Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy
Open accessAbstract
Skeletal muscle regeneration depends on the correct expansion of resident quiescent stem cells (satellite cells), a process that becomes less efficient with aging. Here, we show that mitochondrial dynamics are essential for the successful regenerative capacity of satellite cells. The loss of mitochondrial fission in satellite cells-due to aging or genetic impairment-deregulates the mitochondrial electron transport chain (ETC), leading to inefficient oxidative phosphorylation (OXPHOS) metabolism and mitophagy and increased oxidative stress. This state results in muscle regenerative failure, which is caused by the reduced proliferation and functional loss of satellite cells. Regenerative functions can be restored in fission-impaired or aged satellite cells by the re-establishment of mitochondrial dynamics (by activating fission or preventing fusion), OXPHOS, or mitophagy. Thus, mitochondrial shape and physical networking controls stem cell regenerative functions by regulating metabolism and proteostasis. As mitochondrial fission occurs less frequently in the satellite cells in older humans, our findings have implications for regeneration therapies in sarcopenia.
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During ageing, tissue regenerative functions decline, in part due to stem cell-intrinsic accumulation of damage, functional decay of niche cells and increased inflammation (inflammageing) through uncharacterized mechanisms.
“During ageing, tissue regenerative functions decline, in part due to stem cell-intrinsic accumulation of damage (for example, DNA damage, loss of proteostasis and oxidative damage), functional decay of niche cells and increased inflammation (inflammageing)4–9 through uncharacterized mechanisms.”
From Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration (2023) · cites this paper as [9]
Mitochondrial dynamics is essential for regulating muscle stem cell regeneration by regulating metabolism, protein balance, and mitophagy for regenerative therapies in sarcopenia.
“This process is essential for regulating muscle stem cell regeneration by regulating metabolism, protein balance, and mitophagy for regenerative therapies in sarcopenia [56].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [56]
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BackgroundMitochondrial dysfunction in the regulation of aging and aging-related diseases
Zhang, X., Gao, Y., Zhang, S., Wang, Y., Pei, X., Chen, Y., Zhang, J., Zhang, Y., Du, Y., Hao, S., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02308-7 · Cited by 175 · see citing works
“The re-expression of the DRP1 protein, along with the stimulation of oxidative phosphorylation and autophagy, can accelerate muscle stem cell expansion in aged mice [297].”
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“The normal operation of this network depends on several key processes, including mitochondrial dynamics (mediated by mitochondrial fusion and fission), mitophagy (involving mitochondrial self-clearance and protection), mitochondrial biogenesis, mitochondrial-derived vesicles, and others [18, 19].”
BackgroundEnergy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle
Zhuang, Y., Jiang, S., Deng, X., Lao, A., Hua, X., Xie, Y., Jiang, L., Wang, X., & Lin, K. (2024) · Science Advances · doi:10.1126/sciadv.adl0372 · Cited by 91 · see citing works
“Furthermore, mitophagy has attracted much attention in activating cell functions and rescuing mitochondrial dysfunctions ( 64 , 68 , 69 ).”
BackgroundSong, Z., Xia, Y., Shi, L., Zha, H., Huang, J., Xiang, X., Li, H., Huang, H., Yue, R., Wang, H., et al. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00553-1 · Cited by 79 · see citing works
“Knockout of Drp1 alters mitochondrial shape in muscle stem cells, leading to impaired muscle regeneration [43].”
BackgroundAutophagy in sarcopenia: Possible mechanisms and novel therapies
Xie, G., Jin, H., Mikhail, H., Pavel, V., Yang, G., Ji, B., Lu, B., & Li, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115147 · Cited by 57 · see citing works
Mitochondrial regulation in stem cells
Wang, Y., Barthez, M., & Chen, D. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.10.003 · Cited by 52 · see citing works
A new paradigm in intracellular immunology: Mitochondria emerging as leading immune organelles
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Is mitochondrial morphology important for cellular physiology?
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RetractedMuscle aging and sarcopenia: The pathology, etiology, and most promising therapeutic targets
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Emerging roles of mitochondrial functions and epigenetic changes in the modulation of stem cell fate
Zhang, C., Meng, Y., & Han, J. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05070-6 · Cited by 49 · see citing works
“Mitochondrial fission permits mitophagy in satellite cells during muscle regeneration [262].”
