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Behavioural clusters and predictors of performance during recovery from stroke
Open accessAbstract
We examined the patterns and variability of recovery post-stroke in multiple behavioral domains. A large cohort of first time stroke patients with heterogeneous lesions was studied prospectively and longitudinally at 1-2 weeks, 3 months and one year post-injury with structural MRI to measure lesion anatomy and in-depth neuropsychological assessment. Impairment was described at all timepoints by a few clusters of correlated deficits. The time course and magnitude of recovery was similar across domains, with change scores largely proportional to the initial deficit and most recovery occurring within the first three months. Damage to specific white matter tracts produced poorer recovery over several domains: attention and superior longitudinal fasciculus II/III, language and posterior arcuate fasciculus, motor and corticospinal tract. Finally, after accounting for the severity of the initial deficit, language and visual memory recovery/outcome was worse with lower education, while the occurrence of multiple deficits negatively impacted attention recovery.
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“It is well established that inter-individual variability in TLI in post-stroke aphasia is influenced by an array of factors, including, but not limited to, age12–15, education16–19, aphasia severity11,14,15,20,21, baseline cognitive abilities13,22,23, and, specific to bPWA, bilingual language experience and language of treatment (e.g., whether therapy is delivered in L1 or L2)24,25.”
From Machine Learning Predictions of Recovery in Bilingual Poststroke Aphasia: Aligning Insights With Clinical Evidence (2025) · cites this paper as [18]
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Metadata
- Authors
- Ramsey, L. E., Siegel, J. S., Lang, C. E., Strube, M., Shulman, G. L., & Corbetta, M.
- Affiliations
- Washington University in St. Louis (US)
- University of Padua (IT)
- Corresponding author
- Ramsey, L. E.
- Venue
- Nature Human Behaviour
- Published
- 2017-02-17
- Volume
- 1
- Issue
- 3
- ISSN
- 2397-3374 (ISSN-L)
- PMC
- PMC5508212
- OpenAlex
- W2588745466
- Cited by
- 219
- References
- 68
- Citations by year
- 2026: 18 · 2025: 24 · 2024: 26 · 2023: 22 · 2022: 34 · 2021: 29 · 2020: 16 · 2019: 25 · 2018: 18 · 2017: 7
- FWCI
- 17.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Human Behaviour (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, other-oa)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS095741)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD061117)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Keywords
- stroke recovery, behavioural deficits, white matter tracts, attention recovery, language recovery, motor recovery, educational attainment, superior longitudinal fasciculus, corticospinal tract, recovery time course
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