Cited by 320Lipid metabolism and disordersCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

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Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia

Borén, Jan, Taskinen, Marja-Riitta, Björnson, Elias, Packard, Chris J.·2022·Nature Reviews Cardiology

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Abstract

Accumulating evidence points to the causal role of triglyceride-rich lipoproteins and their cholesterol-enriched remnants in atherogenesis. Genetic studies in particular have not only revealed a relationship between plasma triglyceride levels and the risk of atherosclerotic cardiovascular disease, but have also identified key proteins responsible for the regulation of triglyceride transport. Kinetic studies in humans using stable isotope tracers have been especially useful in delineating the function of these proteins and revealing the hitherto unappreciated complexity of triglyceride-rich lipoprotein metabolism. Given that triglyceride is an essential energy source for mammals, triglyceride transport is regulated by numerous mechanisms that balance availability with the energy demands of the body. Ongoing investigations are focused on determining the consequences of dysregulation as a result of either dietary imprudence or genetic variation that increases the risk of atherosclerosis and pancreatitis. The identification of molecular control mechanisms involved in triglyceride metabolism has laid the groundwork for a 'precision-medicine' approach to therapy. Novel pharmacological agents under development have specific molecular targets within a regulatory framework, and their deployment heralds a new era in lipid-lowering-mediated prevention of disease. In this Review, we outline what is known about the dysregulation of triglyceride transport in human hypertriglyceridaemia.

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Authors: Borén, J., Taskinen, M.-R., Björnson, E., & Packard, C. J.
Affiliations: University of Gothenburg (SE)
University of Helsinki (FI)
University of Glasgow (GB)
Corresponding author: Borén, Jan
ORCID: Borén, Jan
Taskinen, Marja-Riitta
Björnson, Elias
Packard, Chris J.
Venue: Nature Reviews Cardiology
Publisher: Springer Science and Business Media LLC
Published: 2022-03-22
Volume: 19
Issue: 9
Pages: 577-592
ISSN: 1759-5002 (ISSN-L)
1759-5010
DOI: 10.1038/s41569-022-00676-y
OpenAlex: W4220891222
Semantic Scholar: 43b00c155f869658a4650440b8527740c6158985
Cited by: 315
References: 238
Citations by year: 2026: 74 · 2025: 99 · 2024: 78 · 2023: 48 · 2022: 14
FWCI: 12.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Cardiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: triglyceride-rich lipoproteins, lipoprotein metabolism, hypertriglyceridemia, dyslipidemia, atherogenesis, atherosclerotic cardiovascular disease, triglyceride transport, lipoprotein lipase, hepatic lipase, cholesteryl ester transfer protein, stable isotope tracers, genetic variation, pancreatitis, lipid-lowering therapy, precision medicine
MeSH terms: Animals, Humans, Kinetics, Lipoproteins, Mammals, Triglycerides, Hypertriglyceridemia, Dyslipidemias, Atherosclerosis

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Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia

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