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FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age
Abstract
Tissue regeneration declines with ageing but little is known about whether this arises from changes in stem-cell heterogeneity. Here, in homeostatic skeletal muscle, we identify two quiescent stem-cell states distinguished by relative CD34 expression: CD34 High, with stemness properties (genuine state), and CD34 Low, committed to myogenic differentiation (primed state). The genuine-quiescent state is unexpectedly preserved into later life, succumbing only in extreme old age due to the acquisition of primed-state traits. Niche-derived IGF1-dependent Akt activation debilitates the genuine stem-cell state by imposing primed-state features via FoxO inhibition. Interventions to neutralize Akt and promote FoxO activity drive a primed-to-genuine state conversion, whereas FoxO inactivation deteriorates the genuine state at a young age, causing regenerative failure of muscle, as occurs in geriatric mice. These findings reveal transcriptional determinants of stem-cell heterogeneity that resist ageing more than previously anticipated and are only lost in extreme old age, with implications for the repair of geriatric muscle.
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“In muscle, MuSCs also exist as a heterogeneous quiescent population in adult mice30–33, with changes in heterogeneity with ageing32,34,35.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [32]
In the citing paper
“For example, subpopulations of MuSCs become more ‘primed’ (that is, poised towards a myogenic fate) with ageing32, whereas others adopt a more fibrogenic state16.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [32]
In the citing paper
“A subpopulation of MuSCs (identified by higher levels of CD34) appears to be preserved during ageing32.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [32]
In the citing paper
“Consistent with previous reports of the role of FOXO factors in HSC, MuSC and NSC quiescence85–90, constitutive deletion of three of the FOXO genes (FOXO1, FOXO3 and FOXO4) in the MuSC lineage during development results in the impairment of postnatal establishment of the MuSC population and a more rapid MuSC depletion with age32.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [32]
In the citing paper
“For example, FOXO transcription factors integrate growth factors and stress signal transduction pathways, and may represent a ‘hub’ for the action of various systemic factors in stem cells in ageing brain, muscle, blood and intestine32,85–90.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [32]
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
BEDTools: a flexible suite of utilities for comparing genomic features
Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
Kuleshov, M. V., Jones, M. R., Rouillard, A. D., Fernandez, N. F., Duan, Q., Wang, Z., Koplev, S., Jenkins, S. L., Jagodnik, K. M., Lachmann, A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw377 · Cited by 10,799
Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., & Greenleaf, W. J. (2013) · Nature Methods · doi:10.1038/nmeth.2688 · Cited by 6,422
Mechanism of activation of protein kinase B by insulin and IGF‐1.
Alessi, D. R., Andjelković, M., Caudwell, B., Cron, P. D., MORRICE, N. A., Cohen, P., & Hemmings, B. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01045.x · Cited by 3,014
Reimand, J., Isserlin, R., Voisin, V., Kucera, M., Tannus-Lopes, C., Rostamianfar, A., Wadi, L., Meyer, M., Wong, J., Xu, C., et al. (2019) · Nature Protocols · doi:10.1038/s41596-018-0103-9 · Cited by 1,970
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Moiseeva, V., Cisneros, A., Sica, V., Deryagin, O., Lai, Y., Jung, S., Andrés, E., An, J., Segalés, J., Ortet, L., et al. (2023) · Nature · doi:10.1038/s41586-022-05535-x · Cited by 423
Self-citationAgeing and rejuvenation of tissue stem cells and their niches
Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00510-w · Cited by 407
Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 402
Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity
de Morrée, A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00568-6 · Cited by 258
