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Metabolism of immune cells in cancer
Open accessAbstract
Through the successes of checkpoint blockade and adoptive cellular therapy, immunotherapy has become an established treatment modality for cancer. Cellular metabolism has emerged as a critical determinant of the viability and function of both cancer cells and immune cells. In order to sustain prodigious anabolic needs, tumours employ a specialized metabolism that differs from untransformed somatic cells. This metabolism leads to a tumour microenvironment that is commonly acidic, hypoxic and/or depleted of critical nutrients required by immune cells. In this context, tumour metabolism itself is a checkpoint that can limit immune-mediated tumour destruction. Because our understanding of immune cell metabolism and cancer metabolism has grown significantly in the past decade, we are on the cusp of being able to unravel the interaction of cancer cell metabolism and immune metabolism in therapeutically meaningful ways. Although there are metabolic processes that are seemingly fundamental to both cancer and responding immune cells, metabolic heterogeneity and plasticity may serve to distinguish the two. As such, understanding the differential metabolic requirements of the diverse cells that comprise an immune response to cancer offers an opportunity to selectively regulate immune cell function. Such a nuanced evaluation of cancer and immune metabolism can uncover metabolic vulnerabilities and therapeutic windows upon which to intervene for enhanced immunotherapy. This Review discusses our current understanding of adaptive and innate immune cell metabolism in the context of the tumour microenvironment, providing insight into the interaction of cancer cell metabolism and immune metabolism, as well as the potential for leveraging metabolic vulnerabilities to enhance the antitumour immune response.
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“Similarly, HIF-2α directly upregulates PD-L1 expression by binding to the HRE in the PD-L1 promoter in ccRCC cells (Fig. 2C) [73].”
From Revisiting the HIF switch in the tumor and its immune microenvironment. (2022) · cites this paper as [73]
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Cites
1 retracted
RETRACTED: mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation
Moon, J.-S., Hisata, S., Park, M. A., DeNicola, G. M., Ryter, S. W., Nakahira, K., & Choi, A. M. K. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.046 · Cited by 379
Retracted5-Fluorouracil: mechanisms of action and clinical strategies
Longley, D. B., Harkin, D. P., & Johnston, P. G. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1074 · Cited by 5,332
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176
Modulation of oxidative stress as an anticancer strategy
Gorrini, C., Harris, I. S., & Mak, T. W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4002 · Cited by 3,579
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chang, C.-H., Qiu, J., O’Sullivan, D., Buck, M. D., Noguchi, T., Curtis, J. D., Chen, Q., Gindin, M., Gubin, M. M., van der Windt, G. J. W., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.016 · Cited by 3,331
Functional Polarization of Tumour-Associated Macrophages by Tumour-Derived Lactic Acid
Colegio, O. R., Chu, N.-Q., Szabo, A. L., Chu, T., Rhebergen, A. M., Jairam, V., Cyrus, N., Brokowski, C. E., Eisenbarth, S. C., Phillips, G. M., et al. (2014) · Nature · doi:10.1038/nature13490 · Cited by 3,046
Mitochondrial TCA cycle metabolites control physiology and disease
Martínez-Reyes, I., & Chandel, N. S. (2020) · Nature Communications · doi:10.1038/s41467-019-13668-3 · Cited by 2,813
Physiological Roles of Mitochondrial Reactive Oxygen Species
Sena, L. A., & Chandel, N. S. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.025 · Cited by 2,632
Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism
Munn, D. H., Zhou, M., Attwood, J. T., Bondarev, I. E., Conway, S. J., Marshall, B., Brown, C. C., & Mellor, A. L. (1998) · Science · doi:10.1126/science.281.5380.1191 · Cited by 2,589
Cited by
Sorted by citations
Items 101–200 of 899
Song, Q., Yu, H., Cheng, Y., Han, J., Li, K., Zhuang, J., Lv, Q., Yang, X. F., & Yang, H. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03508-2 · Cited by 65
Xie, W., Chen, B., Wen, H., Xiao, P., Wang, L., Liu, W., Wang, D., & Tang, B. Z. (2022) · ACS Nano · doi:10.1021/acsnano.2c02605 · Cited by 64
Wang, D., Sun, Z., Zhu, X., Zheng, X., Zhou, Y., Lu, Y., Yan, P., Wang, H., Liu, H., Jin, J., et al. (2022) · Blood · doi:10.1182/blood.2022015474 · Cited by 67
Targeting Immune Cell Metabolism in the Treatment of Inflammatory Bowel Disease
Zaiatz-Bittencourt, V., Jones, F., Doherty, G. A., & Ryan, E. J. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab024 · Cited by 69
Zhang, D. X., Vu, L. T., Ismail, N. N., Le, M. T. N., & Grimson, A. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.01.007 · Cited by 64
Lakshmanachetty, S., Cruz, J. C., Hoffmeyer, E., Cole, A. P., & Mitra, S. S. (2021) · Cells · doi:10.3390/cells10040893 · Cited by 62
The evolving view of thermogenic fat and its implications in cancer and metabolic diseases
Yin, X., Chen, Y., Ruze, R., Xu, R., Song, J., Wang, C., & Xu, Q. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01178-6 · Cited by 72
Targeting metabolism to enhance immunotherapy within tumor microenvironment
Liang, X., Chen, X., Yan, Y., Cheng, A.-Y., Lin, J.-Y., Jiang, Y.-X., Chen, H., Jin, J., & Luan, X. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01304-w · Cited by 69
Enhanced Glutaminolysis Drives Hypoxia-Induced Chemoresistance in Pancreatic Cancer
Park, S. J., Yoo, H. C., Ahn, E., Luo, E., Kim, Y., Sung, Y., Yu, Y. C., Kim, K., Min, D. S., Lee, H. S., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-2045 · Cited by 63
The tumor microenvironment is an ecosystem sustained by metabolic interactions
Kay, E. J., & Zanivan, S. R. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115432 · Cited by 63
Pan‐cancer analyses reveal molecular and clinical characteristics of cuproptosis regulators
Wu, C., Tan, J., Wang, X., Qin, C., Long, W., Pan, Y., Li, Y., & Liu, Q. (2022) · iMeta · doi:10.1002/imt2.68 · Cited by 61
Mandal, K., Barik, G. K., & Santra, M. K. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02400-z · Cited by 69
Nanomaterial-Based Repurposing of Macrophage Metabolism and Its Applications
Meng, T., He, D., Han, Z., Shi, R., Wang, Y., Ren, B., Zhang, C., Mao, Z., Luo, G., & Deng, J. (2024) · Nano-Micro Letters · doi:10.1007/s40820-024-01455-9 · Cited by 63
Niveau, C., Cettour-Cave, M., Mouret, S., Cuevas, E. S., Pezet, M., Roubinet, B., Gil, H., de Fraipont, F., Landemarre, L., Charles, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56392-x · Cited by 58
DeRosa, A., & Leftin, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.614294 · Cited by 58
Sun, Z., Liu, J., Li, Y., Lin, X., Chu, Y., Wang, W., Huang, S., Li, W., Peng, J., Liu, C., et al. (2022) · Advanced Materials · doi:10.1002/adma.202208555 · Cited by 56
Gallic acid: design of a pyrogallol-containing hydrogel and its biomedical applications
Wu, W., Yunxin, Y., Ziyan, W., Qianzhou, J., & Guo, L. (2024) · Biomaterials Science · doi:10.1039/d3bm01925j · Cited by 56
Current Landscape of Cancer Immunotherapy: Harnessing the Immune Arsenal to Overcome Immune Evasion
Mitra, A., Kumar, A., Amdare, N. P., & Pathak, R. (2024) · Biology · doi:10.3390/biology13050307 · Cited by 61
Metabolic regulation in the immune response to cancer
Wu, Q., Yu, X., Li, J., Sun, S., & Tu, Y. (2021) · 癌症：英文版 · doi:10.1002/cac2.12182 · Cited by 57
Metabolic reprograming of MDSCs within tumor microenvironment and targeting for cancer immunotherapy
