. (2019) · Molecular Plant · doi:10.1016/j.molp.2018.12.007 · Cited by 108 · see citing works
Self-citationHu, J., Wang, D., Li, J., Jing, G., Ning, K., & Xu, J. (2014) · Scientific Reports · doi:10.1038/srep05454 · Cited by 106 · see citing works
Self-citationJungandreas, A., Costa, B. S., Jakob, T., von Bergen�, M., Baumann, S., & Wilhelm, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099727 · Cited by 101 · see citing works
Heintz, U., & Schlichting, I. (2016) · eLife · doi:10.7554/elife.11860 · Cited by 100 · see citing works
Leveraging algal omics to reveal potential targets for augmenting TAG accumulation
Arora, N., Pienkos, P. T., Pruthi, V., Poluri, K. M., & Guarnieri, M. T. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.04.005 · Cited by 98 · see citing works
He, Y., Wang, X., Ma, B., & Xu, J. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.04.010 · Cited by 98 · see citing works
Self-citationChai, G., Qi, G., Cao, Y., Wang, Z., Yu, L., Tang, X., Yu, Y., Wang, D., Kong, Y., & Zhou, G. (2014) · New Phytologist · doi:10.1111/nph.12825 · Cited by 86 · see citing works
Self-citationWang, T., Ji, Y., Wang, Y., Jia, J., Li, J., Huang, S. W., Han, D., Hu, Q., Huang, W. E., & Xu, J. (2014) · Biotechnology for Biofuels · doi:10.1186/1754-6834-7-58 · Cited by 78 · see citing works
Self-citationHe, Y., Zhang, P., Huang, S. W., Wang, T., Ji, Y., & Xu, J. (2017) · Biotechnology for Biofuels · doi:10.1186/s13068-017-0967-x · Cited by 78 · see citing works
Self-citationAutonomic Behaviors in Lipase‐Active Oil Droplets
Wang, L., Lin, Y., Zhou, Y., Xie, H., Song, J., Li, M., Huang, Y., Huang, X. C., & Mann, S. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201812111 · Cited by 65 · see citing works
Combinatorial Control of Light Induced Chromatin Remodeling and Gene Activation in Neurospora
Sancar, C., Ha, N., Yilmaz, R., Tesorero, R. A., Fisher, T., Brunner, M., & Sancar, G. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005105 · Cited by 64 · see citing works
Ji, Y., He, Y., Cui, Y., Wang, T., Wang, Y., Li, Y., Huang, W. E., & Xu, J. (2014) · Biotechnology Journal · doi:10.1002/biot.201400165 · Cited by 62 · see citing works
Self-citationAn update on aureochromes: Phylogeny – mechanism – function
Kroth, P. G., Wilhelm, C., & Kottke, T. (2017) · Journal of Plant Physiology · doi:10.1016/j.jplph.2017.06.010 · Cited by 60 · see citing works
Metabolic pathways for lipid synthesis under nitrogen stress in Chlamydomonas and Nannochloropsis
Banerjee, A., Maiti, S. K., Guria, C., & Banerjee, C. (2016) · Biotechnology Letters · doi:10.1007/s10529-016-2216-y · Cited by 58 · see citing works
Gonçalves, E., Koh, J., Zhu, N., Yoo, M., Chen, S., Matsuo, T., Johnson, J. V., & Rathinasabapathi, B. (2016) · The Plant Journal · doi:10.1111/tpj.13144 · Cited by 58 · see citing works
The Aureochrome Photoreceptor PtAUREO1a Is a Highly Effective Blue Light Switch in Diatoms
Mann, M., Serif, M., Wrobel, T. J., Eisenhut, M., Madhuri, S., Flachbart, S., Weber, A. P. M., Bernard, L., Wilhelm, C., & Kroth, P. G. (2020) · iScience · doi:10.1016/j.isci.2020.101730 · Cited by 44 · see citing works
Ryu, A. J., Kang, N. K., Jeon, S., Hur, D. H., Lee, E. M., Lee, D. Y., Jeong, B., Chang, Y. K., & Jeong, K. J. (2020) · Biotechnology for Biofuels · doi:10.1186/s13068-020-01681-4 · Cited by 38 · see citing works
Ding, J., Li, X., & Hu, H. (2012) · PLANT PHYSIOLOGY · doi:10.1104/pp.112.200840 · Cited by 28 · see citing works
Sukenik, A., Livne, A., Apt, K. E., & Grossman, A. R. (2000) · Journal of Phycology · doi:10.1046/j.1529-8817.2000.99115.x · Cited by 27 · see citing works
