Lesion analysis of the brain areas involved in language comprehension
Open accessAbstract
The cortical regions of the brain traditionally associated with the comprehension of language are Wernicke's area and Broca's area. However, recent evidence suggests that other brain regions might also be involved in this complex process. This paper describes the opportunity to evaluate a large number of brain-injured patients to determine which lesioned brain areas might affect language comprehension. Sixty-four chronic left hemisphere stroke patients were evaluated on 11 subtests of the Curtiss-Yamada Comprehensive Language Evaluation - Receptive (CYCLE-R; Curtiss, S., & Yamada, J. (1988). Curtiss-Yamada Comprehensive Language Evaluation. Unpublished test, UCLA). Eight right hemisphere stroke patients and 15 neurologically normal older controls also participated. Patients were required to select a single line drawing from an array of three or four choices that best depicted the content of an auditorily-presented sentence. Patients' lesions obtained from structural neuroimaging were reconstructed onto templates and entered into a voxel-based lesion-symptom mapping (VLSM; Bates, E., Wilson, S., Saygin, A. P., Dick, F., Sereno, M., Knight, R. T., & Dronkers, N. F. (2003). Voxel-based lesion-symptom mapping. Nature Neuroscience, 6(5), 448-450.) analysis along with the behavioral data. VLSM is a brain-behavior mapping technique that evaluates the relationships between areas of injury and behavioral performance in all patients on a voxel-by-voxel basis, similar to the analysis of functional neuroimaging data. Results indicated that lesions to five left hemisphere brain regions affected performance on the CYCLE-R, including the posterior middle temporal gyrus and underlying white matter, the anterior superior temporal gyrus, the superior temporal sulcus and angular gyrus, mid-frontal cortex in Brodmann's area 46, and Brodmann's area 47 of the inferior frontal gyrus. Lesions to Broca's and Wernicke's areas were not found to significantly alter language comprehension on this particular measure. Further analysis suggested that the middle temporal gyrus may be more important for comprehension at the word level, while the other regions may play a greater role at the level of the sentence. These results are consistent with those seen in recent functional neuroimaging studies and offer complementary data in the effort to understand the brain areas underlying language comprehension.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The ventral aspect of BA46 lies in IFG, participates in language processes, and has been implicated in the genesis of AVHs.
“Although BA46 is typically viewed as a middle frontal region, its ventral aspect lies in IFG and participates in language processes (51–53) and has been implicated in the genesis of AVHs (26,54).”
From Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia (2011) · cites this paper as [53]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798 · see citing works
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565 · see citing works
Berti, A. (1992) · Neuropsychologia · doi:10.1016/0028-3932(92)90076-x · Cited by 4,190 · see citing works
Imaging Cognition II: An Empirical Review of 275 PET and fMRI Studies
Cabeza, R., & Nyberg, L. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/08989290051137585 · Cited by 3,598 · see citing works
Gazzaniga, M. S., & Bizzi, E. (2000) · Cited by 2,525 · see citing works
Towards a neural basis of auditory sentence processing
Friederici, A. D. (2002) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01839-8 · Cited by 2,231 · see citing works
Hickok, G., & Poeppel, D. (2004) · Cognition · doi:10.1016/j.cognition.2003.10.011 · Cited by 2,212 · see citing works
Hécaen, H. (1983) · Neuropsychologia · doi:10.1016/0028-3932(83)90089-1 · Cited by 1,700 · see citing works
A neural basis for lexical retrieval
Damásio, H., Grabowski, T. J., Tranel, D., Hichwa, R. D., & Damásio, A. R. (1996) · Nature · doi:10.1038/380499a0 · Cited by 1,602 · see citing works
Voxel-based lesion-symptom mapping
Bates, E., Wilson, S. M., Saygin, A. P., Dick, F., Sereno, M. I., Knight, R. T., & Dronkers, N. F. (2003) · Nature Neuroscience · doi:10.1038/nn1050 · Cited by 1,457 · see citing works
Self-citationHuman Brain Language Areas Identified by Functional Magnetic Resonance Imaging
Binder, J. R., Frost, J. A., Hammeke, T. A., Cox, R. W., Rao, S. M., & Prieto, T. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00353.1997 · Cited by 1,424 · see citing works
A new brain region for coordinating speech articulation
Dronkers, N. F. (1996) · Nature · doi:10.1038/384159a0 · Cited by 1,192 · see citing works
Self-citationThe neurology of syntax: Language use without Broca's area
Grodzinsky, Y. (2000) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00002399 · Cited by 1,167 · see citing works
Dissociation of algorithmic and heuristic processes in language comprehension: Evidence from aphasia
Caramazza, A., & Zurif, E. (1976) · Brain and Language · doi:10.1016/0093-934x(76)90048-1 · Cited by 1,161 · see citing works
Brain Activation Modulated by Sentence Comprehension
Just, M. A., Carpenter, P. A., Keller, T. A., Eddy, W. F., & Thulborn, K. R. (1996) · Science · doi:10.1126/science.274.5284.114 · Cited by 1,146 · see citing works
Adolphs, R., Damasio, H., Tranel, D., Cooper, G., & Damasio, A. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-07-02683.2000 · Cited by 1,095 · cited 1× · see citing works
“Adolphs, Damasio, Tranel, Cooper, & Damasio, 2000; Kertesz, 1979; Naeser & Hayward, 1978).”