Li, Q., & Xiang, M. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00776-4 · Cited by 54
The emerging roles of TRIM21 in coordinating cancer metabolism, immunity and cancer treatment
Chen, X., Cao, M., Wang, P., Chu, S., Li, M., Hou, P., Zheng, J., Li, Z., & Bai, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.968755 · Cited by 52
Udumula, M. P., Sakr, S., Dar, S. A., Alvero, A. B., Ali‐Fehmi, R., Abdulfatah, E., Li, J., Jiang, J., Tang, A., Buekers, T., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101272 · Cited by 54
Xiong, J., Wang, N., Zhong, H., Cui, B., Cheng, S., Sun, R., Chen, J., Xu, P., Cai, G., Wang, L., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103614 · Cited by 55
Fueling the Revolution: Targeting Metabolism to Enhance Immunotherapy
Leone, R. D., & Powell, J. D. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0791 · Cited by 53
Self-citationHe, W., Hu, Y., Chen, D., Li, Y., Ye, D., Zhao, Q., Li, L., Shi, X., Lu, L., Yin, Z., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.800 · Cited by 55
Correlation between the Warburg effect and progression of triple-negative breast cancer
Liu, S., Li, Y., Yuan, M., Song, Q., & Liu, M. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1060495 · Cited by 58
Ouyang, Y., Ou, Z., Zhong, W., Yang, J., Fu, S., Ouyang, N., Chen, J., Xu, L., Wu, D., Qian, J., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-1065 · Cited by 54
Impacts of Immunometabolism on Male Reproduction
Ye, L., Huang, W., Liu, S., Cai, S., Hong, L., Xiao, W., Thiele, K., Zeng, Y., Song, M., & Diao, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.658432 · Cited by 54
Tumor Metabolism-Rewriting Nanomedicines for Cancer Immunotherapy
Dong, X., Xia, S., Du, S., Zhu, M., Lai, X. P., Yao, S. Q., Chen, H., & Fang, C. (2023) · ACS Central Science · doi:10.1021/acscentsci.3c00702 · Cited by 53
T cell metabolism in homeostasis and cancer immunity
Wei, J., Zheng, W., Chapman, N. M., Geiger, T. L., & Chi, H. (2021) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.02.003 · Cited by 52
Fatty Acid Metabolism and Cancer Immunotherapy
Luo, Y., Wang, H., Liu, B., & Wei, J. (2022) · Current Oncology Reports · doi:10.1007/s11912-022-01223-1 · Cited by 53
Glioblastoma Stem Cells—Useful Tools in the Battle against Cancer
Rodriguez, S. M. B., Staicu, G.-A., Sevastre, A.-S., Baloi, C., Ciubotaru, V. G., Dricu, A., & Tătăranu, L. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094602 · Cited by 54
Cao, H., Huang, T., Dai, M., Kong, X., Liu, H., Zheng, Z., Sun, G., Sun, G., Rong, D., Jin, Z., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.73949 · Cited by 51
Hu, Z., Chen, L., Ma, R., Wei, F., Wen, Y., Zeng, X., Sun, W., & Wen, W. (2021) · Aging · doi:10.18632/aging.202841 · Cited by 52
Xu, J., Shen, R., Jiao, Z., Chen, W., Peng, D., Wang, L., Yu, N., Peng, C., Cai, B., Song, H., et al. (2022) · Nutrients · doi:10.3390/nu14132622 · Cited by 51
Glycolysis in tumor microenvironment as a target to improve cancer immunotherapy
Xiao, C., Tian, H., Zheng, Y., Yang, Z., Li, S., Fan, T. T., Xu, J., Bai, G., Liu, J., Deng, Z., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1013885 · Cited by 50
Wang, R., Zhuang, J., Zhang, Q., Wu, W., Yu, X., Zhang, H., & Xie, Z. (2025) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00689-6 · Cited by 52
Metabolic Cancer-Macrophage Crosstalk in the Tumor Microenvironment
de Goede, K. E., Driessen, A. J. M., & den Bossche, J. V. (2020) · Biology · doi:10.3390/biology9110380 · Cited by 49
Pathogenic mitochondrial dysfunction and metabolic abnormalities
Moos, W. H., Faller, D. V., Glavas, I. P., Harpp, D. N., Kamperi, N., Kanara, I., Kodukula, K., Mavrakis, A. N., Pernokas, J., Pernokas, M., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114809 · Cited by 50
Luby, A., & Alves‐Guerra, M. (2021) · Cancers · doi:10.3390/cancers13235912 · Cited by 49