FOXO transcription factors as mediators of stress adaptation
Colman, M. J. R., Dansen, T. B., & Burgering, B. M. T. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00649-0 · Cited by 228
Multimodal cell atlas of the ageing human skeletal muscle
Lai, Y., Ramírez‐Pardo, I., Isern, J., An, J., Perdiguero, E., Serrano, A. L., Li, J., García-Domínguez, E., Segalés, J., Guo, P.-C., et al. (2024) · Nature · doi:10.1038/s41586-024-07348-6 · Cited by 247
Self-citationHong, X., Isern, J., Campanario, S., Perdiguero, E., Ramírez-Pardo, I., Segalés, J., Hernansanz-Agustín, P., Curtabbi, A., Deryagin, O., Pollán, A., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.07.009 · Cited by 213
Self-citationFOXO transcription factors as therapeutic targets in human diseases
Orea‐Soufi, A., Paik, J., Bragança, J., Donlon, T. A., Willcox, B. J., & Link, W. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.09.010 · Cited by 181
Liu, L. A., Kim, S., Buckley, M. T., Reyes, J. M., Kang, J., Tian, L., Wang, M., Lieu, A. C., Mao, M., Rodríguez-Mateo, C., et al. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.03.016 · Cited by 115
Schüler, S. C., Kirkpatrick, J. M., Schmidt, M., Santinha, D., Koch, P., Di Sanzo, S., Cirri, E., Hemberg, M., Ori, A., & von Maltzahn, J. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109223 · Cited by 106
A stem cell aging framework, from mechanisms to interventions
Liu, B., Qu, J. T., Zhang, W., Belmonte, J. C. I., & Liu, G. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111451 · Cited by 110
Epigenetic regulation of satellite cell fate during skeletal muscle regeneration
Massenet, J., Gardner, E., Chazaud, B., & Dilworth, F. J. (2021) · Skeletal Muscle · doi:10.1186/s13395-020-00259-w · Cited by 99
Interventions on Gut Microbiota for Healthy Aging
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Wang, X., & Zhou, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.952249 · Cited by 101
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Yue, F., Oprescu, S. N., Qiu, J., Gu, L., Zhang, L., Chen, J., Narayanan, N., Deng, M., & Kuang, S. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110267 · Cited by 80
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Huo, F., Liu, Q., & Liu, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.892749 · Cited by 74
Stem cell aging in the skeletal muscle: The importance of communication
Hong, X., Campanario, S., Ramírez‐Pardo, I., Grima-Terrén, M., Isern, J., & Muñoz‐Cánoves, P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101528 · Cited by 73
Self-citationInsights into muscle stem cell dynamics during postnatal development
Bachman, J. F., & Chakkalakal, J. V. (2021) · FEBS Journal · doi:10.1111/febs.15856 · Cited by 57
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Maraldi, T., Angeloni, C., Prata, C., & Hrelia, S. (2021) · Antioxidants · doi:10.3390/antiox10060973 · Cited by 60
Nutritional and Exercise Interventions in Cancer-Related Cachexia: An Extensive Narrative Review
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Zhao, Y. F., Ding, Y., He, L., Zhou, Q., Chen, X., Li, Y., Alfonsi, M. V., Wu, Z., Sun, H., & Wang, H. (2023) · Science Advances · doi:10.1126/sciadv.abo1360 · Cited by 56
Self-citationAnderson, J. E. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-021-04865-4 · Cited by 53
Gellhaus, B., Böker, K. O., Schilling, A. F., & Saul, D. (2023) · Cells · doi:10.3390/cells12242787 · Cited by 54
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Dong, A., Liu, J., Lin, K., Zeng, W., So, W., Hu, S., & Cheung, T. H. (2022) · iScience · doi:10.1016/j.isci.2022.104954 · Cited by 44
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Zhang, S., Yang, F., Huang, Y., He, L., Li, Y., Wan, Y. C. E., Ding, Y., Chan, K. M., Xie, T., Sun, H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40465-w · Cited by 36
Self-citationRestoration of CPEB4 prevents muscle stem cell senescence during aging
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Wang, Y. X., Palla, A. R., Ho, A. T. V., Robinson, D. C. L., Ravichandran, M., Markov, G. J., Mai, T., Still, C., Balsubramani, A., Nair, S., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.05.012 · Cited by 39
