Non-redundant functions of EMT transcription factors

An integrated encyclopedia of DNA elements in the human genome

The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072

Molecular mechanisms of epithelial–mesenchymal transition

Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091

EMT: 2016

Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492

Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?

Peinado, H., Olmeda, D., & Cano, A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2131 · Cited by 3,121

Collective cell migration in morphogenesis, regeneration and cancer

Friedl, P., & Gilmour, D. T. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2720 · Cited by 2,804

EMT and Dissemination Precede Pancreatic Tumor Formation

Rhim, A. D., Mirek, E. T., Aiello, N. M., Maitra, A., Bailey, J. M., McAllister, F., Reichert, M., Beatty, G. L., Rustgi, A. K., Vonderheide, R. H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.025 · Cited by 2,136

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

Zheng, X., Carstens, J. L., Kim, J., Scheible, M., Kaye, J. A., Sugimoto, H., Wu, C.-C., LeBleu, V. S., & Kalluri, R. (2015) · Nature · doi:10.1038/nature16064 · Cited by 2,018

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Viswanathan, V. S., Ryan, M. J., Dhruv, H. D., Gill, S., Eichhoff, O. M., Seashore-Ludlow, B., Kaffenberger, S. D., Eaton, J. K., Shimada, K., Aguirre, A. J., et al. (2017) · Nature · doi:10.1038/nature23007 · Cited by 2,011

EMT in cancer

Brabletz, T., Kalluri, R., Nieto, M. A., & Weinberg, R. A. (2018) · Nature Reviews Cancer · doi:10.1038/nrc.2017.118 · Cited by 1,961

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

Fischer, K. R., Durrans, A., Lee, S., Sheng, J., Li, F., Wong, S. T. C., Choi, H., El Rayes, T., Ryu, S., Troeger, J., et al. (2015) · Nature · doi:10.1038/nature15748 · Cited by 1,791

Oxidative Stress in Cancer

Hayes, J. D., Dinkova-Kostova, A. T., & Tew, K. D. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.001 · Cited by 2,654

Guidelines and definitions for research on epithelial-mesenchymal transition

Yang, J., Antin, P., Berx, G., Blanpain, C., Brabletz, T., Bronner, M., Campbell, K., Cano, A., Casanova, J., Christofori, G., et al. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0237-9 · Cited by 2,226

The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

Huang, Y., Hong, W., & Wei, X. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01347-8 · Cited by 1,097

Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis

Lu, W., & Kang, Y. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.04.010 · Cited by 1,039

EMT, MET, Plasticity, and Tumor Metastasis

Bakir, B. S., Chiarella, A. M., Pitarresi, J. R., & Rustgi, A. K. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.07.003 · Cited by 1,047

Epithelial-Mesenchymal Transition in Cancer: A Historical Overview

Ribatti, D., Tamma, R., & Annese, T. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100773 · Cited by 1,051

Dynamic EMT: a multi‐tool for tumor progression

Brabletz, S., Schuhwerk, H., Brabletz, T., & Stemmler, M. P. (2021) · The EMBO Journal · doi:10.15252/embj.2021108647 · Cited by 800

Tumor biomarkers for diagnosis, prognosis and targeted therapy

Zhou, Y., Tao, L., Qiu, J., Xu, J., Yang, X., Zhang, Y., Tian, X., Guan, X., Cen, X., & Zhao, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01823-2 · Cited by 836

Context-dependent EMT programs in cancer metastasis

Aiello, N. M., & Kang, Y. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181827 · Cited by 586

Linking EMT programmes to normal and neoplastic epithelial stem cells

Lambert, A. W., & Weinberg, R. A. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00332-6 · Cited by 548

Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression

Lüönd, F., Tiede, S., & Christofori, G. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01328-7 · Cited by 463

Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states

Simeonov, K. P., Byrns, C. N., Clark, M. L., Norgard, R. J., Martin, B., Stanger, B. Z., Shendure, J., McKenna, A., & Lengner, C. J. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.05.005 · Cited by 383

