Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 347

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability

Hu, Wang Lai, Jin, Lei, Xu, An, Wang, Yu Fang, Thorne, Rick F., Zhang, Xu Dong, Wu, Mian·2018·Nature Cell Biology
DOI 10.1038/s41556-018-0066-7
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/s41556-018-0066-7

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 17 references

Research works printed but not linked: 52

  1. Hoeijmakers, J. H. J. The key role of DNA damage on cancer, aging and longevity. Environ. Mol. Mutagen. 53, S13 (2012).
  2. Best, B. P. Nuclear DNA damage as a direct cause of aging. Rejuvenation Res. 12, 199–208 (2009). · DOI
  3. Lahtz, C. & Pfeifer, G. P. Epigenetic changes of DNA repair genes in cancer. J. Mol. Cell Biol. 3, 51–58 (2011). · DOI · Paper page
  4. Xin, H. W., Liu, D. & Zhou, S. Y. The telosome/shelterin complex and its functions. Genome Biol. 9, 232 (2008). · DOI · Paper page
  5. Palm, W. & de Lange, T. How shelterin protects mammalian telomeres. Annu. Rev. Genet. 42, 301–334 (2008). · DOI · Paper page
  6. van Tuyn, J. & Adams, P. D. Signalling the end of the line. Nat. Cell Biol. 14, 339–341 (2012). · DOI
  7. Martinez, P. & Blasco, M. A. Role of shelterin in cancer and aging. Aging Cell 9, 653–666 (2010). · DOI · Paper page
  8. Majidinia, M. & Yousefi, B. DNA damage response regulation by microRNAs as a therapeutic target in cancer. DNA Repair 47, 1–11 (2016). · DOI
  9. Idogawa, M. et al. Identification and analysis of large intergenic non-coding RNAs regulated by p53 family members through a genome-wide analysis of p53-binding sites. Hum. Mol. Genet. 23, 2847–2857 (2014). · DOI
  10. Huarte, M. et al. A large intergenic noncoding RNA Induced by p53 mediates global gene repression in the p53 response. Cell 142, 409–419 (2010). · DOI · Paper page
  11. Schmitt, A. M. et al. An inducible long noncoding RNA amplifies DNA damage signaling. Nat. Genet. 48, 1370–1376 (2016). · DOI · Paper page
  12. Wang, W., Cheng, B., Miao, L., Mei, Y. & Wu, M. Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression. Cell Death Dis. 4, e574 (2013). · DOI
  13. Tsang, W. P., Ho, F. Y., Fung, K. P., Kong, S. K. & Kwok, T. T. p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int. J. Cancer 114, 331–336 (2005). · DOI
  14. Liu, D. P., Song, H. & Xu, Y. A common gain of function of p53 cancer mutants in inducing genetic instability. Oncogene 29, 949–956 (2010). · DOI · Paper page
  15. Jiang, P. et al. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat. Cell Biol. 13, 310–316 (2011). · DOI · Paper page
  16. Georgakilas, A. G. et al. Are common fragile sites merely structural domains or highly organized “functional” units susceptible to oncogenic stress? Cell. Mol. Life Sci. 71, 4519–4544 (2014). · DOI
  17. Henrich, K. O., Schwab, M. & Westermann, F. 1p36 tumor suppression—a matter of dosage? Cancer Res. 72, 6079–6088 (2012). · DOI
  18. Hunten, S. et al. p53-regulated networks of protein, mRNA, miRNA, and lncRNA expression revealed by integrated pulsed stable isotope labeling with amino acids in cell culture (pSILAC) and next generation sequencing (NGS) analyses. Mol. Cell. Proteom. 14, 2609–2629 (2015). · DOI
  19. Ashouri, A. et al. Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events. Nat. Commun. 7, 13197 (2016). · DOI
  20. Sarkar, S. et al. Different combinations of genetic/epigenetic alterations inactivate the p53 and pRb pathways in invasive human bladder cancers. Cancer Res. 60, 3862–3871 (2000).
  21. Li, Q. et al. C23 promotes tumorigenesis via suppressing p53 activity. Oncotarget. 7, 58274–58285 (2016). · DOI
  22. Debacq-Chainiaux, F., Erusalimsky, J. D., Campisi, J. & Toussaint, O. Protocols to detect senescence-associated β-galactosidase (SA-β-gal) activity, a biomarker of senescent cells in culture and in vivo. Nat. Protoc. 4, 1798–1806 (2009). · DOI · Paper page
  23. Sharma, V. et al. A BRCA1-interacting lncRNA regulates homologous recombination. EMBO Rep. 16, 1520–1534 (2015). · DOI
  24. Kartha, R. V & Subramanian, S. Competing endogenous RNAs (ceRNAs): new entrants to the intricacies of gene regulation. Front. Genet. 5, 8 (2014). · DOI · Paper page
  25. Dodd, D. W., Gagnon, K. T. & Corey, D. R. Digital quantitation of potential therapeutic target RNAs. Nucleic Acid. Ther. 23, 188–194 (2013). · DOI
  26. Luo, Z. H. et al. mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression. Aging Cell 14, 391–399 (2015). · DOI
  27. Choi, K. H., Farrell, A. S., Lakamp, A. S. & Ouellette, M. M. Characterization of the DNA binding specificity of shelterin complexes. Nucleic Acids Res. 39, 9206–9223 (2011). · DOI
