Endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works

<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression data

Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364 · see citing works

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219 · see citing works

ShinyGO: a graphical gene-set enrichment tool for animals and plants

Ge, S. X., Jung, D., & Yao, R. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btz931 · Cited by 5,270 · see citing works

The Gene Ontology resource: enriching a GOld mine

The Gene Ontology Consortium, Carbon, S., Douglass, E., Good, B. M., Unni, D. R., Harris, N. L., Mungall, C. J., Basu, S., Chisholm, R. L., Dodson, R. J., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkaa1113 · Cited by 3,555 · see citing works

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man

Smith, E. P., Boyd, J., Frank, G. R., Takahashi, H., Cohen, R. M., Specker, B., Williams, T. C., Lubahn, D. B., & Korach, K. S. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410203311604 · Cited by 2,471 · see citing works

The role of estrogens in control of energy balance and glucose homeostasis

Mauvais-Jarvis, F., Clegg, D. J., & Hevener, A. L. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1055 · Cited by 1,329 · see citing works

Functional domains of the human estrogen receptor

Kumar, V., Green, S., Stack, G., Berry, M., Jin, J.-R., & Chambon, P. (1987) · Cell · doi:10.1016/0092-8674(87)90581-2 · Cited by 1,316 · see citing works

Regulated transport of the glucose transporter GLUT4

Bryant, N. J., Govers, R., & James, D. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm782 · Cited by 1,183 · see citing works

Proteome-wide identification of ubiquitin interactions using UbIA-MS

Zhang, X.-F., Smits, A. H., van Tilburg, G. B. A., Ovaa, H., Huber, W. K., & Vermeulen, M. (2018) · Nature Protocols · doi:10.1038/nprot.2017.147 · Cited by 813 · see citing works

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance

Zisman, A., Peroni, O. D., Abel, E. D., Michael, M. D., Mauvais-Jarvis, F., Lowell, B. B., Wojtaszewski, J. F. P., Hirshman, M. F., Virkamaki, A., Goodyear, L. J., et al. (2000) · Nature Medicine · doi:10.1038/78693 · Cited by 743 · see citing works

Integration of the extranuclear and nuclear actions of estrogen

Levin, E. R. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0390 · Cited by 708 · see citing works

Estrogen Modulation of Endothelial Nitric Oxide Synthase

Chambliss, K. L., & Shaul, P. W. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0045 · Cited by 572 · see citing works

Silencing of estrogen receptor α in the ventromedial nucleus of hypothalamus leads to metabolic syndrome

Musatov, S. A., Chen, W. W., Pfaff, D. W., Mobbs, C. V., Yang, X.-J., Clegg, D. J., Kaplitt, M. G., & Ogawa, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610787104 · Cited by 518 · see citing works

Regulation of Splanchnic and Peripheral Glucose Uptake by Insulin and Hyperglycemia in Man

DeFronzo, R. A., Ferrannini, E., Hendler, R., Felig, P., & Wahren, J. (1983) · Diabetes · doi:10.2337/diab.32.1.35 · Cited by 509 · see citing works

VE‐Cadherin‐Cre‐recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells

Alva, J. A., Zovein, A. C., Monvoisin, A., Murphy, T. J., Salazar, A., Harvey, N. L., Carmeliet, P., & Iruela‐Arispe, M. L. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20643 · Cited by 455 · see citing works

Microvascular Recruitment Is an Early Insulin Effect That Regulates Skeletal Muscle Glucose Uptake In Vivo

Keske, M. A., Clerk, L. H., Lindner, J. R., Klibanov, A. L., Clark, M. G., Rattigan, S., & Barrett, E. J. (2004) · Diabetes · doi:10.2337/diabetes.53.6.1418 · Cited by 439 · see citing works

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle

Kubota, T., Kubota, N., Kumagai, H., Yamaguchi, S., Kozono, H., Takahashi, T., Inoue, M., Itoh, S., Takamoto, I., Sasako, T., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.018 · Cited by 435 · cited 1× · see citing works

Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice

Riant, E., Waget, A., Cogo, H., Arnal, J.-F., Burcelin, R., & Gourdy, P. (2009) · Endocrinology · doi:10.1210/en.2008-0971 · Cited by 421 · see citing works

