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Non-redundant functions of EMT transcription factors
Abstract
Epithelial-mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metastasis, continues to be debated. In this Review, we identify and describe specific, non-redundant functions of the different EMT-TFs and discuss the reasons that may underlie disputes about EMT in cancer.
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“Previously, ZEB1 was shown to play a critical role in epithelial-mesenchymal transition in neural crest migration and glioblastoma83,84”
From Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific cis-regulatory elements (2023) · cites this paper as [84]
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Metadata
- Authors
- Stemmler, M. P., Eccles, R. L., Brabletz, S., & Brabletz, T.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Corresponding author
- Brabletz, Thomas
- Venue
- Nature Cell Biology
- Published
- 2019-01
- Volume
- 21
- Issue
- 1
- Pages
- 102-112
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2898606030
- Cited by
- 524
- References
- 174
- Citations by year
- 2026: 31 · 2025: 46 · 2024: 79 · 2023: 69 · 2022: 79 · 2021: 107 · 2020: 79 · 2019: 34
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- epithelial-mesenchymal transition, EMT transcription factors, non-redundant function, cancer, metastasis, embryonic development, transcriptional regulation
- MeSH terms
- Animals, Humans, Models, Genetic, Neoplasms, Transcription Factors, Gene Expression Regulation, Neoplastic, Gene Expression Profiling, Embryonic Development, Epithelial-Mesenchymal Transition
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