Nuclear DNA damage signalling to mitochondria in ageing
Open accessAbstract
Mitochondrial dysfunction is a hallmark of ageing, and mitochondrial maintenance may lead to increased healthspan. Emerging evidence suggests a crucial role for signalling from the nucleus to mitochondria (NM signalling) in regulating mitochondrial function and ageing. An important initiator of NM signalling is nuclear DNA damage, which accumulates with age and may contribute to the development of age-associated diseases. DNA damage-dependent NM signalling constitutes a network that includes nuclear sirtuins and controls genomic stability and mitochondrial integrity. Pharmacological modulation of NM signalling is a promising novel approach for the prevention and treatment of age-associated diseases.
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Nuclear genomic instability can affect mitochondrial physiology during ageing through anterograde signalling.
“Genomic instability in the nucleus can impact mitochondrial physiology during ageing via what is known as anterograde signalling76.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [76]
Oxidative damage to cell proteins, lipids and most importantly nuclear DNA is a critical element of the aging process.
“The oxidative damage to cell proteins, lipids and most importantly nuclear DNA is now believed to be a critical element of the aging process [94,95,96,97,98,99,100].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [95]
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1 retracted
RETRACTED: Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation
Kaidi, A., Weinert, B. T., Choudhary, C., & Jackson, S. P. (2010) · Science · doi:10.1126/science.1192049 · Cited by 366 · see citing works
RetractedLópez-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
The DNA-damage response in human biology and disease
Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092 · see citing works
The BCL-2 protein family: opposing activities that mediate cell death
Youle, R. J., & Strasser, A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2308 · Cited by 4,704 · see citing works
Mitochondrial Fission, Fusion, and Stress
Youle, R. J., & van der Bliek, A. M. (2012) · Science · doi:10.1126/science.1219855 · Cited by 3,674 · see citing works
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510 · see citing works
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300 · see citing works
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works
Mitochondrial diseases in man and mouse
Wallace, D. C. (1999) · Science · doi:10.1126/science.283.5407.1482 · Cited by 3,060 · see citing works
Pathways towards and Away from Alzheimer’s Disease
Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052 · see citing works
Self-citationThe ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
Lazarou, M., Sliter, D. A., Kane, L. A., Sarraf, S. A., Wang, C., Burman, J. L., Sideris, D. P., Fogel, A. I., & Youle, R. J. (2015) · Nature · doi:10.1038/nature14893 · Cited by 2,774 · see citing works
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,653 · see citing works
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600 · see citing works
Wallace, D. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3365 · Cited by 2,404 · see citing works
Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347 · see citing works
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
Pickrell, A. M., & Youle, R. J. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.007 · Cited by 2,310 · see citing works
Hoeijmakers, J. H. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804615 · Cited by 2,239 · see citing works
Self-consumption: the interplay of autophagy and apoptosis
Mariño, G., Niso-Santano, M., Baehrecke, E. H., & Kroemer, G. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3735 · Cited by 2,172 · see citing works
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107 · see citing works
Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works
Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081 · see citing works
Mitochondrial DNA stress primes the antiviral innate immune response
West, A. P., Khoury-Hanold, W., Staron, M., Tal, M. C., Pineda, C. M., Lang, S. M., Bestwick, M., Duguay, B. A., Raimundo, N., MacDuff, D. A., et al. (2015) · Nature · doi:10.1038/nature14156 · Cited by 1,975 · see citing works
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., & Sinclair, D. A. (2004) · Science · doi:10.1126/science.1099196 · Cited by 1,924 · see citing works
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,918 · see citing works
Williamson, D., Lund, P., & Krebs, H. (1967) · Biochemical Journal · doi:10.1042/bj1030514 · Cited by 1,871 · see citing works
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., et al. (2013) · Science · doi:10.1126/science.1227166 · Cited by 1,777 · see citing works
Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775 · see citing works
Defective repair replication of DNA in xeroderma pigmentosum
CLEAVER, J. E. (1968) · Nature · doi:10.1038/218652a0 · Cited by 1,729 · see citing works
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Hirschey, M. D., Shimazu, T., Goetzman, E., Jing, E., Schwer, B., Lombard, D. B., Grueter, C. A., Harris, C., Biddinger, S., Ilkayeva, O. R., et al. (2010) · Nature · doi:10.1038/nature08778 · Cited by 1,687 · see citing works
Induction of autophagy by spermidine promotes longevity
Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1975 · Cited by 1,680 · see citing works
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Shiloh, Y., & Ziv, Y. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3546 · Cited by 1,649 · see citing works
Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648 · see citing works
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6
Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M., et al. (2006) · Cell · doi:10.1016/j.cell.2005.11.044 · Cited by 1,637 · see citing works
Self-citationPrice, N. L., Gomes, A. P., Ling, A. J. Y., Duarte, F. V., Martin-Montalvo, A., North, B. J., Agarwal, B., Ye, L., Ramadori, G., Teodoro, J. S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.003 · Cited by 1,602 · see citing works
Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482 · see citing works
Fasting: molecular mechanisms and clinical applications
Longo, V. D., & Mattson, M. P. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.008 · Cited by 1,425 · see citing works
Self-citationDRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis
Crighton, D., Wilkinson, S., O'Prey, J., Syed, N., Smith, P., Harrison, P. R., Gasco, M., Garrone, O., Crook, T., & Ryan, K. M. (2006) · Cell · doi:10.1016/j.cell.2006.05.034 · Cited by 1,380 · see citing works
The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors
Virág, L., & Szabó, C. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.3.375 · Cited by 1,373 · see citing works
p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
Budanov, A. V., & Karin, M. (2008) · Cell · doi:10.1016/j.cell.2008.06.028 · Cited by 1,326 · see citing works
Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.002 · Cited by 1,320 · see citing works
Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319 · see citing works
NAD <sup>+</sup> in aging, metabolism, and neurodegeneration
Verdin, E. (2015) · Science · doi:10.1126/science.aac4854 · Cited by 1,319 · see citing works
New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs
Gibson, B. A., & Kraus, W. L. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3376 · Cited by 1,226 · see citing works
Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.016 · Cited by 1,210 · see citing works
Oda, K., Arakawa, H., Tanaka, T., Matsuda, K., Tanikawa, C., Mori, T., Nishimori, H., Tamai, K., Tokino, T., Nakamura, Y., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00073-8 · Cited by 1,162 · see citing works
Someya, S., Yu, W., Hallows, W. C., Xu, J., Vann, J. M., Leeuwenburgh, C., Tanokura, M., Denu, J. M., & Prolla, T. A. (2010) · Cell · doi:10.1016/j.cell.2010.10.002 · Cited by 1,150 · see citing works
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Michishita, E., McCord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., Damian, M., Cheung, P., Kusumoto, R., Kawahara, T. L. A., Barrett, J. C., et al. (2008) · Nature · doi:10.1038/nature06736 · Cited by 1,111 · see citing works
Self-citationChu, C. T., Ji, J., Dagda, R. K., Jiang, J. F., Tyurina, Y. Y., Kapralov, A. A., Tyurin, V. A., Yanamala, N., Shrivastava, I. H., Mohammadyani, D., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2837 · Cited by 1,083 · see citing works
The sirtuin SIRT6 regulates lifespan in male mice
Kanfi, Y., Naiman, S., Amir, G., Peshti, V., Zinman, G., Nahum, L., Bar-Joseph, Z., & Cohen, H. Y. (2012) · Nature · doi:10.1038/nature10815 · Cited by 1,059 · see citing works
Transcription-coupled DNA repair: two decades of progress and surprises
Hanawalt, P. C., & Spivak, G. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2549 · Cited by 1,038 · see citing works
Mitonuclear protein imbalance as a conserved longevity mechanism
Houtkooper, R. H., Mouchiroud, L., Ryu, D., Moullan, N., Katsyuba, E., Knott, G., Williams, R. W., & Auwerx, J. (2013) · Nature · doi:10.1038/nature12188 · Cited by 1,035 · see citing works
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
Eliasson, M. J. L., Sampei, K., Mandir, A. S., Hurn, P. D., Traystman, R. J., Bao, J., Pieper, A. A., Wang, Z., Dawson, T. M., Snyder, S. H., et al. (1997) · Nature Medicine · doi:10.1038/nm1097-1089 · Cited by 1,019 · see citing works
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
Zhong, L., D'Urso, A., Toiber, D., Sebastian, C., Henry, R. E., Vadysirisack, D. D., Guimaraes, A., Marinelli, B., Wikstrom, J. D., Nir, T., et al. (2010) · Cell · doi:10.1016/j.cell.2009.12.041 · Cited by 1,001 · see citing works
Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival
Yang, H., Yang, T., Baur, J. A., Perez, E., Matsui, T., Carmona, J. J., Lamming, D. W., Souza-Pinto, N. C., Bohr, V. A., Rosenzweig, A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.035 · Cited by 950 · see citing works
Self-citationSIRT6 Promotes DNA Repair Under Stress by Activating PARP1
Mao, Z., Hine, C., Tian, X., Van Meter, M., Au, M., Vaidya, A., Seluanov, A., & Gorbunova, V. (2011) · Science · doi:10.1126/science.1202723 · Cited by 867 · see citing works
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
Oberdoerffer, P., Michan, S., McVay, M., Mostoslavsky, R., Vann, J., Park, S.-K., Hartlerode, A., Stegmuller, J., Hafner, A., Loerch, P., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.025 · Cited by 852 · see citing works
Compromised autophagy and neurodegenerative diseases
Menzies, F. M., Fleming, A., & Rubinsztein, D. C. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3961 · Cited by 851 · see citing works
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
Bai, P., Cantó, C., Oudart, H., Brunyánszki, A., Cen, Y., Thomas, C., Yamamoto, H., Huber, A., Kiss, B., Houtkooper, R. H., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.004 · Cited by 837 · see citing works
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans
Palikaras, K., Lionaki, E., & Tavernarakis, N. (2015) · Nature · doi:10.1038/nature14300 · Cited by 770 · see citing works
Phenotype and Course of Hutchinson–Gilford Progeria Syndrome
Merideth, M. A., Gordon, L. B., Clauss, S. B., Sachdev, V., Smith, A. C. M., Perry, M. B., Brewer, C. C., Zalewski, C. K., Kim, H. J., Solomon, B. I., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706898 · Cited by 740 · see citing works
ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks
Shanbhag, N. M., Rafalska-Metcalf, I. U., Balane-Bolivar, C., Janicki, S. M., & Greenberg, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.04.038 · Cited by 737 · see citing works
Michikawa, Y., Mazzucchelli, F., Bresolin, N., Scarlato, G., & Attardi, G. M. (1999) · Science · doi:10.1126/science.286.5440.774 · Cited by 725 · see citing works
Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction
Fang, E. F., Scheibye-Knudsen, M., Brace, L. E., Kassahun, H., SenGupta, T., Nilsen, H., Mitchell, J. R., Croteau, D. L., & Bohr, V. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.026 · Cited by 711 · see citing works
Self-citationDeacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation
Huang, R., Xu, Y., Wan, W., Shou, X., Qian, J., You, Z., Liu, B., Chang, C., Zhou, T., Lippincott‐Schwartz, J., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2014.12.013 · Cited by 679 · see citing works
Histone H4 lysine 16 acetylation regulates cellular lifespan
Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., & Berger, S. L. (2009) · Nature · doi:10.1038/nature08085 · Cited by 667 · see citing works
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
Sebastián, C., Zwaans, B. M. M., Silberman, D. M., Gymrek, M., Goren, A., Zhong, L., Ram, O., Truelove, J., Guimaraes, A. R., Toiber, D., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.047 · Cited by 660 · see citing works
Oxidative capacity and ageing in human muscle
Conley, K. E., Jubrias, S. A., & Esselman, P. C. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00203.x · Cited by 651 · see citing works
Sutendra, G., Kinnaird, A. S., Dromparis, P., Paulin, R., Stenson, T. H., Haromy, A., Hashimoto, K., Zhang, N., Flaim, E., & Michelakis, E. D. (2014) · Cell · doi:10.1016/j.cell.2014.04.046 · Cited by 633 · see citing works
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári, M., Piper, M. D., Hoddinott, M., Sutphin, G. L., Leko, V., McElwee, J. J., et al. (2011) · Nature · doi:10.1038/nature10296 · Cited by 624 · see citing works
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation
Barber, M. F., Michishita-Kioi, E., Xi, Y., Tasselli, L., Kioi, M., Moqtaderi, Z., Tennen, R. I., Paredes, S., Young, N. L., Chen, K., et al. (2012) · Nature · doi:10.1038/nature11043 · Cited by 621 · see citing works
Self-citationEvidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
Hubbard, B. P., Gomes, A. P., Dai, H., Li, J., Case, A. W., Considine, T., Riera, T. V., Lee, J. E., Yen, E. S., Lamming, D. W., et al. (2013) · Science · doi:10.1126/science.1231097 · Cited by 618 · see citing works
Interventions to slow aging in humans: are we ready?
Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592 · see citing works
Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome
Liu, G.-H., Barkho, B. Z., Ruiz, S., Diep, D., Qu, J., Yang, S.-L., Panopoulos, A. D., Suzuki, K., Kurian, L., Walsh, C., et al. (2011) · Nature · doi:10.1038/nature09879 · Cited by 575 · see citing works
Shining a light on xeroderma pigmentosum
DiGiovanna, J. J., & Kraemer, K. H. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.426 · Cited by 547 · see citing works
Loss of iron triggers PINK1/Parkin‐independent mitophagy
Allen, G. F. G., Toth, R. L., James, J. L., & Ganley, I. G. (2013) · EMBO Reports · doi:10.1038/embor.2013.168 · Cited by 540 · see citing works
Hoshino, A., Mita, Y., Okawa, Y., Ariyoshi, M., Iwai-Kanai, E., Ueyama, T., Ikeda, K., Ogata, T., & Matoba, S. (2013) · Nature Communications · doi:10.1038/ncomms3308 · Cited by 536 · see citing works
Human RecQ Helicases in DNA Repair, Recombination, and Replication
Croteau, D. L., Popuri, V., Opresko, P. L., & Bohr, V. A. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035428 · Cited by 535 · see citing works
Self-citation(2010) · doi:10.1016/j.cmet.2010.06.009 · Cited by 512 · see citing works
The multifaceted functions of sirtuins in cancer
Chalkiadaki, A., & Guarente, L. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3985 · Cited by 501 · see citing works
A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
Mohrin, M., Shin, J., Liu, Y., Brown, K., Luo, H., Xi, Y., Haynes, C. M., & Chen, D. (2015) · Science · doi:10.1126/science.aaa2361 · Cited by 490 · see citing works
Delayed ageing through damage protection by the Arf/p53 pathway
Matheu, A., Maraver, A., Klatt, P., Flores, I., Garcia-Cao, I., Borras, C., Flores, J. M., Viña, J., Blasco, M. A., & Serrano, M. (2007) · Nature · doi:10.1038/nature05949 · Cited by 466 · see citing works
The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and UpdatePreprint
ALEXEYEV, M. F., Shokolenko, I. N., Wilson, G. L., & LeDoux, S. P. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012641 · Cited by 461 · see citing works
Van Meter, M., Kashyap, M., Rezazadeh, S., Geneva, A. J., Morello, T. D., Seluanov, A., & Gorbunova, V. (2014) · Nature Communications · doi:10.1038/ncomms6011 · Cited by 455 · see citing works
Jeong, S. M., Xiao, C., Finley, L. W. S., Lahusen, T., Souza, A. L., Pierce, K., Li, Y.-H., Wang, X., Laurent, G., German, N. J., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.024 · Cited by 445 · see citing works
DNA Damage, DNA Repair, Aging, and NeurodegenerationPreprint
Maynard, S., Fang, E. F., Scheibye‐Knudsen, M., Croteau, D. L., & Bohr, V. A. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025130 · Cited by 439 · see citing works
Self-citationDisorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity
Cleaver, J. E., Lam, E. T., & Revet, I. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2663 · Cited by 428 · see citing works
A complex barcode underlies the heterogeneous response of p53 to stress
Murray-Zmijewski, F., Slee, E. A., & Lu, X. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2451 · Cited by 420 · see citing works
SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling
Toiber, D., Erdel, F., Bouazoune, K., Silberman, D. M., Zhong, L., Mulligan, P., Sebastian, C., Cosentino, C., Martinez-Pastor, B., Giacosa, S., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.06.018 · Cited by 381 · see citing works
Cheng, A., Yang, Y., Zhou, Y., Maharana, C., Lu, D., Peng, W., Liu, Y., Wan, R., Marosi, K., Misiak, M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.013 · Cited by 371 · see citing works
Self-citationMitochondrial dysfunction in ataxia-telangiectasia
Valentin-Vega, Y. A., MacLean, K. H., Tait-Mulder, J., Milasta, S., Steeves, M., Dorsey, F. C., Cleveland, J. L., Green, D. R., & Kastan, M. B. (2012) · Blood · doi:10.1182/blood-2011-08-373639 · Cited by 365 · see citing works
Role of the Peroxynitrite-Poly(ADP-Ribose) Polymerase Pathway in Human Disease
Pacher, P., & Szabó, C. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080019 · Cited by 364 · see citing works
Kashiwaya, Y., Bergman, C., Lee, J.-H., Wan, R., King, M. T., Mughal, M. R., Okun, E., Clarke, K., Mattson, M. P., & Veech, R. L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.023 · Cited by 363 · see citing works
Self-citationSignaling the mitochondrial unfolded protein response
Pellegrino, M. W., Nargund, A. M., & Haynes, C. M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.02.019 · Cited by 359 · see citing works
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in Cockayne syndrome
Scheibye-Knudsen, M., Mitchell, S. J., Fang, E. F., Iyama, T., Ward, T., Wang, J., Dunn, C. A., Singh, N., Veith, S., Hasan-Olive, M. M., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.005 · Cited by 352 · see citing works
Self-citationProtecting the mitochondrial powerhouse
Scheibye‐Knudsen, M., Fang, E. F., Croteau, D. L., Wilson, D. M., & Bohr, V. A. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.11.002 · Cited by 330 · see citing works
Self-citationDai, D., Karunadharma, P. P., Chiao, Y. A., Basisty, N., Crispin, D. A., Hsieh, E. J., Chen, T., Gu, H., Djukovic, D., Raftery, D., et al. (2014) · Aging Cell · doi:10.1111/acel.12203 · Cited by 328 · see citing works
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair
McCord, R. A., Michishita, E., Hong, T., Berber, E., Boxer, L. D., Kusumoto, R., Guan, S., Shi, X., Gozani, O., Burlingame, A. L., et al. (2009) · Aging · doi:10.18632/aging.100011 · Cited by 313 · see citing works
Self-citationGrube, K., & Bürkle, A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.11759 · Cited by 301 · see citing works
Ross, J. M., Öberg, J., Brené, S., Coppotelli, G., Terzioglu, M., Pernold, K., Goiny, M., Sitnikov, R., Kehr, J., Trifunovic, A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008189107 · Cited by 299 · see citing works
A mitochondrial etiology of Alzheimer and Parkinson disease
Coskun, P. E., Wyrembak, J., Schriner, S. E., Chen, H.-W., Marciniack, C., LaFerla, F. M., & Wallace, D. C. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.08.008 · Cited by 297 · see citing works
SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease
Shin, J., He, M., Liu, Y., Paredes, S., Villanova, L., Brown, K., Qiu, X., Nabavi, N., Mohrin, M., Wojnoonski, K., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.007 · Cited by 287 · see citing works