Dong, Z., Liu, Y., Wang, C., Hao, Y., Fan, Q., Yang, Z., Li, Q., Feng, L., & Liu, Z. (2023) · Advanced Materials · doi:10.1002/adma.202308254 · Cited by 47
Gan, M., Liu, N., Li, W., Chen, M., Bai, Z., Liu, D., & Liu, S. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02193-7 · Cited by 50
Balakin, E. I., Yurku, K. A., Ivanov, M., Izotov, A., Игоревна, Н. В., & Pustovoit, V. I. (2025) · Biology · doi:10.3390/biology14010076 · Cited by 61
Wen, Z., Liu, T., Xu, X., Acharya, N., Shen, Z., Lu, Y., Xu, J., Guo, K., Shen, S., Zhao, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57603-1 · Cited by 46
Cai, Y., Gong, M., Zeng, M., Leng, F., Lv, D., Guo, J., Wang, H., Li, Y., Lin, Q., Jing, J., et al. (2025) · Science Advances · doi:10.1126/sciadv.adv6445 · Cited by 46
Vitamin B6 Metabolism Determines T Cell Anti-Tumor Responses
Bargiela, D., Cunha, P. P., Veliça, P., Foskolou, I. P., Barbieri, L., Rundqvist, H., & Johnson, R. S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.837669 · Cited by 43
Wang, H., Wu, C., Tong, X., & Chen, S. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.11.054 · Cited by 45
Huang, M., Xiong, D., Pan, J., Zhang, Q., Wang, Y., Myers, C. R., Johnson, B. D., Hardy, M., Kalyanaraman, B., & You, M. (2022) · Advanced Science · doi:10.1002/advs.202101267 · Cited by 45
Metabolic adaptations of cancer in extreme tumor microenvironments
Nakahara, R., Maeda, K., Aki, S., & Osawa, T. (2023) · Cancer Science · doi:10.1111/cas.15722 · Cited by 47
Cell metabolism-based optimization strategy of CAR-T cell function in cancer therapy
Li, W., Pan, X., Chen, L., Cui, H., Mo, S., Pan, Y., Shen, Y., Shi, M., Wu, J., Luo, F., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1186383 · Cited by 49
Metabolites as agents and targets for cancer immunotherapy
Trefny, M. P., Kroemer, G., Zitvogel, L., & Kobold, S. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01227-z · Cited by 57
Diet, nutrient supply, and tumor immune responses
McIntyre, C., Temesgen, A., & Lynch, L. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.06.003 · Cited by 43
More TOR: The expanding role of mTOR in regulating immune responses
Patel, C. H., & Powell, J. D. (2025) · Immunity · doi:10.1016/j.immuni.2025.06.010 · Cited by 48
Self-citationT-cell dysfunction in chronic lymphocytic leukemia from an epigenetic perspective
Peters, F. S., Strefford, J. C., Eldering, E., & Kater, A. P. (2021) · Haematologica · doi:10.3324/haematol.2020.267914 · Cited by 43
Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
Samborska, B., Roy, D. G., Rahbani, J. F., Hussain, M. F., Ma, E. H., Jones, R. G., & Kazak, L. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110446 · Cited by 44
Parveen, S., Shen, J., Lun, S., Zhao, L., Alt, J., Koleske, B. N., Leone, R. D., Rais, R., Powell, J. D., Murphy, J. R., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43304-0 · Cited by 40
Self-citationTumor-Associated Inflammation: The Tumor-Promoting Immunity in the Early Stages of Tumorigenesis
Bi, Q., Wu, J., Qiu, X., Zhang, J., Sun, Z., & Wang, W. (2022) · Journal of Immunology Research · doi:10.1155/2022/3128933 · Cited by 47
Lipid peroxidation of immune cells in cancer
Xiao, L., Xian, M., Zhang, C., Guo, Q., & Yi, Q. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1322746 · Cited by 47
The role of metabolic reprogramming in liver cancer and its clinical perspectives
Lu, M., Wu, Y., Xia, M., & Zhang, Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1454161 · Cited by 41
Shi, R., Pan, P., Lv, R., Ma, C., Wu, E., Guo, R., Zhao, Z., Song, H., Zhou, J. Z., Liu, Y., et al. (2022) · Science Advances · doi:10.1126/sciadv.abl4923 · Cited by 41
Glycolysis: A fork in the path of normal and pathological pregnancy
Gou, R., & Zhang, X. (2023) · The FASEB Journal · doi:10.1096/fj.202301230r · Cited by 43
