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Metabolism of immune cells in cancer
Open accessAbstract
Through the successes of checkpoint blockade and adoptive cellular therapy, immunotherapy has become an established treatment modality for cancer. Cellular metabolism has emerged as a critical determinant of the viability and function of both cancer cells and immune cells. In order to sustain prodigious anabolic needs, tumours employ a specialized metabolism that differs from untransformed somatic cells. This metabolism leads to a tumour microenvironment that is commonly acidic, hypoxic and/or depleted of critical nutrients required by immune cells. In this context, tumour metabolism itself is a checkpoint that can limit immune-mediated tumour destruction. Because our understanding of immune cell metabolism and cancer metabolism has grown significantly in the past decade, we are on the cusp of being able to unravel the interaction of cancer cell metabolism and immune metabolism in therapeutically meaningful ways. Although there are metabolic processes that are seemingly fundamental to both cancer and responding immune cells, metabolic heterogeneity and plasticity may serve to distinguish the two. As such, understanding the differential metabolic requirements of the diverse cells that comprise an immune response to cancer offers an opportunity to selectively regulate immune cell function. Such a nuanced evaluation of cancer and immune metabolism can uncover metabolic vulnerabilities and therapeutic windows upon which to intervene for enhanced immunotherapy. This Review discusses our current understanding of adaptive and innate immune cell metabolism in the context of the tumour microenvironment, providing insight into the interaction of cancer cell metabolism and immune metabolism, as well as the potential for leveraging metabolic vulnerabilities to enhance the antitumour immune response.
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“Similarly, HIF-2α directly upregulates PD-L1 expression by binding to the HRE in the PD-L1 promoter in ccRCC cells (Fig. 2C) [73].”
From Revisiting the HIF switch in the tumor and its immune microenvironment. (2022) · cites this paper as [73]
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Cites
1 retracted
RETRACTED: mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation
Moon, J.-S., Hisata, S., Park, M. A., DeNicola, G. M., Ryter, S. W., Nakahira, K., & Choi, A. M. K. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.046 · Cited by 379
Retracted5-Fluorouracil: mechanisms of action and clinical strategies
Longley, D. B., Harkin, D. P., & Johnston, P. G. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1074 · Cited by 5,332
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176
Modulation of oxidative stress as an anticancer strategy
Gorrini, C., Harris, I. S., & Mak, T. W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4002 · Cited by 3,579
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chang, C.-H., Qiu, J., O’Sullivan, D., Buck, M. D., Noguchi, T., Curtis, J. D., Chen, Q., Gindin, M., Gubin, M. M., van der Windt, G. J. W., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.016 · Cited by 3,331
Functional Polarization of Tumour-Associated Macrophages by Tumour-Derived Lactic Acid
Colegio, O. R., Chu, N.-Q., Szabo, A. L., Chu, T., Rhebergen, A. M., Jairam, V., Cyrus, N., Brokowski, C. E., Eisenbarth, S. C., Phillips, G. M., et al. (2014) · Nature · doi:10.1038/nature13490 · Cited by 3,046
Mitochondrial TCA cycle metabolites control physiology and disease
Martínez-Reyes, I., & Chandel, N. S. (2020) · Nature Communications · doi:10.1038/s41467-019-13668-3 · Cited by 2,813
Physiological Roles of Mitochondrial Reactive Oxygen Species
Sena, L. A., & Chandel, N. S. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.025 · Cited by 2,632
Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism
Munn, D. H., Zhou, M., Attwood, J. T., Bondarev, I. E., Conway, S. J., Marshall, B., Brown, C. C., & Mellor, A. L. (1998) · Science · doi:10.1126/science.281.5380.1191 · Cited by 2,589