Self-citationBrown, K. D., Maqsood, S., Huang, J.-Y., Pan, Y., Harkcom, W., Li, W., Sauve, A., Verdin, E., & Jaffrey, S. R. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.003 · Cited by 277 · see citing works
Self and Nonself: How Autophagy Targets Mitochondria and Bacteria
Randow, F., & Youle, R. J. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.03.012 · Cited by 271 · see citing works
NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling
Biton, S., & Ashkenazi, A. (2011) · Cell · doi:10.1016/j.cell.2011.02.023 · Cited by 262 · see citing works
A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function
Ryu, D., Jo, Y. S., Sasso, G. L., Stein, S., Zhang, H., Perino, A., Lee, J. U., Zeviani, M., Romand, R., Hottiger, M. O., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.08.001 · Cited by 258 · see citing works
Mitochondrial DNA Variation in Human Radiation and Disease
Wallace, D. C. (2015) · Cell · doi:10.1016/j.cell.2015.08.067 · Cited by 253 · see citing works
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons
Dobbin, M. M., Madabhushi, R., Pan, L., Chen, Y., Kim, D., Gao, J., Ahanonu, B., Pao, P.-C., Qiu, Y., Zhao, Y., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3460 · Cited by 250 · see citing works
Liu, D., Gharavi, R. B., PITTA, M. G. R., Gleichmann, M., & Mattson, M. P. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8058-1 · Cited by 248 · see citing works
Self-citationP7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage
Wang, G., Han, T., Nijhawan, D., Theodoropoulos, P., Naidoo, J., Yadavalli, S., Mirzaei, H., Pieper, A. A., Ready, J. M., & McKnight, S. L. (2014) · Cell · doi:10.1016/j.cell.2014.07.040 · Cited by 243 · see citing works
Mutations That Increase the Life Span of <i>C. elegans</i> Inhibit Tumor Growth
Pinkston, J. M., Garigan, D., Hansen, M., & Kenyon, C. (2006) · Science · doi:10.1126/science.1121908 · Cited by 242 · see citing works
DNA Damage Links Mitochondrial Dysfunction to Atherosclerosis and the Metabolic Syndrome
Mercer, J. R., Cheng, K., Figg, N. L., Gorenne, I., Mahmoudi, M., Griffin, J. L., Vidal‐Puig, A., Logan, A., Murphy, M. P., & Bennett, M. R. (2010) · Circulation Research · doi:10.1161/circresaha.110.218966 · Cited by 240 · see citing works
Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2–mediated suppression of mTORC1
Tripathi, D. N., Chowdhury, R., Trudel, L. J., Tee, A. R., Slack, R. S., Walker, C. L., & Wogan, G. N. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307736110 · Cited by 235 · see citing works
Small-Molecule Allosteric Activators of Sirtuins
Sinclair, D. A., & Guarente, L. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134657 · Cited by 223 · see citing works
SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA
Fan, W., & Luo, J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.07.006 · Cited by 223 · see citing works
D-beta-hydroxybutyrate extends lifespan in C. elegans
Edwards, C., Canfield, J., Copes, N., Rehan, M., Lipps, D., & Bradshaw, P. C. (2014) · Aging · doi:10.18632/aging.100683 · Cited by 203 · see citing works
Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules
Luo, S., Garcı́a-Arencibia, M., Zhao, R., Puri, C., Toh, P. P. C., Sadiq, O., & Rubinsztein, D. C. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.040 · Cited by 203 · see citing works
Scheibye‐Knudsen, M., Ramamoorthy, M., Sýkora, P., Maynard, S., Lin, P., Minor, R. K., Wilson, D. M., Cooper, M. P., Spencer, R. G. S., de Cabo, R., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111721 · Cited by 203 · see citing works
Self-citationLocal UV‐induced DNA damage in cell nuclei results in local transcription inhibition
Moné, M. J., Volker, M., Nikaido, O., Mullenders, L. H. F., van Zeeland, A. A., Verschure, P. J., Manders, E. M. M., & DRIEL, R. V. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve224 · Cited by 202 · see citing works
Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes
Viswanathan, M., & Guarente, L. (2011) · Nature · doi:10.1038/nature10440 · Cited by 191 · see citing works
Woods, C., & Taylor, A. J. (1992) · QJM · doi:10.1093/oxfordjournals.qjmed.a068657 · Cited by 178 · see citing works
Li, K., Casta, A., Wang, R., Lozada, E., Fan, W., Kane, S. E., Ge, Q., Gu, W. J., Orren, D. K., & Luo, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709707200 · Cited by 177 · see citing works
SIRT1 deacetylates APE1 and regulates cellular base excision repair
Yamamori, T., DeRicco, J. S., Naqvi, A., Hoffman, T. A., Mattagajasingh, I., Kasuno, K., Jung, S.-B., Kim, C., & Irani, K. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1039 · Cited by 176 · see citing works
Extra-telomeric Functions of Human Telomerase: Cancer, Mitochondria and Oxidative Stress
Saretzki, G. C. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140630095606 · Cited by 158 · see citing works
The ATM–BID pathway regulates quiescence and survival of haematopoietic stem cells
Maryanovich, M., Oberkovitz, G., Niv, H., Vorobiyov, L., Zaltsman, Y., Brenner, O. J., Lapidot, T., Jung, S., & Gross, A. (2012) · Nature Cell Biology · doi:10.1038/ncb2468 · Cited by 152 · see citing works
Metabolic regulation by SIRT3: implications for tumorigenesis
Finley, L. W. S., & Haigis, M. C. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.05.004 · Cited by 130 · see citing works
Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair
Ghosh, S., Liu, B., Wang, Y., Hao, Q., & Zhou, Z. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.006 · Cited by 129 · see citing works
Common toxicities of mammalian target of rapamycin inhibitors
Soefje, S. A., Karnad, A. B., & Brenner, A. J. (2011) · Targeted Oncology · doi:10.1007/s11523-011-0174-9 · Cited by 126 · see citing works
SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy
Sampaio‐Marques, B., Felgueiras, C., Silva, A., Rodrigues, M. L., Tenreiro, S., Franssens, V., Reichert, A. S., Outeiro, T. F., Winderickx, J., & Ludovico, P. (2012) · Autophagy · doi:10.4161/auto.21275 · Cited by 123 · see citing works
Mangerich, A., & Bürkle, A. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/321653 · Cited by 121 · see citing works
SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors
Malik, S., Villanova, L., Tanaka, S., Aonuma, M., Roy, N., Berber, E., Pollack, J. R., Michishita-Kioi, E., & Chua, K. F. (2015) · Scientific Reports · doi:10.1038/srep09841 · Cited by 120 · see citing works