Huang, C., Li, D., Liu, J., Hou, S., Yang, W., Wang, H., Wang, J., Wang, Z., Li, F., Hao, Z., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202309447 · Cited by 40
Qin, S., Xie, B., Wang, Q., Yang, R., Sun, J., Hu, C., Liu, S., Tao, Y., & Xiao, D. (2024) · MedComm · doi:10.1002/mco2.551 · Cited by 40
Lee, S., Kim, S., Lee, J., Kim, Y., Joo, Y., Heo, J.-Y., Lee, H., Lee, C., Hwang, G., & Park, H. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101159 · Cited by 40
EPHX2 Inhibits Colon Cancer Progression by Promoting Fatty Acid Degradation
Zhou, Y., Li, X., Guan, A., Zhou, H., Zhu, Y., Wang, R., & Li, R. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.870721 · Cited by 41
SOTIP is a versatile method for microenvironment modeling with spatial omics data
Yuan, Z., Li, Y., Shi, M., Yang, F., Gao, J. T., Yao, J., & Zhang, M. Q. (2022) · Nature Communications · doi:10.1038/s41467-022-34867-5 · Cited by 40
Amino acid metabolism in tumor: New shine in the fog?
Qiu, H., Shao, N., Liu, J., Zhao, J.-J., Chen, C., Li, Q., He, Z., Zhao, X., & Xu, L. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.06.011 · Cited by 38
Chen, Y., Sun, J., Liu, J., Wei, Y., Wang, X., Fang, H., Du, H., Huang, J., Li, Q., Ren, G., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-007487 · Cited by 40
Liu, X., Zhao, Z., Sun, X., Wang, J., Yi, W., Wang, D., & Li, Y. (2022) · Small Methods · doi:10.1002/smtd.202200898 · Cited by 41
Du, M., Yu, T., Zhan, Q., Li, H., Zou, Y., Geng, M., Meng, T., & Xie, Z. (2022) · Cancer Science · doi:10.1111/cas.15468 · Cited by 39
Liu, X., Zhao, Y., Wu, X., Liu, Z., & Liu, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.931104 · Cited by 41
Wang, Y., Gao, D., Jin, L., Ren, X., Ouyang, Y., Zhou, Y., He, X., Jia, L., Tian, Z., Wu, D., et al. (2022) · Advanced Science · doi:10.1002/advs.202203788 · Cited by 39
Intelligent Delivery Systems in Tumor Metabolism Regulation: Exploring the Path Ahead
Li, X., Sun, T., & Jiang, C. (2023) · Advanced Materials · doi:10.1002/adma.202309582 · Cited by 38
Li, Y., Duan, Z., Pan, D., Ren, L. F., Gu, L., Li, X., Xu, G., Zhu, H., Zhang, H., Gu, Z., et al. (2022) · Advanced Materials · doi:10.1002/adma.202210161 · Cited by 38
Immunotherapy: an emerging modality to checkmate brain metastasis
Ahmad, A., Κhan, P., Rehman, A. U., Batra, S. K., & Nasser, M. W. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01818-7 · Cited by 38
Chen, P., Geng, H., Ma, B., Zhang, Y., Zhu, Z., Li, M., Chen, S., Wang, X., & Sun, C. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2505789122 · Cited by 37
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Kumar, S., Mittal, S., Gupta, P., Singh, M., Chaluvally–Raghavan, P., & Pradeep, S. (2022) · Cancers · doi:10.3390/cancers14215224 · Cited by 38
Raman, V., Deshpande, C. P., Khanduja, S., Howell, L. M., Dessel, N. V., & Forbes, N. S. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.09.006 · Cited by 37
Ahuja, S., & Zaheer, S. (2025) · Immunology · doi:10.1111/imm.70045 · Cited by 43
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Gao, Y., Wu, C., Chen, X., Ma, L., Zhang, X., Chen, J., Liao, X., & Liu, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1049043 · Cited by 36
Immunometabolic reprogramming, another cancer hallmark
Kumar, V., & Stewart, J. H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125874 · Cited by 37
Xia, M., Zhang, C., Chen, Y. A., Zhao, X., Zhang, S., Liu, Y., Cai, Y., Wei, Z., Du, Q., Yu, W., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2205469119 · Cited by 35
Shukla, S., Dalai, P., & Agrawal-Rajput, R. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111281 · Cited by 37
Xiao, Y., Xu, Y., Wang, H., Yang, F., Ding, X.-H., Fu, T., Chen, L., Jin, X., Zhao, Y.-X., Wang, Y., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.08.009 · Cited by 38
HIF-Prolyl Hydroxylase Domain Proteins (PHDs) in Cancer—Potential Targets for Anti-Tumor Therapy?