Thiriet-Rupert, S., Carrier, G., Trottier, C., Eveillard, D., Schoefs, B., Bougaran, G., Cadoret, J., Chénais, B., & Saint‐Jean, B. (2018) · Algal Research · doi:10.1016/j.algal.2017.12.011 · Cited by 24 · see citing works
Wei, L., & Xu, J. (2018) · Journal of Phycology · doi:10.1111/jpy.12623 · Cited by 21 · see citing works
Self-citationAureochromes – Blue Light Receptors
Matiiv, A. B., & Chekunova, E. M. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918060044 · Cited by 17 · see citing works
Phototropic Responses of Vaucheria geminata to Intermittent Blue Light Stimuli
Kataoka, H. (1979) · PLANT PHYSIOLOGY · doi:10.1104/pp.63.6.1107 · Cited by 12 · see citing works
Yang, X., & Cui, X. (2019) · Molecular Plant · doi:10.1016/j.molp.2019.03.004 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 57 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [6]Zienkiewicz K Du ZY Ma W Vollheyde K Benning C Stress-induced neutral lipid biosynthesis in microalgae—molecular, cellular and physiological insights BBA-Mol. Cell Biol. L. 2016 1861 1269 1281 26883557
- [26]Chai G Poplar PdC3H17 and PdC3H18 are direct targets of PdMYB3 and PdMYB21, and positively regulate secondary wall formation in Arabidopsis and poplar N. Phytol. 2014 203 520 534 24786865
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“Several studies have specifically investigated the impact of LED light on the enhancement of lipids in microalgae, highlighting the significant role of blue light in this process [137, 145, 146].”
BackgroundA comprehensive review of carbon capture science and technologies
Wu, C., Huang, Q., Xu, Z., Sipra, A. T., Gao, N., Vandenberghe, L. P. D. S., Vieira, S., Soccol, C. R., Zhao, R., Deng, S., et al. (2023) · Carbon Capture Science & Technology · doi:10.1016/j.ccst.2023.100178 · Cited by 179 · see citing works
Hu, J., Meng, W., Su, Y., Qian, C., & Fu, W. (2023) · Frontiers in Marine Science · doi:10.3389/fmars.2023.1260709 · Cited by 125 · see citing works
CRISPR-based bioengineering in microalgae for production of industrially important biomolecules
Dhokane, D., Shaikh, A., Yadav, A., Giri, N., Bandyopadhyay, A., Dasgupta, S., & Bhadra, B. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1267826 · Cited by 106 · see citing works
Liu, H., Liu, T.-J., Guo, H., Wang, Y., Ji, R., Kang, L.-L., Wang, Y., Guo, X., Li, J., Jiang, L.-Q., et al. (2024) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2023.140538 · Cited by 72 · see citing works
Harnessing genetic engineering to drive economic bioproduct production in algae
Gupta, A., Kang, K., Pathania, R., Saxton, L., Saucedo, B., Malik, A., Torres-Tiji, Y., Diaz, C. J., Dutra Molino, J. V., & Mayfield, S. P. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1350722 · Cited by 60 · see citing works
Engineering Fatty Acid Biosynthesis in Microalgae: Recent Progress and Perspectives
Song, Y., Wang, F., Chen, L., & Zhang, W. (2024) · Marine Drugs · doi:10.3390/md22050216 · Cited by 58 · see citing works
Recent Progress and Challenges in CRISPR-Cas9 Engineered Algae and Cyanobacteria
Patel, V. K., Das, A., Kumari, R., & Kajla, S. (2023) · Algal Research · doi:10.1016/j.algal.2023.103068 · Cited by 50 · see citing works
Towards Lipid from Microalgae: Products, Biosynthesis, and Genetic Engineering
Xin, Y., Wu, S., Miao, C., Xu, T., & Lu, Y. (2024) · Life · doi:10.3390/life14040447 · Cited by 40 · see citing works
Self-citationSix, A., Dimitriades-Lemaire, A., Lancelon‐Pin, C., Putaux, J., Dauvillée, D., Petroutsos, D., Diaz, P. A., Sassi, J., Li‐Beisson, Y., & Fleury, G. (2024) · Algal Research · doi:10.1016/j.algal.2024.103515 · Cited by 35 · see citing works
Light, CO2, and carbon storage in microalgae
Yamaoka, Y., Petroutsos, D., Je, S., Yamano, T., & Li‐Beisson, Y. (2025) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2025.102696 · Cited by 34 · see citing works