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Granet, J. A., Robertson, R., Cusmano, A. A., Filippelli, R. L., Lorenz, T. O., Li, S., Yaqubi, M., Stratton, J. A., & Chang, N. C. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07755-1 · Cited by 28
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Wang, J., Broer, T., Chavez, T., Zhou, C. J., Tran, S., Xiang, Y., Khodabukus, A., Diao, Y., & Bursac, N. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121508 · Cited by 28
Xie, C., Chan, L., Pang, Y., Shang, Y., Cao, W., Tuohan, M., Deng, Q., Wang, Y., Zhao, L., & Wang, W. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117158 · Cited by 26
Wang, K., Smith, S. H., Iijima, H., Hettinger, Z. R., Mallepally, A., Shroff, S. G., & Ambrosio, F. (2023) · Advanced Materials · doi:10.1002/adma.202207443 · Cited by 26
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Sun, Y., Wang, L., Xu, X., Han, P., Wu, J., Tian, X., & Li, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.659731 · Cited by 21
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Zhu, M., Lian, C., Chen, G., Zou, P., & Qin, B. G. (2021) · Aging · doi:10.18632/aging.203233 · Cited by 20
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Byun, W. S., Lee, J., & Baek, J.-H. (2024) · Inflammation and Regeneration · doi:10.1186/s41232-024-00354-1 · Cited by 20
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Maimaiti, Y., Abulitifu, M., Ajimu, Z., Su, T., Zhang, Z., Yu, Z., & Xu, H. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05592-1 · Cited by 24
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Self-citationAncel, S., Michaud, J., Sizzano, F., Tauzin, L., Oliveira, M., Migliavacca, E., Schüler, S. C., Raja, S., Dammone, G., Karaz, S., et al. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.05.005 · Cited by 16
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Feng, X., Wang, A. H., Juan, A. H., Ko, K. D., Jiang, K., Riparini, G., Ciuffoli, V., Kaba, A., Lopez, C., Naz, F., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.04.005 · Cited by 16
Self-citationDurand, A., Bonilla, N., Level, T., Ginestet, Z., Lombès, A., Guichard, V., Germain, M., Jacques, S., Letourneur, F., Cruzeiro, M. D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45984-8 · Cited by 20
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Wang, H., Bai, R., Wang, Y., Qu, M., Zhou, Y., Gao, Z., & Wang, Y. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123384 · Cited by 14
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Tan, R., Zhang, K., Si, Y., Zhang, S., Yang, J., & Hu, J. (2023) · ACS Nano · doi:10.1021/acsnano.3c09634 · Cited by 13
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Fujita, R., Mizuno, S., Sadahiro, T., Hayashi, T., Sugasawa, T., Sugiyama, F., Ono, Y., Takahashi, S., & Ieda, M. (2023) · iScience · doi:10.1016/j.isci.2023.106592 · Cited by 12
Forkhead box O proteins: steering the course of stem cell fate
Cheng, M., Nie, Y., Song, M., Chen, F., & Yu, Y. H. (2024) · Cell Regeneration · doi:10.1186/s13619-024-00190-1 · Cited by 13
Tan, Z., Pan, K., Sun, M., Pan, X., Yang, Z., Chang, Z., Yang, X., Zhu, J., Zhan, L., Liu, Y., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01360-z · Cited by 12
Age-Associated Loss in Renal Nestin-Positive Progenitor Cells
Buyan, M. I., Andrianova, N. V., Popkov, V. A., Zorova, L. D., Pevzner, I. B., Silachev, D. N., Zorov, D. B., & Plotnikov, E. Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911015 · Cited by 14
Li, S.-J., He, X.-L., Zhang, X., Li, Z.-R., Liu, H.-L., Zhang, Y., Lu, M.-Q., Chen, J., Dong, X.-M., Long, W., et al. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108109 · Cited by 16
Innovation in culture systems to study muscle complexity
Moyle, L. A., Davoudi, S., & Gilbert, P. M. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112966 · Cited by 13
Zufiría, M., Pikatza‐Menoio, O., Garciandia-Arcelus, M., Bengoetxea, X., Jiménez-Zúñiga, A., Elicegui, A., Levchuk, M., Arnold-García, O., Ondaro, J., Iruzubieta, P., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02794-y · Cited by 13
Self-citationFoxO1 signaling in B cell malignancies and its therapeutic targeting
