The DOI matches its Crossref record; 235 of the 238 references it cites were found in a registry or an index.
Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia
Abstract
Accumulating evidence points to the causal role of triglyceride-rich lipoproteins and their cholesterol-enriched remnants in atherogenesis. Genetic studies in particular have not only revealed a relationship between plasma triglyceride levels and the risk of atherosclerotic cardiovascular disease, but have also identified key proteins responsible for the regulation of triglyceride transport. Kinetic studies in humans using stable isotope tracers have been especially useful in delineating the function of these proteins and revealing the hitherto unappreciated complexity of triglyceride-rich lipoprotein metabolism. Given that triglyceride is an essential energy source for mammals, triglyceride transport is regulated by numerous mechanisms that balance availability with the energy demands of the body. Ongoing investigations are focused on determining the consequences of dysregulation as a result of either dietary imprudence or genetic variation that increases the risk of atherosclerosis and pancreatitis. The identification of molecular control mechanisms involved in triglyceride metabolism has laid the groundwork for a 'precision-medicine' approach to therapy. Novel pharmacological agents under development have specific molecular targets within a regulatory framework, and their deployment heralds a new era in lipid-lowering-mediated prevention of disease. In this Review, we outline what is known about the dysregulation of triglyceride transport in human hypertriglyceridaemia.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A decrease of 1 mmol/L (88.57 mg/dL) in triglycerides has been linked to roughly a 25% reduction in cardiovascular disease risk [24, 25]”
From Ketogenic diet-induced changes in adult lipid metabolism: a comprehensive systematic review and meta-regression of randomized controlled trials (2026) · cites this paper as [24]
In the citing paper
“In the postprandial state, CM are assembled in enterocytes through the packaging of dietary TG, cholesterol, and apolipoprotein B48 [10].”
From Targeting triglycerides for cardiovascular risk reduction (2026) · cites this paper as [10]
In the citing paper
“In parallel, hepatocytes continuously secrete VLDL particles containing apolipoprotein B100, incorporating TG derived from de novo lipogenesis, circulating non-esterified fatty acids, hepatic lipid stores, and remnant uptake [10].”
From Targeting triglycerides for cardiovascular risk reduction (2026) · cites this paper as [10]
In the citing paper
“TRLs, primarily chylomicrons (CM) and very low-density lipoproteins (VLDL), are secreted by the intestine and liver, respectively, and are the main vehicles for TG transport in the circulation.”
From Targeting triglycerides for cardiovascular risk reduction (2026) · cites this paper as [10]
In the citing paper
“Hypercholesterolemia, defined by elevated plasma low‐density lipoprotein (LDL) cholesterol, is a well‐established risk factor not only for cardiovascular disease (Borén et al. 2022; Steinberg 2013; Tabas et al. 2015; Boffa and Koschinsky 2019), but also for cognitive decline and dementia in later life (Kivipelto et al. 2001; Kivipelto and Solomon 2006; Livingston et al. 2024; Sparks et al. 2000, 2”
From LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models (2026) · cites this paper as Borén et al. 2022
Citations
Cites
Mach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz455 · Cited by 8,961
Self-citationMach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.08.014 · Cited by 4,854
Self-citation(2019) · doi:10.1161/cir.0000000000000677 · Cited by 4,501
Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia
Bhatt, D. L., Steg, P. G., Miller, M., Brinton, E. A., Jacobson, T. A., Ketchum, S. B., Doyle, R. T., Juliano, R. A., Jiao, L., Granowitz, C., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1812792 · Cited by 3,317
Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus
(2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001282 · Cited by 2,837
Major lipids, apolipoproteins, and risk of vascular disease
The Emerging Risk Factors Collaboration* (2009) · JAMA · doi:10.1001/jama.2009.1619 · Cited by 2,731
Mechanisms and disease consequences of nonalcoholic fatty liver disease
Loomba, R., Friedman, S. L., & Shulman, G. I. (2021) · Cell · doi:10.1016/j.cell.2021.04.015 · Cited by 2,002
Molecular mediators of hepatic steatosis and liver injury
Browning, J. D., & Horton, J. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422422 · Cited by 1,772
Atherogenesis: a postprandial phenomenon.
