The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Miniature gold nanorods for photoacoustic molecular imaging in the second near-infrared optical window
Open accessAbstract
In photoacoustic imaging, the second near-infrared (NIR-II) window is where tissue generates the least background signal. However, the large size of the few available contrast agents in this spectral range impedes their pharmacokinetics and decreases their thermal stability, leading to unreliable photoacoustic imaging. Here, we report the synthesis of miniaturized gold nanorods absorbing in the NIR-II that are 5–11 times smaller than regular-sized gold nanorods with a similar aspect ratio. Under nanosecond pulsed laser illumination, small nanorods are about 3 times more thermally stable and generate 3.5 times stronger photoacoustic signal than their absorption-matched larger counterparts. These unexpected findings are confirmed using theoretical and numerical analysis, showing that photoacoustic signal is not only proportional to the optical absorption of the nanoparticle solution but also to the surface-to-volume ratio of the nanoparticles. In living tumour-bearing mice, these small targeted nanorods display a 30% improvement in efficiency of agent delivery to tumours and generate 4.5 times greater photoacoustic contrast.Miniaturized gold nanorods are reliable NIR-II photoacoustic agents, showing higher photothermal stability, enhanced photoacoustic signal and more efficient agent-to-tumour delivery compared with their larger counterparts.
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Cites
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Cited by
Design of therapeutic biomaterials to control inflammation
Tu, Z., Zhong, Y., Hu, H., Shao, D., Haag, R., Schirner, M., Lee, J., Sullenger, B., & Leong, K. W. (2022) · Nature Reviews Materials · doi:10.1038/s41578-022-00426-z · Cited by 513
NIR-II light in clinical oncology: opportunities and challenges
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He, T., Jiang, C., He, J., Zhang, Y., He, G., Wu, J., Lin, J., Zhou, X., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202008540 · Cited by 304
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Impact of skin tone on photoacoustic oximetry and tools to minimize bias
Mantri, Y., & Jokerst, J. V. (2022) · Biomedical Optics Express · doi:10.1364/boe.450224 · Cited by 75
Metadata
- Authors
- Chen, Y.-S., Zhao, Y., Yoon, S. J., Gambhir, S. S., & Emelianov, S.
- Venue
- Nature Nanotechnology
- Published
- 2019-03-04
- Volume
- 14
- Issue
- 5
- Pages
- 465-472
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2919380077
- Cited by
- 488
- References
- 31
- FWCI
- 22.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, Y.-S., Zhao, Y., Yoon, S. J., Gambhir, S. S., & Emelianov, S. (2019). Miniature gold nanorods for photoacoustic molecular imaging in the second near-infrared optical window. Nature Nanotechnology. https://doi.org/10.1038/s41565-019-0392-3
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