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Zhang, Z., Li, L., Gao, Y., Xiao, X., Ji, L., Zhou, Z., Jiang, J., Liu, S., An, J., Deng, P., et al. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00873-y · Cited by 7
Liu, P.-W., Lin, J., Hou, R., Cai, Z., Gong, Y., He, P., & Yang, J. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.107926 · Cited by 7
Qiu, J., Wang, Z., Yu, Y., Zheng, Y., Lin, C., & Lin, C. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111940 · Cited by 7
Cao, L., Tang, D., Yu, Z., Shen, Y., Wang, Y., Li, Y., Chen, J., Liu, Z., Yin, J., Xiao, H., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202403225 · Cited by 7
Hasterok, S., Jankovskaja, S., Dahlström, R. M., Prgomet, Z., Ohlsson, L., Björklund, S., & Gustafsson, A. (2024) · Biomolecules · doi:10.3390/biom14070815 · Cited by 7
Interrogation of the tumor microenvironment by nanoparticles
Panja, P., Manne, U., Awasthi, V., Bhattacharya, R., & Mukherjee, P. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217454 · Cited by 8
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Pizzoli, G., Gargaro, M., Drava, G., & Voliani, V. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202404795 · Cited by 7
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Zhan, C., Peng, C., Wei, H., Wei, K., Ou, Y., & Zhang, Z. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062778 · Cited by 9
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Yoon, W., Park, Y., Kim, S., Park, Y., & Kim, C. Y. (2021) · Microorganisms · doi:10.3390/microorganisms9112408 · Cited by 7
Oriuchi, N., Endoh, H., & Kaira, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169394 · Cited by 8
He, L., Liu, Z., Chen, Y., Zhang, X., Wu, N., & Wang, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.999654 · Cited by 7
Kumar, V., & Rani, R. (2020) · Pharmaceutical Patent Analyst · doi:10.4155/ppa-2020-0025 · Cited by 7
Genomic Deletion of PFKFB3 Decreases In Vivo Tumorigenesis
Imbert-Fernandez, Y., Chang, S., Lanceta, L., Sanders, N. M., Chesney, J. A., Clem, B. F., & Telang, S. (2024) · Cancers · doi:10.3390/cancers16132330 · Cited by 6
Focusing on the Immune Cells: Recent Advances in Immunotherapy for Biliary Tract Cancer
Ni, L., Xu, J., Li, Q., Ge, X., Wang, F., Deng, X., & Miao, L. (2024) · Cancer Management and Research · doi:10.2147/cmar.s474348 · Cited by 6
Cytokine-mediated regulation of immune cell metabolic pathways in the tumor microenvironment
Mamalo, A. S., Pashaei, M. R., Valilo, M., & Ojarudi, M. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04133-8 · Cited by 6
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Gong, L., Wu, L., Zhao, S., Xiao, S., Chu, X., Zhang, Y., Li, F., Li, S., Yang, H., & Jiang, P. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5534 · Cited by 6
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Lv, E., Wang, T., Yue, X., Wang, H., Zeng, J., Sun, R., Zhao, W., & Wang, J. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.168145 · Cited by 6
Zhang, M., Xu, J., Yang, Z., Ding, L., Han, H., Ma, M., Ee, P. L. R., Yu, G., Tang, W., & Chen, X. S. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123832 · Cited by 6
Gan, Y., Meng, D., Lang, L., Luo, J., Dai, P., Chang, C., Lu, Z., Guo, Y., Wang, R., Chen, S.-C., et al. (2025) · Advanced Science · doi:10.1002/advs.202510224 · Cited by 6
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Takahashi, R., Yamamoto, K., Toya, H., Shoji, H., Kawanishi, K., Momosaki, K., Yabe, M., Takashima, K., Muromoto, R., Ichikawa, S., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03641-4 · Cited by 7
RBM15/IGF2BP3 promotes immune escape in bladder cancer by enhancing m6A modification of PFKFB4
Chen, M., Zheng, L., Huang, D., Wang, S., Wen, X., Gao, Y., & Zhang, S. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.150142 · Cited by 6
Takeuchi, Y., Wang, Y., Sasaki, K., Sato, O., Tsuchikawa, T., Wang, L., Amaishi, Y., Okamoto, S., Mineno, J., HIROKAWA, Y. S., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116052 · Cited by 7
Does oncolytic viruses‐mediated metabolic reprogramming benefit or harm the immune microenvironment?
