The DOI matches its Crossref record; 160 of the 162 references it cites were found in a registry or an index.
Targeting drugs to tumours using cell membrane-coated nanoparticles
Abstract
Traditional cancer therapeutics, such as chemotherapies, are often limited by their non-specific nature, causing harm to non-malignant tissues. Over the past several decades, nanomedicine researchers have sought to address this challenge by developing nanoscale platforms capable of more precisely delivering drug payloads. Cell membrane-coated nanoparticles (CNPs) are an emerging class of nanocarriers that have demonstrated considerable promise for biomedical applications. Consisting of a synthetic nanoparticulate core camouflaged by a layer of naturally derived cell membranes, CNPs are adept at operating within complex biological environments; depending on the type of cell membrane utilized, the resulting biomimetic nanoformulation is conferred with several properties typically associated with the source cell, including improved biocompatibility, immune evasion and tumour targeting. In comparison with traditional functionalization approaches, cell membrane coating provides a streamlined method for creating multifunctional and multi-antigenic nanoparticles. In this Review, we discuss the history and development of CNPs as well as how these platforms have been used for cancer therapy. The application of CNPs for drug delivery, phototherapy and immunotherapy will be described in detail. Translational efforts are currently under way and further research to address key areas of need will ultimately be required to facilitate the successful clinical adoption of CNPs.
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“many drug delivery systems based on different cells’ membrane coating, such as red cell membrane, brain tumor cell membrane, immune cell membrane, and so on, could endow the brain targeting abilities”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [193]
Citations
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The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906
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“The high drug loading capacity, controlled drug release, and the ability to integrate diagnostic reagents have further expanded the scope of the application of nanogels [357].”
Background
Metadata
- Authors
- Fang, R. H., Gao, W., & Zhang, L.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Zhang, Liangfang
- Venue
- Nature Reviews Clinical Oncology
- Published
- 2022-10-28
- Volume
- 20
- Issue
- 1
- Pages
- 33-48
- ISSN
- 1759-4774 (ISSN-L)
- 1759-4782
- OpenAlex
- W4307475977
- Semantic Scholar
- aad18fe7d6405872bceb0dd4451cf81880d894d6
- Cited by
- 980
- References
- 162
- Citations by year
- 2026: 249 · 2025: 320 · 2024: 281 · 2023: 129 · 2022: 1
- FWCI
- 12.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Reviews Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA200574)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- cell membrane-coated nanoparticles, anticancer drug delivery, tumor targeting, biomimetic nanocarriers, immune evasion, phototherapy, cancer immunotherapy, nanoparticle biocompatibility
- MeSH terms
- Cell Membrane, Pharmaceutical Preparations, Humans, Neoplasms, Drug Delivery Systems, Nanoparticles
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