Estrogen Receptor α and Endothelial Nitric Oxide Synthase Are Organized Into a Functional Signaling Module in Caveolae

Chambliss, K. L., Yuhanna, I. S., Mineo, C., Liu, P., German, Z., Sherman, T. S., Mendelsohn, M. E., Anderson, R. G. W., & Shaul, P. W. (2000) · Circulation Research · doi:10.1161/01.res.87.11.e44 · Cited by 416 · see citing works

Sorting out the cellular functions of sorting nexins

Worby, C. A., & Dixon, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm974 · Cited by 412 · see citing works

SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis

Huang, L., Chambliss, K. L., Gao, X., Yuhanna, I. S., Behling‐Kelly, E. L., Bergaya, S., Ahmed, M. H., Michaely, P., Luby‐Phelps, K., Darehshouri, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1140-4 · Cited by 354 · see citing works

Estrogen-Receptor Biology: Continuing Progress and Therapeutic Implications

Osborne, C. K., & Schiff, R. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.10.036 · Cited by 350 · see citing works

Dysmetabolic Syndrome in a Man with a Novel Mutation of the Aromatase Gene: Effects of Testosterone, Alendronate, and Estradiol Treatment

MAFFEI, L. E., Murata, Y., Rochira, V., Gloria, T., Aranda, C., Vázquez, M., Clyne, C. D., Davis, S. R., Simpson, E. R., & Carani, C. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030313 · Cited by 343 · see citing works

The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action

Barrett, E. J., Eggleston, E. M., Inyard, A. C., Wang, H., Li, G., Chai, W., & Liu, Z. (2009) · Diabetologia · doi:10.1007/s00125-009-1313-z · Cited by 323 · see citing works

Cooperation of proto‐signals for nuclear accumulation of estrogen and progesterone receptors.

Ylikomi, T. J., Bocquel, M. T., Berry, M., Gronemeyer, H., & Chambon, P. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05453.x · Cited by 319 · see citing works

Estrogen acutely stimulates nitric oxide synthase activity in fetal pulmonary artery endothelium

Lantin-Hermoso, R. L., Rosenfeld, C. R., Yuhanna, I. S., German, Z., Chen, Z., & Shaul, P. W. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.273.1.l119 · Cited by 284 · see citing works

The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis

Davis, K. E., D. Neinast, M., Sun, K., M. Skiles, W., D. Bills, J., A. Zehr, J., Zeve, D., D. Hahner, L., W. Cox, D., M. Gent, L., et al. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.05.006 · Cited by 278 · see citing works

Estrogen receptor-α expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice

Feng, Y., Manka, D. R., Wagner, K., & Khan, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706933104 · Cited by 275 · see citing works

Physiologic Hyperinsulinemia Enhances Human Skeletal Muscle Perfusion by Capillary Recruitment

Coggins, M. P., Lindner, J. R., Rattigan, S., Jahn, L. A., Fasy, E. A., Kaul, S., & Barrett, E. J. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2682 · Cited by 260 · see citing works

Non-nuclear estrogen receptor α signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice

Chambliss, K. L., Wu, Q., Oltmann, S. C., Konaniah, E. S., Umetani, M., Korach, K. S., Thomas, G. D., Mineo, C., Yuhanna, I. S., Kim, S. H., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci38291 · Cited by 249 · see citing works

Estrogen Dendrimer Conjugates that Preferentially Activate Extranuclear, Nongenomic Versus Genomic Pathways of Estrogen Action

Harrington, W. R., Kim, S. H., Funk, C. C., Madak‐Erdogan, Z., Schiff, R., Katzenellenbogen, J. A., & Katzenellenbogen, B. S. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0186 · Cited by 246 · see citing works

Identification of a Family of Sorting Nexin Molecules and Characterization of Their Association with Receptors

Haft, C. R., de la Luz Sierra, M., Barr, V. A., Haft, D. H., & Taylor, S. I. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7278 · Cited by 244 · see citing works

Estrogen Receptors and Endothelium

Arnal, J., Fontaine, C., Billon-Galés, A., Favre, J., Laurell, H., Lenfant, F., & Gourdy, P. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.191221 · Cited by 232 · see citing works

Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice

Bryzgalova, G., Lundholm, L., Portwood, N., Gustafsson, J.-Å., Khan, A., Efendić, S., & Dahlman‐Wright, K. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90248.2008 · Cited by 217 · see citing works

The effects of oestrogen and progesterone on insulin sensitivity in female rats

KUMAGAI, S., Holmäng, A. B., & Björntorp, P. A. (1993) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1993.tb09596.x · Cited by 193 · see citing works

The Cholesterol Metabolite 27-Hydroxycholesterol Promotes Atherosclerosis via Proinflammatory Processes Mediated by Estrogen Receptor Alpha

Umetani, M., Ghosh, P., Ishikawa, T., Umetani, J., Ahmed, M. H., Mineo, C., & Shaul, P. W. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.013 · Cited by 192 · see citing works

Progression of Metabolic Syndrome Severity During the Menopausal Transition

Gurka, M. J., Vishnu, A., Santen, R. J., & DeBoer, M. D. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003609 · Cited by 183 · see citing works

Progressive development of insulin resistance phenotype in male mice with complete aromatase (CYP19) deficiency

Takeda, K., Toda, K., Saibara, T., Nakagawa, M., Saika, K., Onishi, T., Sugiura, T., & Shizuta, Y. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1760237 · Cited by 182 · see citing works

Myeloid-specific estrogen receptor α deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development

Ribas, V., Drew, B. G., Le, J., Soleymani, T., Daraei, P., Sitz, D., Mohammad, L., Henstridge, D. C., Febbraio, M. A., Hewitt, S. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104533108 · Cited by 180 · see citing works

The role of estrogen receptors in the control of energy and glucose homeostasis

Ropero, A. B., Alonso-Magdalena, P., Quesada, I., & Nadal, A. (2008) · Steroids · doi:10.1016/j.steroids.2007.12.018 · Cited by 170 · see citing works

A large family of endosome-localized proteins related to sorting nexin 1

Teasdale, R. D., David, L. O. C. I., Houghton, F. J., Karlsson, L., & Gleeson, P. A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3580007 · Cited by 163 · see citing works

Interplay between adipose tissue and blood vessels in obesity and vascular dysfunction

Gu, P., & Xu, A. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-012-9230-8 · Cited by 160 · see citing works

Participation of ERα and ERβ in glucose homeostasis in skeletal muscle and white adipose tissue

Barros, R. P. A., Gabbi, C., Morani, A., Warner, M., & Gustafsson, J.-Å. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00189.2009 · Cited by 155 · see citing works

Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound

Dawson, D. K., Vincent, M. A., Barrett, E. J., Kaul, S., Clark, A., Leong-Poi, H. M., & Lindner, J. R. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00373.2001 · Cited by 152 · see citing works

Influence of menopause on diabetes and diabetes risk

Szmuilowicz, E. D., Stuenkel, C. A., & Seely, E. W. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.166 · Cited by 150 · see citing works

Transendothelial Electrical Resistance Measurement across the Blood–Brain Barrier: A Critical Review of Methods

Vigh, J. P., Kincses, A., Ozgür, B., Walter, F. R., Santa-Maria, A. R., Valkai, S., Vastag, M., Neuhaus, W., Brodin, B., Dér, A., et al. (2021) · Micromachines · doi:10.3390/mi12060685 · Cited by 129 · see citing works

Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification

Zhou, P., Zhang, Y., Ma, Q., Gu, F., Day, D. S., He, A., Zhou, B., Li, J., Stevens, S. M., Romo, D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304124110 · Cited by 116 · see citing works

Impaired estrogen receptor action in the pathogenesis of the metabolic syndrome

Hevener, A. L., Clegg, D. J., & Mauvais-Jarvis, F. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.05.020 · Cited by 112 · see citing works

Non-nuclear Estrogen Receptor Signaling in the Endothelium

Wu, Q., Chambliss, K. L., Umetani, M., Mineo, C., & Shaul, P. W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.191791 · Cited by 110 · see citing works

