Association of the Intestinal Microbiome with the Development of Neovascular Age-Related Macular Degeneration
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Age-related macular degeneration (AMD) is the most frequent cause of blindness in the elderly. There is evidence that nutrition, inflammation and genetic risk factors play an important role in the development of AMD. Recent studies suggest that the composition of the intestinal microbiome is associated with metabolic diseases through modulation of inflammation and host metabolism. To investigate whether compositional and functional alterations of the intestinal microbiome are associated with AMD, we sequenced the gut metagenomes of patients with AMD and controls. The genera Anaerotruncus and Oscillibacter as well as Ruminococcus torques and Eubacterium ventriosum were relatively enriched in patients with AMD, whereas Bacteroides eggerthii was enriched in controls. Patient’s intestinal microbiomes were enriched in genes of the L-alanine fermentation, glutamate degradation and arginine biosynthesis pathways and decreased in genes of the fatty acid elongation pathway. These findings suggest that modifications in the intestinal microbiome are associated with AMD, inferring that this common sight threatening disease may be targeted by microbiome-altering interventions.
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Association studies have linked intestinal microbial products with the development and progression of age-related choroidal neovascularization (CNV) and age-related macular degeneration (AMD).
“Association studies have linked intestinal microbial products with the development and progression of age-related choroidal neovascularization (CNV) and age-related macular degeneration (AMD) [4, 131, 133].”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [131]
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The Human Ocular Surface Microbiome and Its Associations with the Tear Proteome in Dry Eye Disease
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Retinitis pigmentosa is associated with shifts in the gut microbiome
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The Emerging Role of Gut Microbiota in Age-Related Macular Degeneration
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Investigating the Ocular Surface Microbiome: What Can It Tell Us?
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- Authors
- Zinkernagel, M. S., Zysset-Burri, D. C., Keller, I., Berger, L. E., Leichtle, A. B., Largiadèr, C. R., Fiedler, G. M., & Wolf, S.
- Affiliations
- University of Bern (CH)
- Corresponding author
- Zinkernagel, Martin S.
- Venue
- Scientific Reports
- Published
- 2017-01-17
- Volume
- 7
- Issue
- 1
- Pages
- 40826-40826
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5240106
- OpenAlex
- W2572128045
- Cited by
- 229
- References
- 49
- Citations by year
- 2026: 28 · 2025: 24 · 2024: 28 · 2023: 29 · 2022: 31 · 2021: 31 · 2020: 21 · 2019: 16 · 2018: 15 · 2017: 6
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
- Open Access CRIS of the University of Bern
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- age-related macular degeneration, gut microbiota, gut metagenome, neovascular AMD, Anaerotruncus, Oscillibacter, Ruminococcus torques, Eubacterium ventriosum, Bacteroides eggerthii, glutamate degradation, arginine biosynthesis, fatty acid elongation, inflammation, host metabolism, microbiota-targeted interventions
- MeSH terms
- Gastrointestinal Microbiome, Aged, Bacteroides, Female, Humans, Macular Degeneration, Male, Middle Aged, Case-Control Studies, Ruminococcus
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