Zilversmit, D. B. (1979) · Circulation · doi:10.1161/01.cir.60.3.473 · Cited by 1,701
Borén, J., Chapman, M. J., Krauss, R. M., Packard, C. J., Bentzon, J. F., Binder, C. J., Daemen, M. J., Demer, L. L., Hegele, R. A., Nicholls, S. J., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz962 · Cited by 1,601
Self-citationNewly identified loci that influence lipid concentrations and risk of coronary artery disease
Willer, C. J., Sanna, S., Jackson, A. U., Scuteri, A., Bonnycastle, L. L., Clarke, R., Heath, S. C., Timpson, N. J., Najjar, S. S., Stringham, H. M., et al. (2008) · Nature Genetics · doi:10.1038/ng.76 · Cited by 1,585
Tabas, I., Williams, K. J., & Borén, J. (2007) · Circulation · doi:10.1161/circulationaha.106.676890 · Cited by 1,399
Self-citationDietary fats and cardiovascular disease: a presidential advisory from the American Heart Association
Sacks, F. M., Lichtenstein, A. H., Wu, J. H. Y., Appel, L. J., Creager, M. A., Kris-Etherton, P. M., Miller, M., Rimm, E. B., Rudel, L. L., Robinson, J. G., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000510 · Cited by 1,386
Goldstein, J. L., & Brown, M. S. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.179564 · Cited by 1,344
Chapman, M. J., Ginsberg, H. N., Amarenco, P., Andreotti, F., Borén, J., Catapano, A. L., Descamps, O. S., Fisher, E., Kovanen, P. T., Kuivenhoven, J. A., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr112 · Cited by 1,227
Self-citation2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary
Arnett, D. K., Blumenthal, R. S., Albert, M. A., Buroker, A. B., Goldberger, Z. D., Hahn, E. J., Himmelfarb, C. D., Khera, A., Lloyd-Jones, D., McEvoy, J. W., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.03.009 · Cited by 1,193
Nordestgaard, B. G. (2016) · Circulation Research · doi:10.1161/circresaha.115.306249 · Cited by 1,116
Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease
The TG and HDL Working Group of the Exome Sequencing Project, N. H. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1307095 · Cited by 1,071
Nicholls, S. J., Lincoff, A. M., Garcia, M., Bash, D., Ballantyne, C. M., Barter, P. J., Davidson, M. H., Kastelein, J. J. P., Koenig, W., McGuire, D. K., et al. (2020) · JAMA · doi:10.1001/jama.2020.22258 · Cited by 1,028
Subendothelial retention of atherogenic lipoproteins in early atherosclerosis
Skålén, K., Gustafsson, M., Rydberg, E. K., Hultén, L. M., Wiklund, O., Innerarity, T. L., & Borén, J. (2002) · Nature · doi:10.1038/nature00804 · Cited by 1,019
Self-citationGinsberg, H. N., Packard, C. J., Chapman, M. J., Borén, J., Aguilar-Salinas, C. A., Averna, M., Ference, B. A., Gaudet, D., Hegele, R. A., Kersten, S., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab551 · Cited by 979
Self-citationKotseva, K., Backer, G. D., Bacquer, D. D., Rydén, L., Hoes, A. W., Grobbee, D. E., Maggioni, A. P., Marques-Vidal, P. M., Jennings, C. S., Abreu, A., et al. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487318825350 · Cited by 940
Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease
Jørgensen, A. B., Frikke-Schmidt, R., Nordestgaard, B. G., & Tybjærg-Hansen, A. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1308027 · Cited by 919
Diabetic dyslipidaemia: from basic research to clinical practice*
Taskinen, M.-R. (2003) · Diabetologia · doi:10.1007/s00125-003-1111-y · Cited by 888
Self-citationGenetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
Dewey, F. E., Gusarova, V., Dunbar, R. L., O’Dushlaine, C., Schurmann, C., Gottesman, O., McCarthy, S., Van Hout, C. V., Bruse, S., Dansky, H. M., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1612790 · Cited by 885
Evinacumab for Homozygous Familial Hypercholesterolemia
Raal, F. J., Rosenson, R. S., Reeskamp, L. F., Hovingh, G. K., Kastelein, J. J. P., Rubba, P., Ali, S., Banerjee, P., Chan, K.-C., Gipe, D. A., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2004215 · Cited by 793
Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease
Smith, G. I., Shankaran, M., Yoshino, M., Schweitzer, G. G., Chondronikola, M., Beals, J. W., Okunade, A. L., Patterson, B. W., Nyangau, E., Field, T., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134165 · Cited by 771
Exome Sequencing, ANGPTL3 Mutations, and Familial Combined Hypolipidemia
Musunuru, K., Pirruccello, J. P., Do, R., Peloso, G. M., Guiducci, C., Sougnez, C., Garimella, K. V., Fisher, S., Abreu, J., Barry, A. J., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1002926 · Cited by 754
Lipoprotein lipase: from gene to obesity
Wang, H., & Eckel, R. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90920.2008 · Cited by 741
Plasma triglyceride and coronary heart disease
Austin, M. A. (1991) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.11.1.2 · Cited by 697
Overproduction of large VLDL particles is driven by increased liver fat content in man
Adiels, M., Taskinen, M.-R., Packard, C., Caslake, M. J., Soro-Paavonen, A., Westerbacka, J., Vehkavaara, S., Häkkinen, A., Olofsson, S.-O., Yki-Järvinen, H., et al. (2006) · Diabetologia · doi:10.1007/s00125-005-0125-z · Cited by 690
Self-citationCeriello, A., Taboga, C., Tonutti, L., Quagliaro, L., Piconi, L., Bais, B., Da Ros, R., & Motz, E. (2002) · Circulation · doi:10.1161/01.cir.0000027569.76671.a8 · Cited by 655
Role of Estrogens in the Regulation of Liver Lipid Metabolism
Palmisano, B. T., Zhu, L., & Stafford, J. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_12 · Cited by 577
Dysregulated lipid metabolism links NAFLD to cardiovascular disease
Deprince, A., Haas, J. T., & Staels, B. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101092 · Cited by 576
Physiological regulation of lipoprotein lipase
Kersten, S. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.03.013 · Cited by 574
Scott, R., O'Brien, R., Fulcher, G., Pardy, C., d'Emden, M., Tse, D., Taskinen, M.-R., Ehnholm, C., Keech, A., & on behalf of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study Investigators (2009) · Diabetes Care · doi:10.2337/dc08-1543 · Cited by 551