Effect of Postmenopausal Status and Age at Menopause on Type 2 Diabetes and Prediabetes in Japanese Individuals: Toranomon Hospital Health Management Center Study 17 (TOPICS 17)

Heianza, Y., Arase, Y., Kodama, S., Hsieh, S. D., Tsuji, H., Saito, K., Shimano, H., Hara, S., & Sone, H. (2013) · Diabetes Care · doi:10.2337/dc13-1048 · Cited by 108 · see citing works

Modulation of the inflammatory response by estrogens with focus on the endothelium and its interactions with leukocytes

Nilsson, B. (2007) · Inflammation Research · doi:10.1007/s00011-007-6198-z · Cited by 107 · see citing works

Kinetics of Insulin Action In Vivo: Identification of Rate-Limiting Steps

Miles, P. D. G., Levisetti, M. G., Reichart, D. R., Khoursheed, M., Moossa, A. R., & Olefsky, J. M. (1995) · Diabetes · doi:10.2337/diab.44.8.947 · Cited by 101 · see citing works

Direct Administration of Insulin Into Skeletal Muscle Reveals That the Transport of Insulin Across the Capillary Endothelium Limits the Time Course of Insulin to Activate Glucose Disposal

Chiu, J. D., Richey, J. M., Harrison, L. N., Zuniga, E. A., Kolka, C. M., Kirkman, E. L., Ellmerer, M., & Bergman, R. N. (2008) · Diabetes · doi:10.2337/db07-1444 · Cited by 96 · see citing works

Hyposialylated IgG activates endothelial IgG receptor Fc&ggr;RIIB to promote obesity-induced insulin resistance

Tanigaki, K., Sacharidou, A., Peng, J.-Q., Chambliss, K., Yuhanna, I. S., Ghosh, D., Ahmed, M., Szalai, A., Vongpatanasin, W., Mattrey, R., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89333 · Cited by 91 · see citing works

The endothelial cell: An “early responder” in the development of insulin resistance

Barrett, E. J., & Liu, Z. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-012-9232-6 · Cited by 88 · see citing works

Quantitative Mapping of Tumor Vascularity Using Volumetric Contrast-Enhanced Ultrasound

Hoyt, K., Sorace, A. G., & Saini, R. (2011) · Investigative Radiology · doi:10.1097/rli.0b013e318234e6bc · Cited by 88 · see citing works

Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium

Sacharidou, A., Chambliss, K. L., Ulrich, V., Salmon, J. E., Shen, Y.-M. P., Herz, J., Hui, D. Y., Terada, L. S., Shaul, P. W., & Mineo, C. (2018) · Blood · doi:10.1182/blood-2017-11-814681 · Cited by 78 · see citing works

Increased muscle blood supply and transendothelial nutrient and insulin transport induced by food intake and exercise: effect of obesity and ageing

Wagenmakers, A. J. M., Strauss, J. A., Shepherd, S. O., Keske, M. A., & Cocks, M. (2016) · The Journal of Physiology · doi:10.1113/jphysiol.2014.284513 · Cited by 78 · see citing works

Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age‐related insulin resistance

Mohamad, M., Mitchell, S. J., Wu, L. E., White, M. Y., Cordwell, S. J., Mach, J., Solon‐Biet, S. M., Boyer, D., Nines, D., Das, A., et al. (2016) · Aging Cell · doi:10.1111/acel.12481 · Cited by 77 · see citing works

Ultrasound Imaging of Breast Tumor Perfusion and Neovascular Morphology

Hoyt, K., Umphrey, H. R., Lockhart, M. E., Robbin, M. L., & Forero, A. (2015) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2015.04.016 · Cited by 75 · see citing works

Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation

Merino‐Trigo, A., Kerr, M. C., Houghton, F. J., Lindberg, A. L., Mitchell, C. A., Teasdale, R. D., & Gleeson, P. A. (2004) · Journal of Cell Science · doi:10.1242/jcs.01561 · Cited by 73 · see citing works

Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice

Menazza, S., Sun, J., Appachi, S., Chambliss, K. L., Kim, S. H., Aponte, A. M., Khan, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Shaul, P. W., et al. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.04.004 · Cited by 71 · see citing works