Gaete, D., Rodriguez, D., Watts, D., Sormendi, S., Chavakis, T., & Wielockx, B. (2021) · Cancers · doi:10.3390/cancers13050988 · Cited by 35
Zhang, H., Chi, M., Su, D., Xiong, Y., Wei, H., Yao, Y., Zuo, Y., & Yang, L. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.106432 · Cited by 34
Yaman, İ., Çobanoğlu, D. A., Xie, T., Ye, Y., & Amit, M. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108199 · Cited by 35
Ren, Y., Li, R., Feng, H., Xie, J., Gao, L., Chu, S., Li, Y., Meng, F., & Ning, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.985187 · Cited by 32
Medikonda, R. T., Abikenari, M. A., Schonfeld, E., & Lim, M. K. (2025) · Cancers · doi:10.3390/cancers17111881 · Cited by 35
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He, X., Gu, Y., Cao, Y., Hu, B., Fang, H., Fei, Y., Lv, K., Liu, X., Wang, J., Lin, C., et al. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.08.006 · Cited by 34
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Zhelev, Z., Aoki, I., Lazarova, D., Vlaykova, T. I., Higashi, T., & Bakalova, R. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2339584 · Cited by 34
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Xu, Y., Ming, X., Qi, J., Huang, Z., Zhu, H., Wu, M., Feng, S., & Wan, Y. (2025) · ACS Nano · doi:10.1021/acsnano.5c08432 · Cited by 35
Yue, G., Tang, J., Zhang, L., Niu, H., Li, H., & Luo, S. (2021) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-21-50 · Cited by 31
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Aki, S., Nakahara, R., Maeda, K., & Osawa, T. (2023) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2023.130330 · Cited by 33
Li, Z., Deng, Y., Sun, H., Tan, C., Li, H., Mo, F., Wang, Y., Li, J., Zhou, Z., & Sun, M. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.05.013 · Cited by 30
Tang, N., Huang, W., Li, X., Gao, X., Liu, X., Wang, L., & Xing, W. (2024) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2024.141653 · Cited by 30
Tian, R., Xue, Z., Chen, Y., Qi, Y., Zhang, J., Yuan, J., Ruan, D., Lin, J., Liu, J., Wang, D., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63915-z · Cited by 38
Metadata
- Authors
- Leone, R. D., & Powell, J. D.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Powell, Jonathan D.
- Venue
- Nature Reviews Cancer
- Published
- 2020-07-06
- Volume
- 20
- Issue
- 9
- Pages
- 516-531
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC8041116
- OpenAlex
- W3040651070
- Semantic Scholar
- 9e54633c23933564226222b58eee14bffccca97c
- Cited by
- 877
- References
- 228
- Citations by year
- 2026: 137 · 2025: 168 · 2024: 141 · 2023: 135 · 2022: 185 · 2021: 98 · 2020: 12
- FWCI
- 11.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA229451, R01CA226765)
- National Institute of Allergy and Infectious Diseases (R01AI077610)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- immune cell metabolism, cancer metabolism, tumor microenvironment, tumor acidosis, tumor hypoxia, nutrient depletion, adaptive immunity, innate immunity, metabolic heterogeneity, metabolic plasticity, metabolic vulnerability, immunotherapy, antitumor immunity
- MeSH terms
- Animals, Humans, Immune System, Immunotherapy, Neoplasms, Tumor Microenvironment
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