Self-citationRECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity
Croteau, D. L., Rossi, M. L., Canugovi, C., Tian, J. Y., Sýkora, P., Ramamoorthy, M., Wang, Z.-M., Singh, D. K., Akbari, M., Kasiviswanathan, R., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00803.x · Cited by 112 · see citing works
Self-citationCapel, F., Rimbert, V., Lioger, D., Diot, A., Rousset, P., Mirand, P. P., Boirie, Y., Morio, B., & Mosoni, L. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.11.001 · Cited by 108 · see citing works
Double strand break rejoining by mammalian mitochondrial extracts
Lakshmipathy, U. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.4.1198 · Cited by 106 · see citing works
Mitochondrial Localization of Telomeric Protein TIN2 Links Telomere Regulation to Metabolic Control
Chen, L., Zhang, Y., Zhang, Q., Li, H., Luo, Z., Fang, H., Kim, S. H., Qin, L., Yotnda, P., Xu, J., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.002 · Cited by 104 · see citing works
Body Mass Index, Change in Body Mass Index, and Survival in Old and Very Old Persons
Dahl, A., Fauth, E. B., Bravell, M. E., Hassing, L. B., Ram, N., & Gerstorf, D. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12158 · Cited by 98 · see citing works
SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism
Luna, A., Aladjem, M. I., & Kohn, K. W. (2013) · Genome Integrity · doi:10.1186/2041-9414-4-6 · Cited by 94 · see citing works
Role of SIRT1 in homologous recombination
Uhl, M., Csernok, A., DİLSİZ, S. A., Kreienberg, R., Wiesmüller, L., & Gatz, S. A. (2010) · DNA repair · doi:10.1016/j.dnarep.2009.12.020 · Cited by 90 · see citing works
Comparative interactomes of SIRT 6 and SIRT 7: Implication of functional links to aging
Lee, N., Kim, D., Kim, E., Park, S. J., Kwon, J., Shin, J., Park, S., Moon, Y. H., Wang, H.-J., Gho, Y. S., et al. (2014) · PROTEOMICS · doi:10.1002/pmic.201400001 · Cited by 85 · see citing works
Linking JNK Activity to the DNA Damage Response
Picco, V., & Pagès, G. (2013) · Genes & Cancer · doi:10.1177/1947601913486347 · Cited by 84 · see citing works
Lindenbaum, Y., Dickson, D. W., Rosenbaum, P. S., Kraemer, K. H., Robbins, J. H., & Rapin, I. (2001) · European Journal of Paediatric Neurology · doi:10.1053/ejpn.2001.0523 · Cited by 83 · see citing works
van der Meer, A. J., Scicluna, B. P., Moerland, P. D., Lin, J., Jacobson, E. W., Vlasuk, G. P., & van der Poll, T. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000000949 · Cited by 70 · see citing works
Xie, X., Li, L., Fan, Y., Lv, L. L., & Zhang, J. (2012) · Autophagy · doi:10.4161/auto.20250 · Cited by 63 · see citing works
A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging
Scheibye‐Knudsen, M., Scheibye-Alsing, K., Canugovi, C., Croteau, D. L., & Bohr, V. A. (2013) · Aging · doi:10.18632/aging.100546 · Cited by 57 · see citing works
Self-citationContribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders
Scheibye-Knudsen, M., Fang, E. F., Croteau, D. L., & Bohr, V. A. (2014) · Autophagy · doi:10.4161/auto.29321 · Cited by 50 · see citing works
Self-citationMaynard, S., Keijzers, G., Gram, M., Desler, C., Bendix, L., Budtz–Jørgensen, E., Molbo, D., Croteau, D. L., Osler, M., Stevnsner, T., et al. (2013) · Aging · doi:10.18632/aging.100618 · Cited by 47 · see citing works
Self-citationAntitumor Potential and other Emerging Medicinal Properties of Natural Compounds
Fang, E. F., & Ng, T. B. (2013) · Springer eBooks · doi:10.1007/978-94-007-6214-5 · Cited by 45 · see citing works
Self-citationP53 and aging: A fresh look at an old paradigm
Poyurovsky, M. V., & Prives, C. L. (2010) · Aging · doi:10.18632/aging.100179 · Cited by 41 · see citing works
Borrowing Nuclear DNA Helicases to Protect Mitochondrial DNA
Ding, L., & Liu, Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160510870 · Cited by 37 · see citing works
Madabushi, A., Hwang, B., Jin, J., & Lu, A.-L. (2013) · Biochemical Journal · doi:10.1042/bj20130670 · Cited by 36 · see citing works
D-beta-Hydroxybutyrate Extends Lifespan in
Edwards, C., Canfield, J., Copes, N., Rehan, M., Lipps, D., & Bradshaw, P. C. (2014) · Digital Commons - University of South Florida (University of South Florida) · Cited by 34 · see citing works
A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function
Hey‐Mogensen, M., Gram, M., Jensen, M. B., Lund, M. T., HANSEN, C. N., Scheibye‐Knudsen, M., Bohr, V. A., & Dela, F. (2015) · The Journal of Physiology · doi:10.1113/jp270204 · Cited by 14 · see citing works
Self-citationA Putative Antiaging Drug Takes a Step From Mice to Men
Leslie, M. (2013) · Science · doi:10.1126/science.342.6160.789 · Cited by 13 · see citing works
Autophagy Upregulation as a Therapeutic Strategy for Neurodegenerative Diseases
Tanasa, M. P., & Rubinsztein, D. C. (2013) · Springer eBooks · doi:10.1007/978-94-007-6214-5_15 · Cited by 5 · see citing works
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Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Guo, J., Huang, X., Dou, L., Yan, M., Shen, T., Tang, W., & Li, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01251-0 · Cited by 1,834 · see citing works
Autophagy in healthy aging and disease
Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00098-4 · Cited by 1,313 · see citing works
Self-citationNAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Xie, N., Zhang, L., Gao, W. Q., Huang, C., Huber, P., Zhou, X., Li, C. L., Shen, G., & Zou, B. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00311-7 · Cited by 1,076 · see citing works
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works
Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms
Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, V. A., & Fang, E. F. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.01.002 · Cited by 870 · see citing works
Self-citationNAD+ in Brain Aging and Neurodegenerative Disorders
Lautrup, S., Sinclair, D. A., Mattson, M. P., & Fang, E. F. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.001 · Cited by 790 · see citing works
Self-citationCellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation
Lü, Y., Li, Z., Zhang, S., Zhang, T., Liu, Y., & Zhang, L. (2023) · Theranostics · doi:10.7150/thno.79876 · Cited by 717 · see citing works
Fang, E. F., Xie, C., Schenkel, J. A., Wu, C., Long, Q., Cui, H., Aman, Y., Frank, J., Liao, J., Zou, H., et al. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101174 · Cited by 704 · see citing works