Verbal working memory and sentence comprehension
Caplan, D. N., & Waters, G. S. (1999) · Behavioral and Brain Sciences · doi:10.1017/s0140525x99001788 · Cited by 1,079 · see citing works
Broca, P. P. (1861) · MPG.PuRe (Max Planck Society) · Cited by 944 · see citing works
DISTRIBUTION OF CORTICAL NEURAL NETWORKS INVOLVED IN WORD COMPREHENSION AND WORD RETRIEVAL
WISE, R., Chollet, F., Hadar, U., Friston, K. J., HOFFNER, E., & Frackowiak, R. S. J. (1991) · Brain · doi:10.1093/brain/114.4.1803 · Cited by 876 · see citing works
Maintenance versus Manipulation of Information Held in Working Memory: An Event-Related fMRI Study
D’Esposito, M., Postle, B. R., Ballard, D., & Lease, J. (1999) · Brain and Cognition · doi:10.1006/brcg.1999.1096 · Cited by 779 · see citing works
(1979) · Elsevier eBooks · doi:10.1016/c2013-0-07636-0 · Cited by 752 · see citing works
The Cortical Representation of Speech
Mazoyer, B. M., Tzourio‐Mazoyer, N., Frak, V., Syrota, A., Murayama, N., Levrier, O., Salamon, G., Dehaene, S., Cohen, L., & Mehler, J. (1993) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1993.5.4.467 · Cited by 712 · see citing works
Localization of Syntactic Comprehension by Positron Emission Tomography
Stromswold, K., Caplan, D. N., Alpert, N. M., & Rauch, S. L. (1996) · Brain and Language · doi:10.1006/brln.1996.0024 · Cited by 712 · see citing works
Cerebral organization of component processes in reading
Pugh, K. R., Shaywitz, B. A., Shaywitz, S. E., Constable, R. T., Skudlarski, P., Fulbright, R. K., Bronen, R. A., Shankweiler, D. P., Katz, L., Fletcher, J. M., et al. (1996) · Brain · doi:10.1093/brain/119.4.1221 · Cited by 613 · see citing works
Noun and verb retrieval by normal subjects Studies with PET
Warburton, E. A., Wise, R. J. S., Price, C. J., Weiller, C., Hadar, U., Ramsay, S. C., & Frackowiak, R. S. J. (1996) · Brain · doi:10.1093/brain/119.1.159 · Cited by 610 · see citing works
THE CORTICAL LOCALIZATION OF THE LEXICONS: POSITRON EMISSION TOMOGRAPHY EVIDENCE
HOWARD, D., PATTERSON, K., WISE, R., BROWN, W. D., FRISTON, K., WEILLER, C., & FRACKOWIAK, R. (1992) · Brain · doi:10.1093/brain/115.6.1769 · Cited by 585 · see citing works
Friederici, A. D., Meyer, M. E., & von Cramon, D. Y. (2000) · Brain and Language · doi:10.1006/brln.2000.2313 · Cited by 573 · see citing works
The Role of Parietal Cortex in Verbal Working Memory
Jonides, J. J., Schumacher, E. H., Smith, E. E., Koeppe, R. A., Awh, E., Reuter‐Lorenz, P. A., Marshuetz, C., & Willis, C. R. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-13-05026.1998 · Cited by 568 · see citing works
THE SELECTIVE IMPAIRMENT OF AUDITORY VERBAL SHORT-TERM MEMORY
Warrington, E. K., & Shallice, T. (1969) · Brain · doi:10.1093/brain/92.4.885 · Cited by 561 · see citing works
Broca aphasia: Pathologic and clinical
MOHR, J. P., PESSIN, M. S., FINKELSTEIN, S., FUNKENSTEIN, H. H., DUNCAN, G. W., & DAVIS, K. R. (1978) · Neurology · doi:10.1212/wnl.28.4.311 · Cited by 549 · see citing works
The word order problem in agrammatism
Schwartz, M. F., Saffran, E. M., & Marin, O. S. M. (1980) · Brain and Language · doi:10.1016/0093-934x(80)90055-3 · Cited by 492 · see citing works
The new cognitive neurosciences, 2nd ed.