Recent developments in dynamic contrast-enhanced ultrasound imaging of tumor angiogenesis

Saini, R., & Hoyt, K. (2014) · Imaging in Medicine · doi:10.2217/iim.13.74 · Cited by 68 · see citing works

The microcirculation in adipose tissue inflammation

Scalia, R. G. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9236-x · Cited by 65 · see citing works

Super‐Resolution Ultrasound Imaging of Skeletal Muscle Microvascular Dysfunction in an Animal Model of Type 2 Diabetes

Ghosh, D., Peng, J., Brown, K., Sirsi, S. R., Mineo, C., Shaul, P. W., & Hoyt, K. (2019) · Journal of Ultrasound in Medicine · doi:10.1002/jum.14956 · Cited by 64 · see citing works

Insulin Sensitivity and Cardiovascular Risk Factors in Ovariectomized Monkeys with Estradiol Alone or Combined with Nomegestrol Acetate1

Wagner, J. D., Thomas, M. J., Williams, J. K., Zhang, L., Greaves, K. A., & Cefalu, W. T. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4628 · Cited by 56 · see citing works

C-Reactive Protein Causes Insulin Resistance in Mice Through Fcγ Receptor IIB–Mediated Inhibition of Skeletal Muscle Glucose Delivery

Tanigaki, K., Vongpatanasin, W., Barrera, J. A., Atochin, D. N., Huang, P. L., Bonvini, E., Shaul, P. W., & Mineo, C. (2012) · Diabetes · doi:10.2337/db12-0133 · Cited by 54 · see citing works

Hormone–PAMAM Dendrimer Conjugates: Polymer Dynamics and Tether Structure Affect Ligand Access to Receptors

Kim, S. H., & Katzenellenbogen, J. A. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200601923 · Cited by 53 · see citing works

ER Alpha Rapid Signaling Is Required for Estrogen Induced Proliferation and Migration of Vascular Endothelial Cells

Lu, Q. R., Schnitzler, G. R., Ueda, K., Iyer, L. K., Diomede, O. I., Andrade, T., & Karas, R. H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152807 · Cited by 52 · see citing works

Bazedoxifene and conjugated estrogen prevent diet-induced obesity, hepatic steatosis, and type 2 diabetes in mice without impacting the reproductive tract

Barrera, J. A., Chambliss, K. L., Ahmed, M. H., Tanigaki, K., Thompson, B. M., McDonald, J. G., Mineo, C., & Shaul, P. W. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00653.2013 · Cited by 49 · see citing works

Oestradiol replacement treatment and glucose homeostasis in two men with congenital aromatase deficiency: evidence for a role of oestradiol and sex steroids imbalance on insulin sensitivity in men

Rochira, V., Madeo, B., Zirilli, L., Caffagni, G., MAFFEI, L. E., & Carani, C. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02304.x · Cited by 45 · see citing works

Insulin Sensitivity and Cardiovascular Risk Factors in Ovariectomized Monkeys with Estradiol Alone or Combined with Nomegestrol Acetate

Wagner, J. D. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.3.896 · Cited by 41 · see citing works

Protocols for endothelial cell isolation from mouse tissues: brain, choroid, lung, and muscle

Conchinha, N. V., Sokol, L., Teuwen, L.-A. M. N., Veys, K., Dumas, S. J., Meta, E., García‐Caballero, M., Geldhof, V., Chen, R., Treps, L., et al. (2021) · STAR Protocols · doi:10.1016/j.xpro.2021.100508 · Cited by 39 · see citing works

Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice

Chambliss, K. L., Barrera, J. A., Umetani, M., Umetani, J., Kim, S. H., Madak‐Erdogan, Z., Huang, L., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Mineo, C., et al. (2016) · Endocrinology · doi:10.1210/en.2015-1629 · Cited by 36 · see citing works

The extra-nuclear interactome of the estrogen receptors: implications for physiological functions

Acconcia, F., Fiocchetti, M., Busonero, C., Fernandez, V. S., Montalesi, E., Cipolletti, M., Pallottini, V., & Marino, M. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111452 · Cited by 36 · see citing works