Self-citationFang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, M., Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.004 · Cited by 575 · see citing works
Self-citationBrain aging and neurodegeneration: from a mitochondrial point of view
Grimm, A., & Eckert, A. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14037 · Cited by 565 · see citing works
Quantitative Analysis of NAD Synthesis-Breakdown Fluxes
Liu, L., Su, X., Quinn, W. J., Hui, S., Krukenberg, K., Frederick, D. W., Redpath, P., Zhan, L., Chellappa, K., White, E., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.018 · Cited by 564 · see citing works
NAD+ metabolism, stemness, the immune response, and cancer
Navas, L. E., & Carnero, A. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00354-w · Cited by 529 · see citing works
NAD(+) in aging: molecular mechanisms and translational implications
Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P., & Bohr, V. A. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.08.001 · Cited by 501 · see citing works
Self-citationAmyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease
Reddy, P. H., & Oliver, D. M. (2019) · Cells · doi:10.3390/cells8050488 · Cited by 496 · see citing works
“This results in a limitation to biogenesis, and mitochondrial DNA damage with age, which further exacerbates mitophagy dysfunction [117].”
BackgroundInfluentialZhu, X., Chen, Z., Shen, W., Huang, G., Sedivy, J. M., Wang, H., & Ju, Z. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00646-9 · Cited by 410 · see citing works
Mitophagy in neurodegeneration and aging
Fivenson, E. M., Lautrup, S., Sun, N., Scheibye-Knudsen, M., Stevnsner, T., Nilsen, H., Bohr, V. A., & Fang, E. F. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.02.007 · Cited by 364 · see citing works
Self-citationThe role of mitochondrial <scp>ROS</scp> in the aging brain
Stefanatos, R., & Sanz, A. (2018) · FEBS Letters · doi:10.1002/1873-3468.12902 · Cited by 358 · see citing works
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Fang, E. F., Hou, Y., Lautrup, S., Jensen, M. B., Yang, B., SenGupta, T., Caponio, D., Khezri, R., Demarest, T. G., Aman, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13172-8 · Cited by 279 · see citing works
Self-citationRottenberg, H., & Hoek, J. B. (2017) · Aging Cell · doi:10.1111/acel.12650 · Cited by 275 · see citing works
Skeletal Aging and Osteoporosis: Mechanisms and Therapeutics
Chandra, A., & Rajawat, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073553 · Cited by 275 · see citing works
The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration
Azam, S., Haque, M. E., Balakrishnan, R., Kim, I., & Choi, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.683459 · Cited by 257 · see citing works
Raefsky, S. M., & Mattson, M. P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.045 · Cited by 274 · see citing works
Self-citationMertens, J., Reid, D. A., Lau, S., Kim, Y., & Gage, F. H. (2018) · Annual Review of Genetics · doi:10.1146/annurev-genet-120417-031534 · Cited by 252 · see citing works
Zhu, Y., Liu, X., Ding, X., Wang, F., & Geng, X. (2019) · Biogerontology · doi:10.1007/s10522-018-9769-1 · Cited by 255 · see citing works
Dela Cruz, C. S., & Kang, M.-J. (2018) · Mitochondrion · doi:10.1016/j.mito.2017.12.001 · Cited by 255 · see citing works
Xia, M., Zhang, Y., Jin, K., Lu, Z., Zeng, Z., & Xiong, W. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0289-8 · Cited by 243 · see citing works
Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis
Mora, A. L., Bueno, M., & Rojas, M. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci87440 · Cited by 234 · see citing works
Mitochondria in the signaling pathways that control longevity and health span
Akbari, M., Kirkwood, T. B. L., & Bohr, V. A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100940 · Cited by 232 · see citing works
Self-citationAging - Oxidative stress, antioxidants and computational modeling
Warraich, U.-E.-A., Hussain, F., & Kayani, H. U. R. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04107 · Cited by 212 · see citing works
Connolly, N. M. C., Theurey, P., Ádám‐Vizi, V., Bazan, N. G., Bernardi, P., Bolaños, J. P., Culmsee, C., Dawson, V. L., Deshmukh, M., Duchen, M. R., et al. (2017) · Cell Death and Differentiation · doi:10.1038/s41418-017-0020-4 · Cited by 208 · see citing works
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Dawson, K. A., & Yan, Y. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00860-0 · Cited by 207 · see citing works
The multifaceted regulation of mitophagy by endogenous metabolites
Zhang, T., Liu, Q., Gao, W., Sehgal, S. A., & Wu, H. (2021) · Autophagy · doi:10.1080/15548627.2021.1975914 · Cited by 207 · see citing works
Bustamante-Barrientos, F. A., Luque‐Campos, N., Araya, M. J., Lara-Barba, E., Solminihac, J. D., Pradenas, C., Molina, L., Herrera-Luna, Y., Utreras‐Mendoza, Y., Elizondo-Vega, R. J., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04493-w · Cited by 194 · see citing works
Fang, E. F., Waltz, T. B., Kassahun, H., Lu, Q., Kerr, J. S., Morevati, M., Fivenson, E. M., Wollman, B. N., Marosi, K., Wilson, M. A., et al. (2017) · Scientific Reports · doi:10.1038/srep46208 · Cited by 187 · see citing works
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Zia, A., Pourbagher‐Shahri, A. M., Farkhondeh, T., & Samarghandian, S. (2021) · Behavioral and Brain Functions · doi:10.1186/s12993-021-00179-9 · Cited by 186 · see citing works
Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications
Xie, S., Xu, S., Deng, W., & Tang, Q. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01378-8 · Cited by 185 · see citing works
Santos, A. L., Sinha, S., & Lindner, A. B. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1941285 · Cited by 168 · see citing works
DNA Damage Response and Autophagy: A Meaningful Partnership
Eliopoulos, A. G., Havaki, S., & Gorgoulis, V. G. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00204 · Cited by 169 · see citing works
Mitochondrial dysfunction in the regulation of aging and aging-related diseases
Zhang, X., Gao, Y., Zhang, S., Wang, Y., Pei, X., Chen, Y., Zhang, J., Zhang, Y., Du, Y., Hao, S., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02308-7 · Cited by 175 · see citing works
DNA-PKcs: A Multi-Faceted Player in DNA Damage Response
Yue, X., Bai, C., Xie, D., Ma, T., & Zhou, P. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.607428 · Cited by 160 · see citing works