A rapid aureochrome opto-switch enables diatom acclimation to dynamic light
Zhang, H., Xiong, X., Guo, K., Zheng, M., Cao, T., Yang, Y., Song, J., Cen, J., Zhang, J., Jiang, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49991-7 · Cited by 27 · see citing works
Advances and Perspectives of Microalgal Biorefineries for Bioenergy
Choudhary, S., Venkatrayalu, G., Kiran, B. R., & Poluri, K. M. (2025) · Energy & Fuels · doi:10.1021/acs.energyfuels.5c01676 · Cited by 26 · see citing works
Ameliorating microalgal OMEGA production using omics platforms
Mariam, I., Bettiga, M., Rova, U., Christakopoulos, P., Μάτσακας, Λ., & Patel, A. (2024) · Trends in Plant Science · doi:10.1016/j.tplants.2024.01.002 · Cited by 24 · see citing works
Design, construction and application of algae-bacteria synergistic system for treating wastewater
Li, W., Wang, L., Qiang, X., Song, Y.-L., Gu, W., Ma, Z., & Wang, G. (2024) · Journal of Environmental Management · doi:10.1016/j.jenvman.2024.121720 · Cited by 23 · see citing works
Li, H., Sun, X., Liu, R., Ye, L., Sun, X., Hao, R., & Guo, X. (2024) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2024.143590 · Cited by 22 · see citing works
Advances in algal lipid metabolism and their use to improve oil content
Kong, F., Blot, C., Liu, K., Kim, M., & Li‐Beisson, Y. (2024) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2024.103130 · Cited by 20 · see citing works
Duan, Y., Chen, L., Ma, L., Amin, F. R., Zhai, Y., Chen, G., & Li, D. (2024) · Biotechnology Advances · doi:10.1016/j.biotechadv.2024.108460 · Cited by 20 · see citing works
Genome editing for biodiesel production in oleaginous microalga, Nannochloropsis species
Kurita, T., Iwai, M., Ohta, H., Sakuma, T., & Yamamoto, T. (2023) · Gene and Genome Editing · doi:10.1016/j.ggedit.2023.100027 · Cited by 17 · see citing works
Thajuddin, F., Rasheed, A. S., Elumalai, A., Palanivel, P., Thajuddin, N., & Dharumadurai, D. (2025) · Renewable Energy · doi:10.1016/j.renene.2025.123961 · Cited by 17 · see citing works
Sun, Y., Xin, Y., Zhang, L., Wang, Y., Liu, R., Li, X., Zhou, C., Zhang, L., & Han, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.942883 · Cited by 16 · see citing works
Self-citationWang, R., & Miao, X. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.987354 · Cited by 14 · see citing works
Gong, Y., Wang, Q., Wei, L., Liang, W., Wang, L., Lv, N., Du, X., Zhang, J., Shen, C., Yi, X., et al. (2023) · Plant Communications · doi:10.1016/j.xplc.2023.100773 · Cited by 14 · see citing works
Self-citationMachine learning-assisted synthetic biology of cyanobacteria and microalgae
Jin, W., Wang, F., Chen, L., & Zhang, W. (2025) · Algal Research · doi:10.1016/j.algal.2025.103911 · Cited by 14 · see citing works
Polamraju, S. M., Manochkumar, J., Ganeshbabu, M., & Ramamoorthy, S. (2025) · Archives of Microbiology · doi:10.1007/s00203-025-04241-2 · Cited by 14 · see citing works
Astaxanthin biosynthesis for functional food development and space missions
Xie, X., Zhong, M., Huang, X., Yuan, X., Mahna, N., Mussagy, C. U., & Ren, M. (2024) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2024.2410364 · Cited by 12 · see citing works
Sarkar, N., Dhar, S., & Sen, R. (2024) · Energy Conversion and Management · doi:10.1016/j.enconman.2024.119127 · Cited by 11 · see citing works
Xin, Y., Wang, Q., Shen, C., Hu, C., Shi, X., Lv, N., Du, X., Xu, G., & Xu, J. (2022) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiac396 · Cited by 9 · see citing works
Self-citationMa, Y., Liu, S., Cui, L., Fei, Q., & Wang, Q. (2024) · Environmental Research · doi:10.1016/j.envres.2024.119125 · Cited by 8 · see citing works