Molecular Mechanisms of Selective Estrogen Receptor Modulator Activity in Human Breast Cancer Cells: Identification of Novel Nuclear Cofactors of Antiestrogen–ERα Complexes by Interaction Proteomics

Cirillo, F., Nassa, G., Tarallo, R., Stellato, C., Filippo, M. R. D., Ambrosino, C., Baumann, M., Nyman, T. A., & Weisz, A. (2012) · Journal of Proteome Research · doi:10.1021/pr300753u · Cited by 36 · see citing works

Endothelial Estrogen Receptor-α Does Not Protect Against Vascular Stiffness Induced by Western Diet in Female Mice

Manrique, C. M., Lastra, G., Ramirez‐Perez, F. I., Haertling, D., DeMarco, V. G., Aroor, A. R., Jia, G., Chen, D., Barron, B. J., Garro, M., et al. (2016) · Endocrinology · doi:10.1210/en.2015-1681 · Cited by 28 · see citing works

Endothelium-derived essential signals involved in pancreas organogenesis.

Talavera-Adame, D., & Dafoe, D. (2015) · World Journal of Experimental Medicine · doi:10.5493/wjem.v5.i2.40 · Cited by 27 · see citing works

Endothelial Fcγ Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice

Tanigaki, K., Chambliss, K. L., Yuhanna, I. S., Sacharidou, A., Ahmed, M. H., Atochin, D. N., Huang, P. L., Shaul, P. W., & Mineo, C. (2016) · Diabetes · doi:10.2337/db15-1605 · Cited by 26 · see citing works

Transendothelial Insulin Transport is Impaired in Skeletal Muscle Capillaries of Obese Male Mice

Williams, I. M., McClatchey, P. M., Bracy, D. P., Bonner, J. S., Valenzuela, F. A., & Wasserman, D. H. (2020) · Obesity · doi:10.1002/oby.22683 · Cited by 22 · see citing works

Identification of cytoplasmic proteins interacting with unliganded estrogen receptor α and β in human breast cancer cells

Stellato, C., Nassa, G., Tarallo, R., Giurato, G., Ravo, M., Rizzo, F. M., Marchese, G., Alexandrova, E., Cordella, A., Baumann, M., et al. (2015) · PROTEOMICS · doi:10.1002/pmic.201400404 · Cited by 19 · see citing works

Sorting Nexin 5 and Dopamine D1 Receptor Regulate the Expression of the Insulin Receptor in Human Renal Proximal Tubule Cells

Li, F., Yang, J., Jones, J. E., Villar, V. A. M., Yu, P., Armando, I., Felder, R. A., & José, P. A. (2015) · Endocrinology · doi:10.1210/en.2014-1638 · Cited by 17 · see citing works

Multiscale and morphological analysis of microvascular patterns depicted in contrast-enhanced ultrasound images

Özdemir, İ., Peng, J., Ghosh, D., Sirsi, S. R., Mineo, C., Shaul, P. W., & Hoyt, K. (2020) · Journal of medical imaging · doi:10.1117/1.jmi.7.3.034001 · Cited by 17 · see citing works

Ligand Accessibility and Bioactivity of a Hormone–Dendrimer Conjugate Depend on pH and pH History

Kim, S. H., Madak‐Erdogan, Z., Bae, S. C., Carlson, K. E., Mayne, C. G., Granick, S., Katzenellenbogen, B. S., & Katzenellenbogen, J. A. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b05952 · Cited by 15 · see citing works

Sex difference in human diseases: mechanistic insights and clinical implications

Shi, Y., Ma, J., Li, S.-J., Liu, C., Liu, Y.-N., Chen, J., Liu, N.-N., Liu, S.-M., & Huang, H. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01929-7 · Cited by 71 · see citing works

Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan

Lee, A. A., & Den Hartigh, L. J. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1682231 · Cited by 32 · see citing works

Human umbilical cord-derived mesenchymal stromal cells improve myocardial fibrosis and restore miRNA-133a expression in diabetic cardiomyopathy

Liu, B., Wei, Y., He, J., Feng, B., Chen, Y., Guo, R., Griffin, M. D., Hynes, S. O., Shen, S., Liu, Y., et al. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03715-2 · Cited by 25 · see citing works