Self-citationClinical review on triglycerides
Laufs, U., Parhofer, K. G., Ginsberg, H. N., & Hegele, R. A. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz785 · Cited by 544
Exome-wide association study of plasma lipids in >300,000 individuals
Charge Diabetes Working Group, Liu, D. J., The EPIC-InterAct Consortium, EPIC-CVD Consortium, GOLD Consortium, Program, V. M. V., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., et al. (2017) · Nature Genetics · doi:10.1038/ng.3977 · Cited by 540
Role of apoCs in lipoprotein metabolism: functional differences between apoC1, apoC2, and apoC3
Jong, M. C., Hofker, M. H., & Havekes, L. M. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.3.472 · Cited by 539
Lewis, G., Uffelman, K., Szeto, L., Weller, B., & Steiner, G. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117633 · Cited by 533
Romeo, S., Pennacchio, L. A., Fu, Y., Boerwinkle, E., Tybjaerg-Hansen, A., Hobbs, H. H., & Cohen, J. C. (2007) · Nature Genetics · doi:10.1038/ng1984 · Cited by 511
Hepatic uptake of chylomicron remnants
Cooper, A. D. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34932-4 · Cited by 499
Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease
Dewey, F. E., Gusarova, V., O’Dushlaine, C., Gottesman, O., Trejos, J., Hunt, C., Van Hout, C. V., Habegger, L., Buckler, D., Lai, K.-M. V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1510926 · Cited by 497
Targeting APOC3 in the familial chylomicronemia syndrome
Gaudet, D., Brisson, D., Tremblay, K., Alexander, V. J., Singleton, W., Hughes, S. G., Geary, R. S., Baker, B. F., Graham, M. J., Crooke, R. M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1400284 · Cited by 491
ANGPTL3 deficiency and protection against coronary artery disease
Stitziel, N. O., Khera, A. V., Wang, X., Bierhals, A. J., Vourakis, A. C., Sperry, A. E., Natarajan, P., Klarin, D., Emdin, C. A., Zekavat, S. M., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.02.030 · Cited by 467
Fisher, E. A. A., & Ginsberg, H. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100068200 · Cited by 459
Beigneux, A. P., Davies, B. S. J., Gin, P., Weinstein, M. M., Farber, E., Qiao, X., Peale, F., Bunting, S., Walzem, R. L., Wong, J. S., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.02.002 · Cited by 445
New insights into the pathophysiology of dyslipidemia in type 2 diabetes
Taskinen, M.-R., & Borén, J. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.01.039 · Cited by 440
Self-citationIDIOPATHIC HYPERLIPEMIA: METABOLIC STUDIES IN AN AFFECTED FAMILY*
Havel, R. J., & Gordon, R. S. (1960) · Journal of Clinical Investigation · doi:10.1172/jci104202 · Cited by 380
Angptl3 regulates lipid metabolism in mice
Koishi, R., Ando, Y., Ono, M., Shimamura, M., Yasumo, H., Fujiwara, T., Horikoshi, H., & Furukawa, H. (2002) · Nature Genetics · doi:10.1038/ng814 · Cited by 379
PCSK9 and LDLR degradation: regulatory mechanisms in circulation and in cells
Lagace, T. A. (2014) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000114 · Cited by 372
SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis
Huang, L., Chambliss, K. L., Gao, X., Yuhanna, I. S., Behling‐Kelly, E. L., Bergaya, S., Ahmed, M. H., Michaely, P., Luby‐Phelps, K., Darehshouri, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1140-4 · Cited by 360
Johannesen, C. D. L., Mortensen, M. B., Langsted, A., & Nordestgaard, B. G. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.01.027 · Cited by 359
Olofsson, S. ‐., & Borén, J. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01556.x · Cited by 342
Self-citationBorén, J., Olin, K., Lee, I., Chait, A., Wight, T. N., & Innerarity, T. L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2265 · Cited by 331
Self-citationPradhan, A. D., Paynter, N. P., Everett, B. M., Glynn, R. J., Amarenco, P., Elam, M., Ginsberg, H., Hiatt, W. R., Ishibashi, S., Koenig, W., et al. (2018) · American Heart Journal · doi:10.1016/j.ahj.2018.09.011 · Cited by 319
Apolipoprotein B: mRNA Editing, Lipoprotein Assembly, and Presecretory Degradation
Davidson, N. O., & Shelness, G. S. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.169 · Cited by 311
Marston, N. A., Giugliano, R. P., Im, K., Silverman, M. G., O’Donoghue, M. L., Wiviott, S. D., Ference, B. A., & Sabatine, M. S. (2019) · Circulation · doi:10.1161/circulationaha.119.041998 · Cited by 301
Packard, C. J., Munro, A. F., Lorimer, A. R., Gotto, A. M., & Shepherd, J. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111644 · Cited by 298
Self-citationShimamura, M., Matsuda, M., Yasumo, H., Okazaki, M., Fujimoto, K., Kono, K., Shimizugawa, T., Ando, Y., Koishi, R., Kohama, T., et al. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000252827.51626.89 · Cited by 297
Barrows, B. R., & Parks, E. J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1709 · Cited by 282
Gaudet, D., Karwatowska-Prokopczuk, E., Baum, S. J., Hurh, E., Kingsbury, J., Bartlett, V. J., Figueroa, A. L., Piscitelli, P., Singleton, W., Witztum, J. L., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa689 · Cited by 279
Nonfasting mild-to-moderate hypertriglyceridemia and risk of acute pancreatitis
Pedersen, S. B., Langsted, A., & Nordestgaard, B. G. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.6875 · Cited by 270
Morrone, D., Weintraub, W. S., Toth, P. P., Hanson, M. E., Lowe, R. S., Lin, J., Shah, A. K., & Tershakovec, A. M. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.02.016 · Cited by 263
Schneeman, B. O., Kotite, L., Todd, K., & Havel, R. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.2069 · Cited by 255
Semenkovich, C. F., Wims, M., Noé, L., Étienne, J., & Chan, L. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81898-1 · Cited by 249
Cohn, J. S., Johnson, E. J., Millar, J. S., Cohn, S. D., Milne, R. W., Marcel, Y. L., Russell, R. M., & Schaefer, E. J. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)35345-1 · Cited by 248
