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Homeostatic synaptic plasticity rescues neural coding reliability

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Rozenfeld, Eyal, Ehmann, Nadine, Manoim, Julia E., Kittel, Robert J., Parnas, Moshe·2023·Nature Communications
DOI 10.1038/s41467-023-38575-6PMC PMC10209050

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Abstract

To survive, animals must recognize reoccurring stimuli. This necessitates a reliable stimulus representation by the neural code. While synaptic transmission underlies the propagation of neural codes, it is unclear how synaptic plasticity can maintain coding reliability. By studying the olfactory system of Drosophila melanogaster , we aimed to obtain a deeper mechanistic understanding of how synaptic function shapes neural coding in the live, behaving animal. We show that the properties of the active zone (AZ), the presynaptic site of neurotransmitter release, are critical for generating a reliable neural code. Reducing neurotransmitter release probability of olfactory sensory neurons disrupts both neural coding and behavioral reliability. Strikingly, a target-specific homeostatic increase of AZ numbers rescues these defects within a day. These findings demonstrate an important role for synaptic plasticity in maintaining neural coding reliability and are of pathophysiological interest by uncovering an elegant mechanism through which the neural circuitry can counterbalance perturbations.

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  • Emerging evidence suggests that molecular redundancy within chromatin remodeling complexes and homeostatic feedback loops may partially buffer against single-gene loss and dampen the spread of dysregulation.

    “Emerging evidence suggests that molecular redundancy within chromatin remodeling complexes and homeostatic feedback loops may partially buffer against single-gene loss and dampen the spread of dysregulation (Rozenfeld et al., 2023; Fink et al., 2024).”

    From Biological hierarchy from genotype to phenotype in syndromic and non-syndromic autism spectrum disorder (2026) · cites this paper as Rozenfeld et al., 2023

    The Discussion (page not provided) reports that homeostatic synaptic plasticity compensates for reduced release probability after cac knockdown, rescuing neural coding reliability under some conditions. It does not address molecular redundancy in chromatin-remodeling complexes or a general dampening of dysregulation after single-gene loss; it also says compensation fails at elevated firing rates. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Rozenfeld, E., Ehmann, N., Manoim, J. E., Kittel, R. J., & Parnas, M.
Affiliations
  • Tel Aviv University (IL)
  • Leipzig University (DE)
Corresponding author
  • Kittel, Robert J.
  • Parnas, Moshe
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2023-05-24
Volume
14
Issue
1
Pages
2993-2993
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-023-38575-6
PMC
PMC10209050
OpenAlex
W4378172980
Cited by
19
References
5
Citations by year
2026: 6 · 2025: 8 · 2024: 5
FWCI
2.30
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Deutsche Forschungsgemeinschaft (426503586, KFO5001, 430156010, 408264519, SPP2205)
  • H2020 European Research Council (676844)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
homeostatic plasticity, olfactory system, Drosophila melanogaster, active zone, neurotransmitter release probability, olfactory sensory neurons, stimulus representation, synaptic homeostasis
MeSH terms
Animals, Drosophila melanogaster, Homeostasis, Neuronal Plasticity, Reproducibility of Results, Neurotransmitter Agents

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