Cancer cell plasticity during tumor progression, metastasis and response to therapy

Pérez-González, A., Bévant, K., & Blanpain, C. (2023) · Nature Cancer · doi:10.1038/s43018-023-00595-y · Cited by 370

EMT and Cancer: More Than Meets the Eye

Derynck, R., & Weinberg, R. A. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.04.026 · Cited by 313

Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond

Tam, S. Y., Wu, V., & Law, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00486 · Cited by 319

Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance

Bhat, G. R., Sethi, I., Sadida, H. Q., Rah, B., Mir, R., Algehainy, N. A., Albalawi, I. A., Masoodi, T., Subbaraj, G. K., Jamal, F., et al. (2024) · Cancer and Metastasis Reviews · doi:10.1007/s10555-024-10172-z · Cited by 330

Emerging role of tumor cell plasticity in modifying therapeutic response

Qin, S., Jiang, J., Lü, Y., Nice, E. C., Huang, C., Zhang, J., & He, W. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00313-5 · Cited by 289

An early cell shape transition drives evolutionary expansion of the human forebrain

Benito-Kwiecinski, S. K., Giandomenico, S. L., Sutcliffe, M. A., Riis, E. S., Freire-Pritchett, P., Kelava, I., Wunderlich, S., Martin, U., Wray, G. A., McDole, K., et al. (2021) · Cell · doi:10.1016/j.cell.2021.02.050 · Cited by 272

GM-CSF: A Double-Edged Sword in Cancer Immunotherapy

Kumar, A., Khani, A. T., Ortiz, A. S., & Swaminathan, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.901277 · Cited by 287

A cellular hierarchy in melanoma uncouples growth and metastasis

Karras, P., Bordeu, I., Poźniak, J., Nowosad, A., Pazzi, C., Raemdonck, N. V., Landeloos, E., Herck, Y. V., Pedri, D., Bervoets, G., et al. (2022) · Nature · doi:10.1038/s41586-022-05242-7 · Cited by 261

The Role of Epithelial-to-Mesenchymal Plasticity in Ovarian Cancer Progression and Therapy Resistance

Loret, N., Denys, H. G., Tummers, P., & Berx, G. (2019) · Cancers · doi:10.3390/cancers11060838 · Cited by 250

Epigenetic regulation of epithelial-mesenchymal transition: focusing on hypoxia and TGF-β signaling

Lin, Y., & Wu, K. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-00632-3 · Cited by 239

Zinc-Dependent Regulation of ZEB1 and YAP1 Coactivation Promotes Epithelial-Mesenchymal Transition Plasticity and Metastasis in Pancreatic Cancer

Liu, M., Zhang, Y., Yang, J., Zhan, H., Zhou, Z., Jiang, Y., Shi, X., Fan, X., Zhang, J., Luo, W., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.12.077 · Cited by 211

Emerging Mechanisms by which EMT Programs Control Stemness

Wilson, M. M., Weinberg, R. A., Lees, J. A., & Guen, V. J. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.03.011 · Cited by 200

Molecular Bases of Drug Resistance in Hepatocellular Carcinoma

Marı́n, J. J. G., Macı́as, R. I. R., Monte, M. J., Romero, M. R., Asensio, M., Sánchez-Martín, A., Cives-Losada, C., Temprano, Á. G., Espinosa-Escudero, R. A., Reviejo, M., et al. (2020) · Cancers · doi:10.3390/cancers12061663 · Cited by 207

Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension

Gorelova, A., Berman, M., & Ghouleh, I. A. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8169 · Cited by 185

Epithelial-Mesenchymal Transition (EMT) as a Therapeutic Target

Jonckheere, S., Adams, J., Groote, D. D., Campbell, K., Berx, G., & Goossens, S. (2021) · Cells Tissues Organs · doi:10.1159/000512218 · Cited by 179

Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition

Schwab, A., Rao, Z., Zhang, J., Gollowitzer, A., Siebenkäs, K., Bindel, N., D’Avanzo, E., van Roey, R., Hajjaj, Y., Özel, E., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01464-1 · Cited by 183

EMT/MET plasticity in cancer and Go-or-Grow decisions in quiescence: the two sides of the same coin?