Hlavac, K., Petra, P., Ondrišová, L., & Mráz, M. (2024) · FEBS Letters · doi:10.1002/1873-3468.15057 · Cited by 11
The extracellular matrix niche of muscle stem cells
Chrysostomou, E., & Mourikis, P. (2024) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2024.01.021 · Cited by 8
Horiguchi, M., Tsurudome, Y., & Ushijima, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126595 · Cited by 10
Potapov, I. S., García‐Prat, L., Ravichandran, S., Muñoz‐Cánoves, P., & del Sol, A. (2021) · FEBS Journal · doi:10.1111/febs.15832 · Cited by 10
Self-citationRapamycin improves satellite cells’ autophagy and muscle regeneration during hypercapnia
Balnis, J., Jackson, E. L., Drake, L. A., Singer, D. V., Ramos, R. B., Singer, H. A., & Jaitovich, A. (2024) · JCI Insight · doi:10.1172/jci.insight.182842 · Cited by 10
FoxO3 Regulates the Progress and Development of Aging and Aging-Related Diseases
Chang, Z., He, Z., & Xia, J. (2022) · Current Molecular Medicine · doi:10.2174/1566524023666221014140817 · Cited by 10
Satellite cells in the growth and maintenance of muscle
Bachman, J. F., & Chakkalakal, J. V. (2024) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2024.01.020 · Cited by 9
Xing, J., Xie, L., Qi, X., Liu, G., Akhtar, M. F., Li, X., Bou, G., Bai, D., Zhao, Y., Dugarjaviin, M., et al. (2023) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2023.101118 · Cited by 8
Riparini, G., Simone, J. M., & Sartorelli, V. (2022) · Journal of Visualized Experiments · doi:10.3791/63983 · Cited by 9
Self-citationOvercoming muscle stem cell aging
Memczak, S., & Belmonte, J. C. I. (2023) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2023.102127 · Cited by 8
Rodríguez-Outeiriño, L., Hernández‐Torres, F., de Acuña, F. R., Rastrojo, A., Creus, C., Carvajal, A., Salmerón, L. M., Montolio, M., Soblechero‐Martín, P., Arechavala‐Gomeza, V., et al. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.08.025 · Cited by 7
The Role of Nutrients in Maintaining Hematopoietic Stem Cells and Healthy Hematopoiesis for Life
Tadokoro, Y., & Hirao, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031574 · Cited by 11
Collao, N., Johannsen, E. B., Just, J., & Lisio, M. D. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00115.2025 · Cited by 6
Chen, S., Liu, Y., Chen, X., Tao, H., Piao, Y., Huang, H., Han, Z., Han, Z., Chen, X., & Li, Z. (2024) · Cell Proliferation · doi:10.1111/cpr.13679 · Cited by 6
Metadata
- Authors
- García-Prat, L., Perdiguero, E., Alonso-Martín, S., Dell’Orso, S., Ravichandran, S., Brooks, S. R., Juan, A. H., Campanario, S., Jiang, K., Hong, X., Ortet, L., Ruiz-Bonilla, V., Flández, M., Moiseeva, V., Rebollo, E., Jardí, M., Sun, H.-W., Musarò, A., Sandri, M., del Sol, A., Sartorelli, V., & Muñoz-Cánoves, P.
- Affiliations
- Universitat Pompeu Fabra (ES)
- National Institutes of Health (US)
- University of Luxembourg (LU)
- Spanish National Centre for Cardiovascular Research (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Istituto Pasteur (IT)
- University of Padua (IT)
- Corresponding author
- Ravichandran, Srikanth
- Sartorelli, Vittorio
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2020-10-26
- Volume
- 22
- Issue
- 11
- Pages
- 1307-1318
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W3094513505
- Cited by
- 161
- References
- 65
- Citations by year
- 2026: 20 · 2025: 22 · 2024: 28 · 2023: 29 · 2022: 38 · 2021: 23 · 2020: 1
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Open Repository and Bibliography (University of Luxembourg) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- FOXO, skeletal muscle stem cells, stem cell quiescence, aging, CD34, stem cell heterogeneity, insulin-like growth factor I, Akt signaling, myogenesis, muscle regeneration
- MeSH terms
- Cell Self Renewal, Forkhead Box Protein O1, Forkhead Box Protein O3, Age Factors, Animals, Cells, Cultured, Gene Expression Regulation, Male, Mice, Inbred C57BL, Phenotype, Regeneration, Signal Transduction, Mice, SCID, Cellular Senescence, Mice, Knockout, Muscle, Skeletal, Cell Cycle Proteins, Antigens, CD34, Satellite Cells, Skeletal Muscle, Cell Proliferation, Proto-Oncogene Proteins c-akt, Forkhead Transcription Factors, Cardiotoxins, Stem Cell Niche
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