Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularization
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Age-related macular degeneration in its neovascular form (NV AMD) is the leading cause of vision loss among adults above the age of 60. Epidemiological data suggest that in men, overall abdominal obesity is the second most important environmental risk factor after smoking for progression to late-stage NV AMD To date, the mechanisms that underscore this observation remain ill-defined. Given the impact of high-fat diets on gut microbiota, we investigated whether commensal microbes influence the evolution of AMD Using mouse models of NV AMD, microbiotal transplants, and other paradigms that modify the gut microbiome, we uncoupled weight gain from confounding factors and demonstrate that high-fat diets exacerbate choroidal neovascularization (CNV) by altering gut microbiota. Gut dysbiosis leads to heightened intestinal permeability and chronic low-grade inflammation characteristic of inflammaging with elevated production of IL-6, IL-1β, TNF-α, and VEGF-A that ultimately aggravate pathological angiogenesis.
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Altered microbial composition has been associated with neovascularization and immune cell activation in retinal disease models.
“The altered microbial composition has also been associated with neovascularization and immune cell activation in retinal disease models [4, 50, 99].”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [4]
Association studies have linked intestinal microbial products with the development and progression of age-related choroidal neovascularization (CNV) and age-related macular degeneration (AMD).
“Association studies have linked intestinal microbial products with the development and progression of age-related choroidal neovascularization (CNV) and age-related macular degeneration (AMD) [4, 131, 133].”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [4]
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- Authors
- Andriessen, E. M., Wilson, A. M., Mawambo, G., Dejda, A., Miloudi, K., Sennlaub, F., & Sapieha, P.
- Affiliations
- Hôpital Maisonneuve-Rosemont (CA)
- Polytechnique Montréal (CA)
- McGill University (CA)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Sapieha, Przemyslaw
- Venue
- EMBO Molecular Medicine
- Published
- 2016-11-15
- Volume
- 8
- Issue
- 12
- Pages
- 1366-1379
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- PMC
- PMC5167134
- OpenAlex
- W2552235278
- Cited by
- 201
- References
- 70
- Citations by year
- 2026: 23 · 2025: 16 · 2024: 26 · 2023: 32 · 2022: 35 · 2021: 28 · 2020: 18 · 2019: 8 · 2018: 10 · 2017: 4 · 2016: 1
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- EMBO Molecular Medicine (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PolyPublie (École Polytechnique de Montréal) (submittedVersion, cc-by)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Foundation Fighting Blindness Canada
- Canadian Institutes of Health Research (324573)
- Canadian Diabetes Association (OG‐3‐11‐3329‐PS)
- Natural Sciences and Engineering Research Council of Canada (418637)
- Fondation de l'Avenir pour la Recherche Médicale Appliquée (RMA‐2015‐010)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- gut microbiota, choroidal neovascularization, age-related macular degeneration, obesity, abdominal obesity, high-fat diet, gut dysbiosis, intestinal permeability, inflammaging, pathological angiogenesis, VEGF-A, low-grade inflammation, microbiota transplantation
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Animals, Disease Models, Animal, Inflammation, Macular Degeneration, Neovascularization, Pathologic, Obesity, Cytokines, Choroidal Neovascularization, Gastrointestinal Tract, Mice, Diet, High-Fat, Dysbiosis
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