Akhmetkaliyev, A., Alibrahim, N., Shafiee, D., & Tulchinsky, E. M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01793-z · Cited by 174

Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis

Tanaka, K., Yu, H. A., Yang, S., Han, S., Selçuklu, S. D., Kim, K., Ramani, S., Ganesan, Y. T., Moyer, A. F., Sinha, S., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.07.006 · Cited by 169

Metastasis and MAPK Pathways

Kciuk, M., Gielecińska, A., Budzinska, A., Mojzych, M., & Kontek, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073847 · Cited by 170

Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities

Huang, Z., Zhang, Z., Zhou, C., Liu, L., & Huang, C. (2022) · MedComm · doi:10.1002/mco2.144 · Cited by 179

Genome‐wide cooperation of EMT transcription factor ZEB1 with YAP and AP‐1 in breast cancer

Feldker, N., Ferrazzi, F., Schuhwerk, H., Widholz, S. A., Guenther, K., Frisch, I., Jakob, K., Kleemann, J., Riegel, D., Bönisch, U., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019103209 · Cited by 171

Heterogeneity and plasticity of epithelial–mesenchymal transition (EMT) in cancer metastasis: Focusing on partial EMT and regulatory mechanisms

Li, D., Xia, L., Huang, P., Wang, Z., Guo, Q., Huang, C., Leng, W., & Qin, S. (2023) · Cell Proliferation · doi:10.1111/cpr.13423 · Cited by 163

Tumor Plasticity and Resistance to Immunotherapy

Horn, L. A., Fousek, K., & Palena, C. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.02.001 · Cited by 148

Role of Epithelial to Mesenchymal Transition in Colorectal Cancer

Lu, J., Kornmann, M., & Traub, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914815 · Cited by 156

The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation

Haerinck, J., Goossens, S., & Berx, G. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-023-00601-0 · Cited by 142

Endocytosis in the context-dependent regulation of individual and collective cell properties

Sigismund, S., Lanzetti, L., Scita, G., & Di Fiore, P. P. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00375-5 · Cited by 132

Budding epithelial morphogenesis driven by cell-matrix versus cell-cell adhesion

Wang, S., Matsumoto, K., Lish, S. R., Cartagena‐Rivera, A. X., & Yamada, K. M. (2021) · Cell · doi:10.1016/j.cell.2021.05.015 · Cited by 124

RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via stabilizing slug mRNA in an m6A-dependent manner

Yu, D., Pan, M., Li, Y., Lu, T., Wang, Z., Liu, C., & Hu, G. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02212-1 · Cited by 123

Vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced thermogenic adipocytes

Shamsi, F., Piper, M. E., Ho, L., Huang, T. L., Gupta, A., Streets, A., Lynes, M. D., & Tseng, Y. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00373-z · Cited by 123

EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis

Genna, A., Vanwynsberghe, A. M., Villard, A. V., Pottier, C., Ancel, J., Polette, M., & Gilles, C. (2020) · Cancers · doi:10.3390/cancers12061632 · Cited by 118

Single-Cell Analyses Reveal Mechanisms of Cancer Stem Cell Maintenance and Epithelial–Mesenchymal Transition in Recurrent Bladder Cancer

Wang, H., Mei, Y., Luo, C., Huang, Q., Wang, Z., Lu, G.-M., Qin, L., Sun, Z., Huang, C.-W., Yang, Z.-W., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-4796 · Cited by 116

Molecular mechanisms underpinning sarcomas and implications for current and future therapy

Damerell, V., Pepper, M. S., & Prince, S. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00647-8 · Cited by 120