Peng, C., Xiao, P., & Li, N. (2024) · The FASEB Journal · doi:10.1096/fj.202301947rr · Cited by 6
Xu, Z., Li, J., Cao, Z.-Y., Xu, H., Ying, Y., Xu, Z.-H., Liu, R.-J., Guo, Y., Zhang, Z., Wang, W., et al. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001293 · Cited by 6
Yuzhakova, D. V., Sachkova, D. A., Izosimova, A. V., Сергеевич, Я. К., Yusubalieva, G. M., Baklaushev, V. P., Mozherov, A. M., Shcheslavskiy, V. I., & Shirmanova, M. V. (2025) · Cells · doi:10.3390/cells14020097 · Cited by 6
Advances in the design and application of glycolysis-related nanodelivery systems for anti-tumor
Zhou, Y., Liu, M., Lü, N., Deng, X., Chen, X., Tang, L., Xie, Z., Lei, X., Yang, X., Zhou, S., et al. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114844 · Cited by 6
Wang, Q., Zhao, Y., Wang, F., & Tan, G. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1051051 · Cited by 6
Li, Q., Miao, J., Shi, N., Lin, C., Hu, X., & Shen, Y. (2023) · Annals of Translational Medicine · doi:10.21037/atm-23-30 · Cited by 6
RetractedBag, S., Oetjen, J., Shaikh, S., Chaudhary, A., Arun, P., & Mukherjee, G. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04713-3 · Cited by 6
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Xiwei, L., Tian, S., Ma, C., Chen, L., Qin, J., Wang, N., Lin, L., & Liu, A. (2023) · Bioengineering · doi:10.3390/bioengineering10121399 · Cited by 6
Essential Amino Acid Metabolism-Related Molecular Classification in Triple-Negative Breast Cancer
Zhao, Y., Pu, C., Jiao, D., Zhu, J., Guo, X., & Liu, Z. (2021) · Epigenomics · doi:10.2217/epi-2021-0210 · Cited by 6
Fang, Y., Cheng, P. F., Yuan, H., Zhao, H., & Zhang, L. (2023) · Journal of Alloys and Compounds · doi:10.1016/j.jallcom.2023.172692 · Cited by 5
Wang, X., Wang, Z., Liu, Z., Huang, F., Pan, Z., Zhang, Z., & Liu, T. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189322 · Cited by 5
Optimized bacterial delivery approaches for precision immunotherapy in breast cancer models
Park, J.-E., Kang, S. J., Ahn, J.-S., Choi, S.-H., Lee, J., Kim, J., & Park, S. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114004 · Cited by 5
Feng, Q., Wang, C., Shi, S., Fan, J., Chen, Y., Zhang, T., Ruan, Z., Ma, Y., Li, Z., Liu, J., et al. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202503275 · Cited by 5
Zheng, S., Zheng, Y., Hu, H., Liu, M., He, C., Wu, Z., Hou, M., Liu, G., Xu, Y., Yan, C., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03808-x · Cited by 6
Dong, W., Qian, X., Liu, H., Huo, J. A., & Wang, W. (2026) · Biomolecules · doi:10.3390/biom16010160 · Cited by 5
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Zhou, Y., Zhou, Y., Zhu, Q., Guo, W., & Li, C. (2026) · Autoimmunity Reviews · doi:10.1016/j.autrev.2026.103989 · Cited by 6
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Wang, B.-Q., Li, X.-C., Huo, Z., Zeng, K., Chen, S., Wang, Y., Zhu, Y., Huang, Y., Ding, J., Cai, Y., et al. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218338 · Cited by 6
Hasannia, M., Abounoori, M., Mahmoudian, F., Shirzad, M., Rahdar, A., Duguna, S., & Pandey, S. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1812990 · Cited by 6
Ntoukas, A. K., Mouikis, A., & Angelopoulou, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104525 · Cited by 5
Zou, M., Li, H., Su, D., Xiong, Y., Wei, H., Wang, S., Sun, H., Wang, T., Xi, Q., Zuo, Y., et al. (2023) · Briefings in Bioinformatics · doi:10.1093/bib/bbad430 · Cited by 5