The Role of Mitochondria in Mediation of Skeletal Muscle Repair
Alway, S. E., Paez, H. G., & Pitzer, C. R. (2023) · Muscles · doi:10.3390/muscles2020011 · Cited by 42 · see citing works
Refeeding-associated AMPKγ1 complex activity is a hallmark of health and longevity
Ripa, R., Ballhysa, E., Steiner, J. D., Laboy, R., Annibal, A., Hochhard, N., Latza, C., Dolfi, L., Calabrese, C., Meyer, A. M., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00521-y · Cited by 43 · see citing works
The Potential Use of Mitochondrial Extracellular Vesicles as Biomarkers or Therapeutical Tools
Sanz‐Ros, J., Mas‐Bargues, C., Romero-García, N., Huete-Acevedo, J., Dromant, M., & Borrás, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087005 · Cited by 41 · see citing works
Age-Associated Differences in Recovery from Exercise-Induced Muscle Damage
Li, D. C. W., Rudloff, S., Langer, H. T., Norman, K., & Herpich, C. (2024) · Cells · doi:10.3390/cells13030255 · Cited by 41 · see citing works
“Inadequate mitochondrial autophagy (mitophagy) can impact myoblast differentiation and potentially activate the inflammatory process through the release of DAMPs or, in part, through NLRP3 [134–136].”
Endo, T. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.09.048 · Cited by 42 · see citing works
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“The animal health status, including body weight measurement, behavior observation, and responses to external stimuli, was monitored daily.”
Restoration of CPEB4 prevents muscle stem cell senescence during aging
Zeng, W., Zhang, W., Tse, E. H. Y., Liu, J., Dong, A., Lam, K. S. W., Luan, S., Küng, W., Chan, T. C., & Cheung, T. H. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.05.012 · Cited by 34 · see citing works
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“This is supported by a recent study that demonstrated the link between skeletal muscle aging and the proper function of mitochondrial dynamics in terms of energy and nutrient metabolism (Hong et al., 2022).”
Wang, J., Li, D., Zheng, L.-F., Ren, S., Huang, Z.-Q., Tao, Y., Liu, Z., Shang, Y., Pang, D., Guo, H., et al. (2024) · Developmental Cell · doi:10.1016/j.devcel.2023.12.005 · Cited by 30 · see citing works
Gong, S., Chen, H., Fang, S., Li, M., Hu, J., Li, Y., Yu, B., Kou, J., & Li, F. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70022 · Cited by 31 · see citing works
“With synchronized cycles of division, mitochondria can regulate mitophagy and uphold cellular homeostasis in response to different cellular stresses (Hong et al., 2022).”
Li, F., Zhang, F., Shi, H., Xia, H., Wei, X., Liu, S., Wu, T., Li, Y., Feng, S., Chen, M., et al. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13526 · Cited by 27 · see citing works
“…of P16, 6 defective autophagy 2 and diminished cyclin D1 expression 16 result in impaired activation, compromised mitochondrial fi ssion, 23 heightened Janus kinase (JAK)/STAT signalling activation 24 and aberrant epigenetic stress-induced Hoxa9-dependent activation, 25 all contributing…”
Cinat, D., Souza, A. L. D., Soto-Gamez, A., Bruin, A. L. J.-D., Coppes, R. P., & Barazzuol, L. (2023) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2023.110028 · Cited by 27 · see citing works
Sarcopenic obesity and osteoporosis: Research progress and hot spots
Fan, S., Cai, Y., Wei, Y., Yang, J., Gao, J., & Yang, Y. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112544 · Cited by 27 · see citing works
“This research has important implications for regenerative therapy of sarcopenia (Hong et al., 2022).”
Perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscle
Wang, K., Gan, M., Lei, Y., Liao, T., Li, J., Niu, L., Zhao, Y., Chen, L., Wang, Y., Zhu, L., et al. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00771-1 · Cited by 33 · see citing works
“In MuSCs, the effect on mitochondrial fission due to DRP1 deletion may simultaneously have an impact on the level of mitophagy, especially the accumulation of Parkin molecules in the mitochondrial membrane therein, which may lead to a blockage of regenerative processes [175].”
Mitochondrial dynamics and quality control regulate proteostasis in neuronal ischemia-reperfusion
Fogo, G. M., Raghunayakula, S., Emaus, K. J., Torres, F. J. T., Shangguan, G., Wider, J. M., Hüttemann, M., & Sanderson, T. H. (2025) · Autophagy · doi:10.1080/15548627.2025.2472586 · Cited by 26 · see citing works
“An abundance of evidence points to crosstalk between mitochondrial fission/fusion with mitophagy, pro-teostasis, and the mtUPR [54,82,83].”