Gazzaniga, M. S. (2000) · Cited by 470 · see citing works
The brain circuitry of syntactic comprehension
Kaan, E., & Swaab, T. Y. (2002) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(02)01947-2 · Cited by 428 · see citing works
Function of the left planum temporale in auditory and linguistic processing
Binder, J. R., Frost, J. A., Hammeke, T. A., Rao, S. M., & Cox, R. W. (1996) · Brain · doi:10.1093/brain/119.4.1239 · Cited by 408 · see citing works
Brain processing of native and foreign languages
Perani, D., Dehaene, S., Grassi, F., Cohen, L., Cappa, S. F., Emmanuel Dupoux, A., Fazio, F., & Mehler, J. (1996) · Neuroreport · doi:10.1097/00001756-199611040-00007 · Cited by 372 · see citing works
Miyake, A., Carpenter, P. A., & Just, M. A. (1994) · Cognitive Neuropsychology · doi:10.1080/02643299408251989 · Cited by 348 · see citing works
Friedrich, F. J., Egly, R., Rafal, R. D., & Beck, D. M. (1998) · Neuropsychology · doi:10.1037/0894-4105.12.2.193 · Cited by 320 · see citing works
FMRI reveals brain regions mediating slow prosodic modulations in spoken sentences
Meyer, M. E., Alter, K., Friederici, A. D., Lohmann, G., & von Cramon, D. Y. (2002) · Human Brain Mapping · doi:10.1002/hbm.10042 · Cited by 310 · see citing works
The Neurocognition of Language
Green, D. W. (2001) · Journal of Psychophysiology · doi:10.1027//0269-8803.15.1.48a · Cited by 306 · see citing works
Aphasia : a clinical perspective
Benson, D. F., & Ardila, A. (1996) · Oxford University Press eBooks · Cited by 301 · see citing works
The neurocognition of syntactic processing
Hagoort, P., Brown, C. M., & Osterhout, L. (2000) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198507932.003.0009 · Cited by 294 · see citing works
Agrammatism as a variable phenomenon
Kolk, H. H. J., & van Grunsven, M. J. F. (1985) · Cognitive Neuropsychology · doi:10.1080/02643298508252666 · Cited by 294 · see citing works
Berndt, R. S., & Caramazza, A. (1980) · Applied Psycholinguistics · doi:10.1017/s0142716400000552 · Cited by 290 · see citing works
Delineation of single‐word semantic comprehension deficits in aphasia, with anatomical correlation
Hart, J., & Gordon, B. (1990) · Annals of Neurology · doi:10.1002/ana.410270303 · Cited by 280 · see citing works
Language: Structure, Processing, and Disorders
Caplan, D. N. (1992) · Cited by 275 · see citing works
The neural correlates of language production
Indefrey, P., & Levelt, W. J. M. (2000) · MPG.PuRe (Max Planck Society) · Cited by 273 · see citing works
Syntactic determinants of sentence comprehension in aphasia
Caplan, D. N., Baker, C., & Dehaut, F. (1985) · Cognition · doi:10.1016/0010-0277(85)90048-4 · Cited by 272 · see citing works
Immediate memory for word lists and sentences in a patient with deficient auditory short-term memory
Saffran, E. M., & Marin, O. S. M. (1975) · Brain and Language · doi:10.1016/s0093-934x(75)80081-2 · Cited by 252 · see citing works
Aphasia and Associated Disorders: Taxonomy, Localization and Recovery
KERTESZ, A. E. (1979) · Cited by 250 · see citing works
Caplan, D. N., Hildebrandt, N., & Makris, N. (1996) · Brain · doi:10.1093/brain/119.3.933 · Cited by 241 · see citing works
Grammatical judgments of agrammatic aphasics
Zurif, E., Caramazza, A., & Myerson, R. (1972) · Neuropsychologia · doi:10.1016/0028-3932(72)90003-6 · Cited by 238 · see citing works
Contribution of Human Prefrontal Cortex to Delay Performance
Chao, L. L., & Knight, R. T. (1998) · Journal of Cognitive Neuroscience · doi:10.1162/089892998562636 · Cited by 232 · see citing works
Naeser, M. A., & Hayward, R. W. (1978) · Neurology · doi:10.1212/wnl.28.6.545 · Cited by 228 · see citing works
Disorders of Syntactic Comprehension
Caplan, D. N., & Hildebrandt, N. (1988) · Medical Entomology and Zoology · Cited by 220 · see citing works
Aphasia and associated disorders. Taxonomy, localization and recovery
Hécaen, H. (1980) · Neuropsychologia · doi:10.1016/0028-3932(80)90118-9 · Cited by 215 · see citing works
Localizing components of a complex task
Stowe, L. A., Broere, C. A. J., Paans, A. M. J., Wijers, A. A., Mulder, G., Vaalburg, W., & Zwarts, F. (1998) · Neuroreport · doi:10.1097/00001756-199809140-00014 · Cited by 206 · see citing works
Belger, A., Puce, A., Krystal, J. H., Gore, J. C., Goldman‐Rakic, P. S., & McCarthy, G. (1998) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(1998)6:1 · Cited by 203 · see citing works
Broca's area and Broca's aphasia
Mohr, J. P. (1976) · Medical Entomology and Zoology · Cited by 191 · see citing works
Disorders of syntactic comprehension
Lesser, R. (1989) · Biological Psychology · doi:10.1016/0301-0511(89)90025-2 · Cited by 188 · see citing works
Knight, R. T., Scabini, D., Woods, D. L., & Clayworth, C. C. (1988) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(88)90148-4 · Cited by 187 · see citing works
Attention-related modulation of activity in primary and secondary auditory cortex
Grady, C. L., Meter, J. W. V., Maisog, J. M., Pietrini, P., Krasuski, J., & Rauschecker, J. P. (1997) · Neuroreport · doi:10.1097/00001756-199707280-00019 · Cited by 169 · see citing works
Brain Activation During Silent Word Generation Evaluated with Functional MRI
Friedman, L., Kenny, J. T., Wise, A. L., Wu, D. H., Stuve, T. A., Miller, D. A., Jesberger, J. A., & Lewin, J. S. (1998) · Brain and Language · doi:10.1006/brln.1998.1953 · Cited by 169 · see citing works
The Effects of Semantic Category and Knowledge Type on Lexical-Semantic Access: A PET Study
Cappa, S. F., Perani, D., Schnur, T. T., Tettamanti, M., & Fazio, F. (1998) · NeuroImage · doi:10.1006/nimg.1998.0368 · Cited by 167 · see citing works
(1959) · Neurology · doi:10.1212/wnl.9.6.439 · Cited by 147 · see citing works
Language: Structure, processing, and disorders
