Cited by 38Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.

The cerebellum regulates fear extinction through thalamo-prefrontal cortex interactions in male mice

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Abstract

Fear extinction is a form of inhibitory learning that suppresses the expression of aversive memories and plays a key role in the recovery of anxiety and trauma-related disorders. Here, using male mice, we identify a cerebello-thalamo-cortical pathway regulating fear extinction. The cerebellar fastigial nucleus (FN) projects to the lateral subregion of the mediodorsal thalamic nucleus (MD), which is reciprocally connected with the dorsomedial prefrontal cortex (dmPFC). The inhibition of FN inputs to MD in male mice impairs fear extinction in animals with high fear responses and increases the bursting of MD neurons, a firing pattern known to prevent extinction learning. Indeed, this MD bursting is followed by high levels of the dmPFC 4 Hz oscillations causally associated with fear responses during fear extinction, and the inhibition of FN-MD neurons increases the coherence of MD bursts and oscillations with dmPFC 4 Hz oscillations. Overall, these findings reveal a regulation of fear-related thalamo-cortical dynamics by the cerebellum and its contribution to fear extinction.

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  1. Schmahmann, J. D. In Handbook of the Cerebellum and Cerebellar Disorders (eds Manto, M. et al.) (Springer, 2013).

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Metadata

Authors
Frontera, J. L., Sala, R. W., Georgescu, I. A., Baba Aissa, H., d’Almeida, M. N., Popa, D., & Léna, C.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Léna, Clément
Venue
Nature Communications
Published
2023-03-17
Volume
14
Issue
1
Pages
1508-1508
ISSN
2041-1723 (ISSN-L)
OpenAlex
W4327713340
Cited by
38
References
73
Citations by year
2026: 12 · 2025: 11 · 2024: 7 · 2023: 8
FWCI
5.69
Type
journal article
Language
en
Open access
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Repositori digital de la UPF (Universitat Pompeu Fabra) (publishedVersion, cc-by)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Agence Nationale de la Recherche (ANR-21-CE37-0025, ANR-17-CE37-0009, ANR-21-CE16-0017)
  • Fondation pour la Recherche Médicale (FRM-DPP20151033983, FRM-EQU202103012770)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
fear extinction, cerebellum, fastigial nucleus, mediodorsal thalamus, dorsomedial prefrontal cortex, neuronal bursting, inhibitory learning, anxiety disorders, trauma-related disorders, male mice
MeSH terms
Animals, Cerebellum, Extinction, Psychological, Fear, Male, Prefrontal Cortex, Mediodorsal Thalamic Nucleus, Mice

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