Nuclear receptors in metabolism and diseases: Mechanistic and therapeutic insights

Zhu, C.-Y., Yu, P., Sun, Q., Hong, D., Yang, C., & Naranmandura, H. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107862 · Cited by 18 · see citing works

Sex Differences in Kidney Health and Disease

Harvey, B. J., & de la Rosa, D. Á. (2024) · The Nephron journals/Nephron journals · doi:10.1159/000541352 · Cited by 20 · see citing works

Prevalence, Awareness, Treatment, and Control of Type 2 Diabetes in South Korea (1998 to 2022): Nationwide Cross-Sectional Study

Jang, W., Kim, S., Son, Y., Kim, S., Kim, H. J., Jo, H., Park, J., Lee, K., Lee, H., Tully, M. A., et al. (2024) · JMIR Public Health and Surveillance · doi:10.2196/59571 · Cited by 12 · see citing works

Acetobacter and lactobacillus alleviate the symptom of insulin resistance by blocking the JNK-JAK/STAT pathway in Drosophila melanogaster

Meng, Q., Li, Y., Xu, Y., & Wang, Y. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166901 · Cited by 10 · see citing works

Lipin1 ameliorates cognitive ability of diabetic encephalopathy via regulating Ca2+ transfer through mitochondria-associated endoplasmic reticulum membranes

Zhuang, Z., Huang, S., Zhang, X., Han, X., Hua, M., Liang, Z., Lou, N.-J., Lv, L., Zheng, F., Zhang, L. N., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114266 · Cited by 9 · see citing works

Trends in Liver Cirrhosis and Diabetes-Related Mortality Among Adults in the United States: A CDC WONDER Database Analysis (1999–2020)

Irfan, M., Ahmad, R., Ahmed, M. S., Khan, A. M., Aamir, Z., Imran, R., & Ahmed, R. (2025) · Life · doi:10.3390/life15060852 · Cited by 6 · see citing works

Regulation of Insulin Transcytosis Across Endothelium in Metabolic Health and Disease

Mineo, C., & Shaul, P. W. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.321545 · Cited by 6 · see citing works

Metformin as antiviral therapy protects hyperglycemic and diabetic patients

Wang, X., Zheng, X., Ge, H., Cui, N., Lin, L., Yue, M., Zhu, C., Zhou, Q., Song, P., Shang, X., et al. (2025) · mBio · doi:10.1128/mbio.00634-25 · Cited by 5 · see citing works

The sex-specific effects of RAGE signaling and type 2 diabetes on mouse cortical bone mechanics, structure, and material properties

Hung, T., Broz, K. S., Walk, R. E., & Tang, S. Y. (2025) · Mechanobiology in Medicine · doi:10.1016/j.mbm.2025.100132 · Cited by 5 · see citing works

FAM20A is a golgi-localized Type II transmembrane protein

Siddiqui, M. F., Li, J., Wang, S., Zhang, H., Qin, C., & Lu, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-57007-z · Cited by 5 · see citing works

Sex steroids, SHBG and type 2 diabetes in women: what do we really know?

Verhoog, N. J. D., Africander, D., & Storbeck, K. (2026) · Diabetologia · doi:10.1007/s00125-025-06647-5 · Cited by 4 · see citing works

High-Calorie Diet Exacerbates the Crosstalk Between Gestational Diabetes and Youth-Onset Diabetes in Female Offspring Through Disrupted Estrogen Signaling

Jia, X., Cao, X., Wang, Y., Yang, S., & Ji, L. (2025) · Nutrients · doi:10.3390/nu17132128 · Cited by 3 · see citing works

Apolipoprotein E receptor 2 in endothelium promote glucose tolerance by mediating insulin delivery to skeletal muscle

Sacharidou, A., Chambliss, K. L., Peng, J., Tanigaki, K., Islam, M. N., Sirsi, S. R., Lemoff, A. S., Hoyt, K., Mineo, C., & Shaul, P. W. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102238 · Cited by 3 · see citing works

Female Sex is Protective Against MASLD With Clinically Significant Fibrosis in a Large Cross-sectional Cohort of Persons With HIV

