Cited by 530Cancer Cells and MetastasisTGF-β signaling in diseasesDevelopmental Biology and Gene Regulation

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Non-redundant functions of EMT transcription factors

Stemmler, Marc P., Eccles, Rebecca L., Brabletz, Simone, Brabletz, Thomas·2019·Nature Cell Biology

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Abstract

Epithelial-mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metastasis, continues to be debated. In this Review, we identify and describe specific, non-redundant functions of the different EMT-TFs and discuss the reasons that may underlie disputes about EMT in cancer.

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Authors: Stemmler, M. P., Eccles, R. L., Brabletz, S., & Brabletz, T.
Affiliations: Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Corresponding author: Brabletz, Thomas
ORCID: Stemmler, Marc P.
Eccles, Rebecca L.
Brabletz, Simone
Brabletz, Thomas
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2019-01
Volume: 21
Issue: 1
Pages: 102-112
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/s41556-018-0196-y
OpenAlex: W2898606030
Cited by: 524
References: 174
Citations by year: 2026: 31 · 2025: 46 · 2024: 79 · 2023: 69 · 2022: 79 · 2021: 107 · 2020: 79 · 2019: 34
FWCI: 5.77
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: epithelial-mesenchymal transition, EMT transcription factors, non-redundant function, cancer, metastasis, embryonic development, transcriptional regulation
MeSH terms: Animals, Humans, Models, Genetic, Neoplasms, Transcription Factors, Gene Expression Regulation, Neoplastic, Gene Expression Profiling, Embryonic Development, Epithelial-Mesenchymal Transition

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Non-redundant functions of EMT transcription factors

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