Moulin, P., Dufour, R., Averna, M., Arca, M., Cefalù, A. B., Noto, D., D'Erasmo, L., Di Costanzo, A., Marçais, C., Alvarez-Sala Walther, L. A., et al. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.06.814 · Cited by 247
Self-citationGenetics of hypertriglyceridemia
Dron, J. S., & Hegele, R. A. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00455 · Cited by 244
Lee, M., Saver, J. L., Towfighi, A., Chow, J., & Ovbiagele, B. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.04.020 · Cited by 240
Causes and consequences of hypertriglyceridemia
Packard, C. J., Boren, J., & Taskinen, M.-R. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00252 · Cited by 239
Self-citationFatty acid control of lipoprotein lipase: a link between energy metabolism and lipid transport
Peterson, J., Bihain, B. E., Bengtsson-Olivecrona, G., Deckelbaum, R. J., Carpentier, Y. A., & Olivecrona, T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.3.909 · Cited by 237
Borén, J., Lee, I., Zhu, W., Arnold, K. S., Taylor, S., & Innerarity, T. L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1847 · Cited by 233
Self-citationCamejo, G. (1982) · Advances in lipid research · doi:10.1016/b978-0-12-024919-0.50007-2 · Cited by 231
Wolska, A., Dunbar, R. L., Freeman, L. A., Ueda, M., Amar, M. J., Sviridov, D. O., & Remaley, A. T. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.10.025 · Cited by 231
Lipoprotein lipase and its regulators: an unfolding story
Wu, S. A., Kersten, S., & Qi, L. (2021) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2020.11.005 · Cited by 225
Severe hypertriglyceridemia is primarily polygenic
Dron, J. S., Wang, J., Cao, H., McIntyre, A. D., Iacocca, M. A., Menard, J. R., Movsesyan, I., Malloy, M. J., Pullinger, C. R., Kane, J. P., et al. (2019) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2018.10.006 · Cited by 222
Fard, A., Tuck, C. H., Donis, J. A., Sciacca, R. R., Tullio, M. R. D., Wu, H. D., Bryant, T. A., Chen, N.-T., Torres‐Tamayo, M., Ramasamy, R., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.9.2039 · Cited by 221
Angiopoietin-like 3 in lipoprotein metabolism
Kersten, S. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.119 · Cited by 220
Effects of insulin and acipimox on VLDL1 and VLDL2 apolipoprotein B production in normal subjects.
Malmström, R., Packard, C. J., CASLAKE, M. J., Bedford, D. K., Stewart, P., Yki‐Järvinen, H., Shepherd, J., & Taskinen, M. (1998) · Diabetes · doi:10.2337/diabetes.47.5.779 · Cited by 203
Self-citationLee, J.-H., & Hegele, R. A. (2013) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-013-9665-4 · Cited by 202
Adiels, M., Westerbacka, J., Soro‐Paavonen, A., Häkkinen, A. ‐., Vehkavaara, S., CASLAKE, M. J., Packard, C. J., Olofsson, S.-O., Yki‐Järvinen, H., Taskinen, M., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0790-1 · Cited by 197
Self-citationThe Roles of ApoC-III on the Metabolism of Triglyceride-Rich Lipoproteins in Humans
Borén, J., Packard, C. J., & Taskinen, M.-R. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00474 · Cited by 196
Self-citationBruckert, E., Labreuche, J., Deplanque, D., Touboul, P.-J., & Amarenco, P. (2011) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318202709f · Cited by 192
Vallejo-Vaz, A. J., Fayyad, R., Boekholdt, S. M., Hovingh, G. K., Kastelein, J. J., Melamed, S., Barter, P., Waters, D. D., & Ray, K. K. (2018) · Circulation · doi:10.1161/circulationaha.117.032318 · Cited by 187
Postprandial hypertriglyceridemia as a coronary risk factor
Borén, J., Matikainen, N., Adiels, M., & Taskinen, M.-R. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.01.015 · Cited by 182
Self-citationPostprandial metabolism of meal triglyceride in humans
Lambert, J. E., & Parks, E. J. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.01.006 · Cited by 182
Postprandial lipoprotein metabolism: VLDL vs chylomicrons
Nakajima, K., Nakano, T., Tokita, Y., Nagamine, T., Inazu, A., Kobayashi, J., Mabuchi, H., Stanhope, K. L., Havel, P. J., Okazaki, M., et al. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.04.018 · Cited by 179
Metabolic Basis of Hypotriglyceridemic Effects of Insulin in Normal Men
Malmström, R., Packard, C. J., Watson, T. D. G., Rannikko, S., CASLAKE, M. J., Bedford, D. K., Stewart, P., Yki‐Järvinen, H., Shepherd, J., & Taskinen, M. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.7.1454 · Cited by 178
Self-citationBalling, M., Afzal, S., Varbo, A., Langsted, A., Davey Smith, G., & Nordestgaard, B. G. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.09.610 · Cited by 175
Borén, J., Graham, L., WETTESTEN, M., Scott, J., White, A. L., & Olofsson, S. ‐. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50173-9 · Cited by 172
Self-citationThe ever-expanding role of degradation in the regulation of apolipoprotein B metabolism
Ginsberg, H. N., & Fisher, E. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800090-jlr200 · Cited by 172
Nicholls, S. J., Lincoff, A. M., Bash, D., Ballantyne, C. M., Barter, P. J., Davidson, M. H., Kastelein, J. J. P., Koenig, W., McGuire, D. K., Mozaffarian, D., et al. (2018) · Clinical Cardiology · doi:10.1002/clc.23055 · Cited by 167
Gordon, D. A., Jamil, H., Gregg, R. E., Olofsson, S., & Borén, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.33047 · Cited by 165
Self-citationClinical and biochemical features of different molecular etiologies of familial chylomicronemia
Hegele, R. A., Berberich, A. J., Ban, M. R., Wang, J., Digenio, A., Alexander, V. J., D'Erasmo, L., Arca, M., Jones, A., Bruckert, E., et al. (2018) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2018.03.093 · Cited by 165
Koo, S., Stoeckman, A. K., & Towle, H. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010029200 · Cited by 164
Wilson, D. E., Emi, M., Iverius, P., Hata, A., Wu, L. L., Hillas, E., Williams, R. R., & Lalouel, J.-M. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114770 · Cited by 164
Araki, E., Yamashita, S., Arai, H., Yokote, K., Satoh, J., Inoguchi, T., Nakamura, J., Maegawa, H., Yoshioka, N., Tanizawa, Y., et al. (2018) · Diabetes Care · doi:10.2337/dc17-1589 · Cited by 164
