Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

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Thermal proteome profiling for interrogating protein interactions

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Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

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Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat

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Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy

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Identifying drug targets in tissues and whole blood with thermal-shift profiling

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Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC

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ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma

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Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6

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Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors

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Chemoproteomics and Chemical Probes for Target Discovery

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MAST1 drives cisplatin resistance in human cancers by rewiring cRaf-independent MEK activation

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Drug discovery and development for rare genetic disorders

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Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer

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SF2312 is a natural phosphonate inhibitor of enolase

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Repurposing drugs to treat cardiovascular disease in the era of precision medicine

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Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer

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Quantitating drug-target engagement in single cells in vitro and in vivo

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Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors

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A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target

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Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30

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A computational method for detection of ligand-binding proteins from dose range thermal proteome profiles

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Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme

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SLC7A11 Is a Superior Determinant of APR-246 (Eprenetapopt) Response than <i>TP53</i> Mutation Status

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Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein–Protein Interaction

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Compounds from the marine sponge <i>Cribrochalina vasculum</i> offer a way to target IGF-1R mediated signaling in tumor cells

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Mutant thermal proteome profiling for characterization of missense protein variants and their associated phenotypes within the proteome

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Temperature sensitive Mutant Proteome Profiling: a novel tool for the characterization of the global impact of missense mutations on the proteome

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Selective Covalent Targeting of Pyruvate Kinase M2 Using Arsenous Warheads

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20-Hydroxyecdysone inhibits inflammation via SIRT6-mediated NF-κB signaling in endothelial cells

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Hidden information on protein function in censuses of proteome foldedness

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Identification of an allosteric site on the E3 ligase adapter cereblon

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Targeting transcription factors through an IMiD independent zinc finger domain

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Utilizing a cell culture based novel cellular thermal shift assay to understand the isoform-dependent thermal stability of ApoE variants

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