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Shmulevich, R., & Krizhanovsky, V. (2021) · Antioxidants & Redox Signaling · doi:10.1089/ars.2020.8043 · Cited by 157 · see citing works
Mitochondria and oxidative stress in heart aging
Martín‐Fernández, B., & Gredilla, R. (2016) · AGE · doi:10.1007/s11357-016-9933-y · Cited by 155 · see citing works
DNA damage related crosstalk between the nucleus and mitochondria
Saki, M. R., & Prakash, A. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.050 · Cited by 151 · see citing works
Davalli, P., Marverti, G., Lauriola, A., & D’Arca, D. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2389523 · Cited by 151 · see citing works
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Sbodio, J. I., Snyder, S. H., & Paul, B. D. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7321 · Cited by 143 · see citing works
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Lejri, I., Grimm, A., & Eckert, A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00124 · Cited by 141 · see citing works
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Reiten, O. K., Wilvang, M. A., Mitchell, S. J., Hu, Z., & Fang, E. F. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111567 · Cited by 133 · see citing works
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Walker, B. R., & Moraes, C. T. (2022) · Biomolecules · doi:10.3390/biom12030427 · Cited by 136 · see citing works
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Li, Z., Zou, J., & Chen, X. S. (2022) · Advanced Materials · doi:10.1002/adma.202209529 · Cited by 132 · see citing works
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Shadfar, S., Parakh, S., Jamali, M. S., & Atkin, J. D. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00350-4 · Cited by 135 · see citing works
Aging: Molecular Pathways and Implications on the Cardiovascular System
de Almeida, A. J. P. O., Ribeiro, T. P., & de Medeiros, I. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7941563 · Cited by 117 · see citing works
Wu, Z., Qu, J., & Liu, G.-H. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00775-3 · Cited by 118 · see citing works
The aging brain: impact of heavy metal neurotoxicity
Ijomone, O. M., Ifenatuoha, C. W., Aluko, O. M., Ijomone, O. K., & Aschner, M. (2020) · Critical Reviews in Toxicology · doi:10.1080/10408444.2020.1838441 · Cited by 116 · see citing works
Veith, C., Boots, A. W., Idris, M., van Schooten, F., & van der Vliet, A. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7742 · Cited by 113 · see citing works
Genotoxic therapy and resistance mechanism in gliomas
Lang, F., Liu, Y., Chou, F.-J., & Yang, C. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107922 · Cited by 113 · see citing works
Integrating the DNA damage and protein stress responses during cancer development and treatment
Gorgoulis, V. G., Pefani, D., Pateras, I. S., & Trougakos, I. P. (2018) · The Journal of Pathology · doi:10.1002/path.5097 · Cited by 108 · see citing works
DNA damage and mitochondria in cancer and aging
Patel, J., Baptiste, B. A., Kim, E., Hussain, M., Croteau, D. L., & Bohr, V. A. (2020) · Carcinogenesis · doi:10.1093/carcin/bgaa114 · Cited by 106 · see citing works
Self-citationKent, A. C., Baradie, K. B. Y. E., & Hamrick, M. W. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6626484 · Cited by 107 · see citing works
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Ranchoux, B., Meloche, J., Paulin, R., Boucherat, O., Provencher, S., & Bonnet, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060990 · Cited by 105 · see citing works
CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss
Teitz, T., Fang, J., Goktug, A. N., Bonga, J. D., Diao, S., Hazlitt, R. A., Iconaru, L. I., Morfouace, M., Currier, D. G., Zhou, Y., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172246 · Cited by 102 · see citing works
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da Silva, P. F. L., & Schumacher, B. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.11.018 · Cited by 99 · see citing works
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Dombi, E., Mortiboys, H., & Poulton, J. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170616101741 · Cited by 99 · see citing works
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Stallone, G., Infante, B., Prisciandaro, C., & Grandaliano, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112774 · Cited by 97 · see citing works
The mitochondrial permeability transition: Nexus of aging, disease and longevity
Rottenberg, H., & Hoek, J. B. (2021) · Cells · doi:10.3390/cells10010079 · Cited by 94 · see citing works
Pollard, A. K., Craig, E. L., & Chakrabarti, L. (2016) · PLOS ONE · doi:10.1371/journal.pone.0157405 · Cited by 94 · see citing works
Autophagy, its mechanisms and regulation: Implications in neurodegenerative diseases
Moloudizargari, M., Asghari, M. H., Ghobadi, E., Fallah, M., Rasouli, S., & Abdollahi, M. R. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.005 · Cited by 93 · see citing works
Entrenching role of cell cycle checkpoints and autophagy for maintenance of genomic integrity
Anand, S. K., Sharma, A., Singh, N., & Kakkar, P. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.102748 · Cited by 91 · see citing works
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Molinaro, C., Martoriati, A., & Cailliau, K. (2021) · Cancers · doi:10.3390/cancers13153819 · Cited by 93 · see citing works
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Scheibye‐Knudsen, M., Tseng, A. H.-H., Jensen, M. B., Scheibye-Alsing, K., Fang, E. F., Iyama, T., Bharti, S. K., Marosi, K., Froetscher, L., Kassahun, H., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610198113 · Cited by 88 · see citing works
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Wu, Z., Sainz, A. G., & Shadel, G. S. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2021.05.004 · Cited by 83 · see citing works
Bono, S., Feligioni, M., & Corbo, M. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00479-8 · Cited by 83 · see citing works
Culberson, J. W., Kopel, J. J., Sehar, U., & Reddy, P. H. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102001 · Cited by 88 · see citing works
Cao, J., Zhong, M. B., Toro, C. A., Zhang, L., & Cai, D. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.03.016 · Cited by 80 · see citing works