Mobilisation of enterocyte fat stores by oral glucose in humans
Robertson, M. D., Parkes, M., Warren, B. F., Ferguson, D. J. P., Jackson, K. G., Jewell, D. P., & Frayn, K. N. (2003) · Gut · doi:10.1136/gut.52.6.834 · Cited by 156
Gencer, B., Djousse, L., Al-Ramady, O. T., Cook, N. R., Manson, J. E., & Albert, C. M. (2021) · Circulation · doi:10.1161/circulationaha.121.055654 · Cited by 150
GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism
Young, S. G., Fong, L. G., Beigneux, A. P., Allan, C. M., He, C. H., Jiang, H., Nakajima, K., Muthuraman, M., Birrane, G., & Ploug, M. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.023 · Cited by 148
Taskinen, M., & Nikkil�, E. A. (1979) · Diabetologia · doi:10.1007/bf01236268 · Cited by 146
Self-citationFamilial chylomicronemia syndrome: an under‐recognized cause of severe hypertriglyceridaemia
Baass, A., Paquette, M., Bernard, S., & Hegele, R. A. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13016 · Cited by 144
Karpe, F., Bell, M., Björkegren, J., & Hamsten, A. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.2.199 · Cited by 143
Hiukka, A., Ståhlman, M., Pettersson, C., Levin, M. C., Adiels, M., Teneberg, S., Leinonen, E. S., Hultén, L. M., Wiklund, O., Orešič, M., et al. (2009) · Diabetes · doi:10.2337/db09-0206 · Cited by 141
Self-citationLipolysis of triglyceride-rich lipoproteins, vascular inflammation, and atherosclerosis
Schwartz, E. A., & Reaven, P. D. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.09.021 · Cited by 130
Intestinal lipoprotein assembly
Hussain, M. M., Fatma, S., Pan, X., & Iqbal, J. (2005) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000169347.53568.5a · Cited by 127
Borén, J., WETTESTEN, M., Sjöberg, A., Thorlin, T., Bondjers, G., Wiklund, O., & Olofsson, S. ‐. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)86983-6 · Cited by 126
Self-citationRustaeus, S., Stillemark-Billton, P., Lindberg, K., Gordon, D., & Olofsson, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5196 · Cited by 126
Flood, C., Gustafsson, M. V., Pitas, R. E., Arnaboldi, L., Walzem, R. L., & Borén, J. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000117174.19078.85 · Cited by 125
Self-citationA Comprehensive Update on the Chylomicronemia Syndrome
Goldberg, R. B., & Chait, A. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.593931 · Cited by 125
Proctor, S. D., & Mamo, J. C. L. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000084638.14534.0a · Cited by 124
Triacylglycerol hydrolase: role in intracellular lipid metabolism
Dolinsky, V. W., Gilham, D., Alam, M., Vance, D. E., & Lehner, R. S. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-3426-3 · Cited by 123
Alcohol-induced changes in serum lipoproteins and in their metabolism.
Taskinen, M.-R., Nikkilä, E. A., Välimäki, M., Sane, T., Kuusi, T., Kesäniemi, Y. A., & Ylikahri, R. (1987) · American Heart Journal · doi:10.1016/0002-8703(87)90614-4 · Cited by 122
Self-citationGLP-1 and GLP-2 as Yin and Yang of Intestinal Lipoprotein Production
Hein, G. J., Baker, C., Hsieh, J., Farr, S., & Adeli, K. (2012) · Diabetes · doi:10.2337/db12-0202 · Cited by 121
Gilham, D., Ho, S. B., Rasouli, M., Martres, P., Vance, D. E., & Lehner, R. S. (2003) · The FASEB Journal · doi:10.1096/fj.02-0728fje · Cited by 115
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans
Wang, X., Wang, H., Xu, B., Huang, D., Nie, C., Pu, L., Zajac, G. J. M., Yan, H., Zhao, J., Shi, F., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.020 · Cited by 115
Systemic and Forearm Triglyceride Metabolism
Miles, J. M., Park, Y., Walewicz, D., Russell-Lopez, C., Windsor, S. L., Isley, W. L., Coppack, S. W., & Harris, W. S. (2004) · Diabetes · doi:10.2337/diabetes.53.3.521 · Cited by 114
Regulation of Chylomicron Secretion: Focus on Post-Assembly Mechanisms
Xiao, C., Stahel, P., & Lewis, G. F. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.10.015 · Cited by 114
Kirchgessner, T. G., LeBoeuf, R. C., Langner, C., Zollman, S., Chang, C., Taylor, B. A., Schotz, M. C., Gordon, J. I., & Lusis, A. J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94212-2 · Cited by 113
Oro-sensory perception of dietary lipids: new insights into the fat taste transduction
Khan, N. A., & Besnard, P. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.01.001 · Cited by 111
The Diagnosis and Treatment of Hypertriglyceridemia
Parhofer, K. G., & Laufs, U. (2019) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2019.0825 · Cited by 110
Dynamics of fat absorption and effect of sham feeding on postprandial lipema
Chavez–Jauregui, R. N., Mattes, R. D., & Parks, E. J. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.05.002 · Cited by 109
Chapman, M. J., Ginsberg, H. N., Amarenco, P., Andreotti, F., Borén, J., Catapano, A. L., Descamps, O. S., Fisher, E. A. A., Kovanen, P. T., Kuivenhoven, J. A., et al. (2011) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(11)70033-2 · Cited by 108
Self-citationIdentification of the Proteoglycan Binding Site in Apolipoprotein B48
Flood, C., Gustafsson, M. V., Richardson, P. E., Harvey, S. C., Segrest, J. P., & Borén, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204053200 · Cited by 107
Self-citationIncreased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes
Kanter, J. E., Shao, B., Kramer, F., Barnhart, S., Shimizu‐Albergine, M., Vaisar, T., Graham, M. J., Crooke, R. M., Manuel, C. R., Haeusler, R. A., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127308 · Cited by 105
Pavlic, M., Xiao, C., Szeto, L., Patterson, B. W., & Lewis, G. F. (2009) · Diabetes · doi:10.2337/db09-1297 · Cited by 102
FoxO1 and hepatic lipid metabolism
Sparks, J. D., & Dong, H. H. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32832b3f4c · Cited by 96
Hiukka, A., Fruchart‐Najib, J., Leinonen, E. S., Hilden, H., Fruchart, J., & Taskinen, M. (2005) · Diabetologia · doi:10.1007/s00125-005-1753-z · Cited by 96
Self-citationEffects of ethanol intake on lipoproteins and atherosclerosis.