Taylor, M. M., & Taylor, I. K. (1993) · Biological Psychology · doi:10.1016/0301-0511(93)90072-g · Cited by 135 · see citing works
Receptive and expressive language activations for sentences: a PET study
Müller, R.-A., Rothermel, R. D., Behen, M. E., Muzik, O., Mangner, T. J., & Chugani, H. T. (1997) · Neuroreport · doi:10.1097/00001756-199712010-00022 · Cited by 111 · see citing works
DeArmond, S. J. (1976) · Cited by 107 · see citing works
Syntax in the brain: Linguistic versus neuroanatomical specificity
Friederici, A. D., & von Cramon, D. Y. (2000) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0034239x · Cited by 13 · see citing works
Baldo, J. V., & Dronkers, N. F. (1999) · Brain and Language · Cited by 3 · see citing works
Self-citationBroca's region subserves imagery of motion: A combined cytoarchitectonic and fMRI study
Binkofski, F., Amunts, K., Stephan, K. M., Posse, S., Schormann, T., Freund, H.-J., Zilles, K., & Seitz, R. J. (2000) · Human Brain Mapping · doi:10.1002/1097-0193(200012)11:4
Flagged first, then by citations
2 of the 72 references couldn’t be matched to a known paper.
Research works printed but not linked: 6
- Baddeley, A. D. (1986). Working memory. Oxford: Oxford University Press.
- Dronkers, N. F., Redfern, B. B., & Ludy, C. (1995). Lesion localization in chronic Wernicke's aphasia. Brain and Language, 51(1), 62-65.
- Dronkers, N. F., Redfern, B. B., Ludy, C., & Baldo, J. (1998). Brain regions associated with conduction aphasia and echoic rehearsal. Journal of the International Neuropsychological Society, 4, 23-24.
- Dronkers, N. F., Shapiro, J. K., Redfern, B., & Knight, R. T. (1992). The role of Broca's area in Broca's aphasia. Journal of Clinical and Experimental Neuropsychology, 14, 52 -53.
- Dronkers, N. F., Wilkins, D. P., Van Valin, R., Jr., Redfern, B., & Jaeger, J. (1994b). A reconsideration of the brain areas involved in the disruption of morphosyntactic comprehension. Brain and Language, 47(3), 461-463.
- Schlosser, M. J., Aoyagi, N., Fulbright, R. K., Gore, J. C., & McCarthy, G. (1998). Functional MRI studies of auditory comprehension. Human Brain Mapping, 6(1), 1-13.
Cited by
Sorted by citations
Binder, J. R., Desai, R. H., Graves, W. W., & Conant, L. L. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp055 · Cited by 4,060 · see citing works
The neurobiology of semantic memory
Binder, J. R., & Desai, R. H. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.10.001 · Cited by 2,114 · see citing works
Meta-analyzing left hemisphere language areas: phonology, semantics, and sentence processing.
Vigneau, M., Beaucousin, V., Hervé, P. Y., Duffau, H., Crivello, F., Houdé, O., Mazoyer, B., & Tzourio-Mazoyer, N. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.11.002 · Cited by 1,851 · see citing works
A cortical network for semantics: (de)constructing the N400
Lau, E. F., Phillips, C., & Poeppel, D. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2532 · Cited by 1,688 · see citing works
Turken, A. U., & Dronkers, N. F. (2011) · Frontiers in System Neuroscience · doi:10.3389/fnsys.2011.00001 · Cited by 1,012 · see citing works
Self-citationThe Neural Bases of Social Cognition and Story Comprehension
Mar, R. A. (2011) · Annual Review of Psychology · doi:10.1146/annurev-psych-120709-145406 · Cited by 950 · see citing works
Cortical representation of the constituent structure of sentences
Pallier, C., Devauchelle, A.-D., & Dehaene, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018711108 · Cited by 691 · see citing works
Cognitive control and parsing: Reexamining the role of Broca’s area in sentence comprehension
Novick, J. M., Trueswell, J. C., & Thompson-Schill, S. L. (2005) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.5.3.263 · Cited by 682 · see citing works
The Neural Mechanisms of Speech Comprehension: fMRI studies of Semantic Ambiguity
Rodd, J. M., Davis, M. H., & Johnsrude, I. S. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi009 · Cited by 622 · see citing works
How neurons make meaning: brain mechanisms for embodied and abstract-symbolic semantics
Pulvermüller, F. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.06.004 · Cited by 631 · see citing works
Bornkessel‐Schlesewsky, I., & Schlesewsky, M. (2006) · Psychological Review · doi:10.1037/0033-295x.113.4.787 · Cited by 623 · see citing works
A complementary systems account of word learning: neural and behavioural evidence
Davis, M. H., & Gaskell, M. G. (2009) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2009.0111 · Cited by 577 · see citing works
Jefferies, E. (2013) · Cortex · doi:10.1016/j.cortex.2012.10.008 · Cited by 555 · see citing works
Broca and Wernicke are dead, or moving past the classic model of language neurobiology
Tremblay, P., & Dick, A. S. (2016) · Brain and Language · doi:10.1016/j.bandl.2016.08.004 · Cited by 548 · see citing works
Mapping anatomical correlations across cerebral cortex (MACACC) using cortical thickness from MRI
Lerch, J. P., Worsley, K. J., Shaw, P., GREENSTEIN, D. K., Lenroot, R., Giedd, J. N., & Evans, A. C. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.01.042 · Cited by 538 · see citing works
Resting-state brain networks: literature review and clinical applications
Rosazza, C., & Minati, L. (2011) · Neurological Sciences · doi:10.1007/s10072-011-0636-y · Cited by 509 · see citing works
Insights into Human Behavior from Lesions to the Prefrontal Cortex
Szczepanski, S. M., & Knight, R. T. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.011 · Cited by 504 · see citing works
Turken, U., Whitfield-Gabrieli, S., Bammer, R., Baldo, J. V., Dronkers, N. F., & Gabrieli, J. D. E. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.057 · Cited by 500 · see citing works
Self-citationSuperior Temporal Sulcus—It's My Area: Or Is It?
