The monoaminergic system is a bilaterian innovation
Open accessAbstract
Monoamines like serotonin, dopamine, and adrenaline/noradrenaline (epinephrine/norepinephrine) act as neuromodulators in the nervous system. They play a role in complex behaviours, cognitive functions such as learning and memory formation, as well as fundamental homeostatic processes such as sleep and feeding. However, the evolutionary origin of the genes required for monoaminergic modulation is uncertain. Using a phylogenomic approach, in this study, we show that most of the genes involved in monoamine production, modulation, and reception originated in the bilaterian stem group. This suggests that the monoaminergic system is a bilaterian novelty and that its evolution may have contributed to the Cambrian diversification.
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Monoaminergic and glutamatergic systems play a critical role in mood, behavioral, and cognitive regulation, including predictive performance.
“both playing a critical role in mood, behavioral, and cognitive regulation, including predictive performance (Gilbert et al., 2022; Goulty et al., 2023; Pal, 2021; Sanacora et al., 2008).”
From Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review. (2025) · cites this paper as Goulty et al., 2023
The Introduction says monoamines regulate behaviour and contribute to cognitive functions and emotional states. It does not establish the same role for glutamatergic systems or address predictive performance; searches for those terms found no supporting passage in our copy. Page numbers were not supplied. (LLM, conf=0.88)
Experimental — accuracy not yet measuredMood disorders are typically managed with medications acting on the monoaminergic and glutamatergic systems.
“mood disorders are typically managed with medications acting on the monoaminergic and glutamatergic systems”
From Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review. (2025) · cites this paper as Goulty et al., 2023
The Introduction (page unavailable) describes monoamines’ roles in emotional states and the mechanisms of monoamine signalling, but does not address how mood disorders are managed. Searches for mood-disorder medications, glutamatergic treatments, and antidepressants found no passage supporting the treatment claim. (LLM, conf=0.76)
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Carlberg, M., Jergil, B., Lindbladh, C., & Rosengren, E. (1984) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(84)90005-3 · Cited by 19 · see citing works
Metazoan innovation: from aromatic amino acids to extracellular signaling
Kutchko, K. M., & Siltberg-Liberles, J. (2013) · Amino Acids · doi:10.1007/s00726-013-1509-x · Cited by 18 · see citing works
Hsieh, S., Plotnick, R. E., & Bush, A. M. (2022) · Paleobiology · doi:10.1017/pab.2021.46 · Cited by 18 · see citing works
Carlberg, M., & Elofsson, R. (1987) · Neurochemistry International · doi:10.1016/0197-0186(87)90005-2 · Cited by 16 · see citing works
Alcañiz, S., & Silva, F. J. (1997) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/s0742-8413(96)00148-x · Cited by 15 · see citing works
Serotonergic control of excitability: from neuron to networks
Giovanni, G. D., Chagraoui, A., Bharatiya, R., & Deurwaerdère, P. D. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-444-64125-0.00010-4 · Cited by 10 · see citing works
The power and limitations of species tree-aware phylogeneticsPreprint
Williams, T. A., Davín, A., Morel, B., Szánthó, L. L., Spang, A., Stamatakis, A., Hugenholtz, P., & Szöllősi, G. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.17.533068 · Cited by 6 · see citing works
Plasticity in Dopamine Neurons
Quraishi, S., & Paladini, C. A. (2016) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-802206-1.00018-0 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [6]Di Giovanni, G., Chagraoui, A., Bharatiya, R. & De Deurwaerdère, P. in Handbook of Behavioral Neuroscience (eds. Müller, C. P. & Cunningham, K. A.) Vol. 31, 197–215 (Elsevier, 2020).
- [7]Quraishi, S. A. & Paladini, C. A. in Handbook of Behavioral Neuroscience (eds. Steiner, H. & Tseng, K. Y.) Vol. 24, 361–372 (Elsevier, 2016).
- [8]Azmitia, E. C. in Handbook of Behavioral Neuroscience (eds. Müller, C. P. & Jacobs, B. L.) vol. 21 3–22 (Elsevier, 2010).
Cited by
Sorted by citations
Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review.
Qela, B., Damiani, S., De Santis, S., Groppi, F., Pichiecchio, A., Asteggiano, C., Brondino, N., Monteleone, A. M., Grassi, L., Politi, P., et al. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106020 · Cited by 26 · see citing works
“…mood disorders are typically managed with medications acting on the monoaminergic and glutamatergic systems, both playing a critical role in mood, behavioral, and cognitive regulation, including predictive performance (Gilbert et al., 2022; Goulty et al., 2023; Pal, 2021; Sanacora et al., 2008).”
- Authors
- Goulty, M., Botton-Amiot, G., Rosato, E., Sprecher, S. G., & Feuda, R.
- Affiliations
- University of Leicester (GB)
- University of Fribourg (CH)
- Corresponding author
- Feuda, Roberto
- Venue
- Nature Communications
- Published
- 2023-06-06
- Volume
- 14
- Issue
- 1
- Pages
- 3284-3284
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC10244343
- OpenAlex
- W4379533981
- Cited by
- 60
- References
- 104
- Citations by year
- 2026: 23 · 2025: 14 · 2024: 17 · 2023: 6
- FWCI
- 12.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Royal Society (UF160226, RGF\EA\180052)
- EC | Horizon 2020 Framework Programme (765937)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (IZCOZ0_182957, 310030_188471)
- Topics
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- monoaminergic systems, monoamines, serotonin, dopamine, norepinephrine, epinephrine, neuromodulation, evolutionary origin, phylogenomics, gene evolution
- MeSH terms
- Catecholamines, Dopamine, Epinephrine, Norepinephrine, Serotonin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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