Molecular regulation of Snai2 in development and disease

Zhou, W., Gross, K. M., & Kuperwasser, C. (2019) · Journal of Cell Science · doi:10.1242/jcs.235127 · Cited by 109

PRMT5 activates AKT via methylation to promote tumor metastasis

Huang, L., Zhang, X.-O., Rozen, E. J., Sun, X., Sallis, B., Verdejo‐Torres, O., Wigglesworth, K., Moon, D., Huang, T., Cavaretta, J. P., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31645-1 · Cited by 109

Endothelial to mesenchymal transition: at the axis of cardiovascular health and disease

Hall, I. F., Kishta, F., Xu, Y., Baker, A. H., & Kovacic, J. C. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae021 · Cited by 111

A PLCB1–PI3K–AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression

Liang, S., Guo, H., Ma, K., Li, X., Wu, D., Wang, Y., Wang, W., Zhang, S., Cui, Y., Liu, Y., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-1538 · Cited by 105

Dual role of E-cadherin in cancer cells

Rubtsova, S. N., Zhitnyak, I. Y., & Gloushankova, N. A. (2021) · Tissue Barriers · doi:10.1080/21688370.2021.2005420 · Cited by 104

EMT and Stemness—Key Players in Pancreatic Cancer Stem Cells

Rodríguez-Aznar, E., Wiesmüller, L., Sáinz, B., & Hermann, P. C. (2019) · Cancers · doi:10.3390/cancers11081136 · Cited by 99

Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer

Tagliazucchi, G. M., Wiecek, A. J., Withnell, E., & Secrier, M. (2023) · Nature Communications · doi:10.1038/s41467-023-36439-7 · Cited by 98

New Insights Into the Role of Phenotypic Plasticity and EMT in Driving Cancer Progression

Bhatia, S., Wang, P., Toh, A. K. L., & Thompson, E. W. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00071 · Cited by 99

A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer

Francescangeli, F., Contavalli, P., Angelis, M. L. D., Careccia, S., Signore, M., Haas, T. L., Salaris, F., Baiocchi, M., Boe, A., Giuliani, A., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1505-4 · Cited by 95

The transcription factor BACH1 at the crossroads of cancer biology: From epithelial–mesenchymal transition to ferroptosis

Igarashi, K., Nishizawa, H., Saiki, Y., & Matsumoto, M. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101032 · Cited by 89

Epithelial-to-Mesenchymal Transition in Fibrosis: Concepts and Targeting Strategies

Lovisa, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.737570 · Cited by 84

Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific cis-regulatory elements

Anderson, A. G., Rogers, B. B., Loupe, J. M., Rodriguez-Nunez, I., Roberts, S. C., White, L. M., Brazell, J. N., Bunney, W. E., Bunney, B. G., Watson, S. J., et al. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100263 · Cited by 82

Glioblastoma Microenvironment and Cellular Interactions

Crivii, C.-B., Boșca, A. B., Melincovici, C. S., Constantin, A.-M., Mărginean, M., Dronca, E., Suflețel, R., Gonciar, D., Bungărdean, M., & Șovrea, A. (2022) · Cancers · doi:10.3390/cancers14041092 · Cited by 81

Targeting cancer stem cells in squamous cell carcinoma

Chen, D., & Wang, C. (2019) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbz016 · Cited by 83

A “NOTCH” Deeper into the Epithelial-To-Mesenchymal Transition (EMT) Program in Breast Cancer

Kar, R., Jha, N. K., Jha, S. K., Sharma, A., Dholpuria, S., Asthana, N., Chaurasiya, K., Singh, V. K., Burgee, S., & Nand, P. (2019) · Genes · doi:10.3390/genes10120961 · Cited by 81