Hein, G., & Knight, R. T. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.20148 · Cited by 486 · see citing works
Verdon, V., Schwartz, S., Lövblad, K., Hauert, C.-A., & Vuilleumier, P. O. (2009) · Brain · doi:10.1093/brain/awp305 · Cited by 486 · see citing works
Phoneme and word recognition in the auditory ventral stream
DeWitt, I., & Rauschecker, J. P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113427109 · Cited by 459 · see citing works
Syntactic and Semantic Modulation of Neural Activity during Auditory Sentence Comprehension
Humphries, C., Binder, J. R., Medler, D. A., & Liebenthal, E. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.4.665 · Cited by 449 · see citing works
Neural Substrates of Phonemic Perception
Liebenthal, E., Binder, J. R., Spitzer, S. M., Possing, E. T., & Medler, D. A. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi040 · Cited by 448 · see citing works
The functional neuroanatomy of language
Hickok, G. S. (2009) · Physics of Life Reviews · doi:10.1016/j.plrev.2009.06.001 · Cited by 439 · see citing works
Common Behavioral Clusters and Subcortical Anatomy in Stroke
Corbetta, M., Ramsey, L., Callejas, A., Baldassarre, A., Hacker, C. D., Siegel, J. S., Astafiev, S. V., Rengachary, J., Zinn, K., Lang, C. E., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.027 · Cited by 442 · see citing works
Language processing in the occipital cortex of congenitally blind adults
Bedny, M., Pascual‐Leone, Á., Dodell‐Feder, D., Fedorenko, E. G., & Saxe, R. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014818108 · Cited by 424 · see citing works
Schwartz, M. F., Kimberg, D. Y., Walker, G. M., Faseyitan, O. K., Brecher, A. R., Dell, G. S., & Coslett, H. B. (2009) · Brain · doi:10.1093/brain/awp284 · Cited by 379 · see citing works
Neural localization of semantic context effects in electromagnetic and hemodynamic studies
Petten, C. K. V., & Luka, B. J. (2005) · Brain and Language · doi:10.1016/j.bandl.2005.11.003 · Cited by 374 · see citing works
The Cortical Organization of Syntax
Matchin, W., & Hickok, G. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhz180 · Cited by 370 · see citing works
Pelphrey, K. A., Morris, J. P., Michelich, C. R., Allison, T., & McCarthy, G. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi064 · Cited by 369 · see citing works
Advanced lesion symptom mapping analyses and implementation as BCBtoolkit
Foulon, C., Cerliani, L., Kinkingnéhun, S., Lévy, R., Rosso, C., Urbanski, M., Emmanuelle Volle, C., & de Schotten, M. T. (2018) · GigaScience · doi:10.1093/gigascience/giy004 · Cited by 359 · see citing works
Consequences, Action, and Intention as Factors in Moral Judgments: An fMRI Investigation
Schaich Borg, J., Hynes, C., Van Horn, J., Grafton, S., & Sinnott-Armstrong, W. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.5.803 · Cited by 355 · see citing works
Coupled neural systems underlie the production and comprehension of naturalistic narrative speech
Silbert, L. J., Honey, C. J., Simony, E., Poeppel, D., & Hasson, U. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323812111 · Cited by 352 · see citing works
The eloquent ape: genes, brains and the evolution of language
Fisher, S. E., & Marcus, G. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1747 · Cited by 349 · see citing works
Superior temporal and premotor brain areas necessary for biological motion perception
Saygın, A. P. (2007) · Brain · doi:10.1093/brain/awm162 · Cited by 341 · see citing works
Reconciling time, space and function: A new dorsal–ventral stream model of sentence comprehension
Bornkessel‐Schlesewsky, I., & Schlesewsky, M. (2013) · Brain and Language · doi:10.1016/j.bandl.2013.01.010 · Cited by 334 · see citing works
Acevedo, B. P., Aron, E. N., Aron, A. P., Sangster, M.-D. D., Collins, N. L., & Brown, L. L. (2014) · Brain and Behavior · doi:10.1002/brb3.242 · Cited by 329 · see citing works
Diversity of the inferior frontal gyrus—A meta-analysis of neuroimaging studies
Liakakis, G., Nickel, J., & Seitz, R. J. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.06.022 · Cited by 328 · see citing works
Neural bases of personal and extrapersonal neglect in humans
Committeri, G., Pitzalis, S., Galati, G., Patria, F., Pelle, G., Sabatini, U., Castriota-Scanderbeg, A., Piccardi, L., Guariglia, C., & Pizzamiglio, L. (2007) · Brain · doi:10.1093/brain/awl265 · Cited by 322 · see citing works
Lesion identification using unified segmentation-normalisation models and fuzzy clustering
Seghier, M. L., Ramlackhansingh, A. F., Crinion, J., Leff, A. P., & Price, C. J. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.028 · Cited by 319 · see citing works
