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The cerebellum regulates fear extinction through thalamo-prefrontal cortex interactions in male mice
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Fear extinction is a form of inhibitory learning that suppresses the expression of aversive memories and plays a key role in the recovery of anxiety and trauma-related disorders. Here, using male mice, we identify a cerebello-thalamo-cortical pathway regulating fear extinction. The cerebellar fastigial nucleus (FN) projects to the lateral subregion of the mediodorsal thalamic nucleus (MD), which is reciprocally connected with the dorsomedial prefrontal cortex (dmPFC). The inhibition of FN inputs to MD in male mice impairs fear extinction in animals with high fear responses and increases the bursting of MD neurons, a firing pattern known to prevent extinction learning. Indeed, this MD bursting is followed by high levels of the dmPFC 4 Hz oscillations causally associated with fear responses during fear extinction, and the inhibition of FN-MD neurons increases the coherence of MD bursts and oscillations with dmPFC 4 Hz oscillations. Overall, these findings reveal a regulation of fear-related thalamo-cortical dynamics by the cerebellum and its contribution to fear extinction.
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These ROIs have been previously associated with fear memory and align with work at the circuit level.
“These ROIs have been previously associated with fear memory56,59-66 and align with work at the circuit level62.”
From Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice (2026) · cites this paper as [60]
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Ce qui se passe dans notre cerveau quand on a peur
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Self-citationMedial prefrontal cortex encodes implicit temporal expectations in micePreprint
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Self-citation
Metadata
- Authors
- Frontera, J. L., Sala, R. W., Georgescu, I. A., Baba Aissa, H., d’Almeida, M. N., Popa, D., & Léna, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Léna, Clément
- Venue
- Nature Communications
- Published
- 2023-03-17
- Volume
- 14
- Issue
- 1
- Pages
- 1508-1508
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC10023697
- OpenAlex
- W4327713340
- Cited by
- 38
- References
- 73
- Citations by year
- 2026: 12 · 2025: 11 · 2024: 7 · 2023: 8
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (publishedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agence Nationale de la Recherche (ANR-21-CE37-0025, ANR-17-CE37-0009, ANR-21-CE16-0017)
- Fondation pour la Recherche Médicale (FRM-DPP20151033983, FRM-EQU202103012770)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- fear extinction, cerebellum, fastigial nucleus, mediodorsal thalamus, dorsomedial prefrontal cortex, neuronal bursting, inhibitory learning, anxiety disorders, trauma-related disorders, male mice
- MeSH terms
- Animals, Cerebellum, Extinction, Psychological, Fear, Male, Prefrontal Cortex, Mediodorsal Thalamic Nucleus, Mice
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