Impact of skin tone on photoacoustic oximetry and tools to minimize bias
Open accessAbstract
The major optical absorbers in tissue are melanin and oxy/deoxy-hemoglobin, but the impact of skin tone and pigmentation on biomedical optics is still not completely understood or adequately addressed. Melanin largely governs skin tone with higher melanin concentration in subjects with darker skin tones. Recently, there has been extensive debate on the bias of pulse oximeters when used with darker subjects. Photoacoustic (PA) imaging can measure oxygen saturation similarly as pulse oximeters and could have value in studying this bias. More importantly, it can deconvolute the signal from the skin and underlying tissue. Here, we studied the impact of skin tone on PA signal generation, depth penetration, and oximetry. Our results show that subjects with darker skin tones exhibit significantly higher PA signal at the skin surface, reduced penetration depth, and lower oxygen saturation compared to subjects with lighter skin tones. We then suggest a simple way to compensate for these signal differences.
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The penetration depth of light for imaging purposes and the results from medical wearable devices are affected by skin color.
“the penetration depth of light for imaging purposes and the results from medical wearable devices are affected by skin color.7–10”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [9]
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- Authors
- Mantri, Y., & Jokerst, J. V.
- Affiliations
- University of California San Diego (US)
- Venue
- Biomedical Optics Express
- Publisher
- Optica Publishing Group
- Published
- 2022-01-20
- Volume
- 13
- Issue
- 2
- Pages
- 875
- ISSN
- 2156-7085 (ISSN-L)
- PMC
- PMC8884230
- OpenAlex
- W4205674836
- Cited by
- 75
- References
- 59
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 21 · 2023: 21 · 2022: 7
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Biomedical Optics Express (publishedVersion)
- PubMed Central (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Funders
- University of California, San Diego (Galvanizing Engineering in Medicine program)
- National Institutes of Health (S10 OD021821)
- National Institute on Aging (R21 AG065776)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Keywords
- skin tone, melanin, photoacoustic imaging, oxygen saturation, skin pigmentation, penetration depth, signal compensation, hemoglobin
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