Pan, X., Zhao, Y., Li, Y., Chen, J., Zhang, W., Yang, L., Xiong, Y. Z., Ying, Y., Xu, H., Zhang, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54720-1 · Cited by 24 · see citing works
“…which regulates fi ssion and fusion cycles, in cell culture and physiological development in animal models 54,77 , including stem cell plur-ipotency in culture 78 – 81 , neural stem cell and T-cell differentiation in development 15,82 – 84 , and competence of skeletal muscle stem cells 85 .”
The Essential Role of Mitochondrial Dynamics in Viral Infections
Duan, X., Liu, R., Lan, W., & Liu, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051955 · Cited by 24 · see citing works
“Disrupting the interaction of proteins related to mitochondrial fission adversely affects mitochondrial dynamics and consequently cell function [47,48].”
PINK1 deficiency alters muscle stem cell fate decision and muscle regenerative capacity
Cairns, G., Thumiah-Mootoo, M., Abbasi, M. R., Gourlay, M., Racine, J., Larionov, N., Prola, A., Khacho, M., & Burelle, Y. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.03.004 · Cited by 23 · see citing works
Deng, Y., Liu, Z., & Lü, M. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150021 · Cited by 23 · see citing works
Li, Y., Zhao, W., & Yang, Q. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1554222 · Cited by 23 · see citing works
Surma, M. L., Anbarasu, K., Dutta, S., Perez, L. J. O., Huang, K.-C., Meyer, J. S., & Das, A. (2023) · Communications Biology · doi:10.1038/s42003-023-04576-w · Cited by 23 · see citing works
Mitochondrial stress and aging: Lessons from C. elegans
Chen, P. X., Zhang, L., Chen, D., & Tian, Y. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.02.010 · Cited by 22 · see citing works
Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis
Wang, J., Jia, D., Zhang, Z., & Wang, D. (2025) · Metabolites · doi:10.3390/metabo15010059 · Cited by 23 · see citing works
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Peng, Y., Zhao, T., Rong, S., Yang, S., Teng, W., Xie, Y., & Wang, Y. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02818-5 · Cited by 22 · see citing works
“Mitochondrial dynamics, a highly controlled process that modulates the mitochondrial network, controls the regenerative capacities of stem cells [80].”
BackgroundMitochondrial Control for Healthy and Autoimmune T Cells
Li, J., Zhang, L., Liu, M., Ji, H., Wen, Z., & Wang, C. (2023) · Cells · doi:10.3390/cells12131800 · Cited by 19 · see citing works
“In addition, mitochondrial mitophagy also plays a vital role in autoimmune diseases [27].”
BackgroundCHK1 attenuates cardiac dysfunction via suppressing SIRT1-ubiquitination
Yang, T., Zhou, L., Gu, L., Qian, L.-L., Bao, Y.-L., Jing, P., Sun, J., Du, C., Shan, T., Wang, S., et al. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156048 · Cited by 18 · see citing works
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Mitochondria-targeting materials and therapies for regenerative engineering
Fu, H., Cheng, J., Hu, L., Heng, B. C., Zhang, X., Deng, X., & Liu, Y. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.123023 · Cited by 18 · see citing works
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RNA modifications: emerging players in the regulation of reproduction and development
Wen, J., Zhu, Q., Liu, Y., & Gou, L. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024201 · Cited by 19 · see citing works
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Energetic Calcium Phosphate Nanominerals for Osteoporosis Treatment
Cheng, X., Li, Y., Chui, X., Xin, Z., Ma, Z., Mei, P., Liu, C., Zhang, X., Wang, J., & Jian, X. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202415906 · Cited by 17 · see citing works
Maimaiti, Y., Abulitifu, M., Ajimu, Z., Su, T., Zhang, Z., Yu, Z., & Xu, H. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05592-1 · Cited by 18 · see citing works
Wang, M., Yang, Q., Li, Y., Zhao, Y., Zou, J., Luan, F., Peng, X., Huang, Z., & Liu, F. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01222-x · Cited by 17 · see citing works
“Insufficient or impaired mitophagy may accumulate damaged mitochondria in skeletal muscle [90].”
Wang, Y., Li, Q., Zhao, J., Chen, J., Wu, D., Zheng, Y., Wu, J., Liu, J., Lu, J., Zhang, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41700-0 · Cited by 17 · see citing works
“It was reported that the enhancement of oxidative phosphorylation could surmount mitochondrial fi ssion and functional failure 52 , while glycolysis was associated with mitochondrial dysfunction 53 .”