A Neurocomputational Model of the N400 and the P600 in Language Processing
Brouwer, H., Crocker, M. W., Venhuizen, N. J., & Hoeks, J. C. J. (2016) · Cognitive Science · doi:10.1111/cogs.12461 · Cited by 319 · see citing works
Hippocampus activity differentiates good from poor learners of a novel lexicon
Breitenstein, C., Jansen, A., Deppe, M., Förster, A., Sommer, J. B., Wolbers, T., & Knecht, S. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.12.019 · Cited by 307 · see citing works
Neural organization of spoken language revealed by lesion–symptom mapping
Mirman, D., Chen, Q., Zhang, Y.-S., Wang, Z., Faseyitan, O. K., Coslett, H. B., & Schwartz, M. F. (2015) · Nature Communications · doi:10.1038/ncomms7762 · Cited by 290 · see citing works
The language network as a natural kind within the broader landscape of the human brain
Fedorenko, E. G., Ivanova, A. A., & Regev, T. I. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00802-4 · Cited by 327 · see citing works
Herbet, G., & Duffau, H. (2020) · Physiological Reviews · doi:10.1152/physrev.00033.2019 · Cited by 299 · see citing works
Modelling the N400 brain potential as change in a probabilistic representation of meaning
Rabovsky, M., Hansen, S. S., & McClelland, J. L. (2018) · Nature Human Behaviour · doi:10.1038/s41562-018-0406-4 · Cited by 290 · see citing works
Towards a New Neurobiology of Language
Poeppel, D., Emmorey, K. D., Hickok, G. S., & Liina Pylkkänen, A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3244-12.2012 · Cited by 287 · see citing works
Leff, A. P., Schofield, T. M., Crinion, J., Seghier, M. L., Grogan, A., Green, D. W., & Price, C. J. (2009) · Brain · doi:10.1093/brain/awp273 · Cited by 286 · see citing works
Lebel, C. A., & Beaulieu, C. (2009) · Human Brain Mapping · doi:10.1002/hbm.20779 · Cited by 281 · see citing works
Expectancy Constraints in Degraded Speech Modulate the Language Comprehension Network
Obleser, J., & Kotz, S. A. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp128 · Cited by 283 · see citing works
Martino, J., De Witt Hamer, P. C., Berger, M. S., Lawton, M. T., Arnold, C. M., de Lucas, E. M., & Duffau, H. (2013) · Brain Structure and Function · doi:10.1007/s00429-012-0386-5 · Cited by 280 · see citing works
Syntactic structure building in the anterior temporal lobe during natural story listening
Brennan, J., Nir, Y., Hasson, U., Malach, R., Heeger, D. J., & Pylkkänen, L. (2012) · Brain and Language · doi:10.1016/j.bandl.2010.04.002 · Cited by 279 · see citing works
Hutchinson, J. B., Uncapher, M. R., & Wagner, A. D. (2009) · Learning & Memory · doi:10.1101/lm.919109 · Cited by 277 · see citing works
Resting functional connectivity of language networks: characterization and reproducibility
Tomasi, D. G., & Volkow, N. D. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.177 · Cited by 269 · see citing works
Corina, D., Loudermilk, B. C., Detwiler, L. T., Martin, R. F., Brinkley, J., & Ojemann, G. (2010) · Brain and Language · doi:10.1016/j.bandl.2010.04.001 · Cited by 214 · see citing works
Okada, K., Rong, F., Venezia, J., Matchin, W., Hsieh, I.-H., Saberi, K., Serences, J. T., & Hickok, G. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp318 · Cited by 262 · see citing works
Whitney, C., Kirk, M., O'Sullivan, J., Ralph, M. A. L., & Jefferies, E. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00123 · Cited by 262 · see citing works
Hickok, G. S. (2012) · Journal of Communication Disorders · doi:10.1016/j.jcomdis.2012.06.004 · Cited by 260 · see citing works
Fusion and Fission of Cognitive Functions in the Human Parietal Cortex
Humphreys, G. F., & Ralph, M. A. L. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu198 · Cited by 252 · see citing works
Damage to ventral and dorsal language pathways in acute aphasia
Kümmerer, D., Hartwigsen, G., Kellmeyer, P., Glauche, V., Mader, I., Klöppel, S., Suchan, J., Karnath, H., Weiller, C., & Saur, D. (2013) · Brain · doi:10.1093/brain/aws354 · Cited by 255 · see citing works
TYLER, L. K., Marslen‐Wilson, W. D., Randall, B., Wright, P. K., Devereux, B. J., Zhuang, J., Papoutsi, M., & Stamatakis, E. A. (2011) · Brain · doi:10.1093/brain/awq369 · Cited by 258 · see citing works
Lesion Mapping of Cognitive Abilities Linked to Intelligence
Gläscher, J. P., Tranel, D., Paul, L. K., Rudrauf, D., Rorden, C., Hornaday, A., Grabowski, T. J., Damásio, H., & Adolphs, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.026 · Cited by 258 · see citing works
TYLER, L. K., Shafto, M. A., Randall, B., Wright, P. K., Marslen‐Wilson, W. D., & Stamatakis, E. A. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp105 · Cited by 246 · see citing works