Torke, S., Walther, W., & Stein, U. (2024) · Cancers · doi:10.3390/cancers16071330 · Cited by 5
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Xi, Y., Min, Z., Liu, M., Lin, X., & Yuan, Z.-H. (2024) · Purinergic Signalling · doi:10.1007/s11302-024-10027-w · Cited by 5
Liu, Q., Huang, W., Liang, W., & Ye, Q. (2023) · Molecules · doi:10.3390/molecules28052211 · Cited by 5
Hu, X., Guo, B., Sun, T., & Wang, W. (2023) · Open Medicine · doi:10.1515/med-2023-0635 · Cited by 5
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Dang, C. V. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041530 · Cited by 5
Hua, Y., Duan, N., Sun, C., Yang, F., Tian, M., Sun, Y., Zhao, S., Gong, J., Liu, Q., Huang, X., et al. (2025) · eLife · doi:10.7554/elife.103953 · Cited by 5
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Zhang, T., Zhou, W., Fan, T., Yuan, Y., Tang, X., Zhang, Q., Zou, J., & Li, Y. (2025) · Discover Oncology · doi:10.1007/s12672-025-02364-y · Cited by 4
Ren, Z., Zhao, J., Li, S., & Yuan, H. (2025) · Discover Nano · doi:10.1186/s11671-025-04393-6 · Cited by 4
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Choi, J. (2023) · Evolution Medicine and Public Health · doi:10.1093/emph/eoad042 · Cited by 4
Zhou, S., Li, Y., Wu, R., Chen, T., Xu, Y., Le, H., Tang, Y., Wu, Q., & Gong, C. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102451 · Cited by 4
Colombo, A., Porretto, C. M., Gebbia, V., Sambataro, D., Scandurra, G., & Valerio, M. R. (2024) · In Vivo · doi:10.21873/invivo.13802 · Cited by 4
Shaik, R., Suthar, K., Balija, C., Aleem, S., Syeda, F. S., Syeda, S., & Begum, S. (2025) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1177/10849785251362585 · Cited by 5
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Li, J., Yan, Z., Zhang, Y., Hu, J., Hui, X., Zhang, J., Zhang, R., Xin, T., Liu, Q., & Wang, Y. (2025) · JCO Precision Oncology · doi:10.1200/po-24-00928 · Cited by 4
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Wu, C.-Y., Huang, C.-X., Yuan, W., & Kuang, D. (2025) · Trends in Immunology · doi:10.1016/j.it.2025.11.002 · Cited by 4
Huang, Q., Wang, F., Li, X., Zou, W., Huang, Z., Li, X., Yang, W., Lei, T., Yue, S., Wang, Q., et al. (2025) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-025-04268-w · Cited by 4
Cheng, M., Liu, Y., Suo, M., Wang, K., Chen, X., & Li, Z. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031133 · Cited by 6
Xu, Y., Liu, X.-Y., Zhang, H., Chen, L. J., Wang, H., Shao, Z.-M., Xiao, Y., & Jiang, Y.-Z. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.102659 · Cited by 4
Sagini, M. N., Hotz‐Wagenblatt, A., & Berger, M. R. (2020) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2020.109354 · Cited by 4
Thiazolidinedione enhances the efficacy of anti-PD-1 monoclonal antibody in murine melanoma
Zhang, X., Gao, Y., Tang, K., Li, Z., Halberstam, A. A., Zhou, L., & Perry, R. J. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00346.2023 · Cited by 4
Krug, A., Mhaidly, R., Tosolini, M., Mondragón, L., Tari, G., Martinez-Turtos, A., Paul, R., Asnafi, V., Marchetti, S., Mascio, L. D., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02061-9 · Cited by 4
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Liao, Y., Yang, P., Yang, C., Zhuang, K., Fahira, A., Wang, J., Liu, Z., Lin, Y., & Huang, Z. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70100 · Cited by 4