Optimised Skeletal Muscle Mass as a Key Strategy for Obesity Management
Barber, T. M., Kabisch, S., Pfeiffer, A. F. H., & Weickert, M. O. (2025) · Metabolites · doi:10.3390/metabo15020085 · Cited by 19 · see citing works
“It is beyond the scope of this review to provide a detailed exposition of the intra-cellular regulation of the SM in response to NEB, which has been described eloquently elsewhere [85].”
Huang, D., Yang, L., Guo, Y., Weng, M., Ye, H., Zhang, T., Lin, F., Zhang, K., & Fang, X. (2025) · Communications Biology · doi:10.1038/s42003-025-07654-3 · Cited by 15 · see citing works
“Disruption of the mitochondrial network leads to a disturbance in cellular energy metabolism 13 .”
Xie, Z., Zhang, X., Li, Y., & Zhu, R. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112913 · Cited by 16 · see citing works
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Chaperone-mediated autophagy sustains muscle stem cell regenerative functions but declines with age
Ramírez‐Pardo, I., Campanario, S., Chavda, B., Santiago‐Fernández, O., Flández, M., Grima-Terrén, M., Cisneros, A., Calls, A., Itzhak, D. N., Ngo, B., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01411-w · Cited by 14 · see citing works
“In this Article https://doi.org/10.1038/s42255-025-01411-w respectively) 12 .”
InfluentialBone regeneration strategies based on organelle homeostasis of mesenchymal stem cells
Xin, L., Wen, Y., Song, J., Chen, T., & Zhai, Q. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1151691 · Cited by 14 · see citing works
Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy
Xiao, Q., Sun, C., & Tang, C. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112335 · Cited by 14 · see citing works
“Mitochondria, as an important and essential organelle of skeletal muscle, produce ATP through oxidative phosphorylation (OXPHOS) and maintain energy homeostasis to meet the energy and contraction needs of skeletal muscle (Hong et al., 2022).”
BackgroundLiu, Q., Xie, L., & Chen, W. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113794 · Cited by 14 · see citing works
DBC1 maintains skeletal muscle integrity by enhancing myogenesis and preventing myofibre wasting
Liang, N., He, J., Yan, J., Han, X., Zhang, X., Niu, Y., Sha, W., & Li, J. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13398 · Cited by 14 · see citing works
Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure
Yoo, Y., Yeon, M., Kim, W., Shin, H.-B., Lee, S.-M., Yoon, M., Ro, H., & Seo, Y. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01199-x · Cited by 15 · see citing works
“4m), con fi rming that CL regulation by Crls1 during myogenesis affects muscle cell differentiation. shCrls1-mediated Crls1 downregulation induces mitochondrial dysfunction via mitochondrial structure disorder Next, we focused on comprehensively evaluating mitochondrial activity, cristae structure, the oxygen consumpti…”
BackgroundInfluentialMitonuclear Communication in Stem Cell Function
Peng, B., Wang, Y., & Zhang, H. (2024) · Cell Proliferation · doi:10.1111/cpr.13796 · Cited by 14 · see citing works
“Besides, through activating fission or preventing fusion, the re-establishment of mitochondrial dynamics can restore regenerative functions in fission-impaired or aged MuSCs [375].”
Xu, A., Wang, Y., Luo, D., Xia, Y., Xue, H., Yao, H., & Li, S. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31190 · Cited by 12 · see citing works
“Mitochondrial dynamics ‐ related proteins not only regulate the integrity of mitochondrial structure but also participate in various biological processes of mitochondria (Hong et al., 2022; Liu et al., 2019; Liu et al., 2023).”
BackgroundLiraglutide promotes angiogenesis in adipose tissue via suppression of adipocyte-derived IL-6
Zhang, R., Yao, K., Chen, S., Pan, X., Wu, F., & Gao, P. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.02.007 · Cited by 12 · see citing works
Ding, P., Wang, X., Gao, C., Wei, Y., Gan, L., Zhu, W., Wang, N., Fu, W., Fang, Q., Meng, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61808-9 · Cited by 11 · see citing works
Zhang, K., Wang, X., Zhang, Y., Li, Y., Wu, Y., Nuerlan, G., Li, Q., Mao, J., Gong, S., & Liu, Y. (2025) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.70031 · Cited by 13 · see citing works
Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva
Sun, L., Jin, Y., Nishio, M., Watanabe, M., Kamakura, T., Nagata, S., Fukuda, M., Maekawa, H., Kawai, S., Yamamoto, T., et al. (2024) · Life Science Alliance · doi:10.26508/lsa.202302219 · Cited by 11 · see citing works
Nanodrug Delivery Systems for Myasthenia Gravis: Advances and Perspectives
Huang, J., Zhao, Y., Song, Y., & Chen, T. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16050651 · Cited by 11 · see citing works
“Mitochondrial fission increases after muscle injury, leading to the induction of OXPHOS for maintaining normal mitochondrial dynamics and promoting muscle regeneration [91].”