Flowers, H. L., Silver, F. L., Fang, J., Rochon, E., & Martino, R. (2013) · Journal of Communication Disorders · doi:10.1016/j.jcomdis.2013.04.001 · Cited by 249 · see citing works
The neuroanatomic and neurophysiological infrastructure for speech and language
Poeppel, D. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.07.005 · Cited by 245 · see citing works
Rapp, A. M., Mutschler, D. E., & Erb, M. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.06.022 · Cited by 247 · see citing works
Caspers, S., Eickhoff, S. B., Tobias Rick, A., Anette Von Kapri, A., Kuhlen, T., Huang, R., Shah, N. J., & Zilles, K. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.027 · Cited by 246 · see citing works
The Selectivity and Functional Connectivity of the Anterior Temporal Lobes
Simmons, W. K., Reddish, M., Bellgowan, P. S. F., & Martin, A. D. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp149 · Cited by 244 · see citing works
The role of inferior parietal and inferior frontal cortex in working memory.
Baldo, J. V., & Dronkers, N. F. (2006) · Neuropsychology · doi:10.1037/0894-4105.20.5.529 · Cited by 241 · see citing works
Self-citationTime course of semantic processes during sentence comprehension: An fMRI study
Humphries, C., Binder, J. R., Medler, D. A., & Liebenthal, E. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.059 · Cited by 235 · see citing works
Is problem solving dependent on language?
BALDO, J., DRONKERS, N., WILKINS, D., LUDY, C., RASKIN, P., & KIM, J. (2005) · Brain and Language · doi:10.1016/j.bandl.2004.06.103 · Cited by 236 · see citing works
Self-citationRogalsky, C., & Hickok, G. S. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn126 · Cited by 236 · see citing works
Neural correlates of metaphor processing: The roles of figurativeness, familiarity and difficulty
Schmidt, G. L., & Seger, C. A. (2009) · Brain and Cognition · doi:10.1016/j.bandc.2009.06.001 · Cited by 231 · see citing works
Current Controversies on Wernicke’s Area and its Role in Language
Binder, J. R. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0764-8 · Cited by 231 · see citing works
Spatiotemporal dynamics of word processing in the human brain
Canolty, R. T. (2007) · Frontiers in Neuroscience · doi:10.3389/neuro.01.1.1.014.2007 · Cited by 222 · see citing works
Binder, J. R. (2015) · Neurology · doi:10.1212/wnl.0000000000002219 · Cited by 225 · see citing works
Compassion meditation enhances empathic accuracy and related neural activity
Mascaro, J. S., Rilling, J. K., Tenzin Negi, L., & Raison, C. L. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss095 · Cited by 223 · see citing works
Ivanova, M. V., Isaev, D. Y., Dragoy, O. V., Akinina, Y. S., Petrushevskiy, A. G., Fedina, O. N., Shklovsky, V. M., & Dronkers, N. F. (2016) · Cortex · doi:10.1016/j.cortex.2016.04.019 · Cited by 221 · see citing works
Self-citationUnderstanding understanding source code with functional magnetic resonance imaging
Siegmund, J., Kästner, C., Apel, S., Parnin, C., Bethmann, A., Leich, T., Saake, G., & Brechmann, A. (2014) · Proceedings of the 36th International Conference on Software Engineering · doi:10.1145/2568225.2568252 · Cited by 219 · see citing works
Behavioural clusters and predictors of performance during recovery from stroke
Ramsey, L. E., Siegel, J. S., Lang, C. E., Strube, M., Shulman, G. L., & Corbetta, M. (2017) · Nature Human Behaviour · doi:10.1038/s41562-016-0038 · Cited by 219 · see citing works
Novick, J. M., Kan, I. P., Trueswell, J. C., & Thompson‐Schill, S. L. (2009) · Cognitive Neuropsychology · doi:10.1080/02643290903519367 · Cited by 217 · see citing works
The Role of Broca's Area in Sentence Comprehension
Rogalsky, C., & Hickok, G. S. (2010) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2010.21530 · Cited by 218 · see citing works
Spatiotemporal imaging of cortical activation during verb generation and picture naming
Edwards, E., Nagarajan, S. S., Dalal, S. S., Canolty, R. T., Kirsch, H. E., Barbaro, N. M., & Knight, R. T. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.035 · Cited by 213 · see citing works
fMRI reveals language-specific predictive coding during naturalistic sentence comprehension
Shain, C., Blank, I. A., van Schijndel, M., Schuler, W., & Fedorenko, E. (2020) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2019.107307 · Cited by 215 · see citing works
Bemis, D., & Liina Pylkkänen, A. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs170 · Cited by 215 · see citing works
Delineation of the middle longitudinal fascicle in humans: A quantitative, in vivo, DT-MRI study
Makris, N., Papadimitriou, G. M., Kaiser, J. R., Sorg, S., Kennedy, D. N., & Pandya, D. N. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn124 · Cited by 214 · see citing works