  28. Yan, Y., Liang, Z., Du, Q., Yang, M. & Geller, D. A. MicroRNA-23a downregulates the expression of interferon regulatory factor-1 in hepatocellular carcinoma cells. Oncol. Rep. 36, 633–640 (2016). · DOI
  29. Baer, R. & Ludwig, T. The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity. Curr. Opin. Genet. Dev. 12, 86–91 (2002). · DOI · Paper page
  30. Brzovic, P. S., Rajagopal, P., Hoyt, D. W., King, M. C. & Klevit, R. E. Structure of a BRCA1–BARD1 heterodimeric RING–RING complex. Nat. Struct. Biol. 8, 833–837 (2001). · DOI
  31. Shrivastav, M., De Haro, L. P. & Nickoloff, J. A. Regulation of DNA double-strand break repair pathway choice. Cell Res. 18, 134–147 (2008). · DOI · Paper page
  32. Yin, D. et al. miR-34a functions as a tumor suppressor modulating EGFR in glioblastoma multiforme. Oncogene 32, 1155–1163 (2013). · DOI
  33. Okada, N. et al. A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression. Genes Dev. 28, 438–450 (2014). · DOI · Paper page
  34. Wynford-Thomas, D. p53: guardian of cellular senescence. J. Pathol. 180, 118–121 (1996). · doi:10.1002/(sici)1096-9896(199610)180:2<118::aid-path673>3.0.co;2-i
  35. Takai, H., Smogorzewska, A. & de Lange, T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549–1556 (2003). · DOI · Paper page
  36. Friedenson, B. The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers. BMC Cancer 7, 152 (2007). · DOI · Paper page
  37. Tapia, T. et al. Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors. Epigenetics 3, 157–163 (2008). · DOI
  38. Shen, J., Ambrosone, C. B. & Zhao, H. Novel genetic variants in microRNA genes and familial breast cancer. Int. J. Cancer 124, 1178–1182 (2009). · DOI
  39. Badie, S. et al. BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres. EMBO J. 34, 410–424 (2015). · DOI
  40. Isono, M. et al. BRCA1 directs the repair pathway to homologous recombination by promoting 53BP1 dephosphorylation. Cell Rep. 18, 520–532 (2017). · DOI · Paper page
  41. Feng, Z. & Zhang, J. A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest. Nucleic Acids Res. 40, 726–738 (2012). · DOI
  42. Bau, D. T., Mau, Y. C. & Shen, C. Y. The role of BRCA1 in non-homologous end-joining. Cancer Lett. 240, 1–8 (2006). · DOI
  43. Jiang, G. et al. BRCA1–Ku80 protein interaction enhances end-joining fidelity of chromosomal double-strand breaks in the G1 phase of the cell cycle. J. Biol. Chem. 288, 8966–8976 (2013). · DOI
  44. Brown, J. S., O’Carrigan, B., Jackson, S. P. & Yap, T. A. Targeting DNA repair in cancer: beyond PARP inhibitors. Cancer Discov. 7, 20–37 (2017). · DOI · Paper page
  45. Audeh, M. W. et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet 376, 245–251 (2010). · DOI · Paper page
  46. Tutt, A. et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet 376, 235–244 (2010). · DOI · Paper page
  47. Dong, L. et al. Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress. Oncogene 30, 3716–3726 (2011). · DOI
  48. Dodd, D. W., Gagnon, K. T. & Corey, D. R. Digital quantitation of potential therapeutic target RNAs. Nucleic Acid. Ther. 23, 188–194 (2013). · DOI
  49. Karbaschi, M. & Cooke, M. S. Novel method for the high-throughput processing of slides for the comet assay. Sci. Rep. 4, 7200 (2014). · doi:10.1038/srep07200
  50. Liu, X. Y. et al. RIP1 kinase is an oncogenic driver in melanoma. Cancer Res. 75, 1736–1748 (2015). · DOI
  51. Jin, L. et al. MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma. Proc. Natl Acad. Sci. USA 108, 15840–15845 (2011). · DOI · Paper page
  52. Guzman, C., Bagga, M., Kaur, A., Westermarck, J. & Abankwa, D. ColonyArea: an ImageJ plugin to automatically quantify colony formation in clonogenic assays. PLoS ONE 9, e92444 (2014). · DOI · Paper page

Cited by

See all 347

Metadata

Authors
Hu, W. L., Jin, L., Xu, A., Wang, Y. F., Thorne, R. F., Zhang, X. D., & Wu, M.
Venue
Nature Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2018-03-28
Volume
20
Issue
4
Pages
492-502
ISSN
  • 1465-7392 (ISSN-L)
  • 1476-4679
DOI
10.1038/s41556-018-0066-7
OpenAlex
W2795075229
Cited by
347
References
17
FWCI
14.16
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability. https://app.cochat.ai/papers/10.1038/s41556-018-0066-7
The paper
Hu, W. L., Jin, L., Xu, A., Wang, Y. F., Thorne, R. F., Zhang, X. D., & Wu, M. (2018). GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability. Nature Cell Biology. https://doi.org/10.1038/s41556-018-0066-7

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.