GREM1 is required to maintain cellular heterogeneity in pancreatic cancer

Lan, L., Evan, T., Li, H., Hussain, A., Ruiz, E. J., Thin, M. Z., Ferreira, R. M. M., Hari, P. S., Riising, E. M., Zen, Y., et al. (2022) · Nature · doi:10.1038/s41586-022-04888-7 · Cited by 86

The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype

Khatib, A., Solaimuthu, B., Yosef, M. B., Rmaileh, A. A., Tanna, M., Oren, G., Frisch, M. S., Axelrod, J. H., Lichtenstein, M., & Shaul, Y. D. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2010275117 · Cited by 80

The Post-Translational Regulation of Epithelial–Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis

Kang, E., Seo, J., Yoon, H., & Cho, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073591 · Cited by 81

Physiological functions of junctional adhesion molecules (JAMs) in tight junctions

Hartmann, C., Schwietzer, Y. A., Otani, T., Furuse, M., & Ebnet, K. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183299 · Cited by 84

Aneuploid Circulating Tumor-Derived Endothelial Cell (CTEC): A Novel Versatile Player in Tumor Neovascularization and Cancer Metastasis

Lin, P. P. (2020) · Cells · doi:10.3390/cells9061539 · Cited by 78

Quantifying Cancer Epithelial-Mesenchymal Plasticity and its Association with Stemness and Immune Response

Jia, D., Li, X., Bocci, F., Tripathi, S., Deng, Y., Jolly, M. K., Onuchic, J. N., & Levine, H. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050725 · Cited by 72

FAM83A signaling induces epithelial-mesenchymal transition by the PI3K/AKT/Snail pathway in NSCLC

Zhou, F., Geng, J., Xu, S., Meng, Q., Chen, K., Liu, F., Yang, F., Pan, B., & Yu, Y. (2019) · Aging · doi:10.18632/aging.102163 · Cited by 75

Roles of the Phosphorylation of Transcriptional Factors in Epithelial-Mesenchymal Transition

Xu, R., Won, J.-Y., Kim, C.-H., Kim, D., & Yim, H. (2019) · Journal of Oncology · doi:10.1155/2019/5810465 · Cited by 73

NCAPG2 overexpression promotes hepatocellular carcinoma proliferation and metastasis through activating the STAT3 and NF-κB/miR-188-3p pathways

Meng, F., Zhang, S., Song, R., Liu, Y., Wang, J., Liang, Y., Wang, J., Han, J., Song, X., Lu, Z., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.05.053 · Cited by 73

Snail1: A Transcriptional Factor Controlled at Multiple Levels

Baulida, J., Diaz, V. M., & de Herreros, A. G. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060757 · Cited by 78

EN1 Is a Transcriptional Dependency in Triple-Negative Breast Cancer Associated with Brain Metastasis

Peluffo, G., Subedee, A., Harper, N. W., Kingston, N. L., Jovanović, B., Flores, F. N., Stevens, L. E., de Beça, F. F., Trinh, A. C., Chilamakuri, C. S. R., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3264 · Cited by 69

Determinants of renal cell carcinoma invasion and metastatic competence

Kim, K., Zhou, Q.-B., Christie, A., Stevens, C., Ma, Y., Onabolu, O., Chintalapati, S., McKenzie, T., Tcheuyap, V., Woolford, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25918-4 · Cited by 69

Ubiquitin-specific protease 11 promotes partial epithelial-to-mesenchymal transition by deubiquitinating the epidermal growth factor receptor during kidney fibrosis

Shi, Y., Tao, M., Chen, H., Ma, X., Wang, Y., Hu, Y., Zhou, X. C., Li, J., Cui, B., Qiu, A., et al. (2022) · Kidney International · doi:10.1016/j.kint.2022.11.027 · Cited by 72

Inducible mouse models of colon cancer for the analysis of sporadic and inflammation-driven tumor progression and lymph node metastasis

Neufert, C. F., Heichler, C., Brabletz, T., Koop, K., Boonsanay, V., Greten, F. R., & Neurath, M. F. (2020) · Nature Protocols · doi:10.1038/s41596-020-00412-1 · Cited by 65