Selective autophagy as a therapeutic target for neurological diseases
Xu, W., Ocak, U., Gao, L., Tu, S., Lenahan, C., Zhang, J., & Shao, A. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03667-9 · Cited by 82 · see citing works
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Hosp, F., & Mann, M. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.025 · Cited by 77 · see citing works
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Fakouri, N. B., Hou, Y., Demarest, T. G., Christiansen, L. S., Okur, M. N., Mohanty, J. G., Croteau, D. L., & Bohr, V. A. (2019) · The FEBS Journal · doi:10.1111/febs.14663 · Cited by 77 · see citing works
Self-citationLiao, Q., Deng, J., Tong, J., Gan, Y., Hong, W., Dong, H., Cao, M., Chen, X., Chen, Y., Xie, B., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.11.013 · Cited by 76 · see citing works
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Ijsselsteijn, R., Jansen, J. G., & de Wind, N. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102923 · Cited by 76 · see citing works
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Wu, W.-J., Yang, W., & Tsai, M.-D. (2017) · Nature Reviews Chemistry · doi:10.1038/s41570-017-0068 · Cited by 76 · see citing works
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Babbar, M., Basu, S., Yang, B., Croteau, D. L., & Bohr, V. A. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111207 · Cited by 73 · see citing works
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Ding, D., Xie, L., Shen, Y., Li, J., Guo, Y., Fu, Y., Liu, F.-Y., & Han, F. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8388258 · Cited by 72 · see citing works
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Wang, C.-L., Ohkubo, R., Mu, W., Chen, W., Fan, J. L., Song, Z., Maruichi, A., Sudmant, P. H., Pisco, A. O., Dubal, D. B., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.04.012 · Cited by 72 · see citing works
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Sampath, H., & Lloyd, R. S. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.102667 · Cited by 67 · see citing works
Zhang, L., Zeng, H., & Cheng, W. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.067 · Cited by 66 · see citing works
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Croteau, D. L., Fang, E. F., Nilsen, H. L., & Bohr, V. A. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1285631 · Cited by 65 · see citing works
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Ghosh‐Choudhary, S. K., Liu, J., & Finkel, T. (2021) · The FASEB Journal · doi:10.1096/fj.202101462r · Cited by 65 · see citing works
Current and emerging roles of Cockayne syndrome group B (CSB) protein
Tiwari, V., Baptiste, B. A., Okur, M. N., & Bohr, V. A. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab085 · Cited by 63 · see citing works
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Rodríguez-Cano, A. M., Calzada‐Mendoza, C. C., Estrada‐Gutiérrez, G., Mendoza-Ortega, J. A., & Perichart‐Perera, O. (2020) · Nutrients · doi:10.3390/nu12072166 · Cited by 62 · see citing works
Yu, Y., Li, Z., Cao, G.-T., Huang, S., & Yang, H.-S. (2019) · Journal of Food Science · doi:10.1111/1750-3841.14609 · Cited by 55 · see citing works
Li, Y., Berliocchi, L., Li, Z., & Rasmussen, L. J. (2023) · Aging Cell · doi:10.1111/acel.13942 · Cited by 65 · see citing works
Li, H., Cai, R., Zhou, Y., Jiang, Y., & Tan, S. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03563-8 · Cited by 70 · see citing works
Aman, Y., Frank, J., Lautrup, S., Matysek, A., Niu, Z., Yang, G., Shi, L., Bergersen, L. H., Storm‐Mathisen, J., Rasmussen, L. J., et al. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.111194 · Cited by 59 · see citing works
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Juretschke, T., & Beli, P. (2021) · Matrix Biology · doi:10.1016/j.matbio.2021.02.004 · Cited by 57 · see citing works
Genome Instability and DNA Repair in Somatic and Reproductive Aging
Panier, S., Wang, S., & Schumacher, B. (2023) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-051122-093128 · Cited by 60 · see citing works
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Demarest, T. G., Babbar, M., Okur, M. N., Dan, X., Croteau, D. L., Fakouri, N. B., Mattson, M. P., & Bohr, V. A. (2018) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055905 · Cited by 57 · see citing works
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English, J., Son, J. M., Cardamone, M. D., Lee, C., & Perissi, V. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105161 · Cited by 55 · see citing works
DNA Damage-Induced Neurodegeneration in Accelerated Ageing and Alzheimer’s Disease
Wang, H., Lautrup, S., Caponio, D., Zhang, J., & Fang, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136748 · Cited by 55 · see citing works
Self-citationMitochondria and mitochondria-induced signalling molecules as longevity determinants
Rose, G., Santoro, A., & Salvioli, S. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.002 · Cited by 56 · see citing works
Sarcopenia, Aging and Prospective Interventional Strategies
Waltz, T. B., Fivenson, E. M., Morevati, M., Li, C., Becker, K. G., Bohr, V. A., & Fang, E. F. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170801095850 · Cited by 54 · see citing works
Self-citation
- Authors
- Fang, E. F., Scheibye-Knudsen, M., Chua, K. F., Mattson, M. P., Croteau, D. L., & Bohr, V. A.
- Affiliations
- National Institutes of Health (US)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Bohr, Vilhelm A.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2016-03-09
- Volume
- 17
- Issue
- 5
- Pages
- 308-321
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC5161407
- OpenAlex
- W2296494566
- Cited by
- 387
- References
- 153
- Citations by year
- 2026: 26 · 2025: 34 · 2024: 39 · 2023: 31 · 2022: 41 · 2021: 51 · 2020: 46 · 2019: 34 · 2018: 31 · 2017: 38 · 2016: 15
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1z01ag000723-02, Z01 AG000723)
- National Institute on Aging (R56AG050997)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- nuclear DNA damage, aging, mitochondrial dysfunction, mitochondrial integrity, genome stability, age-related diseases, healthspan, lifespan, pharmacological modulation
- MeSH terms
- Aging, Animals, Cell Nucleus, DNA Damage, DNA Repair, Humans, Mitochondria, Signal Transduction, Apoptosis, Reactive Oxygen Species, Genomic Instability, Mitophagy
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