Neurophysiological mechanisms involved in language learning in adults
Rodríguez-Fornells, A., Cunillera, T., Mestres-Missé, A., & de Diego-Balaguer, R. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2009.0130 · Cited by 223 · see citing works
Pei, X., Leuthardt, E. C., Gaona, C. M., Brunner, P., Wolpaw, J. R., & Schalk, G. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.10.029 · Cited by 204 · see citing works
Zhao, L., Biesbroek, J. M., Shi, L., Liu, W., Kuijf, H. J., Chu, C. W., Abrigo, J., Lee, R. K. L., Leung, T. W. H., Lau, A. Y. L., et al. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17728162 · Cited by 208 · see citing works
Processing Syntax and Morphology: A Neurocognitive Perspective
Bornkessel‐Schlesewsky, I., & Schlesewsky, M. (2009) · doi:10.1093/oso/9780199207817.001.0001 · Cited by 204 · see citing works
Devereux, B. J., Clarke, A., Marouchos, A., & TYLER, L. K. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3809-13.2013 · Cited by 202 · see citing works
“Aha!”: The neural correlates of verbal insight solutions
Aziz‐Zadeh, L., Kaplan, J., & Iacoboni, M. (2008) · Human Brain Mapping · doi:10.1002/hbm.20554 · Cited by 199 · see citing works
Abstract linguistic structure correlates with temporal activity during naturalistic comprehension
Brennan, J., Stabler, E. P., Wagenen, S. E. V., Luh, W., & Hale, J. (2016) · Brain and Language · doi:10.1016/j.bandl.2016.04.008 · Cited by 201 · see citing works
Subcortical Structures and Cognition
Koziol, L. F., & Budding, D. E. (2009) · Springer eBooks · doi:10.1007/978-0-387-84868-6 · Cited by 273 · see citing works
A comparison of five fMRI protocols for mapping speech comprehension systems
Binder, J. R., Swanson, S. J., Hammeke, T. A., & Sabsevitz, D. S. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01683.x · Cited by 198 · see citing works
Functional MRI is a valid noninvasive alternative to Wada testing
Binder, J. R. (2010) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2010.08.004 · Cited by 197 · see citing works
Neural Correlates of Syntactic Processing in the Nonfluent Variant of Primary Progressive Aphasia
Wilson, S. M., Dronkers, N. F., Ogar, J. M., Jang, J. Y., Growdon, M. E., Agosta, F., Henry, M. L., Miller, B. L., & Gorno‐Tempini, M. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2547-10.2010 · Cited by 191 · see citing works
Self-citationBilingual language processing: A meta-analysis of functional neuroimaging studies
Sulpizio, S., Maschio, N. D., Fedeli, D., & Abutalebi, J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.014 · Cited by 190 · see citing works
Anterior temporal lobe connectivity correlates with functional outcome after aphasic stroke
Warren, J. E., Crinion, J., Ralph, M. A. L., & Wise, R. J. S. (2009) · Brain · doi:10.1093/brain/awp270 · Cited by 188 · see citing works
Continuity, Divergence, and the Evolution of Brain Language Pathways
Rilling, J. K., Glasser, M. F., Jbabdi, S., Andersson, J., & Preuss, T. M. (2012) · Frontiers in Evolutionary Neuroscience · doi:10.3389/fnevo.2011.00011 · Cited by 189 · see citing works
- Authors
- Dronkers, N. F., Wilkins, D. P., Van Valin, R. D., Redfern, B. B., & Jaeger, J. J.
- Affiliations
- VA Northern California Health Care System (US)
- University at Buffalo, State University of New York (US)
- Corresponding author
- Dronkers, Nina F
- Venue
- Cognition
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 92
- Issue
- 1-2
- Pages
- 145-177
- ISSN
- 0010-0277 (ISSN-L)
- OpenAlex
- W2125711977
- Cited by
- 1,035
- References
- 72
- Citations by year
- 2026: 20 · 2025: 41 · 2024: 38 · 2023: 38 · 2022: 92 · 2021: 53 · 2020: 85 · 2019: 54 · 2018: 37 · 2017: 64 · 2016: 52 · 2015: 68 · 2014: 52 · 2013: 57 · 2012: 56
- FWCI
- 13.96
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Cognition (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- National Science Foundation (9207484)
- U.S. Department of Veterans Affairs
- National Institute on Deafness and Other Communication Disorders (2 R01DC00216, R01DC000216)
- National Institute of Neurological Disorders and Stroke (P01 NS177786, P01 NS 40813, P01NS040813)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
- Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
- Keywords
- language comprehension, receptive language, stroke, lesion-symptom mapping, Wernicke's area, Broca's area, left hemisphere, right hemisphere, middle temporal gyrus, superior temporal sulcus, angular gyrus, Brodmann area 46
- MeSH terms
- Aged, Aphasia, Brain, Female, Humans, Functional Laterality, Male, Middle Aged, Neuropsychological Tests, Speech Perception
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
