The role of estrogen receptors in the control of energy and glucose homeostasis
Abstract
Estrogens have been related to energy balance and glucose metabolism for a long time; however, the mechanisms involved in their actions are now being unveiled. The development of ERalpha and ERbeta knockout mice has demonstrated the participation of these receptors in the regulation of many processes related to the control of energy homeostasis. These include food intake and energy expenditure, insulin sensitivity in the liver and muscle, adipocyte growth and its body distribution as well as the pancreatic beta-cell function. In addition, other membrane receptors unrelated to ERalpha and ERbeta function in key tissues involved in energy balance and glucose homeostasis, i.e. the islet of Langerhans and the hypothalamus. Along with naturally occurring estrogens, there are endocrine disrupters that act as environmental estrogens and can impair the physiological action of ERalpha, ERbeta and other membrane ERs. New research is revealing a link between environmental estrogenic pollutants and the metabolic syndrome.
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Estrogen actions in skeletal muscle, liver, adipose tissue, and immune cells are involved in insulin sensitivity and prevention of lipid accumulation and inflammation.
“Estrogen actions in skeletal muscle, liver, adipose tissue, and immune cells are involved in insulin sensitivity as well as prevention of lipid accumulation and inflammation [20,21,67,68].”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [67]
Estrogen actions in hypothalamic nuclei differentially control food intake, energy expenditure, and white adipose tissue distribution.
“Estrogen actions in hypothalamic nuclei differentially control food intake, energy expenditure, and white adipose tissue distribution [22,66,67].”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [67]
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Self-citation
- Authors
- Ropero, A. B., Alonso-Magdalena, P., Quesada, I., & Nadal, A.
- Affiliations
- Universitat de Miguel Hernández d'Elx (ES)
- ORCID
- Ropero, Ana B.
- Venue
- Steroids
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 73
- Issue
- 9-10
- Pages
- 874-879
- ISSN
- 0039-128X (ISSN-L)
- OpenAlex
- W2053127012
- Cited by
- 170
- References
- 67
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 13 · 2022: 6 · 2021: 12 · 2020: 7 · 2019: 6 · 2018: 10 · 2017: 13 · 2016: 6 · 2015: 10 · 2014: 9 · 2013: 8 · 2012: 10
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Steroids (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Educación, Cultura y Deporte (BFU2005-01052)
- Instituto de Salud Carlos III (ISCIII-RETIC RD06)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- estrogen receptor, estrogen receptor alpha, estrogen receptor beta, energy homeostasis, glucose homeostasis, dietary intake, energy expenditure, insulin sensitivity, beta-cell function, pancreatic islets, hypothalamus, membrane estrogen receptor, endocrine disruptors, xenoestrogens, metabolic syndrome
- MeSH terms
- Animals, Blood Glucose, Estrogens, Glucose, Models, Biological, Pancreas, Receptors, Estrogen, Transcription Factors, Mice, Knockout, Muscle, Skeletal, Estrogen Receptor alpha, Estrogen Receptor beta, Insulin-Secreting Cells, Glucose Transporter Type 4, Mice
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