Associations of the intestinal microbiome with the complement system in neovascular age-related macular degeneration
Open accessAbstract
Age-related macular degeneration (AMD) is a leading cause of severe vision loss in the aged population. The etiology of AMD is multifactorial including nutritional factors, genetic variants mainly in the complement pathway, environmental risk factors and alterations in the intestinal microbiome. However, it remains unexplored whether there is an interdependency of these factors leading to the development of AMD. To investigate this issue, a shotgun metagenomics analysis of 57 neovascular AMD and 58 healthy controls as well as of 16 complement C3-deficient mice and 16 wildtypes was performed. Whereas the class Negativicutes was more abundant in patients, the genus Oscillibacter and species Bacteroides had a significantly higher prevalence in persons without AMD. Similar taxonomic features were identified that distinguished wildtype mice from C3-deficient mice. Moreover, several purine signaling pathways were associated with both, neovascular AMD and C3 deficiency. While SNPs within the complement factor B gene were more abundant in controls, SNPs within the high temperature requirement A serine peptidase 1 and complement factor H (CFH) genes were associated with neovascular AMD. Using a classification model, Negativicutes was identified as a potential biomarker for AMD and furthermore, it positively correlated with CFH. This study suggests an association between the intestinal microbiome and the complement system in neovascular AMD.
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Association studies have linked intestinal microbial products with the development and progression of age-related choroidal neovascularization (CNV) and age-related macular degeneration (AMD).
“Association studies have linked intestinal microbial products with the development and progression of age-related choroidal neovascularization (CNV) and age-related macular degeneration (AMD) [4, 131, 133].”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [133]
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- Authors
- Zysset-Burri, D. C., Keller, I., Berger, L. E., Largiadèr, C. R., Wittwer, M., Wolf, S., & Zinkernagel, M. S.
- Affiliations
- University of Bern (CH)
- Spiez Laboratory (CH)
- ORCID
- Venue
- npj Genomic Medicine
- Published
- 2020-09-01
- Volume
- 5
- Issue
- 1
- Pages
- 34-34
- ISSN
- 2056-7944 (ISSN-L)
- PMC
- PMC7463023
- OpenAlex
- W3082307877
- Cited by
- 94
- References
- 61
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 20 · 2023: 15 · 2022: 19 · 2021: 10
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- npj Genomic Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- BORIS (University Library Bern) (submittedVersion, cc-by)
- Open Access CRIS of the University of Bern
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Keywords
- neovascular age-related macular degeneration, gut microbiota, complement system, complement C3 deficiency, Negativicutes, Oscillibacter, Bacteroides, complement factor H, factor B, HTRA1, genetic susceptibility, biomarkers, shotgun metagenomics, C3-deficient mice
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