βIII-tubulin overexpression in cancer: Causes, consequences, and potential therapies

Kanakkanthara, A., & Miller, J. H. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188607 · Cited by 66

Epithelial-mesenchymal transition in colorectal cancer metastasis and progression: molecular mechanisms and therapeutic strategies

Nie, F., Sun, X., Sun, J., Zhang, J., & Wang, Y. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02593-8 · Cited by 77

Pathogenesis of periodontitis – A potential role for epithelial-mesenchymal transition

Saliem, S. S., Bede, S. Y. H., Cooper, P. R., Abdulkareem, A. A., Milward, M. R., & Abdullah, B. H. (2022) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2022.09.001 · Cited by 75

Epithelial to Mesenchymal Transition: Key Regulator of Pancreatic Ductal Adenocarcinoma Progression and Chemoresistance

Palamaris, K., Felekouras, E. S., & Sakellariou, S. (2021) · Cancers · doi:10.3390/cancers13215532 · Cited by 70

The roles of intratumour heterogeneity in the biology and treatment of pancreatic ductal adenocarcinoma

Evan, T., Wang, V. M.-Y., & Behrens, A. (2022) · Oncogene · doi:10.1038/s41388-022-02448-x · Cited by 66

GINS4 suppresses ferroptosis by antagonizing p53 acetylation with Snail

Chen, L., Cai, Q., Yang, R., Wang, H., Ling, H., Li, T., Liu, N., Wang, Z., Sun, J., Tao, T., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2219585120 · Cited by 63

Zeb2 drives invasive and microbiota-dependent colon carcinoma

Slowicka, K., Πέττα, Ι., Blancke, G., Hoste, E., Dumas, E., Sze, M., Vikkula, H., Radaelli, E., Haigh, J. J., Jonckheere, S., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-0070-2 · Cited by 64

Epithelial–Mesenchymal Transition Signaling and Prostate Cancer Stem Cells: Emerging Biomarkers and Opportunities for Precision Therapeutics

Chaves, L. P., Melo, C. M., Saggioro, F. P., dos Reis, R. B., & Squire, J. A. (2021) · Genes · doi:10.3390/genes12121900 · Cited by 66

Transcriptional census of epithelial-mesenchymal plasticity in cancer

Cook, D. P., & Vanderhyden, B. C. (2022) · Science Advances · doi:10.1126/sciadv.abi7640 · Cited by 59

Contribution of Epithelial Plasticity to Therapy Resistance

Santamaría, P. G., Moreno‐Bueno, G., & Cano, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050676 · Cited by 66

Epithelial–mesenchymal plasticity in kidney fibrosis

Hadpech, S., & Thongboonkerd, V. (2023) · genesis · doi:10.1002/dvg.23529 · Cited by 62

EMT and cancer: what clinicians should know

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Patel, S. A., Rodrigues, P., Wesolowski, L., & Vanharanta, S. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01127-6 · Cited by 57

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Zhu, Q., Sang, F., Withey, S., Tang, W. W. C., Dietmann, S., Klisch, D., Ramos‐Ibeas, P., Zhang, H., Requena, C. E., Hájková, P., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108735 · Cited by 58

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Cui, Y., Wu, L., Cao, R., Xu, H., Xia, J., Wang, Z. P., & Ma, J. (2019) · Journal of Cancer · doi:10.7150/jca.37890 · Cited by 57

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Guo, Q., Xu, J., Huang, Z., Yao, Q., Chen, F.-S., Liu, H., Zhang, Z., & Lin, J. (2020) · Clinical & Translational Oncology · doi:10.1007/s12094-020-02422-7 · Cited by 53

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Yang, Y., Feng, M., Bai, L., Liao, W., Zhou, K., Zhang, M., Wu, Q., Wen, F., Lei, W., Zhang, P., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03065-0 · Cited by 52

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