BackgroundLiposome‐Enabled Nanomaterials for Muscle Regeneration
Wu, S., & Lu, J. (2025) · Small Methods · doi:10.1002/smtd.202402154 · Cited by 11 · see citing works
Vitamin A retinoic acid contributes to muscle stem cell and mitochondrial function loss in old age
Fraczek, P., Duran, P., Yang, B. A., Ferre, V., Alawieh, L., Castor-Macias, J. A., Wong, V., Guzman, S. D., Piotto, C., Itsani, K., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.183706 · Cited by 13 · see citing works
Mitochondrial disorders as a mechanism for the development of obese Sarcopenia
Liao, T., Xiong, L., Wang, X., Yang, S., & Liang, Z. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-01192-w · Cited by 10 · see citing works
“This research has implications for regeneration therapies in sarcopenia because mitochondrial fission occurs less frequently in satellite cells in older humans [100].”
BackgroundTrophoblast Syncytialization: A Metabolic Crossroads
Podinić, T., MacAndrew, A., & Raha, S. (2023) · Results and problems in cell differentiation · doi:10.1007/978-3-031-37936-9_6 · Cited by 10 · see citing works
Targeting Mitophagy as a Potential Therapeutic Approach for Age‐Related Bone Diseases
Zhang, K., Li, Q., Zhang, Y., Nuerlan, G., Li, Y., Mao, J., & Gong, S. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202400078 · Cited by 10 · see citing works
Lu, M., Li, W., Zhou, J., Shang, J., Lin, L., Liu, Y., & Zhu, X. (2024) · BMC Medicine · doi:10.1186/s12916-024-03675-7 · Cited by 10 · see citing works
Arcaro, A., Lepore, A., Cetrangolo, G. P., Paventi, G., Ames, P. R. J., & Gentile, F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167787 · Cited by 10 · see citing works
Hsu, W.-J., Hsu, M.-C., Chu, C., Lee, Y., Yang, C.-C., Liu, Z., Lee, C., Lin, Y.-S., & Lin, C. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103845 · Cited by 10 · see citing works
“Growing evidence suggests that stem-like tumor cells exhibit highly fragmented mitochondrial networks [26 – 28].”
Leveraging mitochondrial stress to improve healthy aging
Gorgori-González, A., Soto-Rodriguez, S., Tamayo-Torres, E., García-Domínguez, E., Sebastiá, V., Gambini, J., González, G. O., & Gómez‐Cabrera, M. C. (2025) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2025.10.003 · Cited by 12 · see citing works
Wang, L., Zheng, G., Wang, P., & Jia, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1343805 · Cited by 9 · see citing works
Mitochondria and pluripotency: from established models to emerging roles in adult stem cells
Labusca, L. S., & Zară-Dănceanu, C.-M. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1654593 · Cited by 10 · see citing works
Zhang, C., Zheng, X., Xiang, L., & Su, Z. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05441-6 · Cited by 9 · see citing works
Zhu, Y., Xiang, W., He, S., San, Z., Liu, W., Wu, J., Hayashi, T., Mizuno, K., Hattori, S., Fujisaki, H., et al. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.109905 · Cited by 9 · see citing works
Wang, J., Sun, T., Zhang, R., Wang, T., & Li, Y. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156176 · Cited by 8 · see citing works
dos Santos, F., Correia, M., Dias, R., Bola, B., Noberini, R., Ferreira, R. S., Trigo, D., Domingues, P. M., Teixeira, J., Bonaldi, T., et al. (2024) · Aging Cell · doi:10.1111/acel.14371 · Cited by 9 · see citing works
Zhao, Y., Zhang, C., Zhang, C., Zheng, X., Qi, Y., Kong, B., Hou, Y., Ti, Y., & Bu, P. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156571 · Cited by 9 · see citing works
DNM1L-mediated fission governs mitophagy & mitochondrial biogenesis during myogenic differentiation
Rahman, F. A., Yap, J. M. F., Joseph, T. M., Adam, A., Chapman, S. M., & Quadrilatero, J. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02142-x · Cited by 8 · see citing works
“The need for mitochondrial fission is also corroborated by more recent work in skeletal muscle stem cells (i.e., satellite cells) that lack DNM1L [24].”