Brinton, E. A. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32833c1f41 · Cited by 95
New insights into angiopoietin-like proteins in lipid metabolism and cardiovascular disease risk
Kersten, S. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000600 · Cited by 95
A new dawn for managing dyslipidemias: The era of rna-based therapies
Macchi, C., Sirtori, C. R., Corsini, A., Santos, R. D., Watts, G. F., & Ruscica, M. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104413 · Cited by 95
Determinants of VLDL-triglycerides production
Nielsen, S., & Karpe, F. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283544956 · Cited by 94
Chylomicrons: Advances in biology, pathology, laboratory testing, and therapeutics
Julve, J., Martín-Campos, J. M., Escolá‐Gil, J. C., & Blanco‐Vaca, F. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.02.004 · Cited by 94
Molecular mechanisms of apolipoprotein B mRNA editing
Anant, S., & Davidson, N. O. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200104000-00009 · Cited by 91
Borén, J., Rustaeus, S., WETTESTEN, M., Andersson, M., Wiklund, A., & Olofsson, S. ‐. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.12.1743 · Cited by 88
Self-citationRemnant lipoproteins: are they equal to or more atherogenic than LDL?
Salinas, C. A. A., & Chapman, M. J. (2020) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000682 · Cited by 87
Triglycerides and cardiovascular disease
Esan, O., & Wierzbicki, A. S. (2021) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000862 · Cited by 87
Remnant cholesterol predicts progression of diabetic nephropathy and retinopathy in type 1 diabetes
Sigfrids, F. J., Dahlström, E. H., Forsblom, C. M., Sandholm, N., Harjutsalo, V., Taskinen, M., & Groop, P. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13298 · Cited by 87
Self-citationDoi, T., Langsted, A., & Nordestgaard, B. G. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab555 · Cited by 87
Tremblay, A. J., Lamarche, B., Cohn, J. S., Hogue, J., & Couture, P. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000216750.09611.ec · Cited by 85
Exome-wide association study of plasma lipids in > 300,000 individuals
Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C. A., Alam, D. S., Alves, A. C., et al. (2017) · Figshare · Cited by 82
Martínez‐González, M. Á., Fernandez-Lazaro, C. I., Toledo, E., Díaz‐López, A., Corella, D., Goday, A., Romaguera, D., Vioqué, J., Alonso‐Gómez, Á. M., Wärnberǵ, J., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz298 · Cited by 82
ApoA5 lowers triglyceride levels via suppression of ANGPTL3/8-mediated LPL inhibition
Chen, Y. Q., Pottanat, T. G., Zhen, E. Y., Siegel, R. W., Ehsani, M., Qian, Y.-W., & Konrad, R. J. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100068 · Cited by 82
Effects of TM6SF2 E167K on hepatic lipid and very low-density lipoprotein metabolism in humans
Borén, J., Adiels, M., Björnson, E., Matikainen, N., Söderlund, S., Rämö, J., Ståhlman, M., Ripatti, P., Ripatti, S., Palotie, A., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.144079 · Cited by 81
Self-citationApolipoprotein B metabolism in homozygous familial hypercholesterolemia.