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Fu, Y., Guo, X., Sun, L., Cui, T., Wang, J., Liu, Y., & Liu, L. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0834 · Cited by 4
Gao, Z., Chen, S., & Ye, W. (2025) · Scientific Reports · doi:10.1038/s41598-024-84024-9 · Cited by 4
LeGrand, E. K. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1508767 · Cited by 4
Qiao, Q., Liu, B., Shang, J., Sun, W., Zhou, X., Fang, X., Hu, S., & Wang, X. (2025) · APOPTOSIS · doi:10.1007/s10495-025-02112-1 · Cited by 4
Huang, B., Zheng, J.-Q., Chen, B., Wu, M., & Xiao, L.-H. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1514383 · Cited by 4
Shimada, Y., Nakano, M., Matsumoto, A., Ozeki, H., Abe, K., Tajima, Y., Yamai, D., Nogami, H., Nakano, M., Tani, T., et al. (2025) · Cancers · doi:10.3390/cancers17132233 · Cited by 4
Liu, Y., Liu, N., Zhou, X., Zhao, L., Wei, W., Hu, J., & Luo, Z. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1245629 · Cited by 4
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Narayan, S. (2021) · Springer eBooks · doi:10.1007/978-981-15-7564-8_10 · Cited by 4
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Raja, R., Wu, C. W., Limbeck, F., Butler, K. A., Acharya, A. P., & Curtis, M. (2021) · Cancers · doi:10.3390/cancers13133327 · Cited by 4
Bao, S., & Jiang, X. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11617 · Cited by 4
Song, Q., Yu, H., Cheng, Y., Han, J., Li, K., Zuang, J., Lv, Q., Yang, X. F., & Yang, H. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.3999041 · Cited by 4
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Dong, Q., Nelson, P. J., & Zhao, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.803213 · Cited by 4
Deecke, L., Homann, J., Goldeck, D., Luessi, F., Vandebergh, M., Ohlei, O., Toepfer, S., Zipp, F., Demuth, I., Morgan, S. L., et al. (2024) · medRxiv · doi:10.1101/2024.02.08.24302520 · Cited by 3
He, S., Tan, Y., Ye, Q., M Gubin, M., Dede, M., Rafei, H., Peng, W., Rezvani, K., Mohanty, V., & Chen, K. (2026) · npj Artificial Intelligence · doi:10.1038/s44387-025-00060-4 · Cited by 3
Tian, R.-F., Feng, L.-L., Liang, X., Shi, Y., Wang, H., Fan, J., Fan, X.-Y., Zhang, J., Ke, Y., Yang, T., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.142945 · Cited by 3
Li, Z., Deng, J., Wang, H., Liu, T., Zhou, Y., Ouyang, P., Liang, X., Zhang, X., Qi, S., & Li, Y. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101834 · Cited by 3
Wang, M., Yang, X., Zhang, Q., Qiu, Y., Qu, J., Xu, H., & Li, Q. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157325 · Cited by 3
Zhang, F., Ni, R., Liang, Q., Chen, Z., Yu, S., Awadasseid, A., Cai, Z.-X., Xiong, X., & Zhang, W. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.109238 · Cited by 3
Chen, Z., Yin, Y., Yang, C., Ye, L., Yang, M. J., Du, H., Fan, Y., Ji, D., & He, Y. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102566 · Cited by 3
Song, R., Zhao, M., Zhang, T., Zhang, Y., Guo, F., He, H., Zhou, H., Li, K., Wang, J., Du, J., et al. (2025) · Protein & Cell · doi:10.1093/procel/pwaf111 · Cited by 3
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Li, W., Ge, M., Luo, Z., Ni, M., Tang, K., Han, C., J, Y., Ma, Y., Liu, X., Ma, K., et al. (2026) · Science Immunology · doi:10.1126/sciimmunol.adz0348 · Cited by 3
Sharma, S. R. K., Saha, S., Arora, S., Ahlawa, Y. K., Sheoran, S., Mukherjee, S., Sinha, A., Chaudhary, K., & Gosipatala, S. B. (2026) · Disease and Therapeutics · doi:10.1016/j.dist.2026.100012 · Cited by 3