InfluentialWu, J., Xu, J., Zhang, M., Zhong, J., Gao, W., & Wu, M. (2025) · Advances in Wound Care · doi:10.1089/wound.2024.0270 · Cited by 8 · see citing works
“81 DRP1 is recruited to the OMM by resident protein receptors.”
Li, H., Zhao, L., Li, J.-W., Zhang, K.-L., Bai, W., & Chen, Y. (2025) · Cell Biology and Toxicology · doi:10.1007/s10565-025-10035-5 · Cited by 7 · see citing works
“The fluorescence signal statistics were evaluated from five distinct dimensions (Hong et al. 2022).”
Mechanisms of Exercise in Improving Sarcopenia
Su, M., Shao, Y., Fang, Q., Li, Y., Qiu, F., Che, T., & Zhang, S. (2025) · Comprehensive physiology · doi:10.1002/cph4.70030 · Cited by 8 · see citing works
“…Dynamin-related Protein 1 (DRP1) gene knockout in mice leads to reduced MuSCs proliferation and impaired regenerative capacity, accompanied by dysfunctional oxidative phosphorylation, disrupted mitochondrial autophagy, excessive ROS accumulation, and abnormal mtDNA replication (Hong et al. 2022).”
TRPV1 signaling in skeletal muscle: A mini review of physiological and pathological roles
Ding, X., Zhu, C., Lu, Q., Zhang, Y., & Gao, B. (2025) · Cell Calcium · doi:10.1016/j.ceca.2025.103057 · Cited by 8 · see citing works
Imbalanced mitochondrial homeostasis in ocular diseases: unique pathogenesis and targeted therapy
Sun, H., Li, B., Gu, Y., Li, F., Di, G., & Chen, P. (2025) · Experimental Eye Research · doi:10.1016/j.exer.2025.110632 · Cited by 8 · see citing works
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“Mitochondria play a crucial role in cellular energy metabolism and homeostasis, exerting significant influence on cell fate determination and bioactivities [18,19].”
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“…fat infiltration, protein metabolism dysregulation, satellite cell dysfunction, oxidative stress, hormonal changes, neuronal dysfunction, and increased inflammatory cytokines are intricately linked to the onset of sarcopenia (Cruz-Jentoft and Sayer, 2019; Chen et al., 2024; Hong et al., 2022).”
Metabolic and molecular regulation in skeletal muscle dysfunction and regeneration
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- Authors
- Hong, X., Isern, J., Campanario, S., Perdiguero, E., Ramírez-Pardo, I., Segalés, J., Hernansanz-Agustín, P., Curtabbi, A., Deryagin, O., Pollán, A., González-Reyes, J. A., Villalba, J. M., Sandri, M., Serrano, A. L., Enríquez, J. A., & Muñoz-Cánoves, P.
- Affiliations
- Spanish National Centre for Cardiovascular Research (ES)
- Universitat Pompeu Fabra (ES)
- University of Córdoba (ES)
- University of Padua (IT)
- ORCID
- Venue
- Cell stem cell
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 29
- Issue
- 9
- Pages
- 1298-1314.e10
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W4292646798
- Cited by
- 213
- References
- 81
- Citations by year
- 2026: 53 · 2025: 68 · 2024: 51 · 2023: 36 · 2022: 5
- FWCI
- 13.05
- Type
- journal article
- Language
- en
- Update notices
- erratum (2022-10-06)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion, cc-by-nc-nd)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES16/10/00282)
- Milky Way Research Foundation
- European Commission (H2020, 202033, 825825)
- Associazione Italiana per la Ricerca sul Cancro
- Centro Nacional de Investigaciones Cardiovasculares (MDM-2014-0370, SEV‐2015‐0505, HR17-00040, ERC-2016-AdG-741966, UPGRADE-H2020-825825)
- Horizon 2020 Framework Programme (UPGRADE-H2020-825825, 825825)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- mitochondrial dynamics, satellite cells, muscle regeneration, aging, mitochondrial fission, mitochondrial fusion, mitophagy, oxidative phosphorylation, electron transport chain, oxidative stress, stem cell quiescence, sarcopenia, skeletal muscle stem cells
- MeSH terms
- Aged, Humans, Mitochondria, Muscles, Stem Cells, Muscle, Skeletal, Mitochondrial Dynamics, Mitophagy
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