James, R. W., Martin, B., Pometta, D., Fruchart, J., Duriez, P., Puchois, P., Farriaux, J. P., Tacquet, A., Demant, T., & Clegg, R. J. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38378-4 · Cited by 79
Recent advances in triacylglycerol mobilization by the gut
Xiao, C., Stahel, P., Carreiro, A. L., Buhman, K. K., & Lewis, G. F. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2017.12.001 · Cited by 77
Stillemark-Billton, P., Borén, J., Andersson, M., Larsson, T. P., Rustaeus, S., Karlsson, K., & Olofsson, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10506 · Cited by 76
Self-citationRegulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin
Nidhina Haridas, P. A., Soronen, J., Sädevirta, S., Mysore, R., Quagliarini, F., Pasternack, A., Metso, J., Perttilä, J., Leivonen, M., Smas, C. M., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1254 · Cited by 75
Vergès, B., Duvillard, L., Pais de Barros, J. P., Bouillet, B., Baillot-Rudoni, S., Rouland, A., Sberna, A.-L., Petit, J.-M., Degrace, P., & Demizieux, L. (2018) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.118.310990 · Cited by 75
Cummings, M. H., Watts, G. F., Umpleby, A. M., Hennessy, T. R., Kelly, J. M., Jackson, N. C., & Sönksen, P. H. (1995) · Diabetes · doi:10.2337/diab.44.9.1059 · Cited by 74
Lipid Lowering Drugs: Present Status and Future Developments
Ruscica, M., Ferri, N., Santos, R. D., Sirtori, C. R., & Corsini, A. (2021) · Current Atherosclerosis Reports · doi:10.1007/s11883-021-00918-3 · Cited by 73
Gaw, A. J., Packard, C. J., Lindsay, G. M., Griffin, B. A., CASLAKE, M. J., Lorimer, A. R., & Shepherd, J. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39764-9 · Cited by 72
Self-citationFischer, A. W., Jaeckstein, M. Y., Gottschling, K., Heine, M., Sass, F., Mangels, N., Schlein, C., Worthmann, A., Bruns†, O. T., Yuan, Y., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.001 · Cited by 70
Apolipoprotein B Secretory Regulation by Degradation
Olofsson, S., & Borén, J. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.251116 · Cited by 69
Self-citationSpectrum of Mutations and Long-Term Clinical Outcomes in Genetic Chylomicronemia Syndromes
D’Erasmo, L., Costanzo, A. D., Cassandra, F., Minicocci, I., Polito, L., Montali, A., Ceci, F., & Arca, M. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313401 · Cited by 69
Wolska, A. T., Lo, L., Sviridov, D. O., Pourmousa, M., Pryor, M., Ghosh, S. S., Kakkar, R. K., Davidson, M., Wilson, S. R., Pastor, R. W., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw7905 · Cited by 69
Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue
Ruppert, P. M. M., Michielsen, C. C. J. R., Hazebroek, E. J., Pirayesh, A., Olivecrona, G., Afman, L. A., & Kersten, S. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101033 · Cited by 69
The pathophysiology of intestinal lipoprotein production
Giammanco, A., Cefalu, A. B., Noto, D., & Averna, M. R. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00061 · Cited by 68
Olivecrona, G., & Beisiegel, U. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.8.1545 · Cited by 68
Hiukka, A., Leinonen, E., Jauhiainen, M., Sundvall, J., Ehnholm, C., Keech, A. C., & Taskinen, M. R. (2007) · Diabetologia · doi:10.1007/s00125-007-0751-8 · Cited by 68
Self-citationAdiels, M., Matikainen, N., Westerbacka, J., Söderlund, S., Larsson, T. P., Olofsson, S., Borén, J., & Taskinen, M. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.02.001 · Cited by 68
Self-citationMattes, R. D. (2002) · Journal of Nutrition · doi:10.1093/jn/132.12.3656 · Cited by 65
Hansen, S. E. J., Madsen, C. M., Varbo, A., & Nordestgaard, B. G. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz059 · Cited by 64
RNA-targeted therapeutics for lipid disorders
Tsimikas, S. (2018) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000549 · Cited by 62
Xiao, C., Pavlic, M., Szeto, L., Patterson, B. W., & Lewis, G. F. (2010) · Diabetes · doi:10.2337/db10-0763 · Cited by 61
Triglycerides and residual risk
Vallejo‐Vaz, A. J., Corral, P., Schreier, L. E., & Ray, K. K. (2020) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000530 · Cited by 60
Hansen, S. E. J., Madsen, C. M., Varbo, A., Tybjærg‐Hansen, A., & Nordestgaard, B. G. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.08.016 · Cited by 59
Sortilin as a Regulator of Lipoprotein Metabolism
Strong, A., & Rader, D. J. (2012) · Current Atherosclerosis Reports · doi:10.1007/s11883-012-0248-x · Cited by 58
Romeo, S., Yin, W., Kozlitina, J., Pennacchio, L. A., Boerwinkle, E., Hobbs, H. H., & Cohen, J. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci37118 · Cited by 58
Apolipoprotein C-II: the re-emergence of a forgotten factor
Wolska, A. T., Reimund, M., & Remaley, A. T. (2020) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000680 · Cited by 58
Fielding, B. A., Grady, G. R. M., Humphreys, S. M., Evans, K., & Frayn, K. N. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500000763 · Cited by 57
Intracellular events in the assembly of chylomicrons in rabbit enterocytes
Cartwright, I. J., Plonné, D., & Higgins, J. A. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31966-0 · Cited by 57
Jackson, K. G., Wolstencroft, E. J., Bateman, P. A., Yaqoob, P., & Williams, C. M. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.25 · Cited by 56
Blom, D. J., Raal, F. J., Santos, R. D., & Marais, A. D. (2019) · Current Atherosclerosis Reports · doi:10.1007/s11883-019-0809-3 · Cited by 56
Pieke, B., von Eckardstein, A., Gülbahçe, E., Chirazi, A., Schulte, H., Assmann, G., & Wahrburg, U. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801440 · Cited by 55
Role of apolipoprotein C-III overproduction in diabetic dyslipidaemia
Adiels, M., Taskinen, M., Björnson, E., Andersson, L., Matikainen, N., Söderlund, S., Kahri, J., Hakkarainen, A., Lundbom, N., Sihlbom, C., et al. (2019) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13744 · Cited by 55
Self-citationBjörnson, E., Packard, C. J., Adiels, M., Andersson, L., Matikainen, N., Söderlund, S., Kahri, J., Sihlbom, C., Thorsell, A., Zhou, H., et al. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12877 · Cited by 54