Self-citationXing, C., Fu, X., Du, Y., Liu, K., Yuan, H., Liu, J., & Yang, J. (2025) · Bioresource Technology · doi:10.1016/j.biortech.2025.132708 · Cited by 8 · see citing works
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Self-citationMoroi, K., Yamamoto, T., & Kurita, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-26657-y · Cited by 5 · see citing works
Zhiwei, 蒲. P., Wang, X., Chen, Y.-L., Li, J., He, X., Chen, W., & Zhao, C. C. (2026) · Biotechnology Advances · doi:10.1016/j.biotechadv.2026.108796 · Cited by 6 · see citing works
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Pancha, I., & Imamura, S. (2026) · Frontiers in Plant Science · doi:10.3389/fpls.2026.1736651 · Cited by 4 · see citing works
Doan, L., Tran, A. Q. V., Ong, Q. K. L., Huynh, K. G., Tran, K., & Phung, T. K. (2026) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2026.109210 · Cited by 4 · see citing works
Liu, P., Ai, Y., Li, M., Shi, J., Xiao, N., Zhang, X., Yu, H., Ma, F., Sun, S., & Xie, S. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.03.019 · Cited by 4 · see citing works
Wu, S., She, Y., Chen, X., Huang, X., Xu, T., Miao, C., Wu, Q., Li, Z., Li, C., Cheng, Y., et al. (2025) · Plant Cell Reports · doi:10.1007/s00299-025-03511-z · Cited by 4 · see citing works
Self-citationLin, P., Chai, J., Wang, A., Zhong, H., & Wang, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168840 · Cited by 4 · see citing works
Qin, S., Liu, J., Chen, Y., Yang, H., Zhao, Z., Shi, Q., Huang, Q., & Wang, H. (2024) · IEEE International Conference on Real-time Computing and Robotics (RCAR) · doi:10.1109/rcar61438.2024.10671247 · Cited by 2 · see citing works
Gupta, A., Oliver, A., Molino, J. V. D., Wnuk-Fink, K. M. J., Tessman, M., Kang, K., Santo, É. D. E., Torres-Tiji, Y., Burkart, M. D., & Mayfield, S. P. (2025) · Algal Research · doi:10.1016/j.algal.2025.104192 · Cited by 2 · see citing works
Xu, T., Jiang, X., Chen, X., Li, Z., Miao, C., Wu, S., Cheng, Y., Li, C., Xin, Y., & Lu, Y. (2025) · Aquaculture · doi:10.1016/j.aquaculture.2025.743471 · Cited by 2 · see citing works
Self-citationLi, H., Sun, X., Ye, L., Batool, N., & Turab, A. (2025) · Bioresource Technology · doi:10.1016/j.biortech.2025.133800 · Cited by 2 · see citing works
Sansone, C., Russo, M. T., Paris, D., Pistelli, L., Maselli, M., Corato, F., Tramice, A., Iodice, A., Margiotta, F., Smerilli, A., et al. (2025) · Frontiers in Photobiology · doi:10.3389/fphbi.2025.1715336 · Cited by 2 · see citing works
Gan, Q., Wang, X., Liang, S., Lei, S., Lu, X., Xin, Y., & Lu, Y. (2026) · Industrial Crops and Products · doi:10.1016/j.indcrop.2025.122553 · Cited by 2 · see citing works
Self-citationWang, Q., Gong, Y., Wang, L., Lv, N., Du, X., Zhang, J., Xin, Y., Nikoloski, Z., Li‐Beisson, Y., Sun, L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-74304-5 · Cited by 2 · see citing works
Self-citationHasan, M. M., Sana, A. R., Kumari, S., Benny, J. A., Mathew, S., & Balamurugan, S. (2025) · Renewable Energy · doi:10.1016/j.renene.2025.124061 · Cited by 2 · see citing works
Hasanath, M. A., Panigrahi, A., Chaitanya, N. K., & Chatterjee, P. (2025) · Bioresource Technology Reports · doi:10.1016/j.biteb.2025.102467 · Cited by 1 · see citing works
Recent advances in omics-driven research of photosynthetic microorganisms in green biotechnology
Sorokin, B., Gusev, E., Namsaraev, Z. B., Buzdin, A. A., Osmakova, A., & Kuzmin, D. (2026) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2026.2655676 · Cited by 2 · see citing works
Goyal, E., Fayaz, T., Ratha, S. K., & Renuka, N. (2026) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-026-05056-z · Cited by 1 · see citing works