Wegermann, K., Suzuki, A., Sarmiento, E. J., Boyd, L. J., Li, Y., Wilson, L., Lloyd, A. R., Debroy, P., Price, J. C., Woreta, T. A., et al. (2025) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofaf637 · Cited by 2 · see citing works

Cognitive Resilience in Apolipoprotein ε4 Carrier Women Predicted by Neuron‐Derived Extracellular Vesicles

Manolopoulos, A., Mustapić, M., Nogueras‐Ortiz, C. J., Delgado‐Peraza, F., Pucha, K. A., Yao, P. J., Blommer, J. M., Vreones, M. P., York, W., Knight, D. L., et al. (2025) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.70143 · Cited by 2 · see citing works

Synergistic and mediating roles of the triglyceride-glucose index and stress hyperglycemia ratio in predicting in-hospital adverse events in acute aortic syndrome patients: a large retrospective cohort study

Xin, Y., Lyu, S., Wang, Y., & Yang, Y. (2026) · International Journal of Surgery · doi:10.1097/js9.0000000000005016 · Cited by 1 · see citing works

Endothelial NPR-C promotes insulin resistance via Caveolin-1-mediated insulin transcytosis

Xu, Z.-Q., Yu, X., Wei, J., Deng, Q.-W., Zhai, W.-H., Rong, W., Li, M.-Y., Zhang, Q.-R., Gao, P., Li, X.-D., et al. (2026) · Metabolism · doi:10.1016/j.metabol.2026.156686 · Cited by 1 · see citing works

A comparison of adiponectin-deficient mice reveals the fundamental role of intracellular adiponectinPreprint

Onodera, T., Kim, D.-S., Wang, M.-Y., Virostek, M., Chen, S., Kipp, Z. A., Bates, E. A., Li, Y., Crewe, C., Li, C., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.12.664095

Self-supervised localization of microbubbles for super-resolution ultrasound

Palaskar, R. J., & Hoyt, K. (2025) · IEEE International Ultrasonics Symposium · doi:10.1109/ius62464.2025.11201861

Burden and causes due to high fasting plasma glucose in China from 1990 to 2021: a systematic analysis and comparison with the global burden

Jia, F. (2026) · BMC Public Health · doi:10.1186/s12889-025-23115-2

Beyond GnRH analogues: The renaissance of estrogens in prostate cancer management

Matthys, M., Klein, C., Roumeguère, T., Bladou, F., Robert, G., & TOMBAL, B. F. (2026) · The French Journal of Urology · doi:10.1016/j.fjurol.2026.103139

Loss of Female Cardiovascular Protection in Diabetes: From Mechanisms to Intervention

Gady, J. P., Akter, S., VandeWiele, M., & Dong, F. (2026) · Cells · doi:10.3390/cells15211972

Abstract 392: Endothelial ERα Promotes Insulin Sensitivity by Enhancing Endothelial Insulin Transcytosis and Insulin Delivery to Skeletal Muscle

Chambliss, K. L., Peng, J., Sacharidou, A., Tanigaki, K., Barrera, J. A., Khan, S., Mineo, C., & Shaul, P. W. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.39.suppl_1.392

Regulation of Insulin Transcytosis Across Endothelium in Metabolic Health and Disease

Mineo, C., & Shaul, P. W. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.321545 · Cited by 6 · see citing works

<i>In vivo</i> stimulation of oestrogen receptor α increases insulin‐stimulated skeletal muscle glucose uptake

Gorres, B. K., Bomhoff, G. L., Morris, J. K., & Geiger, P. C. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.199018 · Cited by 116 · see citing works

Apolipoprotein E receptor 2 in endothelium promote glucose tolerance by mediating insulin delivery to skeletal muscle

Sacharidou, A., Chambliss, K. L., Peng, J., Tanigaki, K., Islam, M. N., Sirsi, S. R., Lemoff, A. S., Hoyt, K., Mineo, C., & Shaul, P. W. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102238 · Cited by 3 · see citing works

Activation of Estrogen Receptor · Potentiates Insulin-stimulated Glucose Uptake into Skeletal Muscle of Female Rats

Gorres, B. K., Bomhoff, G. L., & Geiger, P. C. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000389422.16514.33