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Cited by 114Microplastics and Plastic PollutionMicrofluidic and Bio-sensing TechnologiesEnvironmental Toxicology and Ecotoxicology

Nominally identical microplastic models differ greatly in their particle-cell interactions

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Wieland, Simon, Ramsperger, Anja F. R. M., Gross, Wolfgang, Lehmann, Moritz, Witzmann, Thomas, Caspari, Anja, Obst, Martin, Gekle, Stephan +4 more·2024·Nature Communications
DOI 10.1038/s41467-024-45281-4PMC PMC10830523
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Abstract

Due to the abundance of microplastics in the environment, research about its possible adverse effects is increasing exponentially. Most studies investigating the effect of microplastics on cells still rely on commercially available polystyrene microspheres. However, the choice of these model microplastic particles can affect the outcome of the studies, as even nominally identical model microplastics may interact differently with cells due to different surface properties such as the surface charge. Here, we show that nominally identical polystyrene microspheres from eight different manufacturers significantly differ in their ζ-potential, which is the electrical potential of a particle in a medium at its slipping plane. The ζ-potential of the polystyrene particles is additionally altered after environmental exposure. We developed a microfluidic microscopy platform to demonstrate that the ζ-potential determines particle-cell adhesion strength. Furthermore, we find that due to this effect, the ζ-potential also strongly determines the internalization of the microplastic particles into cells. Therefore, the ζ-potential can act as a proxy of microplastic-cell interactions and may govern adverse effects reported in various organisms exposed to microplastics.

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  • Relatively minor surface modifications resulting from UV-radiation, such as changes in electrical potential, can modify interactions of plastics with living cells, and hence can cause toxicity.

    “Relatively minor surface modifications resulting from UV-radiation, such as changes in electrical potential, can modify interactions of plastics with living cells, and hence can cause toxicity [136].”

    From Environmental consequences of interacting effects of changes in stratospheric ozone, ultraviolet radiation, and climate: UNEP Environmental Effects Assessment Panel, Update 2024 (2025) · cites this paper as [136]

    The Discussion (page not provided) says UV irradiation can change microplastics’ ζ-potential and therefore their interactions with cells. It also proposes that particles with a more negative ζ-potential could potentially be more toxic, but does not demonstrate that UV-induced changes cause toxicity or establish that those changes are relatively minor. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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Authors
Wieland, S., Ramsperger, A. F. R. M., Gross, W., Lehmann, M., Witzmann, T., Caspari, A., Obst, M., Gekle, S., Auernhammer, G. K., Fery, A., Laforsch, C., & Kress, H.
Affiliations
  • University of Bayreuth (DE)
  • Leibniz Institute of Polymer Research (DE)
Corresponding author
  • Laforsch, Christian
  • Kress, Holger
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2024-01-31
Volume
15
Issue
1
Pages
922-922
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-024-45281-4
PMC
PMC10830523
OpenAlex
W4391387772
Cited by
114
References
5
Citations by year
2026: 44 · 2025: 51 · 2024: 19
FWCI
11.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • EPub Bayreuth (University of Bayreuth) (acceptedVersion, other-oa)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Deutsche Forschungsgemeinschaft (391977956 – SFB 1357, INST 91/427–1 FUGG, OB362/4-1)
  • EC | Horizon 2020 Framework Programme (965367 (PlasticsFatE))
Topics
  • Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
Keywords
microplastics, polystyrene microspheres, particle-cell interactions, surface charge, environmental exposure
MeSH terms
Microplastics, Cell Communication, Environmental Monitoring, Microspheres, Plastics, Polystyrenes, Water Pollutants, Chemical

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