Xiao, H., Zhang, Q., Chen, H., Hao, J., Tang, H., Wang, K., & Sun, X. W. (2026) · Bioresource Technology · doi:10.1016/j.biortech.2026.135189 · Cited by 1 · see citing works
O’Higgins, L., & Hamed, I. (2024) · Developments in applied phycology. · doi:10.1007/978-3-031-43969-8_18 · Cited by 1 · see citing works
Nannochloropsis artificial chromosomes (NannoACs) loom on the horizon
Guo, L., & Yang, G. (2023) · Journal of Oceanology and Limnology · doi:10.1007/s00343-022-2302-z · Cited by 1 · see citing works
A rapid aureochrome opto-switch enables diatom acclimation to dynamic lightPreprint
Li, X., Zhang, H., Xiong, X., Guo, K., Zheng, M., Cao, T., Yang, Y., Song, J., Cen, J., Zhang, J., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-2947310/v1
Microalgal Technology Challenges
Zaharieva, M. M., Scheifelle, F. B., Kroumov, A. D., & Najdenski, H. M. (2026) · Sustainable materials and technology · doi:10.1007/978-981-95-2597-3_4
Gao, Y., Tong, T., Zeng, Z., Hou, K., Miao, D., Huang, C., & Xiong, R. (2026) · Journal of Bioresources and Bioproducts · doi:10.1016/j.jobab.2026.100249
Iwai, M., Hori, K., Kurita, T., Okazaki, K., Maeda, S., Takami, A., Yamamoto, T., Sakamoto, A., Ohta, H., & Shimojima, M. (2026) · Journal of Phycology · doi:10.1111/jpy.70203
Liu, Y., Zhang, Z. Q., Chen, Y., Li, J., Xu, Y., Yang, W., Xu, Q., Ma, W., & Sun, X. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6c04126
A Recent Update on Biofuel Production from Microalgae
Kumar, A., Rani, M., & Singh, S. K. (2026) · Springer eBooks · doi:10.1007/978-3-032-22849-9_13
Quantitative analysis of background interference for robust RGB-based microalgae density measurement
Chen, H. Y., Zhang, Q., Jiang, Q., Amenorfenyo, D. K., Hu, Z., Li, F., & Xiao, H. (2026) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2026.109946
Zhou, R., Mu, K., Shi, Y., Li, Y., Luo, L., Tan, Y., Wang, Z., Tang, Y., & Li, X. (2026) · Bioresource Technology · doi:10.1016/j.biortech.2026.135724
Self-citationOliveira, V. P., & Winck, F. V. (2026) · SynBio · doi:10.3390/synbio4030017
Abu‐Ghosh, S. (2026) · Biotechnology Advances · doi:10.1016/j.biotechadv.2026.109068
CRISPR‐Cas Tools for Dissecting and Engineering Environmental Responses in Microalgae
Zhao, W., Li, X., Hu, Z., & Wang, S. (2026) · Plant Cell & Environment · doi:10.1111/pce.70903
Wang, H., & Liu, J. (2026) · Biotechnology Advances · doi:10.1016/j.biotechadv.2026.109079
- Authors
- Zhang, P., Xin, Y., He, Y., Tang, X., Shen, C., Wang, Q., Lv, N., Li, Y., Hu, Q., & Xu, J.
- Affiliations
- Chinese Academy of Sciences (CN)
- Shenzhen University (CN)
- Corresponding author
- Xu, Jian
- Venue
- Nature Communications
- Published
- 2022-03-29
- Volume
- 13
- Issue
- 1
- Pages
- 1664-1664
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC8964759
- OpenAlex
- W4221029076
- Cited by
- 67
- References
- 57
- Citations by year
- 2026: 20 · 2025: 17 · 2024: 20 · 2023: 7 · 2022: 3
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (31800071, 31425002, 31900074, 31600059, 2018YFA0902500, 31900047)
- Chinese Academy of Sciences (XDPB18)
- Natural Science Foundation of Shandong Province (ZR201709180185)
- National Key Research and Development Program of China (XDPB18, 31900074, 31900047, 31600059, 2018YFA0902500, 2018M642716, ZR2019BC016, 31800071, ZR201709180185, 31425002)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- Nannochloropsis oceanica, bZIP transcription factors, blue light sensing, triglyceride synthesis, diacylglycerol acyltransferase, nitrogen starvation, oleaginous microalgae, light quality, oil productivity, promoter binding, knockout mutants
- MeSH terms
- Nitrogen, Transcription Factors, Triglycerides, Stramenopiles, Microalgae
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