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Ji, P., Lin, C., Wang, J., Fang, C., Li, M., Shi, Y., Zhong, Y., Wang, F., Xie, H.-Y., Zhao, Y., et al. (2026) · ACS Nano · doi:10.1021/acsnano.6c02876 · Cited by 3
Abdesheikhi, J., Sedghy, F., Mahmoodi, M., Fallah, H., & Ranjkesh, M. (2023) · Iranian Biomedical Journal · doi:10.52547/ibj.3811 · Cited by 4
Tang, Z., Feng, H., Shu, L., Guo, M., Qi, B., Pu, L., Shi, H., Ren, J., & Li, C. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01553-4 · Cited by 3
Wu, Z., Liu, Z., Gu, C., Wu, Y., Li, Y., Zhou, Z., & Yang, X. (2024) · ONCOLOGIE · doi:10.1515/oncologie-2023-0455 · Cited by 3
Dong, W., Zhang, H., Li, H., Zhao, H., Zhang, Y., Liu, S., Zhang, J., Niu, B., & Xiao, W. (2024) · Aging · doi:10.18632/aging.205807 · Cited by 3
Valence‐Transforming O 2 ‐Depleting Nano‐Assembly Enable In Situ Tumor Depositional Embolization
Kong, W., Meng, Q., Kong, R., Zhao, Y., & Qu, F. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202402899 · Cited by 3
Huerta, D. A., Pizzo, R. D., Kowar, A., Baig, A. H., Palazzo, G., Stepanova, E., Ramirez, C. C. A., D’Agostino, S., Ratto, E., Pechincha, C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59986-7 · Cited by 3
Xu, Y., Hu, J., Cao, C., Zhang, M., Liu, Y., Chen, H., Wei, S., Zhu, Z., Yang, Y., Yu, L., et al. (2021) · Journal of Oncology · doi:10.1155/2021/2427427 · Cited by 5
TCR-Independent Metabolic Reprogramming Precedes Lymphoma-Driven Changes in T-cell Fate
Hesterberg, R. S., Liu, M., Elmarsafawi, A. G., Koomen, J. M., Welsh, E. A., Hesterberg, S. G., Ranatunga, S., Yang, C., Li, W., Lawrence, H. R., et al. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0813 · Cited by 3
Proteomics and Protein Biomarkers in Cancer Metastasis
Gezici, S. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_150-1 · Cited by 3
Ma, X., Zhang, Y., Jiang, J., Ru, Y., Luo, Y., Luo, Y., Fei, X., Song, J., Ma, X., Li, B., et al. (2023) · International Wound Journal · doi:10.1111/iwj.14223 · Cited by 3
Amino acids and their roles in tumor immunotherapy of breast cancer
Xia, H., Zhu, J., Zheng, Z., Xiao, P., Yu, X., Wu, M., Xue, L., Xu, X. Y., Wang, X., Guo, Y., et al. (2023) · The Journal of Gene Medicine · doi:10.1002/jgm.3647 · Cited by 3
Zhang, C., Zeng, J., Ye, C., Tian, K., & Xian, Z. (2024) · Translational Cancer Research · doi:10.21037/tcr-23-1383 · Cited by 3
Metadata
- Authors
- Leone, R. D., & Powell, J. D.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Powell, Jonathan D.
- Venue
- Nature Reviews Cancer
- Published
- 2020-07-06
- Volume
- 20
- Issue
- 9
- Pages
- 516-531
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC8041116
- OpenAlex
- W3040651070
- Semantic Scholar
- 9e54633c23933564226222b58eee14bffccca97c
- Cited by
- 877
- References
- 228
- Citations by year
- 2026: 137 · 2025: 168 · 2024: 141 · 2023: 135 · 2022: 185 · 2021: 98 · 2020: 12
- FWCI
- 11.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA229451, R01CA226765)
- National Institute of Allergy and Infectious Diseases (R01AI077610)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- immune cell metabolism, cancer metabolism, tumor microenvironment, tumor acidosis, tumor hypoxia, nutrient depletion, adaptive immunity, innate immunity, metabolic heterogeneity, metabolic plasticity, metabolic vulnerability, immunotherapy, antitumor immunity
- MeSH terms
- Animals, Humans, Immune System, Immunotherapy, Neoplasms, Tumor Microenvironment
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