Self-citationCasula, M., Olmastroni, E., Gazzotti, M., Galimberti, F., Zambon, A., & Catapano, A. L. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105060 · Cited by 54
Brief oral stimulation, but especially oral fat exposure, elevates serum triglycerides in humans
Mattes, R. D. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90591.2008 · Cited by 50
Ginsberg, H. N. (1997) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1997.tb03051.x · Cited by 47
Oral Glucose Mobilizes Triglyceride Stores From the Human Intestine
Xiao, C., Stahel, P., Carreiro, A. L., Hung, Y.-H., Dash, S., Bookman, I. D., Buhman, K. K., & Lewis, G. F. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.10.002 · Cited by 46
Björnson, E., Packard, C. J., Adiels, M., Andersson, L., Matikainen, N., Söderlund, S., Kahri, J., Hakkarainen, A., Lundbom, N., Lundbom, J., et al. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13017 · Cited by 46
Self-citationAhmed, O., Littmann, K., Gustafsson, U. O., Pramfalk, C., Öörni, K., Larsson, L., Minniti, M. E., Sahlin, S., Camejo, G., Parini, P., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009876 · Cited by 45
Dai, W., Zhang, Z., Yao, C., & Zhao, S. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1166-5 · Cited by 44
Familial Chylomicronemia Syndrome (FCS): Recent Data on Diagnosis and Treatment
Gallo, A., Béliard, S., D’Erasmo, L., & Bruckert, É. (2020) · Current Atherosclerosis Reports · doi:10.1007/s11883-020-00885-1 · Cited by 44
Liu, H., Talmud, P. J., Lins, L., Brasseur, R., Olivecrona, G., Peelman, F., Vandekerckhove, J. S., Rosseneu, M., & Labeur, C. (2000) · Biochemistry · doi:10.1021/bi0009441 · Cited by 42
Regulation of human apolipoprotein B gene expression at multiple levels
Wang, A., Liu, D., & Liang, C. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00313-6 · Cited by 42
Insights into incretin-based therapies for treatment of diabetic dyslipidemia
Stemmer, K., Finan, B., DiMarchi, R. D., Tschöp, M. H., & Müller, T. D. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.05.008 · Cited by 42
Transport of LDLs into the arterial wall: impact in atherosclerosis
Zhang, X., & Fernandez-Hernando, C. F. (2020) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000701 · Cited by 42
Reeskamp, L. F., Tromp, T. R., & Stroes, E. S. G. (2020) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000679 · Cited by 40
Effects of liraglutide on the metabolism of triglyceride-rich lipoproteins in type 2 diabetes
Taskinen, M., Björnson, E., Matikainen, N., Söderlund, S., Pietiläinen, K. H., Ainola, M., Hakkarainen, A., Lundbom, N., Fuchs, J., Thorsell, A., et al. (2021) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14328 · Cited by 40
Self-citationChan, D. C., Watts, G. F., Somaratne, R. M., Wasserman, S. M., Scott, R. C., & Barrett, P. H. R. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.310882 · Cited by 39
Role of the Gut in Diabetic Dyslipidemia
Stahel, P., Xiao, C., Nahmias, A., & Lewis, G. F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00116 · Cited by 39
Genetics of hypertriglyceridemia and atherosclerosis
Gill, P. K., Dron, J. S., & Hegele, R. A. (2021) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000839 · Cited by 39
Bini, S., D’Erasmo, L., Costanzo, A. D., Minicocci, I., Pecce, V., & Arca, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020742 · Cited by 38
The angiopoietin-like protein 3
Arca, M., Minicocci, I., & Maranghi, M. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283630cf0 · Cited by 37
Endogenous cholesterol synthesis is associated with VLDL-2 apoB-100 production in healthy humans
Prinsen, B. H. C. M. T., Romijn, J. A., Bisschop, P. H. L. T., de Barse, M. M. J., Barrett, P. H. R., Ackermans, M. T., Berger, R., Rabelink, T. J., & der Velden, M. G. M. D. S. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300023-jlr200 · Cited by 37
Research works printed but not linked: 1
- Chan, L. et al. From editosome to proteasome. Recent. Prog. Horm. Res. 55, 93–125 (2000). discussion 126.
Cited by
Sorted by citations
Björnson, E., Adiels, M., Taskinen, M.-R., Burgess, S., Rawshani, A., Borén, J., & Packard, C. J. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad337 · Cited by 183
“1–5 In analogy with the pathogenic mechanisms linked to low-density lipoproteins (LDL), remnant lipoproteins can penetrate the sub-endothelial space in artery walls and bind to proteoglycans, thereby initiating cholesterol deposition and foam cell formation.”
Self-citationLi, Z., Zhang, B., Liu, Q., Tao, Z., Ding, L., Guo, B., Zhang, E., Zhang, H., Meng, Z., Guo, S., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104543 · Cited by 136
Zhao, Y., Zhuang, Z., Li, Y., Xiao, W., Song, Z., Huang, N., Wang, W., Dong, X., Jia, J., Clarke, R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46686-x · Cited by 117
Xu, H., She, P., Zhao, Z., Ma, B., Li, G., & Wang, Y. (2023) · Advanced Materials · doi:10.1002/adma.202300439 · Cited by 103
Apolipoprotein B-containing lipoproteins in atherogenesis
Borén, J., Packard, C. J., & Binder, C. J. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01111-0 · Cited by 110
Self-citation
Metadata
- Authors
- Borén, J., Taskinen, M.-R., Björnson, E., & Packard, C. J.
- Affiliations
- University of Gothenburg (SE)
- University of Helsinki (FI)
- University of Glasgow (GB)
- Corresponding author
- Borén, Jan
- Venue
- Nature Reviews Cardiology
- Published
- 2022-03-22
- Volume
- 19
- Issue
- 9
- Pages
- 577-592
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- OpenAlex
- W4220891222
- Semantic Scholar
- 43b00c155f869658a4650440b8527740c6158985
- Cited by
- 315
- References
- 238
- Citations by year
- 2026: 74 · 2025: 99 · 2024: 78 · 2023: 48 · 2022: 14
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- triglyceride-rich lipoproteins, lipoprotein metabolism, hypertriglyceridemia, dyslipidemia, atherogenesis, atherosclerotic cardiovascular disease, triglyceride transport, lipoprotein lipase, hepatic lipase, cholesteryl ester transfer protein, stable isotope tracers, genetic variation, pancreatitis, lipid-lowering therapy, precision medicine
- MeSH terms
- Animals, Humans, Kinetics, Lipoproteins, Mammals, Triglycerides, Hypertriglyceridemia, Dyslipidemias, Atherosclerosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
